Cited by 701Posttraumatic Stress Disorder ResearchChild Abuse and TraumaMemory Processes and Influences

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder

Open access

Bremner, J. Douglas, Narayan, Meena, Staib, Lawrence H., Southwick, Steven M., McGlashan, Thomas, Charney, Dennis S.·1999·American Journal of Psychiatry

DOI 10.1176/ajp.156.11.1787PMC PMC3233772

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Childhood sexual abuse is very common in our society, but little is known about the long-term effects of abuse on brain function. The purpose of this study was to measure neural correlates of memories of childhood abuse in sexually abused women with and without the diagnosis of posttraumatic stress disorder (PTSD). METHOD: Twenty-two women with a history of childhood sexual abuse underwent injection of [15O]H2O, followed by positron emission tomography imaging of the brain while they listened to neutral and traumatic (personalized childhood sexual abuse events) scripts. Brain blood flow during exposure to traumatic and neutral scripts was compared for sexually abused women with and without PTSD. RESULTS: Memories of childhood sexual abuse were associated with greater increases in blood flow in portions of anterior prefrontal cortex (superior and middle frontal gyri-areas 6 and 9), posterior cingulate (area 31), and motor cortex in sexually abused women with PTSD than in sexually abused women without PTSD. Abuse memories were associated with alterations in blood flow in medial prefrontal cortex, with decreased blood flow in subcallosal gyrus (area 25), and a failure of activation in anterior cingulate (area 32). There was also decreased blood flow in right hippocampus, fusiform/inferior temporal gyrus, supramarginal gyrus, and visual association cortex in women with PTSD relative to women without PTSD. CONCLUSIONS: These findings implicate dysfunction of medial prefrontal cortex (subcallosal gyrus and anterior cingulate), hippocampus, and visual association cortex in pathological memories of childhood abuse in women with PTSD. Increased activation in posterior cingulate and motor cortex was seen in women with PTSD. Dysfunction in these brain areas may underlie PTSD symptoms provoked by traumatic reminders in subjects with PTSD.

Integrity signals

Registry

Crossref · 10.1176/ajp.156.11.1787

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Why stress is bad for your brain
Sapolsky, R. M. (1996) · Science · doi:10.1126/science.273.5276.749 · Cited by 1,306 · cited 1×
“Stress results in damage to hippocampal neurons with associated deficits in memory (14, 15).”
Background
Clinical Characteristics of Women With a History of Childhood Abuse: Unhealed Wounds
McCauley, J. (1997) · JAMA · doi:10.1001/jama.1997.03540410040028 · Cited by 904
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · cited 2×
“Animals with lesions of the medial prefrontal cortex are unable to extinguish fear responses after trials of fear conditioning (9).”
Background
Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS).
Bremner, J. D., Krystal, J. H., Putnam, F. W., Southwick, S. M., Marmar, C., Charney, D. S., & Mazure, C. M. (1998) · Journal of Traumatic Stress · doi:10.1023/a:1024465317902 · Cited by 817
Self-citation
Cerebral Representation of One’s Own Past: Neural Networks Involved in Autobiographical Memory
Fink, G. R., Markowitsch, H. J., Reinkemeier, M., Bruckbauer, T., Kessler, J., & Heiss, W.-D. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04275.1996 · Cited by 803

