Myokines: metabolic regulation in obesity and type 2 diabetes

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

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Muscles, exercise and obesity: skeletal muscle as a secretory organ

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Type 2 diabetes

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

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Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

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Satellite Cells and the Muscle Stem Cell Niche

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Double muscling in cattle due to mutations in the myostatin gene

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Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor

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Muscle–Organ Crosstalk: The Emerging Roles of Myokines

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The integrative biology of type 2 diabetes

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Osteonectin, a bone-specific protein linking mineral to collagen

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IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

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Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

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Interleukin-6, a Major Cytokine in the Central Nervous System

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Adipokines in health and disease

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FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

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Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation

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Epigenetics in Human Obesity and Type 2 Diabetes

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Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions

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Function and biological roles of the Dickkopf family of Wnt modulators

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

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Why does obesity cause diabetes?

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Exerkines in health, resilience and disease

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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Understanding the Physiology of FGF21

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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

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Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

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Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

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Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

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Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

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Physical activity and muscle-brain crosstalk

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Interleukin-6 stimulates lipolysis and fat oxidation in humans

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

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Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

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Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

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Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

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β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

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Physiology and role of irisin in glucose homeostasis

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The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance

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Searching for the exercise factor: is IL-6 a candidate?

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GDF11 increases with age and inhibits skeletal muscle regeneration

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Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

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The myokine irisin increases cortical bone mass

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Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

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Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines

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Suppression of body fat accumulation in myostatin-deficient mice

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The role of hepatokines in metabolism

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Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

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Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

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FGF21 is an Akt‐regulated myokine

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The exerkine apelin reverses age-associated sarcopenia

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Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

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Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease

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Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation

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Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver

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The varying faces of IL-6: From cardiac protection to cardiac failure

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A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

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The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo

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Physical activity and autoimmune diseases: Get moving and manage the disease

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Exercise Metabolism and Adaptation in Skeletal Muscle

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BioID: A Screen for Protein‐Protein Interactions

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A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

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Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat Brain

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Evidence against a Beneficial Effect of Irisin in Humans

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Increased secretion and expression of myostatin in skeletal muscle from extremely obese women

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Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

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FGF21 as Modulator of Metabolism in Health and Disease

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Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome

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A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

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Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

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Dynamics of the skeletal muscle secretome during myoblast differentiation

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Interleukin 6 as an Energy Allocator in Muscle Tissue

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Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

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Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

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Apelin is necessary for the maintenance of insulin sensitivity

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The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

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Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

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Quantitative Fluxomics of Circulating Metabolites

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Myostatin decreases with aerobic exercise and associates with insulin resistance

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Diverse biological functions of the SPARC family of proteins

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Hepatokines and metabolism: Deciphering communication from the liver

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Human and Rat Hepatic Stellate Cells Express Neurotrophins and Neurotrophin Receptors

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Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway

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Progress and Challenges in the Biology of FNDC5 and Irisin

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The role of exercise-induced myokines in regulating metabolism

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