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Neurobiology of Pavlovian Fear Conditioning

Maren, Stephen·2001·Annual Review of Neuroscience

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Abstract

▪ Abstract Learning the relationships between aversive events and the environmental stimuli that predict such events is essential to the survival of organisms throughout the animal kingdom. Pavlovian fear conditioning is an exemplar of this form of learning that is exhibited by both rats and humans. Recent years have seen an incredible surge in interest in the neurobiology of fear conditioning. Neural circuits underlying fear conditioning have been mapped, synaptic plasticity in these circuits has been identified, and biochemical and genetic manipulations are beginning to unravel the molecular machinery responsible for the storage of fear memories. These advances represent an important step in understanding the neural substrates of a rapidly acquired and adaptive form of associative learning and memory in mammals.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
Conditioned emotional reactions.
Watson, J. B., & Rayner, R. (1920) · Journal of Experimental Psychology · doi:10.1037/h0069608 · Cited by 2,005
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
Double Dissociation of Conditioning and Declarative Knowledge Relative to the Amygdala and Hippocampus in Humans
Bechara, A., Tranel, D., Damasio, H., Adolphs, R., Rockland, C., & Damasio, A. R. (1995) · Science · doi:10.1126/science.7652558 · Cited by 1,400
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala
Pitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980
The role of ventromedial prefrontal cortex in the recovery of extinguished fear
Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897
Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
Rampon, C., Tang, Y.-P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z. (2000) · Nature Neuroscience · doi:10.1038/72945 · Cited by 755 · cited 1×
“Contextual fear conditioning deficits in hippocampal NMDA receptor–knockout mice are overcome by P1: FQP April 4, 2001 18:39 Annual Reviews AR121-29 918 MAREN environmental enrichment (Rampon et al 2000).”
Background
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673
Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage
Chun, M. M., & Phelps, E. A. (1999) · Nature Neuroscience · doi:10.1038/12222 · Cited by 554
Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment
Beck, C., & Fibiger, H. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00709.1995 · Cited by 547
Different Training Procedures Recruit Either One or Two Critical Periods for Contextual Memory Consolidation, Each of Which Requires Protein Synthesis and PKA
Bourtchouladze, R., Abel, T., Berman, N., Gordon, R., Lapidus, K., & Kandel, E. R. (1998) · Learning & Memory · doi:10.1101/lm.5.4.365 · Cited by 525
Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to psychological stress in the rat
Goldstein, L. E., Rasmusson, A. M., Bunney, B. S., & Roth, R. H. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04787.1996 · Cited by 387
Cardiovascular responses elicited by stimulation of neurons in the central amygdaloid nucleus in awake but not anesthetized rats resemble conditioned emotional responses
Iwata, J., Chida, K., & LeDoux, J. E. (1987) · Brain Research · doi:10.1016/0006-8993(87)90978-4 · Cited by 272
A selective role for corticosterone in contextual-fear conditioning
Pugh, C. R., Tremblay, D., Fleshner, M., & Rudy, J. W. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.3.503 · Cited by 272
Independence of memory functions and emotional behavior: Separate contributions of the hippocampal formation and the amygdala
Zola‐Morgan, S., Squire, L. R., Clower, R. P., & Alvarez‐Royo, P. (1991) · Hippocampus · doi:10.1002/hipo.450010208 · Cited by 265 · cited 4×
“Neurosci.108:19–29 Zola Morgan S, Squire LR, Alvarez Royo P, Clower RP. 1991.”
BackgroundInfluential
Correlation between the Pharmacology of Long-Term Potentiation and the Pharmacology of Memory
Izquierdo, I., & Medina, J. H. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.1002 · Cited by 230
Differential effects of the N-methyl-d-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues
Fanselow, M. S., Kim, J. J., Yipp, J., & De Oca, B. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.2.235 · Cited by 142
Lesions of the central nucleus of the amygdala block conditioned excitation, but not conditioned inhibition of fear as measured with the fear-potentiated startle effect.
Falls, W. A., & Davis, M. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.379 · Cited by 110 · cited 1×
“A number of brain structures known to be important for excitatory fear conditioning, including the amygdala, perirhinal cortex, and medial geniculate nucleus, do not appear to be involved in conditioned inhibition of fear (Falls et al 1997, Falls & Davis 1995, Heldt & Falls 1998).”
Background

