Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880

Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,934

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889

Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001450 · Cited by 1,367

Extracellular vesicles for drug delivery.

Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,319

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,175

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

Kosaka, N., Iguchi, H., & Ochiya, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01650.x · Cited by 1,147

Advances in therapeutic applications of extracellular vesicles

Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & EL Andaloussi, S. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav8521 · Cited by 1,039

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Muralidharan-Chari, V., Clancy, J., Plou, C., Romao, M., Chavrier, P., Raposo, G., & D'Souza-Schorey, C. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.059 · Cited by 912

Exosomes in cancer development, metastasis, and immunity

Zhang, L., & Yu, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.004 · Cited by 870

Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer

Hu, Z., Chen, X., Zhao, Y., Tian, T., Jin, G., Shu, Y., Chen, Y., Xu, L., Zen, K., Zhang, C., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.9342 · Cited by 798

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

Kourembanas, S. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071641 · Cited by 761

Extracellular vesicles round off communication in the nervous system

Budnik, V., Ruiz-Cañada, C., & Wendler, F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.29 · Cited by 712

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes

Park, J. E., Tan, H. S., Datta, A., Lai, R. C., Zhang, H., Meng, W., Lim, S. K., & Sze, S. K. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900381-mcp200 · Cited by 582

Microfluidic isolation and transcriptome analysis of serum microvesicles

Chen, C., Skog, J., Hsu, C.-H., Lessard, R. T., Balaj, L., Wurdinger, T., Carter, B. S., Breakefield, X. O., Toner, M., & Irimia, D. (2010) · Lab Chip · doi:10.1039/b916199f · Cited by 572

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553

Extracellular Membrane Vesicles as a Mechanism of Cell-to-Cell Communication: Advantages and Disadvantages

Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483

Exosomes in cancer development and clinical applications

Tai, Y., Chen, K., Hsieh, J., & Shen, T. (2018) · Cancer Science · doi:10.1111/cas.13697 · Cited by 426

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Takasugi, M., Okada, R., Takahashi, A., Virya Chen, D., Watanabe, S., & Hara, E. (2017) · Nature Communications · doi:10.1038/ncomms15728 · Cited by 410

Extracellular vesicles: novel promising delivery systems for therapy of brain diseases.

Rufino-Ramos, D., Albuquerque, P. R., Carmona, V., Perfeito, R., Nobre, R. J., & Pereira de Almeida, L. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.001 · Cited by 418

Exosomes in the tumor microenvironment as mediators of cancer therapy resistance

Li, I., & Nabet, B. Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0975-5 · Cited by 416

Mechanisms associated with biogenesis of exosomes in cancer

McAndrews, K. M., & Kalluri, R. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0963-9 · Cited by 394

Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan

Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

Antonucci, F., Turola, E., Riganti, L., Caleo, M., Gabrielli, M., Perrotta, C., Novellino, L., Clementi, E., Giussani, P., Viani, P., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.489 · Cited by 328

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

Verderio, C., Muzio, L., Turola, E., Bergami, A., Novellino, L., Ruffini, F., Riganti, L., Corradini, I., Francolini, M., Garzetti, L., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23627 · Cited by 326

Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?

Gangoda, L., Boukouris, S., Liem, M., Kalra, H., & Mathivanan, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400234 · Cited by 301

hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

Sun, G., Li, G., Li, D., Huang, W., Zhang, R., Zhang, H., Duan, Y., & Wang, B. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.04.006 · Cited by 314

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells

Svensson, K. J., Kucharzewska, P., Christianson, H. C., Sköld, S., Löfstedt, T., Johansson, M. C., Mörgelin, M., Bengzon, J., Ruf, W., & Belting, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104261108 · Cited by 288

Emerging roles of exosomes in neuron-glia communication

Frühbeis, C., Fröhlich, D., & Krämer-Albers, E.-M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00119 · Cited by 275

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

Huan, J., Hornick, N. I., Shurtleff, M. J., Skinner, A. M., Goloviznina, N. A., Roberts, C. T., & Kurre, P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2184 · Cited by 259

Extracellular Vesicles in Liver Pathobiology: Small Particles With Big Impact

Hirsova, P., Ibrahim, S. H., Verma, V. K., Morton, L. A., Shah, V. H., LaRusso, N. F., Gores, G. J., & Malhi, H. (2016) · Hepatology · doi:10.1002/hep.28814 · Cited by 229

The Cilium Secretes Bioactive Ectosomes

Wood, C. R., Huang, K., Diener, D. R., & Rosenbaum, J. L. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.019 · Cited by 233

Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration

Arscott, W. T., Tandle, A. T., Zhao, S., Shabason, J. E., Gordon, I. K., Schlaff, C. D., Zhang, G., Tofilon, P. J., & Camphausen, K. A. (2013) · Translational Oncology · doi:10.1593/tlo.13640 · Cited by 229