Show all 14 references

Research works printed but not linked: 42

10.1016/0006-3223(89)90033-4 · DOI
10.1002/jts.2490080403 · DOI
10.1111/j.1749-6632.1988.tb42102.x · DOI · Paper page
Vogt BA, Finch DM, Olson CR: Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex 1992; 2:435–443 · DOI
Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR: The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 1994; 264:1102–1105 · DOI
10.1146/annurev.ne.15.030192.002033 · DOI · Paper page
McEwen BS, Gould EA, Sakai RR: The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress. Br J Psychiatry 1992; 160:18–24 · DOI
Selemon LD, Goldman-Rakic PS: Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior. J Neurosci 1988; 8:4049–4068 · DOI
10.3928/0048-5713-19980801-08 · DOI
10.1176/ajp.152.7.973 · DOI · Paper page
10.1016/S0006-3223(96)00229-6 · DOI
10.1001/archpsyc.1997.01830150070011 · DOI
10.1016/0925-4927(96)02735-7 · DOI
10.1001/archpsyc.1996.01830050014003 · DOI · Paper page
10.1001/archpsyc.1997.01830150057010 · DOI
10.1016/S0006-3223(98)00297-2 · DOI
10.1016/S0006-3223(96)00162-X · DOI · Paper page
10.1017/S0033291797005242 · DOI · Paper page
10.1001/archpsyc.1987.01800230050009 · DOI · Paper page
10.1037/0021-843X.102.1.152 · DOI
10.1037/0021-843X.99.1.49 · DOI
10.1176/ajp.150.4.620 · DOI · Paper page
10.1001/archpsyc.1993.01820160036003 · DOI
10.1038/jcbfm.1991.122 · DOI
Fischer H, Wik G, Fredrikson M: Functional neuroanatomy of robbery re-experience: affective memories studied with PET. Neuroreport 1996; 7:2081–2086 · DOI
10.1016/S0925-4927(97)00018-8 · DOI
10.1038/363623a0 · DOI
10.1176/jnp.9.3.439 · DOI
Adolphs R, Damasio H, Tranel D, Damasio AR: Cortical systems for the recognition of emotion in facial expressions. J Neurosci 1996; 516:7678–7687 · DOI
Tulving E, Kapur S, Craik FIM, Moscovitch M, Houle S: Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings. Proc Natl Acad Sci USA 1994; 91:2016–2020 · DOI
10.1176/ajp.152.3.341 · DOI · Paper page
10.1176/jnp.5.4.384 · DOI
10.1176/ajp.154.7.926 · DOI
Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M, Milot S, Gjedde A, Evans A: Functional neuroanatomy of CCK 4 -induced anxiety in normal healthy volunteers. Am J Psychiatry 1995; 152:1180–1184 · DOI
Mayberg HS, Brannan SK, Mahurin RK, Jerabek PA, Brickman JS, Tekell JL, Silva JA, McGinnis S, Glass TG, Martin CC, Fox PT: Cingulate function in depression: a potential predictor of treatment response. Neuroreport 1997; 8:1057–1061 · DOI · Paper page
10.1002/cne.902900205 · DOI · Paper page
10.1002/cne.903630408 · DOI · Paper page
10.1037/0735-7044.109.4.681 · DOI · Paper page
10.1176/ajp.143.4.469 · DOI
Leiner HC: Reappraising the cerebellum: what does the hindbrain contribute to the forebrain? Behav Neurosci 1989; 103:998–1008 · DOI
10.1037/0735-7044.106.5.731 · DOI
Cahill L, Haier RJ, Fallon J, Alkire MT, Tang C, Keator D, Wu J, McGaugh JL: Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proc Natl Acad Sci USA 1996; 93:8016–8021 · DOI

