Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus

Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267

Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine · doi:10.1038/78693 · Cited by 743

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028

Mechanisms linking obesity with cardiovascular disease

Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682

Adipocytes as regulators of energy balance and glucose homeostasis

Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086

A transgenic model of visceral obesity and the metabolic syndrome

Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Samuel, V. T., & Shulman, G. I. (2016) · Journal of Clinical Investigation · doi:10.1172/jci77812 · Cited by 1,484

The SLC2 (GLUT) family of membrane transporters

Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328

Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,155

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094

Role of Mitochondrial Dysfunction in Insulin Resistance

Kim, J.-A., Wei, Y., & Sowers, J. R. (2008) · Circulation Research · doi:10.1161/circresaha.107.165472 · Cited by 1,103

Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

Wood, I. S., & Trayhurn, P. (2003) · British Journal of Nutrition · doi:10.1079/bjn2002763 · Cited by 889

Regulation of glucose transport by insulin: traffic control of GLUT4

Leto, D., & Saltiel, A. R. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3351 · Cited by 848

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753

Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

Gregor, M. F., & Hotamisligil, G. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700007-jlr200 · Cited by 586

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575

Vitamin A metabolism: An update

D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011) · Nutrients · doi:10.3390/nu3010063 · Cited by 562

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542

The cell biology of fat expansion

Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541

Glucocorticoids, metabolism and metabolic diseases

Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Chadt, A., & Al-Hasani, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02417-x · Cited by 510

Glyceroneogenesis and the triglyceride/fatty acid cycle

Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M., & Hanson, R. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300017200 · Cited by 475

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462

Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450

Current views on type 2 diabetes

Lin, Y., & Sun, Z. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0260 · Cited by 457

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y.-J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308617100 · Cited by 436

Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

Zhao, H., Zhang, J., Cheng, X., Nie, X., & He, B. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-022-01091-0 · Cited by 408

The protein family of glucose transport facilitators: It's not only about glucose after all

Augustin, R. (2010) · IUBMB Life · doi:10.1002/iub.315 · Cited by 398

Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis

McLaughlin, T., Sherman, A., Tsao, P., Gonzalez, O., Yee, G., Lamendola, C., Reaven, G. M., & Cushman, S. W. (2007) · Diabetologia · doi:10.1007/s00125-007-0708-y · Cited by 364

Mitochondria are impaired in the adipocytes of type 2 diabetic mice.

Choo, H.-J., Kim, J.-H., Kwon, O.-B., Lee, C. S., Mun, J. Y., Han, S. S., Yoon, Y.-S., Yoon, G., Choi, K.-M., & Ko, Y.-G. (2006) · Diabetologia · doi:10.1007/s00125-006-0170-2 · Cited by 365

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359

Obesity-related derangements in metabolic regulation

Muoio, D. M., & Newgard, C. B. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142512 · Cited by 345

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

Lee, K. Y., Russell, S. J., Ussar, S., Boucher, J., Vernochet, C., Mori, M. A., Smyth, G., Rourk, M., Cederquist, C., Rosen, E. D., et al. (2013) · Diabetes · doi:10.2337/db12-1089 · Cited by 328

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling

Corbould, A., Kim, Y.-B., Youngren, J. F., Pender, C., Kahn, B. B., Lee, A., & Dunaif, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2004 · Cited by 283

Essential role of mitochondrial function in adiponectin synthesis in adipocytes

Koh, E. H., Park, J.-Y., Park, H.-S., Jeon, M. J., Ryu, J. W., Kim, M., Kim, S. Y., Kim, M.-S., Kim, S.-W., Park, I. S., et al. (2007) · Diabetes · doi:10.2337/db07-0510 · Cited by 275

The adipocyte as an active participant in energy balance and metabolism

Badman, M. K., & Flier, J. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.058 · Cited by 256

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.016 · Cited by 245

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes

Powelka, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26040 · Cited by 236

RBP4: a controversial adipokine

Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0431 · Cited by 233

Sweet Sixteenth for ChREBP: Established Roles and Future Goals

Abdul-Wahed, A., Guilmeau, S., & Postic, C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.004 · Cited by 231

Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies

Giorgino, F., Laviola, L., & Eriksson, J. W. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01385.x · Cited by 230

Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women

Corbould, A. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07070 · Cited by 184

Adipose Tissue and Metabolic Health

An, S.-M., Cho, S.-H., & Yoon, J. C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0011 · Cited by 184

Brain regulation of energy balance and body weight

Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

Fazakerley, D. J., Chaudhuri, R., Yang, P., Maghzal, G. J., Thomas, K. C., Krycer, J. R., Humphrey, S. J., Parker, B. L., Fisher-Wellman, K. H., Meoli, C. C., et al. (2018) · eLife · doi:10.7554/elife.32111 · Cited by 160

