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Cited by 2,378

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

The Metabolic Syndrome: Time for a Critical Appraisal

Open access
Kahn, Richard, Buse, John, Ferrannini, Ele, Stern, Michael·2005·Diabetes Care
DOI 10.2337/diacare.28.9.2289
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Abstract

The term “metabolic syndrome” refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance. Since the term is widely used in research and clinical practice, we undertook an extensive review of the literature in relation to the syndrome’s definition, underlying pathogenesis, and association with CVD and to the goals and impact of treatment. While there is no question that certain CVD risk factors are prone to cluster, we found that the metabolic syndrome has been imprecisely defined, there is a lack of certainty regarding its pathogenesis, and there is considerable doubt regarding its value as a CVD risk marker. Our analysis indicates that too much critically important information is missing to warrant its designation as a “syndrome.” Until much needed research is completed, clinicians should evaluate and treat all CVD risk factors without regard to whether a patient meets the criteria for diagnosis of the “metabolic syndrome.”

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Metadata

Authors
Kahn, R., Buse, J., Ferrannini, E., & Stern, M.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2005-09-01
Volume
28
Issue
9
Pages
2289-2304
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.28.9.2289
OpenAlex
W2120862552
Cited by
2,378
References
34
FWCI
172.95
Type
journal article
Language
en
Open access
bronze

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