Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

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Untitled work

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Hyperinsulinemia as an independent risk factor for ischemic heart disease

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Hormone-fuel interrelationships during fasting.

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Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome

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The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids

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A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women

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A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

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Plasma Amino Acid Levels and Insulin Secretion in Obesity

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Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

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The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

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A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations

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Glucose metabolism during leg exercise in man

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Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.

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Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

Gelfand, R. A., & Barrett, E. J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113033 · Cited by 522

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

Baura, G. D., Foster, D. M., Porte, D., Kahn, S. E., Bergman, R. N., Cobelli, C., & Schwartz, M. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116773 · Cited by 489

Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.

Horwitz, D. L., Starr, J. I., Mako, M. E., Blackard, W. G., & Rubenstein, A. H. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108047 · Cited by 473

Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome1

Ehrmann, D. A., Schneider, D. J., Sobel, B. E., Cavaghan, M. K., Imperial, J., Rosenfield, R. L., & Polonsky, K. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4069 · Cited by 461

Quantitative study of insulin secretion and clearance in normal and obese subjects

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Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep

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The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations

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Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes.

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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

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The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.

Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418

Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.

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A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*

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Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.

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Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., & Holloszy, J. O. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1033 · Cited by 353

Suppression of Serum Insulin by Diazoxide Reduces Serum Testosterone Levels in Obese Women with Polycystic Ovary Syndrome*

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Norepinephrine: hormone and neurotransmitter in man.

Silverberg, A. B., Shah, S. D., Haymond, M. W., & Cryer, P. E. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.3.e252 · Cited by 338

A mathematical model of compartmentalized neurotransmitter metabolism in the human brain

Gruetter, R., Seaquist, E. R., & Ugurbil, K. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e100 · Cited by 326

Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity

Breda, E., Cavaghan, M. K., Toffolo, G., Polonsky, K. S., & Cobelli, C. (2001) · Diabetes · doi:10.2337/diabetes.50.1.150 · Cited by 320

SERUM-ALPHA-FETOPROTEIN LEVELS IN PATIENTS WITH ATAXIA-TELANGIECTASIA

Waldmann, T., & Mcintire, K. R. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92717-1 · Cited by 319

Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus

Amiel, S. A., Tamborlane, W. V., Simonson, D. C., & Sherwin, R. S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705283162205 · Cited by 309

Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet

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A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-MEAT).

Crimarco, A., Springfield, S., Petlura, C., Streaty, T., Cunanan, K., Lee, J., Fielding-Singh, P., Carter, M. M., Topf, M. A., Wastyk, H. C., et al. (2020) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa203 · Cited by 286

The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

Nieves, D. J., Cnop, M., Retzlaff, B., Walden, C. E., Brunzell, J. D., Knopp, R. H., & Kahn, S. E. (2003) · Diabetes · doi:10.2337/diabetes.52.1.172 · Cited by 281

Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

Ward, W. K., LaCava, E. C., Paquette, T. L., Beard, J. C., Wallum, B. J., & Porte, D. (1987) · Diabetologia · doi:10.1007/bf00296991 · Cited by 275

Insulin in the Cerebrospinal Fluid

MARGOLIS, R. U., & ALTSZULER, N. (1967) · Nature · doi:10.1038/2151375a0 · Cited by 278

Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men: A Randomized Controlled Trial

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Postexercise nutrient intake timing in humans is critical to recovery of leg glucose and protein homeostasis

Levenhagen, D. K., Gresham, J. D., Carlson, M. G., Maron, D. J., Borel, M. J., & Flakoll, P. J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.6.e982 · Cited by 239

Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm

Van Cauter, E., Shapiro, E. T., Tillil, H., & Polonsky, K. S. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.4.e467 · Cited by 240

Inhibition of Insulin Release by Norepinephrine in Man

Porte, D., & Williams, R. H. (1966) · Science · doi:10.1126/science.152.3726.1248 · Cited by 238

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults

Villareal, D. T., Miller, B. V., Banks, M., Fontana, L., Sinacore, D. R., & Klein, S. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1317 · Cited by 235

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

Ikeda, H., West, D. B., Pustek, J. J., Figlewicz, D. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1986) · Appetite · doi:10.1016/s0195-6663(86)80006-x · Cited by 230

Effect of experimental potassium deficiency on glucose and insulin metabolism

Rowe, J. W., Tobin, J. D., Rosa, R. M., & Andres, R. (1980) · Metabolism · doi:10.1016/0026-0495(80)90074-8 · Cited by 226

Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus

Kirwan, J. P., Solomon, T. P. J., Wojta, D. M., Staten, M. A., & Holloszy, J. O. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00210.2009 · Cited by 218

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

Cavaghan, M. K., Ehrmann, D. A., Byrne, M. M., & Polonsky, K. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119562 · Cited by 216

Metabolic Effects of Short-Term Elevations of Plasma Cortisol Are More Pronounced in the Evening Than in the Morning1

Plat, L., Leproult, R., L’Hermite-Baleriaux, M., Fery, F., Mockel, J., Polonsky, K. S., & Van Cauter, E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5978 · Cited by 225

Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids.

