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Clock Mutants of Drosophila melanogaster
Open accessAbstract
Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.
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Citations
Cites
RNA-dependent DNA Polymerase Activity in Virus-like Particles isolated from Human Milk
SCHLOM, J., SPIEGELMAN, S., & MOORE, D. (1971) · Nature · doi:10.1038/231097a0 · Cited by 157
Cited by
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology ? A · doi:10.1007/bf01417860 · Cited by 1,636
An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059
The Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81638-4 · Cited by 968
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900
A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879
Circadian oscillation of a mammalian homologue of the Drosophila period gene
Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., & Sakaki, Y. (1997) · Nature · doi:10.1038/39086 · Cited by 792
A framework for studying emotions across species
Anderson, D. J., & Adolphs, R. (2014) · Cell · doi:10.1016/j.cell.2014.03.003 · Cited by 691
Circadian rhythm disturbances in depression
Germain, A., & Kupfer, D. J. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.964 · Cited by 644
Livingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
Duffy, J. F., Rimmer, D. W., & Czeisler, C. A. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.895 · Cited by 571
Circadian Mechanisms in Medicine
Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519
Circadian rhythms and the molecular clock in cardiovascular biology and disease
Crnko, S., Du Pré, B. C., Sluijter, J. P. G., & Van Laake, L. W. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0167-4 · Cited by 499
Stress response genes protect against lethal effects of sleep deprivation in Drosophila
Shaw, P. J., Tononi, G., Greenspan, R. J., & Robinson, D. F. (2002) · Nature · doi:10.1038/417287a · Cited by 488
Clocks not winding down: unravelling circadian networks
Zhang, E. E., & Kay, S. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2995 · Cited by 446
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
Wong, A., Boutis, P., & Hekimi, S. (1995) · Genetics · doi:10.1093/genetics/139.3.1247 · Cited by 416
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-18 · Cited by 308
A genomic view of the sea urchin nervous system
Burke, R. D., Angerer, L. M., Elphick, M. R., Humphrey, G. W., Yaguchi, S., Kiyama, T., Liang, S., Mu, X., Agca, C., Klein, W. H., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.007 · Cited by 293
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282
Discovering imaging endophenotypes for major depression
Hasler, G., & Northoff, G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.23 · Cited by 274
Genetics of circadian rhythms and sleep in human health and disease
Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236
Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198
Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.014 · Cited by 173
Circadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178
Evolution of circadian rhythms: from bacteria to human
Bhadra, U., Thakkar, N., Das, P., & Pal Bhadra, M. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.04.008 · Cited by 167
Control of developmental timing in animals
Rougvie, A. E. (2001) · Nature Reviews Genetics · doi:10.1038/35088566 · Cited by 137
Chronobiology of Marine Organisms
Naylor, E. (2010) · doi:10.1017/cbo9780511803567 · Cited by 132
Trojanowski, N. F., & Raizen, D. M. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2015.12.005 · Cited by 132
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115
Stimuli-sensitive hydrogels: ideal carriers for chronobiology and chronotherapy
Peppas, N. A., & Leobandung, W. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856204322793539 · Cited by 112
Genetic contributions to behavioural diversity at the gene-environment interface
Bendesky, A., & Bargmann, C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3065 · Cited by 103
Kuhlman, S. J., Craig, L. M., & Duffy, J. F. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033613 · Cited by 107
Foundations of circadian medicine
Kramer, A., Lange, T., Spies, C., Finger, A.-M., Berg, D., & Oster, H. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001567 · Cited by 99
“In the 1970s, Ron Konopka and Seymour Benzer identified the first clock gene mutants in the fruit fly Drosophila, thus establishing a genetic basis for behavior [11].”
BackgroundCoordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior
Top, D., & Young, M. W. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033589 · Cited by 89
Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters
Von Schantz, M. (2008) · Journal of Genetics · doi:10.1007/s12041-008-0074-7 · Cited by 85
Environmental Control of Biological Rhythms: Effects on Development, Fertility and Metabolism
Amaral, F. G., Castrucci, A. M., Cipolla‐Neto, J., Poletini, M. O., Mendez, N., Richter, H. G., & Sellix, M. T. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12144 · Cited by 80
The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae
Almeida-Carvalho, M. J., Berh, D., Braun, A., Chen, Y.-C., Eichler, K., Eschbach, C., Fritsch, P. M. J., Gerber, B., Hoyer, N., Jiang, X., et al. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.156646 · Cited by 51
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58
“…organisms that carry clock gene mutations that abolish molecular rhythmicity, such as mutations in Bmal1 in mice (Bunger et al., 2000; Laposky et al., 2005) or in period ( per0) in flies (Konopka and Benzer, 1971), might not be the optimal models in which to study age-related circadian deficits.”
BackgroundCircadian clocks: an overview on its adaptive significance
Krittika, S., & Yadav, P. (2020) · Biological Rhythm Research · doi:10.1080/09291016.2019.1581480 · Cited by 50
Brady, A. K., Willis, B. L., Harder, L. D., & Vize, P. D. (2016) · The Biological Bulletin · doi:10.1086/bblv230n2p130 · Cited by 48
Vitaterna, M. H., Shimomura, K., & Jiang, P. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.05.002 · Cited by 36
Kaiser, T. S., & Heckel, D. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032092 · Cited by 37
Genetics of Human Sleep Behavioral Phenotypes
Hsu, P.-K., Ptáček, L. J., & Fu, Y.-H. (2015) · Methods in Enzymology · doi:10.1016/bs.mie.2014.10.046 · Cited by 29
Palm, D., Uzoni, A., Simon, F., Fischer, M., Coogan, A., Tucha, O., Thome, J., & Faltraco, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.007 · Cited by 20
Greenspan, R. J. (2008) · Current Biology · doi:10.1016/j.cub.2007.12.039 · Cited by 8
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Ricci, C. G., Philpott, J. M., Torgrimson, M. R., Freeberg, A. M., Narasimamurthy, R., Pécora de Barros, E., Amaro, R., Virshup, D. M., McCammon, J. A., & Partch, C. L. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.09.022 · Cited by 3
Metadata
- Authors
- Konopka, R. J., & Benzer, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-09
- Volume
- 68
- Issue
- 9
- Pages
- 2112-2116
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073036589
- Cited by
- 2,280
- References
- 1
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- green
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