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Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
Open accessAbstract
Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis is involved in the occurrence, development and progression of PD. Numerous clinical trials have identified the characteristics of the changed gut microbiota profiles, and preclinical studies in PD animal models have indicated that gut dysbiosis can influence the progression and onset of PD via increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels of α-synuclein fibrils, increasing oxidative stress, and decreasing neurotransmitter production. The gut microbiota can be considered promising diagnostic and therapeutic targets for PD, which can be regulated by probiotics, psychobiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, diet modifications, and Chinese medicine. This review summarizes the recent studies in PD-associated gut microbiota profiles and functions, the potential roles, and mechanisms of gut microbiota in PD, and gut microbiota-targeted interventions for PD. Deciphering the underlying roles and mechanisms of the PD-associated gut microbiota will help interpret the pathogenesis of PD from new perspectives and elucidate novel therapeutic strategies for PD.
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“gut microbial dysbiosis not only leads to intestinal inflammation but also increases intestinal permeability.”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [15]
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The gut microbiota–brain axis in neurological disorder
Ullah, H., Arbab, S., Tian, Y., Liu, C., Chen, Y., Li, Q., Khan, M. I. U., Hassan, I. U., & Li, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225875 · Cited by 292
Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities
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The gut microbiota–brain axis in neurological disorders
You, M., Chen, N., Yang, Y., Cheng, L., He, H., Cai, Y., Liu, Y., Liu, H., & Hong, G. (2024) · MedComm · doi:10.1002/mco2.656 · Cited by 113
Metadata
- Authors
- Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Lishui Central Hospital (CN)
- Corresponding author
- Chen, Feng
- Ling, Zongxin
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2022-06-24
- Volume
- 13
- Pages
- 937555-937555
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC9263276
- OpenAlex
- W4283465314
- Cited by
- 177
- References
- 218
- Citations by year
- 2026: 27 · 2025: 62 · 2024: 61 · 2023: 22 · 2022: 4
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (2019BINCMCF045, tsqn202103119, 31700800, JNL-2022033C, 81790631, LGF20H090016, 81771724, 2018YFC2000500, 2022C03060)
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
- Basic Public Welfare Research Program of Zhejiang Province (81790631, 31700800, 2019BINCMCF045, JNL-2022033C, LGF20H090016, 2022C03060, tsqn202103119, 2018YFC2000500, 81771724)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, gut microbiota, gut dysbiosis, intestinal permeability, neuroinflammation, alpha-synuclein aggregation, oxidative stress, neurotransmitter production, probiotics, psychobiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, diet, traditional Chinese medicine, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Parkinson Disease, Neurodegenerative Diseases, Dysbiosis
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