Recent progress in non-native nucleic acid modifications

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

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In vitro selection of RNA molecules that bind specific ligands

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FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

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mRNA vaccines — a new era in vaccinology

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Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

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A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems

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Light-Directed, Spatially Addressable Parallel Chemical Synthesis

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Genomic atlas of the human plasma proteome

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Conformational analysis of the sugar ring in nucleosides and nucleotides. New description using the concept of pseudorotation

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Advances in oligonucleotide drug delivery

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Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

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Copper-free click chemistry for dynamic in vivo imaging

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Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

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Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

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Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

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Cu-free click cycloaddition reactions in chemical biology

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Therapeutic siRNA: state of the art

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A DNA enzyme that cleaves RNA

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DNA secondary structures: stability and function of G-quadruplex structures

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The current state and future directions of RNAi-based therapeutics

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Approved Antiviral Drugs over the Past 50 Years

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Light-generated oligonucleotide arrays for rapid DNA sequence analysis.

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Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

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Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

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A tetrameric DNA structure with protonated cytosine-cytosine base pairs

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The chemical evolution of oligonucleotide therapies of clinical utility

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Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

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Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

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Inverse electron demand Diels–Alder reactions in chemical biology

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Mechanochemistry for Synthesis

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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

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LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

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The Structure and Function of DNA G-Quadruplexes

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Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.

Stephenson, M. L., & Zamecnik, P. C. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.285 · Cited by 906

Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

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Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

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Nucleoside syntheses, XXII1) Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts

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Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

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Click chemistry with DNA

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Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array

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Synthetic genetic polymers capable of heredity and evolution

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Plasmon induced thermoelectric effect in graphene

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Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

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Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

Eckstein, F. (2014) · Nucleic Acid Therapeutics · doi:10.1089/nat.2014.0506 · Cited by 684

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

Hua, Y., Sahashi, K., Hung, G., Rigo, F., Passini, M. A., Bennett, C. F., & Krainer, A. R. (2010) · Genes & Development · doi:10.1101/gad.1941310 · Cited by 664

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

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Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

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A semi-synthetic organism with an expanded genetic alphabet

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Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

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Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

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Design of antisense oligonucleotides stabilized by locked nucleic acids

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Molecular Digital Data Storage Using DNA

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Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

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Microarray technology: beyond transcript profiling and genotype analysis

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Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation

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The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

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RNA Interference in Mammalian Cells by Chemically-Modified RNA

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Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution †

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Generation of high-affinity DNA aptamers using an expanded genetic alphabet

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Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology

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Hachimoji DNA and RNA: A genetic system with eight building blocks.

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DNA Switches: From Principles to Applications

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Light‐Induced Click Reactions

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Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

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AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

Hong, D., Kurzrock, R., Kim, Y., Woessner, R., Younes, A., Nemunaitis, J., Fowler, N., Zhou, T., Schmidt, J., Jo, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac5272 · Cited by 445

The Medicinal Chemistry of Therapeutic Oligonucleotides

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Pharmacology of Antisense Drugs

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i-Motif DNA: structural features and significance to cell biology

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Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo

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De novo generation of hit-like molecules from gene expression signatures using artificial intelligence

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Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

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Aptamer chemistry

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Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology

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Accurate multiplex gene synthesis from programmable DNA microchips

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Modifications and functional genomics of human transfer RNA

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Assessment of Variability in the SOMAscan Assay

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i-Motif DNA: Structure, stability and targeting with ligands

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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

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RNA-catalysed carbon–carbon bond formation

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Portable and Error-Free DNA-Based Data Storage

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A CRISPR–Cas9-triggered strand displacement amplification method for ultrasensitive DNA detection

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RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality

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Mechanochemistry for Organic Chemists: An Update

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Prebiotic Peptides: Molecular Hubs in the Origin of Life

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The triple helix: 50 years later, the outcome

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Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers

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Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution

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Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

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A thymidine triphosphate shape analog lacking Watson–Crick pairing ability is replicated with high sequence selectivity

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A Simple Glycol Nucleic Acid

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Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization

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3H-1,2-Benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonucleoside phosphorothioates

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Unlocking P(V): Reagents for chiral phosphorothioate synthesis

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Synthesis of thymidine oligonucleotides by phosphite triester intermediates

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The Efficiency of Light-Directed Synthesis of DNA Arrays on Glass Substrates

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Catalysts from synthetic genetic polymers

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Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips

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