Sorted by citations

Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292
Self-citation
Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083
Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future
Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203
Functional neuroanatomy of emotions: A meta-analysis
MURPHY, F. C., NIMMO-SMITH, I., & LAWRENCE, A. D. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.3.207 · Cited by 1,135
A Functional Magnetic Resonance Imaging Study of Amygdala and Medial Prefrontal Cortex Responses to Overtly Presented Fearful Faces in Posttraumatic Stress Disorder
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960
The Biological Effects of Childhood Trauma
De Bellis, M. D., & Zisk, A. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.01.002 · Cited by 892
Regional Cerebral Blood Flow in the Amygdala and Medial PrefrontalCortex During Traumatic Imagery in Male and Female Vietnam Veterans With PTSD
Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., Peters, P. M., Metzger, L. J., Dougherty, D. D., Cannistraro, P. A., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.168 · Cited by 790
Post-traumatic stress disorder: the neurobiological impact of psychological trauma
Sherin, J. E., & Nemeroff, C. B. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/jsherin · Cited by 750
Traumatic stress: effects on the brain
Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738
Self-citation
Posttraumatic stress disorder: a state-of-the-science review
Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., & Stein, M. B. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.005 · Cited by 675
Self-citation
Neuroimaging of child abuse: a critical review
Hart, H., & Rubia, K. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00052 · Cited by 660
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory, E., De Brito, S. A., & Viding, E. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02271.x · Cited by 598
Fear extinction in rats: Implications for human brain imaging and anxiety disorders
Milad, M. R., Rauch, S. L., Pitman, R. K., & Quirk, G. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.008 · Cited by 597
The functional neuroanatomy of PTSD: a critical review
Liberzon, I., & Sripada, C. S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67011-3 · Cited by 594
Neurocircuitry models of posttraumatic stress disorder and beyond: A meta-analysis of functional neuroimaging studies
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546
Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: A preliminary report
Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., et al. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110379283 · Cited by 535
The psychobiology of neglect
De Bellis, M. D. (2005) · Child Maltreatment · doi:10.1177/1077559505275116 · Cited by 531
Importance of studying the contributions of early adverse experience to neurobiological findings in depression
Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514
Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation
Lanius, R. A., Williamson, P. C., Boksman, K., Densmore, M., Gupta, M., Neufeld, R. W. J., Gati, J. S., & Menon, R. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01367-7 · Cited by 505
How psychotherapy changes the brain – the contribution of functional neuroimaging
Linden, D. E. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001816 · Cited by 491
Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)?
Elzinga, B. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00351-2 · Cited by 473
Neuroimaging studies of amygdala function in anxiety disorders
RAUCH, S. L., SHIN, L. M., & WRIGHT, C. I. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07096.x · Cited by 463
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0039-7 · Cited by 456
Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders
Liotti, M., Mayberg, H. S., Brannan, S. K., McGinnis, S., Jerabek, P., & Fox, P. T. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00874-x · Cited by 424
The Study of Fear Extinction: Implications for Anxiety Disorders
Graham, B. M., & Milad, M. R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040557 · Cited by 387
Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery.
Hopper, J. W., Frewen, P. A., van der Kolk, B. A., & Lanius, R. A. (2007) · Journal of Traumatic Stress · doi:10.1002/jts.20284 · Cited by 376
A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder
O'Doherty, D. C. M., Chitty, K. M., Saddiqui, S., Bennett, M. R., & Lagopoulos, J. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.01.002 · Cited by 375
Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder
BREMNER, J. D., VERMETTEN, E., SCHMAHL, C., VACCARINO, V., VYTHILINGAM, M., AFZAL, N., GRILLON, C., & CHARNEY, D. S. (2005) · Psychological Medicine · doi:10.1017/s0033291704003290 · Cited by 370
Self-citation
ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW: Theoretical Review: Brain Activity in PTSD during Rest
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Depression and Anxiety · doi:10.1002/da.22478 · Cited by 334
Effects of cannabidiol (CBD) on regional cerebral blood flow
