β-catenin is a target for the ubiquitin–proteasome pathway

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THE UBIQUITIN SYSTEM

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Wnt/β-catenin signaling in cancers and targeted therapies

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β-catenin: a key mediator of Wnt signaling

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How the ubiquitin–proteasome system controls transcription

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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

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Mechanical regulation of bone remodeling

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The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

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A common human skin tumour is caused by activating mutations in β-catenin

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Structure of a β-TrCP1-Skp1-β-Catenin Complex

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Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

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Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

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WNT signalling in the immune system: WNT is spreading its wings

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Metabolic zonation of the liver: The oxygen gradient revisited

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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

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Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

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Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

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The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

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Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα

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A Mouse Model of Hepatocellular Carcinoma

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Linking β-Catenin to Androgen-signaling Pathway

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Control of β-Catenin Stability

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TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

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Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

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Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

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Mitotic and mitogenic Wnt signalling

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Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

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Changes in Wnt/β–Catenin Pathway During Regulated Growth in Rat Liver Regeneration

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Dishevelled Proteins Lead to Two Signaling Pathways

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Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

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Expression of Concern: Up‐regulation of Wnt‐1 and β‐catenin production in patients with advanced metastatic prostate carcinoma

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The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway

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Canonical Wnt signaling negatively modulates regulatory T cell function.

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Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

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CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes

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Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling

Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212

Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling

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β-catenin mediates glandular formation and dysregulation of β-catenin induces hyperplasia formation in the murine uterus

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Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

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Roles and regulation of Wnt signaling and β-catenin in prostate cancer

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Role of CRMP-2 in neuronal polarity

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The WNT signaling pathways in wound healing and fibrosis

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Liganded Androgen Receptor Interaction with β-Catenin

Pawlowski, J. E., Ertel, J. R., Allen, M. P., Xu, M., Butler, C., Wilson, E. M., & Wierman, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200545200 · Cited by 166

A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways

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Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

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Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?

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Cell-Cell Contacts Prevent Anoikis in Primary Human Colonic Epithelial Cells

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WNT Signaling and Lymphocyte Development

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Animal models of bipolar mania: The past, present and future

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Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

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Wnt/β-catenin signalling in adrenal physiology and tumour development

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Regulation of Tcf7l1 DNA Binding and Protein Stability as Principal Mechanisms of Wnt/β-Catenin Signaling

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A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

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Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated -Catenin Signaling

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Wnt-7a Induces Presynaptic Colocalization of α7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons

Farías, G. G., Vallés, A. S., Colombres, M., Godoy, J. A., Toledo, E. M., Lukas, R. J., Barrantes, F. J., & Inestrosa, N. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3934-06.2007 · Cited by 108

Lymphoid enhancer factor/T cell factor expression in colorectal cancer

Waterman, M. L. (2004) · Cancer and Metastasis Reviews · doi:10.1023/a:1025858928620 · Cited by 106

Wnt Signaling in Renal Cell Carcinoma

Xu, Q., Krause, M., Samoylenko, A., & Vainio, S. (2016) · Cancers · doi:10.3390/cancers8060057 · Cited by 99

Wnt/β-Catenin Signaling in Alzheimer’s Disease

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Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways

Konsavage, W. M., & Yochum, G. S. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms084 · Cited by 94

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia

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The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium

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Cognitive flexibility and long-term depression (LTD) are impaired following β-catenin stabilization in vivo

Mills, F., Bartlett, T. E., Dissing-Olesen, L., Wisniewska, M. B., Kuznicki, J., Macvicar, B. A., Wang, Y. T., & Bamji, S. X. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404670111 · Cited by 82

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation

Atlasi, Y., Noori, R., Gaspar, C., Franken, P., Sacchetti, A., Rafati, H., Mahmoudi, T., Decraene, C., Calin, G. A., Merrill, B. J., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003424 · Cited by 84

SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling

Rui, H.-L., Fan, E., Zhou, H.-M., Xu, Z., Zhang, Y., & Lin, S.-C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208099200 · Cited by 83

NLK positively regulates Wnt/β‐catenin signalling by phosphorylating LEF1 in neural progenitor cells

Ota, S., Ishitani, S., Shimizu, N., Matsumoto, K., Itoh, M., & Ishitani, T. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.46 · Cited by 82

Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APCMin/+ Mice

Datta, K., Suman, S., Kallakury, B. V. S., & Fornace, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059295 · Cited by 75

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

Reddy, V. S., Valente, A. J., Delafontaine, P., & Chandrasekar, B. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22676 · Cited by 68

Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development

Zeng, Y. A., & Verheyen, E. M. (2004) · Development · doi:10.1242/dev.01177 · Cited by 60

Elucidating the interactions between the adhesive and transcriptional functions of -catenin in normal and cancerous cells

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M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway

Farías, G. G., Godoy, J. A., Hernández, F., Avila, J., Fisher, A., & Inestrosa, N. C. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.016 · Cited by 59

Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded

Noutsou, M., Duarte, A. M. S., Anvarian, Z., Didenko, T., Minde, D. P., Kuper, I., de Ridder, I., Oikonomou, C., Friedler, A., Boelens, R., et al. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.11.013 · Cited by 58

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens

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Evidence of Wnt/β-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease

Dengler-Crish, C. M., Ball, H. C., Lin, L., Novak, K. M., & Cooper, L. N. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.021 · Cited by 58

The USP7 protein interaction network and its roles in tumorigenesis

Al-Eidan, A., Wang, Y., Skipp, P., & Ewing, R. M. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2020.10.004 · Cited by 57

The osteoblastic niche in the context of multiple myeloma

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The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home

van Loosdregt, J., & Coffer, P. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800633 · Cited by 50

A Class III Semaphorin (Sema3e) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro

Hughes, A., Kleine-Albers, J., Helfrich, M. H., Ralston, S. H., & Rogers, M. J. (2012) · Calcified Tissue International · doi:10.1007/s00223-011-9560-7 · Cited by 46

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis

Benham-Pyle, B. W., Sim, J. Y., Hart, K. C., Pruitt, B. L., & Nelson, W. J. (2016) · eLife · doi:10.7554/elife.19799 · Cited by 46

Wnt3a/β-Catenin Signaling Conditions Differentiation of Partially Exhausted T-effector Cells in Human Cancers

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GSK-3 as a novel prognostic indicator in leukemia

Ruvolo, P. P. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.05.001 · Cited by 39

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