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Losing balance: the origin and impact of aneuploidy in cancer: ‘Exploring aneuploidy: the significance of chromosomal imbalance’ review series
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Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro . Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.
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Metadata
- Authors
- Holland, A. J., & Cleveland, D. W.
- Venue
- EMBO reports
- Published
- 2012-05-08
- Volume
- 13
- Issue
- 6
- Pages
- 501-514
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2028666395
- Cited by
- 288
- References
- 177
- FWCI
- 13.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.