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. C. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 202

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., Kolsteeg, C.-J., Dusoswa, S. A., Ting, D. T., Hickman, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.036 · Cited by 199

Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems

Al‐Nedawi, K., Mian, M. F., Hossain, N., Karimi, K., Mao, Y., Forsythe, P., Min, K. K., Stanisz, A. M., Kunze, W. A., & Bienenstock, J. (2015) · The FASEB Journal · doi:10.1096/fj.14-259721 · Cited by 177

Exosomes and stem cells in degenerative disease diagnosis and therapy

Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C. (2018) · Cell Transplantation · doi:10.1177/0963689717723636 · Cited by 159

In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts

Le Bihan, M.-C., Bigot, A., Jensen, S. S., Dennis, J. L., Rogowska-Wrzesinska, A., Lainé, J., Gache, V., Furling, D., Jensen, O. N., Voit, T., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.09.008 · Cited by 153

Elevated concentration of microvesicles isolated from peripheral blood in breast cancer patients

Galindo-Hernandez, O., Villegas-Comonfort, S., Candanedo, F., González-Vázquez, M.-C., Chavez-Ocaña, S., Jimenez-Villanueva, X., Sierra-Martinez, M., & Salazar, E. P. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.03.002 · Cited by 152

Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides

Geekiyanage, H., Rayatpisheh, S., Wohlschlegel, J. A., Brown, R., & Ambros, V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008323117 · Cited by 148

Skeletal Muscle-Released Extracellular Vesicles: State of the Art

Rome, S., Forterre, A., Mizgier, M. L., & Bouzakri, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00929 · Cited by 139

Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research

Ramirez-Garrastacho, M., Bajo-Santos, C., Line, A., Martens-Uzunova, E. S., de la Fuente, J. M., Moros, M., Soekmadji, C., Tasken, K. A., & Llorente, A. (2022) · British Journal of Cancer · doi:10.1038/s41416-021-01610-8 · Cited by 130

The Emerging Roles of Extracellular Vesicles As Communication Vehicles within the Tumor Microenvironment and Beyond

Sullivan, R., Maresh, G., Zhang, X., Salomon, C., Hooper, J., Margolin, D., & Li, L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00194 · Cited by 112

Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine

Tao, S., Guo, S., & Zhang, C. (2018) · Advanced Science · doi:10.1002/advs.201700449 · Cited by 100

Extracellular vesicles as new players in angiogenesis

Kholia, S., Ranghino, A., Garnieri, P., Lopatina, T., Deregibus, M. C., Rispoli, P., Brizzi, M. F., & Camussi, G. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.03.005 · Cited by 97

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

Setti, M., Osti, D., Richichi, C., Ortensi, B., Del Bene, M., Fornasari, L., Beznoussenko, G., Mironov, A., Rappa, G., Cuomo, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5105 · Cited by 93

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

Brown Harding, H., Kwaku, G. N., Reardon, C. M., Khan, N. S., Zamith-Miranda, D., Zarnowski, R., Tam, J. M., Bohaen, C. K., Richey, L., Mosallanejad, K., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01546-0 · Cited by 82

Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials

Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K. (2022) · Small · doi:10.1002/smll.202104783 · Cited by 81

A novel population of extracellular vesicles smaller than exosomes promotes cell proliferation

Lee, S.-S., Won, J.-H., Lim, G. J., Han, J., Lee, J. Y., Cho, K.-O., & Bae, Y.-K. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0401-z · Cited by 79

Information transfer by exosomes: A new frontier in hematologic malignancies

Boyiadzis, M., & Whiteside, T. L. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.01.004 · Cited by 79

Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles

Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79

Quantitative Proteomic Analysis of Hepatocyte-Secreted Extracellular Vesicles Reveals Candidate Markers for Liver Toxicity

Rodríguez-Suárez, E., Gonzalez, E., Hughes, C., Conde-Vancells, J., Rudella, A., Royo, F., Palomo, L., Elortza, F., Lu, S. C., Mato, J. M., et al. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.04.008 · Cited by 76

Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions

Schiera, G., Di Liegro, C. M., & Di Liegro, I. (2015) · BioMed Research International · doi:10.1155/2015/152926 · Cited by 70

Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)

Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61

The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60

miR-137: A Novel Therapeutic Target for Human Glioma

Wang, Y., Chen, R., Zhou, X., Guo, R., Yin, J., Li, Y., & Ma, G. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.06.028 · Cited by 40

NeuroEVs: Characterizing Extracellular Vesicles Generated in the Neural Domain

Fowler, C. D. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0146-18.2019 · Cited by 35

Liquid biopsy: creating opportunities in brain space

Trivedi, R., & Bhat, K. P. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02446-0 · Cited by 27