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Cited by 373

The DOI matches its Crossref record; 570 of the 570 references it cites were found in a registry or an index.

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Open access
Burhans, Maggie S., Hagman, Derek K., Kuzma, Jessica N., Schmidt, Kelsey A., Kratz, Mario·2018·Comprehensive Physiology
DOI 10.1002/cphy.c170040
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Abstract

The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low‐grade, chronic adipose tissue inflammation is characterized by infiltration of macrophages and other immune cell populations into adipose tissue, and a shift toward more proinflammatory subtypes of leukocytes. The infiltration of proinflammatory cells in adipose tissue is associated with an increased production of key chemokines such as C‐C motif chemokine ligand 2, proinflammatory cytokines including tumor necrosis factor α and interleukins 1β and 6 as well as reduced expression of the key insulin‐sensitizing adipokine, adiponectin. In both rodent models and humans, adipose tissue inflammation is consistently associated with excess fat mass and insulin resistance. In humans, associations with insulin resistance are stronger and more consistent for inflammation in visceral as opposed to subcutaneous fat. Further, genetic alterations in mouse models of obesity that reduce adipose tissue inflammation are—almost without exception—associated with improved insulin sensitivity. However, a dissociation between adipose tissue inflammation and insulin resistance can be observed in very few rodent models of obesity as well as in humans following bariatric surgery‐ or low‐calorie‐diet‐induced weight loss, illustrating that the etiology of insulin resistance is multifactorial. Taken together, adipose tissue inflammation is a key factor in the development of insulin resistance and type 2 diabetes in obesity, along with other factors that likely include inflammation and fat accumulation in other metabolically active tissues. © 2019 American Physiological Society.Compr Physiol 9:1‐58, 2019.

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Metadata

Authors
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M.
Venue
Comprehensive Physiology
Publisher
Wiley
Published
2018-12-13
Volume
9
Issue
1
Pages
1-58
ISSN
2040-4603 (ISSN-L)
DOI
10.1002/cphy.c170040
OpenAlex
W2905533535
Cited by
373
References
570
Type
other
Language
en
Open access
green

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