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miR-15 and miR-16 induce apoptosis by targeting BCL2
Open accessAbstract
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
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Metadata
- Authors
- Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., Rassenti, L., Alder, H., Volinia, S., Liu, C.-G., Kipps, T. J., Negrini, M., & Croce, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-09-15
- Volume
- 102
- Issue
- 39
- Pages
- 13944-13949
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1985563073
- Cited by
- 3,517
- References
- 5
- FWCI
- 50.56
- Type
- journal article
- Language
- en
- Open access
- green
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