Research works printed but not linked: 214

10.1016/S0092-8674(00)81904-2 · DOI · Paper page
10.1016/0092-8674(93)90613-U · DOI
10.1016/0092-8674(93)90614-V · DOI
10.1523/JNEUROSCI.15-09-05879.1995 · DOI · Paper page
10.1016/S0028-3932(99)00039-1 · DOI
10.1038/71145 · DOI · Paper page
10.1101/lm.6.5.491 · DOI
10.1002/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7 · DOI
10.1016/S0166-4328(97)00115-0 · DOI
10.1523/JNEUROSCI.19-03-01106.1999 · DOI
10.1016/S0893-133X(99)00083-4 · DOI
10.1016/S0166-4328(99)00121-7 · DOI · Paper page
10.1523/JNEUROSCI.18-07-02592.1998 · DOI
10.1037//0735-7044.113.2.276 · DOI
10.1037//0735-7044.110.4.727 · DOI
10.1037/h0033521 · DOI
10.1113/jphysiol.1973.sp010273 · DOI · Paper page
10.1016/0092-8674(94)90400-6 · DOI · Paper page
10.1037//0033-2909.114.1.80 · DOI · Paper page
10.1037/h0055426 · DOI
10.1038/36849 · DOI
10.1016/0006-8993(87)90994-2 · DOI
10.1002/cne.900870102 · DOI
10.1098/rstb.1888.0011 · DOI
10.1523/JNEUROSCI.19-24-10869.1999 · DOI
10.1016/S0166-2236(97)01214-9 · DOI · Paper page
10.1016/S0896-6273(00)80774-6 · DOI
10.1523/JNEUROSCI.15-03-02312.1995 · DOI
10.1523/JNEUROSCI.15-03-02301.1995 · DOI · Paper page
10.1016/0006-8993(91)91669-R · DOI
10.1037//0735-7044.106.3.569 · DOI
10.1002/syn.890110406 · DOI
10.1002/syn.890060306 · DOI
10.1016/S0166-4328(98)00054-0 · DOI
10.1523/JNEUROSCI.10-08-02818.1990 · DOI
10.1101/lm.7.2.97 · DOI · Paper page
10.1037//0735-7044.112.5.1092 · DOI
10.1016/S1364-6613(98)01265-0 · DOI · Paper page
10.1146/annurev.ne.15.030192.002033 · DOI · Paper page
10.1523/JNEUROSCI.18-09-03426.1998 · DOI
10.1037//0735-7044.106.1.81 · DOI
10.1037//0735-7044.111.4.712 · DOI
10.1037//0735-7044.109.3.379 · DOI · Paper page
10.3758/BF03205285 · DOI
10.1111/1467-8721.ep10768969 · DOI
10.3758/BF03210947 · DOI · Paper page
10.1017/S0140525X97251599 · DOI
10.1016/S0166-4328(99)00186-2 · DOI
10.1037//0735-7044.108.1.210 · DOI
10.1037//0735-7044.108.2.235 · DOI · Paper page
10.1016/S0896-6273(00)80775-8 · DOI
Fonberg E, 1965, Bull. Acad. Pol. Sci. Biol., 13, 429
10.1016/0006-8993(94)91120-7 · DOI
10.1037//0735-7044.112.4.863 · DOI · Paper page
10.1037//0735-7044.114.3.647 · DOI
10.1097/00001756-199202000-00018 · DOI
10.1038/46286 · DOI · Paper page
10.1016/0006-8993(83)91344-6 · DOI
10.1038/41325 · DOI
10.1037//0735-7044.111.4.712 · DOI
10.1016/S0166-4328(99)00187-4 · DOI
10.1037//0735-7044.113.3.507 · DOI
10.1037/h0044853 · DOI
10.1037//0735-7044.111.5.996 · DOI
10.1016/S0166-4328(00)00224-2 · DOI
10.1038/347477a0 · DOI · Paper page
10.1016/S0006-8993(99)01291-3 · DOI
10.1037/0735-7044.113.5.925 · DOI
10.1523/JNEUROSCI.20-07-j0002.2000 · DOI
10.1016/S0006-8993(98)01047-6 · DOI
10.1037//0735-7044.106.3.518 · DOI
10.1037//0735-7044.108.5.1005 · DOI
10.1016/S0091-6773(74)92231-7 · DOI · Paper page