Crippa, J. A. D. S., Zuardi, A. W., Garrido, G. E. J., Wichert-Ana, L., Guarnieri, R., Ferrari, L., Azevedo-Marques, P. M., Hallak, J. E. C., McGuire, P. K., & Busatto, G. F. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300340 · Cited by 307
Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302
Functional neuroimaging studies of post-traumatic stress disorder
Hughes, K. C., & Shin, L. M. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.198 · Cited by 290
Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery
Britton, J. C., Phan, K. L., Taylor, S. F., Fig, L. M., & Liberzon, I. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.025 · Cited by 265
Functional connectivity of dissociative responses in posttraumatic stress disorder: a functional magnetic resonance imaging investigation.
Lanius, R. A., Williamson, P. C., Bluhm, R. L., Densmore, M., Boksman, K., Neufeld, R. W. J., Gati, J. S., & Menon, R. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.011 · Cited by 260
The nature of traumatic memories: a 4-T FMRI functional connectivity analysis
Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Neufeld, R. W., Gati, J. S., & Menon, R. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.36 · Cited by 262
Focal brain damage protects against post-traumatic stress disorder in combat veterans
Koenigs, M., Huey, E. D., Raymont, V., Cheon, B., Solomon, J., Wassermann, E. M., & Grafman, J. (2008) · Nature Neuroscience · doi:10.1038/nn2032 · Cited by 255
The neural networks of inhibitory control in posttraumatic stress disorder
Falconer, E., Bryant, R., Felmingham, K. L., Kemp, A. H., Gordon, E., Peduto, A., Olivieri, G., & Williams, L. M. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0839 · Cited by 249
A Functional Magnetic Resonance Imaging Study of Deliberate Emotion Regulation in Resilience and Posttraumatic Stress Disorder
New, A. S., Fan, J., Murrough, J. W., Liu, X., Liebman, R. E., Guise, K. G., Tang, C. Y., & Charney, D. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.020 · Cited by 252
Self-citation
Long-term effects of childhood abuse on brain and neurobiology
Bremner, J. D. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(02)00098-6 · Cited by 243
Self-citation
Autobiographical memory for trauma: update on four controversies
Brewin, C. R. (2007) · Memory · doi:10.1080/09658210701256423 · Cited by 242
Neural systems underlying approach and avoidance in anxiety disorders
Robin L., A., & Martin, P. P. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/raupperle · Cited by 227
Altered amygdala resting-state functional connectivity in post-traumatic stress disorder
Rabinak, C. A., Angstadt, M., Welsh, R. C., Kenndy, A. E., Lyubkin, M., Martis, B., & Phan, K. L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00062 · Cited by 230
Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study
Pissiota, A., Frans, Ö., Fernandez, M., von Knorring, L., Fischer, H., & Fredrikson, M. (2002) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060200014 · Cited by 228
Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder
Gilboa, A., Shalev, A. Y., Laor, L., Lester, H., Louzoun, Y., Chisin, R., & Bonne, O. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.004 · Cited by 213
Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder
Osuch, E. A., Benson, B., Geraci, M., Podell, D., Herscovitch, P., McCann, U. D., & Post, R. M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01107-6 · Cited by 204
Neuroimaging Studies of Emotional Responses in PTSD
LIBERZON, I., & MARTIS, B. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.009 · Cited by 198
Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children
De Brito, S. A., Viding, E., Sebastian, C. L., Kelly, P. A., Mechelli, A., Maris, H., & McCrory, E. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02597.x · Cited by 194
Neuroimaging studies in post-traumatic stress disorder
Bremner, J. D. (2002) · Current Psychiatry Reports · doi:10.1007/s11920-996-0044-9 · Cited by 194
Neuropsychological Findings in Pediatric Maltreatment: Relationship of PTSD, Dissociative Symptoms, and Abuse/Neglect Indices to Neurocognitive Outcomes
De Bellis, M. D., Woolley, D. P., & Hooper, S. R. (2013) · Child Maltreatment · doi:10.1177/1077559513497420 · Cited by 183
Structural brain abnormalities in borderline personality disorder: a voxel-based morphometry study
Soloff, P., Nutche, J., Goradia, D., & Diwadkar, V. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.02.003 · Cited by 177
An fMRI study on mental pain and suicidal behavior
Reisch, T., Seifritz, E., Esposito, F., Wiest, R., Valach, L., & Michel, K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.03.005 · Cited by 173
The traumatic stress response in child maltreatment and resultant neuropsychological effects
Wilson, K. R., Hansen, D. J., & Li, M. (2011) · Aggression and Violent Behavior · doi:10.1016/j.avb.2010.12.007 · Cited by 175
Clinical and neural correlates of alexithymia in posttraumatic stress disorder.
Frewen, P. A., Lanius, R. A., Dozois, D. J. A., Neufeld, R. W. J., Pain, C., Hopper, J. W., Densmore, M., & Stevens, T. K. (2008) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.117.1.171 · Cited by 168
