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Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Open accessAbstract
The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low‐grade, chronic adipose tissue inflammation is characterized by infiltration of macrophages and other immune cell populations into adipose tissue, and a shift toward more proinflammatory subtypes of leukocytes. The infiltration of proinflammatory cells in adipose tissue is associated with an increased production of key chemokines such as C‐C motif chemokine ligand 2, proinflammatory cytokines including tumor necrosis factor α and interleukins 1β and 6 as well as reduced expression of the key insulin‐sensitizing adipokine, adiponectin. In both rodent models and humans, adipose tissue inflammation is consistently associated with excess fat mass and insulin resistance. In humans, associations with insulin resistance are stronger and more consistent for inflammation in visceral as opposed to subcutaneous fat. Further, genetic alterations in mouse models of obesity that reduce adipose tissue inflammation are—almost without exception—associated with improved insulin sensitivity. However, a dissociation between adipose tissue inflammation and insulin resistance can be observed in very few rodent models of obesity as well as in humans following bariatric surgery‐ or low‐calorie‐diet‐induced weight loss, illustrating that the etiology of insulin resistance is multifactorial. Taken together, adipose tissue inflammation is a key factor in the development of insulin resistance and type 2 diabetes in obesity, along with other factors that likely include inflammation and fat accumulation in other metabolically active tissues. © 2019 American Physiological Society.Compr Physiol 9:1‐58, 2019.
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Items 201–400 of 570
Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.012 · Cited by 598
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Herman, M. A., Peroni, O. D., Villoria, J., Schön, M. R., Abumrad, N. A., Blüher, M., Klein, S., & Kahn, B. B. (2012) · Nature · doi:10.1038/nature10986 · Cited by 596
Korenblat, K. M., Fabbrini, E., Mohammed, B. S., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.075 · Cited by 592
Age-Associated Loss of Power and Strength in the Upper Extremities in Women and Men
Metter, E. J., Conwit, R., Tobin, J., & Fozard, J. L. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.5.b267 · Cited by 592
Gregor, M. F., & Hotamisligil, G. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700007-jlr200 · Cited by 586
EPIC-InterAct Consortium, Lotta, L. A., Cambridge FPLD1 Consortium, Gulati, P., Day, F. R., Payne, F., Ongen, H., van de Bunt, M., Gaulton, K. J., Eicher, J. D., et al. (2017) · Nature Genetics · doi:10.1038/ng.3714 · Cited by 585
The macrophage switch in obesity development
Castoldi, A., Naffah de Souza, C., Câmara, N. O. S., & Moraes-Vieira, P. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00637 · Cited by 575
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Lee, Y. S., Li, P., Huh, J. Y., Hwang, I. J., Lu, M., Kim, J. I., Ham, M., Talukdar, S., Chen, A., Lu, W. J., et al. (2011) · Diabetes · doi:10.2337/db11-0194 · Cited by 566
Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging
Gabriely, I., Ma, X. H., Yang, X. M., Atzmon, G., Rajala, M. W., Berg, A. H., Scherer, P., Rossetti, L., & Barzilai, N. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2951 · Cited by 563
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 558
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
Hundal, R. S., Petersen, K. F., Mayerson, A. B., Randhawa, P. S., Inzucchi, S., Shoelson, S. E., & Shulman, G. I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214955 · Cited by 557
Mechanisms of Insulin Resistance in Aging
Fink, R. I., Kolterman, O. G., Griffin, J., & Olefsky, J. M. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110908 · Cited by 555
Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity
Vendrell, J., Broch, M., Vilarrasa, N., Molina, A., Gómez, J. M., Gutiérrez, C., Simón, I., Soler, J., & Richart, C. (2004) · Obesity Research · doi:10.1038/oby.2004.118 · Cited by 554
Combs, T. P., Pajvani, U. B., Berg, A. H., Lin, Y., Jelicks, L. A., Laplante, M., Nawrocki, A. R., Rajala, M. W., Parlow, A. F., Cheeseboro, L., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1068 · Cited by 545
Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.007 · Cited by 544
The role of adipose tissue immune cells in obesity and low-grade inflammation
Mraz, M., & Haluzik, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0283 · Cited by 543
Body Fat Distribution and Insulin Resistance in Healthy Asian Indians and Caucasians
Raji, A., Seely, E. W., Arky, R. A., & Simonson, D. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7992 · Cited by 541
The cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541
Larsen, G. L., & Henson, P. M. (1983) · Annual Review of Immunology · doi:10.1146/annurev.iy.01.040183.002003 · Cited by 541
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Fasshauer, M., Kralisch, S., Klier, M., Lossner, U., Bluher, M., Klein, J., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 531
Ridker, P. M., Howard, C. P., Walter, V., Everett, B., Libby, P., Hensen, J., & Thuren, T. (2012) · Circulation · doi:10.1161/circulationaha.112.122556 · Cited by 530
Xu, X., Grijalva, A., Skowronski, A., van Eijk, M., Serlie, M. J., & Ferrante, A. W. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.001 · Cited by 523
Leptin-specific patterns of gene expression in white adipose tissue