10.1037//0735-7044.100.1.11 · DOI
10.1016/S0959-4388(99)80027-0 · DOI
10.1016/S1364-6613(98)01271-6 · DOI
10.1523/JNEUROSCI.19-20-09054.1999 · DOI
10.1037//0735-7044.107.1.23 · DOI
10.1016/S0959-4388(00)00069-6 · DOI
10.1037/h0041108 · DOI
10.1016/S0896-6273(00)80524-3 · DOI · Paper page
10.1523/JNEUROSCI.20-17-06317.2000 · DOI
10.1016/S0896-6273(00)80909-5 · DOI
10.1038/2830 · DOI
10.1016/0006-8993(86)90020-X · DOI
10.1016/S0091-6773(78)92836-5 · DOI
10.1016/0006-8993(82)90866-6 · DOI
10.2466/pr0.1963.12.2.351 · DOI
10.1038/41097 · DOI
10.1037/0735-7044.105.1.126 · DOI
10.1037//0735-7044.106.2.336 · DOI
10.1037//0735-7044.107.6.1093 · DOI · Paper page
10.1016/0163-1047(93)91075-X · DOI
10.1037//0735-7044.107.6.1088 · DOI
10.1097/00005053-195801000-00006 · DOI
10.1523/JNEUROSCI.18-17-06704.1998 · DOI
Klüver H, 1937, Am. J. Physiol., 119, 352
10.1146/annurev.ps.46.020195.003101 · DOI
10.1002/cne.901780205 · DOI · Paper page
10.1016/S0896-6273(00)80475-4 · DOI · Paper page
10.1523/JNEUROSCI.15-10-06846.1995 · DOI · Paper page
10.1146/annurev.ps.46.020195.001233 · DOI · Paper page
10.1523/JNEUROSCI.10-04-01062.1990 · DOI · Paper page
10.1523/JNEUROSCI.08-07-02517.1988 · DOI · Paper page
10.1016/0306-4522(86)90034-5 · DOI
10.1523/JNEUROSCI.18-20-08444.1998 · DOI
10.1037//0735-7044.110.4.836 · DOI
10.1523/JNEUROSCI.18-05-01662.1998 · DOI
10.1007/BF00242185 · DOI
10.1016/0166-4328(82)90002-X · DOI
10.1016/S0306-4522(00)00058-0 · DOI
10.1007/BF02740749 · DOI
10.1017/S0140525X97321591 · DOI
10.1523/JNEUROSCI.18-08-03088.1998 · DOI
10.1016/S0166-2236(99)01465-4 · DOI
10.1523/JNEUROSCI.19-19-08696.1999 · DOI
10.1037//0735-7044.113.2.283 · DOI
10.1016/S0166-2236(00)01600-3 · DOI
Maren S, 2001, Eur. J. Neurosci.
Maren S. 2001b. Multiple roles for synaptic plasticity in Pavlovian fear conditioning. In Neuronal Mechanisms of Memory Formation , ed. C Holscher, pp. 77–99. Cambridge: Cambridge Univ. Press · DOI
10.1037//0735-7044.110.4.718 · DOI
10.1016/S0166-4328(97)00088-0 · DOI
10.1037//0735-7044.110.6.1365 · DOI
10.1016/S1364-6613(98)01123-1 · DOI
10.1006/nlme.1995.1001 · DOI
10.1037//0735-7044.108.3.645 · DOI
10.1037//0735-7044.108.1.44 · DOI
10.1016/0006-8993(94)91176-2 · DOI
10.1523/JNEUROSCI.15-11-07548.1995 · DOI
10.1016/S0896-6273(00)80041-0 · DOI
10.1006/nlme.1996.3752 · DOI
10.1037//0097-7403.24.3.369 · DOI
10.1016/S0166-4328(99)00188-6 · DOI · Paper page
10.1016/0006-8993(91)90473-9 · DOI
10.1146/annurev.neuro.23.1.649 · DOI · Paper page
10.1126/science.274.5293.1678 · DOI · Paper page
10.1016/0006-8993(93)91623-Z · DOI
10.1016/S0301-0082(98)00003-3 · DOI · Paper page
10.1002/(SICI)1098-1063(1998)8:6<638::AID-HIPO6>3.0.CO;2-Q · DOI
10.1523/JNEUROSCI.16-03-01273.1996 · DOI
10.1016/0006-8993(95)00331-J · DOI
10.1126/science.287.5451.248 · DOI · Paper page