The worried mind: Autonomic and prefrontal activation during worrying
Hofmann, S. G., Moscovitch, D. A., Litz, B. T., Kim, H.-J., Davis, L. L., & Pizzagalli, D. A. (2005) · Emotion · doi:10.1037/1528-3542.5.4.464 · Cited by 167
Regional brain activity in women grieving a romantic relationship breakup
Najib, A., Lorberbaum, J. P., Kose, S., Bohning, D. E., & George, M. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2245 · Cited by 161
Resilience: The Science of Mastering Life's Greatest Challenges
Southwick, S., & Charney, D. (2018) · doi:10.1017/9781108349246 · Cited by 153
Self-citation
Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder
Shin, L. M., Lasko, N. B., Macklin, M. L., Karpf, R. D., Milad, M. R., Orr, S. P., Goetz, J. M., Fischman, A. J., Rauch, S. L., & Pitman, R. K. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.138 · Cited by 151
Neural correlates of attention bias to threat in post-traumatic stress disorder
Fani, N., Jovanovic, T., Ely, T. D., Bradley, B., Gutman, D., Tone, E. B., & Ressler, K. J. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.001 · Cited by 150
Evidence of early neurobiological alternations in adolescents with posttraumatic stress disorder: a functional MRI study
Yang, P., Wu, M.-T., Hsu, C.-C., & Ker, J.-H. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.033 · Cited by 138
Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial.
Lindauer, R. J. L., Booij, J., Habraken, J. B. A., van Meijel, E. P. M., Uylings, H. B. M., Olff, M., Carlier, I. V. E., den Heeten, G. J., van Eck-Smit, B. L. F., & Gersons, B. P. R. (2008) · Psychological Medicine · doi:10.1017/s0033291707001432 · Cited by 131
The impact of early trauma and recent life-events on symptom severity in patients with conversion disorder
Roelofs, K., Spinhoven, P., Sandijck, P., Moene, F. C., & Hoogduin, K. A. L. (2005) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000172472.60197.4d · Cited by 132
Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans
Morey, R. A., Petty, C. M., Cooper, D. A., LaBar, K. S., & McCarthy, G. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.07.007 · Cited by 131
Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology
Pannu Hayes, J., LaBar, K. S., Petty, C. M., McCarthy, G., & Morey, R. A. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.05.005 · Cited by 130
Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness
Hains, A. B., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.921708 · Cited by 127
Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid posttraumatic stress disorder: a pilot study
Ludäscher, P., Valerius, G., Stiglmayr, C., Mauchnik, J., Lanius, R. A., Bohus, M., & Schmahl, C. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090022 · Cited by 131
Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigation.
Lanius, R. A., Frewen, P. A., Girotti, M., Neufeld, R. W. J., Stevens, T. K., & Densmore, M. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2006.11.006 · Cited by 126
The Health Impact of Childhood Trauma: An Interdisciplinary Review, 1997-2003
Mulvihill, D. (2005) · Issues in Comprehensive Pediatric Nursing · doi:10.1080/01460860590950890 · Cited by 125
Neural correlates of the individual emotional Stroop in borderline personality disorder
Wingenfeld, K., Rullkoetter, N., Mensebach, C., Beblo, T., Mertens, M., Kreisel, S., Toepper, M., Driessen, M., & Woermann, F. G. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.024 · Cited by 124
Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder
Lindauer, R. J. L., Booij, J., Habraken, J. B. A., Uylings, H. B. M., Olff, M., Carlier, I. V. E., den Heeten, G. J., van Eck-Smit, B. L. F., & Gersons, B. P. R. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.003 · Cited by 119
Increased activation of the left hippocampus region in Complex PTSD during encoding and recognition of emotional words: A pilot study
Thomaes, K., Dorrepaal, E., Draijer, N. P. J., de Ruiter, M. B., Elzinga, B. M., van Balkom, A. J., Smoor, P. L. M., Smit, J., & Veltman, D. J. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.03.003 · Cited by 116
Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study
Richert, K. A., Carrion, V. G., Karchemskiy, A., & Reiss, A. L. (2006) · Depression and Anxiety · doi:10.1002/da.20131 · Cited by 118
Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: a functional magnetic resonance imaging study
Yin, Y., Jin, C., Hu, X., Duan, L., Li, Z., Song, M., Chen, H., Feng, B., Jiang, T., Jin, H., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.016 · Cited by 114
Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex
Henigsberg, N., Kalember, P., Petrović, Z. K., & Šečić, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.003 · Cited by 105
Increased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative words
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., Sjoerds, Z., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr084 · Cited by 103
Neurobiology of PTSD: A Review of Neuroimaging Findings
Garfinkel, S. N., & Liberzon, I. (2009) · Psychiatric Annals · doi:10.3928/00485713-20090527-01 · Cited by 102