Schalch, D. S., & Kipnis, D. M. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105308 · Cited by 210

Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity

Elahi, D., Nagulesparan, M., Hershcopf, R. J., Muller, D. C., Tobin, J. D., Blix, P. M., Rubenstein, A. H., Unger, R. H., & Andres, R. (1982) · New England Journal of Medicine · doi:10.1056/nejm198205203062002 · Cited by 210

Diet and Exercise Interventions Reduce Intrahepatic Fat Content and Improve Insulin Sensitivity in Obese Older Adults

Shah, K., Stufflebam, A., Hilton, T. N., Sinacore, D. R., Klein, S., & Villareal, D. T. (2009) · Obesity · doi:10.1038/oby.2009.126 · Cited by 194

Branched-Chain Amino Acid Supplementation Before Squat Exercise and Delayed-Onset Muscle Soreness

Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto, G., Sato, J., Shimomura, N., Kobayashi, H., & Mawatari, K. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.3.236 · Cited by 166

Effect of Weight Loss with Reduction of Intra-Abdominal Fat on Lipid Metabolism in Older Men

Purnell, J. Q. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.3.977 · Cited by 161

Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.

Polonsky, K., Jaspan, J., Pugh, W., Cohen, D., Schneider, M., Schwartz, T., Moossa, A. R., Tager, H., & Rubenstein, A. H. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111036 · Cited by 158

Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects

Vega-López, S., Ausman, L. M., Jalbert, S. M., Erkkilä, A. T., & Lichtenstein, A. H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.54 · Cited by 160

Effect of diet composition on the hyperinsulinemia of obesity

Grey, N., & Kipnis, D. M. (1971) · New England Journal of Medicine · doi:10.1056/nejm197110072851504 · Cited by 156

Quinides of roasted coffee enhance insulin action in conscious rats

Shearer, J., Farah, A., de Paulis, T., Bracy, D. P., Pencek, R. R., Graham, T. E., & Wasserman, D. H. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.11.3529 · Cited by 154

Effects of Gender on Neuroendocrine and Metabolic Counterregulatory Responses to Exercise in Normal Man1

Davis, S. N., Galassetti, P., Wasserman, D. H., & Tate, D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6328 · Cited by 152

Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome.

Elder, S. J., Lichtenstein, A. H., Pittas, A. G., Roberts, S. B., Fuss, P. J., Greenberg, A. S., McCrory, M. A., Bouchard, T. J., Saltzman, E., & Neale, M. C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.p900033-jlr200 · Cited by 139

Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus.

O'Meara, N. M., Sturis, J., Van Cauter, E., & Polonsky, K. S. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116560 · Cited by 132

The 24-hour excursion and diurnal rhythm of glucose, insulin, and C-peptide in normal pregnancy

Cousins, L., Rigg, L., Hollingsworth, D., Brink, G., Aurand, J., & Yen, S. S. C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90675-4 · Cited by 130

Aerobic power and insulin action improve in response to endurance exercise training in healthy 77–87 yr olds

Evans, E. M., Racette, S. B., Peterson, L. R., Villareal, D. T., Greiwe, J. S., & Holloszy, J. O. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00928.2004 · Cited by 112

Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function

Utzschneider, K. M., Carr, D. B., Hull, R. L., Kodama, K., Shofer, J. B., Retzlaff, B. M., Knopp, R. H., & Kahn, S. E. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2867 · Cited by 109

Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome

Blaese, R. M., Strober, W., Levy, A. L., & Waldmann, T. A. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106731 · Cited by 108

Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.

Greenbaum, C. J., Havel, P. J., Taborsky, G. J., & Klaff, L. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115375 · Cited by 106

Functional Significance of Polycystic-Size Ovaries in Healthy Adolescents

Mortensen, M., Rosenfield, R. L., & Littlejohn, E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0835 · Cited by 103

Circulating proinsulin in patients with maturity onset diabetes

Mako, M. E., Starr, J. I., & Rubenstein, A. H. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90538-1 · Cited by 99

The thermic effect of feeding in older men: the importance of the sympathetic nervous system

Schwartz, R. S., Jaeger, L. F., & Veith, R. C. (1990) · Metabolism · doi:10.1016/0026-0495(90)90109-p · Cited by 98

Direct measurement of plasma proinsulin in normal and diabetic subjects

Duckworth, W. C., Kitabchi, A. E., & Heinemann, M. (1972) · The American Journal of Medicine · doi:10.1016/0002-9343(72)90137-4 · Cited by 99