10.1523/JNEUROSCI.17-23-09353.1997 · DOI
10.1037//0735-7044.114.1.64 · DOI
10.1038/37605 · DOI · Paper page
10.1046/j.1460-9568.1999.00854.x · DOI
10.1037//0735-7044.109.4.681 · DOI · Paper page
10.1037//0735-7044.111.4.683 · DOI
10.1037/h0036973 · DOI
10.1037//0735-7044.113.5.891 · DOI
10.1038/35021052 · DOI · Paper page
10.1523/JNEUROSCI.20-07-02701.2000 · DOI
Pavlov IP, 1927, Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex.
10.1038/39051 · DOI · Paper page
Phillips RG, 1994, Learn. Mem., 1, 34, 10.1101/lm.1.1.34 · DOI · Paper page
10.1523/JNEUROSCI.15-07-05308.1995 · DOI
10.1523/JNEUROSCI.19-21-09635.1999 · DOI
10.1037//0735-7044.111.3.512 · DOI
10.1016/S0896-6273(00)80375-X · DOI
10.1016/0896-6273(95)90092-6 · DOI · Paper page
10.1046/j.1460-9568.2000.00108.x · DOI
10.1037//0003-066X.43.3.151 · DOI · Paper page
10.1037/0735-7044.113.6.1189 · DOI
10.1097/00001756-199707280-00013 · DOI
10.1037/h0045711 · DOI
10.1016/0896-6273(95)90070-5 · DOI
10.1016/S0092-8674(00)81247-7 · DOI
10.1523/JNEUROSCI.17-15-05928.1997 · DOI
10.1037//0735-7044.107.3.444 · DOI · Paper page
10.1523/JNEUROSCI.12-11-04501.1992 · DOI
10.1016/0031-9384(91)90017-I · DOI
10.1016/S0006-8993(98)00294-7 · DOI
10.1523/JNEUROSCI.12-12-04624.1992 · DOI
10.1037//0033-295X.105.2.325 · DOI
10.1037//0735-7044.107.5.887 · DOI
10.1006/nlme.1996.0008 · DOI
10.1037//0735-7044.113.2.316 · DOI
10.1037//0735-7044.113.5.867 · DOI
10.1523/JNEUROSCI.19-21-09570.1999 · DOI
10.1037//0735-7044.106.1.72 · DOI
Schafe GE, 1999, Learn. Mem., 6, 97, 10.1101/lm.6.2.97 · DOI
10.1016/0306-4522(91)90379-3 · DOI
10.1523/JNEUROSCI.19-01-00420.1999 · DOI
10.1017/S0140525X97001593 · DOI
10.1037//0735-7044.103.6.1276 · DOI
10.1016/S0166-2236(98)01265-X · DOI · Paper page
10.1038/43432 · DOI
10.1146/annurev.ne.17.030194.002511 · DOI
10.1016/0006-8993(91)91382-B · DOI
10.1037//0735-7044.111.3.653 · DOI
10.1037//0735-7044.107.5.770 · DOI
10.1016/S0166-2236(00)01599-X · DOI
10.1073/pnas.95.25.15003 · DOI · Paper page
10.1523/JNEUROSCI.19-15-06615.1999 · DOI
10.1037/0735-7044.114.4.720 · DOI
10.1037//0735-7044.112.4.875 · DOI
10.1523/JNEUROSCI.17-23-09375.1997 · DOI · Paper page
10.1523/JNEUROSCI.19-24-10656.1999 · DOI
10.1037//0735-7044.107.2.402 · DOI
Watson JB, 1920, Experimental Investigation of Babies.

200 of 214 shown

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Authors: Maren, S.
Affiliations: Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109-1109;
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2001-03
Volume: 24
Issue: 1
Pages: 897-931
ISSN: 0147-006X
1545-4126
DOI: 10.1146/annurev.neuro.24.1.897
Cited by: 1,543
References: 28
Language: en

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Neurobiology of Pavlovian Fear Conditioning

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