Is posttraumatic stress disorder a stress‐induced fear circuitry disorder?
Shin, L. M., & Handwerger, K. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20442 · Cited by 102
Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
Kim, S. J., Jeong, D.-U., Sim, M. E., Bae, S. C., Chung, A., Kim, M. J., Chang, K. H., Ryu, J., Renshaw, P. F., & Lyoo, I. K. (2006) · Neuropsychobiology · doi:10.1159/000098262 · Cited by 102
Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder: neural correlates of generalized emotional response
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., & Babiloni, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.024 · Cited by 101
Default mode network subsystems are differentially disrupted in posttraumatic stress disorder
Miller, D. R., Hayes, S. M., Hayes, J. P., Spielberg, J. M., Lafleche, G., & Verfaellie, M. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.12.006 · Cited by 101
A neurocognitive model of borderline personality disorder: Effects of childhood sexual abuse and relationship to adult social attachment disturbance
Minzenberg, M. J., Poole, J. H., & Vinogradov, S. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000163 · Cited by 91
FOCAL AND ABERRANT PREFRONTAL ENGAGEMENT DURING EMOTION REGULATION IN VETERANS WITH POSTTRAUMATIC STRESS DISORDER: Research Article: Prefrontal Regulation of Affect in PTSD
Rabinak, C. A., MacNamara, A., Kennedy, A. E., Angstadt, M., Stein, M. B., Liberzon, I., & Phan, K. L. (2014) · Depression and Anxiety · doi:10.1002/da.22243 · Cited by 89
Clinical Perspectives on Neurobiological Effects of Psychological Trauma
Weber, D. A., & Reynolds, C. R. (2004) · Neuropsychology Review · doi:10.1023/b:nerv.0000028082.13778.14 · Cited by 89
The responses to script-driven imagery scale (RSDI): assessment of state posttraumatic symptoms for psychobiological and treatment research.
Hopper, J. W., Frewen, P. A., Sack, M., Lanius, R. A., & van der Kolk, B. A. (2007) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-007-9046-0 · Cited by 86
Stress, Synaptic Plasticity, and Psychopathology
Garcia, R. (2002) · Reviews in the Neurosciences · doi:10.1515/revneuro.2002.13.3.195 · Cited by 81
Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress
Licznerski, P., Duric, V., Banasr, M., Alavian, K. N., Ota, K. T., Kang, H. J., Jonas, E. A., Ursano, R., Krystal, J. H., Duman, R. S., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002282 · Cited by 79
The innate alarm circuit in post-traumatic stress disorder: conscious and subconscious processing of fear-and trauma-related cues.
Rabellino, D., Densmore, M., Frewen, P. A., Théberge, J., & Lanius, R. A. (2016) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.12.005 · Cited by 67
Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: Does gender matter?
Crozier, J. C., Wang, L., Huettel, S. A., & De Bellis, M. D. (2014) · Development and Psychopathology · doi:10.1017/s095457941400008x · Cited by 64
A Pilot Study of Mindfulness-Based Exposure Therapy in OEF/OIF Combat Veterans with PTSD: Altered Medial Frontal Cortex and Amygdala Responses in Social–Emotional Processing
King, A. P., Block, S. R., Sripada, R. K., Rauch, S. A. M., Porter, K. E., Favorite, T. K., Giardino, N., & Liberzon, I. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00154 · Cited by 64
Reduced mismatch negativity in posttraumatic stress disorder: a compensatory mechanism for chronic hyperarousal?
Menning, H., Renz, A., Seifert, J., & Maercker, A. (2008) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2007.12.003 · Cited by 56
Decreased Premotor Cortex Volume in Victims of Urban Violence with Posttraumatic Stress Disorder
Rocha-Rego, V., Pereira, M. G., Oliveira, L., Mendlowicz, M. V., Fiszman, A., Marques-Portella, C., Berger, W., Chu, C., Joffily, M., Moll, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042560 · Cited by 55
Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene
Coplan, J. D., Fathy, H. M., Jackowski, A. P., Tang, C. Y., Perera, T. D., Mathew, S. J., Martinez, J., Abdallah, C. G., Dwork, A. J., Pantol, G., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00342 · Cited by 47
Altered emotion processing circuits during the anticipation of emotional stimuli in women with borderline personality disorder
Scherpiet, S., Brühl, A. B., Opialla, S., Roth, L., Jäncke, L., & Herwig, U. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0444-x · Cited by 46
Biological correlates of complex posttraumatic stress disorder—state of research and future directions
Marinova, Z., & Maercker, A. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.25913 · Cited by 42
Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions
Nardo, D., Högberg, G., Flumeri, F., Jacobsson, H., Larsson, S. A., Hällström, T., & Pagani, M. (2011) · Psychological Medicine · doi:10.1017/s0033291711000912 · Cited by 41
Effects of minocycline add-on treatment on brain morphometry and cerebral perfusion in recent-onset schizophrenia
Chaves, C., Marque, C. R., Maia-de-Oliveira, J. P., Wichert-Ana, L., Ferrari, T. B., Santos, A. C., Araújo, D., Machado-de-Sousa, J. P., Bressan, R. A., Elkis, H., et al. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.11.031 · Cited by 41