Physiological Concentrations of Cholecystokinin Stimulate Amino Acid-Induced Insulin Release in Humans*

RUSHAKOFF, R. J., GOLDFINE, I. D., CARTER, J. D., & LIDDLE, R. A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-3-395 · Cited by 96

Evaluation of an alternating-calorie diet with and without exercise in the treatment of obesity

Hill, J. O., Schlundt, D. G., Sbrocco, T., Sharp, T., Pope-Cordle, J., Stetson, B., Kaler, M., & Heim, C. (1989) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.2.248 · Cited by 93

Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat

Brozinick, J. T., Etgen, G. J., Yaspelkis, B. B., & Ivy, J. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.1.382 · Cited by 89

The influence of age and dietary conditions on diabetes in the db mouse

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Relationship of Islet Function to Insulin Action in Human Obesity*

BEARD, J. C., WARD, W. K., WALLUM, B. J., & PORTE, D. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-1-59 · Cited by 75

Diet-Induced Weight Loss Is Associated with an Improvement in β-Cell Function in Older Men

Utzschneider, K. M., Carr, D. B., Barsness, S. M., Kahn, S. E., & Schwartz, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031827 · Cited by 73

Compartmental modeling of glucagon kinetics in the conscious dog

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A Reduced-Fat Diet and Aerobic Exercise in J apanese A mericans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not β-Cell Function

Carr, D. B., Utzschneider, K. M., Boyko, E. J., Asberry, P. J., Hull, R. L., Kodama, K., Callahan, H. S., Matthys, C. C., Leonetti, D. L., Schwartz, R. S., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.340 · Cited by 69

The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus

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Hepatic metabolism of glucagon in the dog: contribution of the liver to overall metabolic disposal of glucagon

Jaspan, J. B., Polonsky, K. S., Lewis, M., Pensler, J., Pugh, W., Moossa, A. R., & Rubenstein, A. H. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.3.e233 · Cited by 68

β-hydroxy-β-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans

Vukovich, M. D., Slater, G., Macchi, M. B., Turner, M. J., Fallon, K., Boston, T., & Rathmacher, J. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00182-6 · Cited by 66

Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat

Halseth, A. E., Bracy, D. P., & Wasserman, D. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1064 · Cited by 57

Elevated immunoreactive insulin concentration during spontaneous attacks in thyrotoxic periodic paralysis

Shishiba, Y., Shimizu, T., Saito, T., & Shizume, K. (1972) · Metabolism · doi:10.1016/0026-0495(72)90071-6 · Cited by 56

Intractable Early Childhood Obesity as the Initial Sign of Insulin Resistant Hyperinsulinism and Precursor of Polycystic Ovary Syndrome

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The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase

Patalay, M., Lofgren, I. E., Freake, H. C., Koo, S. I., & Fernandez, M. L. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.4.735 · Cited by 53

Sulfonylurea-Induced Factitious Hypoglycemia: A Growing Problem

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Weight loss on low-fat vs. low-carbohydrate diets by insulin resistance status among overweight adults and adults with obesity: a randomized pilot trial

Gardner, C. D., Offringa, L. C., Hartle, J. C., Kapphahn, K., & Cherin, R. (2016) · Obesity · doi:10.1002/oby.21331 · Cited by 47

Tissue Oxidative Capacity, Fuel Stores and Skeletal Muscle Fatty Acid Composition In Obesity‐Prone and Obesity‐Resistant Rats

Pagliassotti, M. J., Pan, D. A., Prach, P. A., Koppenhafer, T. A., Storlien, L., & Hill, J. O. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00175.x · Cited by 47

Modest Lifestyle Intervention and Glucose Tolerance in Obese African Americans

Racette, S. B., Weiss, E. P., Obert, K. A., Kohrt, W. M., & Holloszy, J. O. (2001) · Obesity Research · doi:10.1038/oby.2001.45 · Cited by 46

The effect of modafinil on counter-regulatory and cognitive responses to hypoglycaemia

Smith, D., Pernet, A., Rosenthal, J. M., Bingham, E. M., Reid, H., Macdonald, I. A., & Amiel, S. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1513-5 · Cited by 31

Changes in insulin sensitivity, glucose effectiveness, and B-cell function in regularly exercising subjects

Prigeon, R. L., Kahn, S. E., & Porte, D. (1995) · Metabolism · doi:10.1016/0026-0495(95)90026-8 · Cited by 30

A glucose-responsive insulinoma.

Power, L. (1969) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1969.03150180023004 · Cited by 24

Serial Changes in Glucose Utilization and Insulin and Growth Hormone Secretion in Acute Cerebrovascular Disease

Huff, T. A., Lebovitz, H. E., HEYMAN, A., & Davis, L. (1972) · Stroke · doi:10.1161/01.str.3.5.543 · Cited by 10