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

Wang, C., Wang, C., Huang, H., & Wei, Y. (2013) · The FEBS Journal · doi:10.1111/febs.12096 · Cited by 165

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity

Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157

Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance

Hammarstedt, A., Jansson, P.-A., Wesslau, C., Yang, X., & Smith, U. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00014-7 · Cited by 156

Transgenic rescue of insulin receptor–deficient mice

Okamoto, H., Nakae, J., Kitamura, T., Park, B.-C., Dragatsis, I., & Accili, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421645 · Cited by 151

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling

Boucher, J., Mori, M. A., Lee, K. Y., Smyth, G., Liew, C. W., Macotela, Y., Rourk, M., Bluher, M., Russell, S. J., & Kahn, C. R. (2012) · Nature Communications · doi:10.1038/ncomms1905 · Cited by 142

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Tsai, S., Sitzmann, J. M., Dastidar, S. G., Rodriguez, A. A., Vu, S. L., McDonald, C. E., Academia, E. C., O’Leary, M. N., Ashe, T. D., La Spada, A. R., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77361 · Cited by 126

Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue

Murabayashi, N., Sugiyama, T., Zhang, L., Kamimoto, Y., Umekawa, T., Ma, N., & Sagawa, N. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.02.003 · Cited by 114

Sleep duration and circulating adipokine levels

Hayes, A. L., Xu, F., Babineau, D., & Patel, S. R. (2011) · Sleep · doi:10.1093/sleep/34.2.147 · Cited by 114

CD36-Facilitated Fatty Acid Uptake Inhibits Leptin Production and Signaling in Adipose Tissue

Hajri, T., Hall, A. M., Jensen, D. R., Pietka, T. A., Drover, V. A., Tao, H., Eckel, R., & Abumrad, N. A. (2007) · Diabetes · doi:10.2337/db06-1699 · Cited by 111

Adipose tissue as an endocrine organ

Prins, J. B. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0222 · Cited by 121

Exercise and GLUT4

Flores-Opazo, M., McGee, S. L., & Hargreaves, M. (2020) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000224 · Cited by 102

Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood

Salomäki, H., Vähätalo, L. H., Laurila, K., Jäppinen, N. T., Penttinen, A.-M., Ailanen, L., Ilyasizadeh, J., Pesonen, U., & Koulu, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056594 · Cited by 92

Redox implications in adipose tissue (dys)function-A new look at old acquaintances

Jankovic, A., Korac, A., Buzadzic, B., Otasevic, V., Stancic, A., Daiber, A., & Korac, B. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.018 · Cited by 91

Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes

Pan, X., Zaarur, N., Singh, M., Morin, P., & Kandror, K. V. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-11-0777 · Cited by 89

A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods

Mullican, S. E., Tomaru, T., Gaddis, C. A., Peed, L. C., Sundaram, A., & Lazar, M. A. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1267 · Cited by 83

Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter

Pessler, D., Rudich, A., & Bashan, N. (2001) · Diabetologia · doi:10.1007/s001250100024 · Cited by 82

Insulin hypersensitivity in mice lacking the V1b vasopressin receptor

Fujiwara, Y., Hiroyama, M., Sanbe, A., Aoyagi, T., Birumachi, J., Yamauchi, J., Tsujimoto, G., & Tanoue, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.136481 · Cited by 75

Metabolic control by AMPK in white adipose tissue

Göransson, O., Kopietz, F., & Rider, M. H. (2023) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2023.08.011 · Cited by 74

Role of macrophages in the endocrine system

Rehman, A., Pacher, P., & Haskó, G. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.12.001 · Cited by 71

Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase

Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., & Wu, D. (2011) · Biochemical Journal · doi:10.1042/bj20101680 · Cited by 68

From a glucocentric to a lipocentric approach towards metabolic syndrome

Mittra, S., Bansal, V. S., & Bhatnagar, P. K. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.01.006 · Cited by 48

Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet

M., B., L., A.-K., A., D., E., N., S., R., J., Z., & P., A. (2002) · Diabetologia · doi:10.1007/s00125-002-0875-9 · Cited by 28

Intramyocellular ceramides and skeletal muscle mitochondrial respiration are partially regulated by Toll-like receptor 4 during hindlimb unloading

Kwon, O. S., Nelson, D. S., Barrows, K. M., O'Connell, R. M., & Drummond, M. J. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00253.2016 · Cited by 24

The Degree of Menstrual Disturbance Is Associated With the Severity of Insulin Resistance in PCOS

Li, X., Yang, D., Pan, P., Azziz, R., Yang, D., Cheng, Y., & Zhao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873726 · Cited by 18