Authors: Bremner, J. D., Narayan, M., Staib, L. H., Southwick, S. M., McGlashan, T., & Charney, D. S.
Affiliations: Yale University (US)
ORCID: Bremner, J. Douglas
Staib, Lawrence H.
Southwick, Steven M.
McGlashan, Thomas
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1999-11-01
Volume: 156
Issue: 11
Pages: 1787-1795
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.156.11.1787
PMC: PMC3233772
OpenAlex: W1763274674
Cited by: 701
References: 14
Citations by year: 2026: 5 · 2025: 16 · 2024: 15 · 2023: 13 · 2022: 18 · 2021: 19 · 2020: 20 · 2019: 36 · 2018: 25 · 2017: 20 · 2016: 26 · 2015: 25 · 2014: 37 · 2013: 32 · 2012: 28
FWCI: 22.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH056120)
National Center for Research Resources (M01RR000125)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: child sexual abuse, post-traumatic stress disorder, memory reconsolidation, neural correlates, cerebral blood flow, anterior cingulate cortex, medial prefrontal cortex, hippocampus, posterior cingulate cortex, motor cortex, visual association cortex, traumatic memory, women
MeSH terms: Adult, Brain, Child, Child Abuse, Sexual, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Memory, Motor Cortex, Regional Blood Flow, Sex Factors, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Visual Cortex, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks