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Cited by 390

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging

Open access
Drummond, Micah J., Dreyer, Hans C., Pennings, Bart, Fry, Christopher S., Dhanani, Shaheen, Dillon, Edgar L., Sheffield-Moore, Melinda, Volpi, Elena, Rasmussen, Blake B.·2008·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00021.2008
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Abstract

Skeletal muscle loss during aging leads to an increased risk of falls, fractures, and eventually loss of independence. Resistance exercise is a useful intervention to prevent sarcopenia; however, the muscle protein synthesis (MPS) response to resistance exercise is less in elderly compared with young subjects. On the other hand, essential amino acids (EAA) increase MPS equally in both young and old subjects when sufficient EAA is ingested. We hypothesized that EAA ingestion following a bout of resistance exercise would stimulate anabolic signaling and MPS similarly between young and old men. Each subject ingested 20 g of EAA 1 h following leg resistance exercise. Muscle biopsies were obtained before and 1, 3, and 6 h after exercise to measure the rate of MPS and signaling pathways that regulate translation initiation. MPS increased early in young (1–3 h postexercise) and later in old (3–6 h postexercise). At 1 h postexercise, ERK1/2 MNK1 phosphorylation increased and eIF2α phosphorylation decreased only in the young. mTOR signaling (mTOR, S6K1, 4E-BP1, eEF2) was similar between groups at all time points, but MNK1 phosphorylation was lower at 3 h and AMP-activated protein kinase-α (AMPKα) phosphorylation was higher in old 1–3 h postexercise. We conclude that the acute MPS response after resistance exercise and EAA ingestion is similar between young and old men; however, the response is delayed with aging. Unresponsive ERK1/2 signaling and AMPK activation in old muscle may be playing a role in the delayed activation of MPS. Notwithstanding, the combination of resistance exercise and EAA ingestion should be a useful strategy to combat sarcopenia.

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Metadata

Authors
Drummond, M. J., Dreyer, H. C., Pennings, B., Fry, C. S., Dhanani, S., Dillon, E. L., Sheffield-Moore, M., Volpi, E., & Rasmussen, B. B.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2008-05
Volume
104
Issue
5
Pages
1452-1461
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00021.2008
OpenAlex
W2102837285
Cited by
390
References
19
FWCI
11.83
Type
journal article
Language
en
Open access
green

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