Cited by 415Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin and Vasopressin (V1a) Receptors: Gender Differences

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Francis, D. D., Young, L. J., Meaney, M. J., Insel, T. R.·2002·Journal of Neuroendocrinology

Abstract

Variations in maternal care have been associated with long‐term changes in neurochemistry and behaviour in adult rats. Rats receiving high levels of licking and grooming as pups are less fearful and more maternal than rats receiving low levels of maternal licking and grooming. Central pathways for oxytocin and vasopressin have been implicated in the neurobiology of anxiety and social behaviours. We assessed whether variations in maternal care were associated with differences in oxytocin receptors (OTR) or vasopressin (V1a) receptors in the brains of adult offspring. In the central nucleus of the amygdala and bed nucleus of the stria terminalis, OTR binding was increased in adult females, but not adult males, that had received high levels of maternal licking and grooming as pups. Conversely, amygdala V1a receptor binding was increased in males, but not females, that had received high levels of maternal licking and grooming. These findings suggest that variations in maternal care may influence the expression of oxytocin and vasopressin receptors in a gender‐specific manner.

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Crossref · 10.1046/j.0007-1331.2002.00776.x

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Metadata

Authors
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R.
Affiliations
  • Emory University (US)
  • Douglas Mental Health University Institute (CA)
Corresponding author
Francis, D. D.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2002-05
Volume
14
Issue
5
Pages
349-353
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W1511351296
Cited by
415
References
34
Citations by year
2026: 8 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 13 · 2021: 17 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 24 · 2016: 25 · 2015: 26 · 2014: 14 · 2013: 25 · 2012: 21
FWCI
26.16
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
maternal care, oxytocin receptor, vasopressin V1a receptor, gender differences, amygdala, bed nucleus of the stria terminalis, anxiety, social behavior, early life experience
MeSH terms
Animals, Autoradiography, Female, Male, Maternal Behavior, Sex Characteristics, Vasopressins, Vasotocin, Receptors, Vasopressin, Receptors, Oxytocin, Rats, Long-Evans, Rats

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