Soukas, A., Cohen, P., Socci, N. D., & Friedman, J. M. (2000) · Genes & Development · doi:10.1101/gad.14.8.963 · Cited by 516
Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513
Kim, C.-S., Park, H.-S., Kawada, T., Kim, J.-H., Lim, D., Hubbard, N. E., Kwon, B.-S., Erickson, K. L., & Yu, R. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803259 · Cited by 511
Ofei, F., Hurel, S., Newkirk, J., Sopwith, M., & Taylor, R. (1996) · Diabetes · doi:10.2337/diab.45.7.881 · Cited by 510
BMI Cut Points to Identify At-Risk Asian Americans for Type 2 Diabetes Screening
Hsu, W. C., Araneta, M. R. G., Kanaya, A. M., Chiang, J. L., & Fujimoto, W. (2015) · Diabetes Care · doi:10.2337/dc14-2391 · Cited by 500
Dietary obesity in nine inbred mouse strains
West, D. B., Boozer, C. N., Moody, D. L., & Atkinson, R. L. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.262.6.r1025 · Cited by 491
Loll, P. J., Picot, D., & Garavito, R. M. (1995) · Nature Structural Biology · doi:10.1038/nsb0895-637 · Cited by 490
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
Elgazar-Carmon, V., Rudich, A., Hadad, N., & Levy, R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800132-jlr200 · Cited by 487
Summers, S. A., Garza, L. A., Zhou, H., & Birnbaum, M. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5457 · Cited by 475
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471
McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468
Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.014 · Cited by 466
Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
Trayhurn, P., Wang, B., & Wood, I. S. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508971282 · Cited by 464
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
Takeuchi, K., & Reue, K. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90958.2008 · Cited by 463
Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461
Hevener, A. L., Olefsky, J. M., Reichart, D., Nguyen, M. T. A., Bandyopadyhay, G., Leung, H.-Y., Watt, M. J., Benner, C., Febbraio, M. A., Nguyen, A.-K., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31561 · Cited by 459
Saberi, M., Woods, N.-B., de Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., Verma, I. M., & Olefsky, J. M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.006 · Cited by 456
Raichur, S., Wang, S. T., Chan, P. W., Li, Y., Ching, J., Chaurasia, B., Dogra, S., Öhman, M. K., Takeda, K., Sugii, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.015 · Cited by 455
Fraulob, J. C., Ogg-Diamantino, R., Fernandes-Santos, C., Aguila, M. B., & Mandarim-de-Lacerda, C. A. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-83 · Cited by 448
Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative
Culver, A. L. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.625 · Cited by 444
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance
Basu, R., Breda, E., Oberg, A. L., Powell, C. C., Dalla Man, C., Basu, A., Vittone, J. L., Klee, G. G., Arora, P., Jensen, M. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1738 · Cited by 440
Immunological Goings-on in Visceral Adipose Tissue
Mathis, D. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.008 · Cited by 437
Thorpe, K. E., Florence, C. S., Howard, D. H., & Joski, P. (2004) · Health Affairs · doi:10.1377/hlthaff.w4.480 · Cited by 436
Santomauro, A. T., Boden, G., Silva, M. E., Rocha, D. M., Santos, R. F., Ursich, M. J., Strassmann, P. G., & Wajchenberg, B. L. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1836 · Cited by 431
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
Meikle, P. J., & Summers, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.169 · Cited by 423
Association between adiponectin and mediators of inflammation in obese women
Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.942 · Cited by 422
Steven, S., Hollingsworth, K. G., Al-Mrabeh, A., Avery, L., Aribisala, B., Caslake, M., & Taylor, R. (2016) · Diabetes Care · doi:10.2337/dc15-1942 · Cited by 418
Insulin and Obesity in the Zucker Genetically Obese Rat “Fatty”
ZUCKER, L. M., & ANTONIADES, H. N. (1972) · Endocrinology · doi:10.1210/endo-90-5-1320 · Cited by 418
Genetic control of de novo lipogenesis: role in diet-induced obesity
Strable, M. S., & Ntambi, J. M. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409231003667500 · Cited by 416
Miyazaki, M., Flowers, M. T., Sampath, H., Chu, K., Otzelberger, C., Liu, X., & Ntambi, J. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.014 · Cited by 414
Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K. (2012) · Scientific Reports · doi:10.1038/srep00799 · Cited by 402
Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31986 · Cited by 401
Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., Blin-Wakkach, C., Anty, R., Iannelli, A., Gugenheim, J., et al. (2012) · Diabetes · doi:10.2337/db11-1274 · Cited by 399
Vascular endothelial senescence: from mechanisms to pathophysiology
Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399
Adiponectin signaling and function in insulin target tissues
Ruan, H., & Dong, L. Q. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw014 · Cited by 395
Serum Adiponectin and Leptin Levels in Patients with Lipodystrophies
Haque, W. A. (2002) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.2395 · Cited by 395
Characterization of the insulin resistance of aging.
Rowe, J. W., Minaker, K. L., Pallotta, J. A., & Flier, J. S. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110914 · Cited by 394
Evans, D. J., Hoffman, R. G., Kalkhoff, R. K., & Kissebah, A. H. (1984) · Metabolism · doi:10.1016/0026-0495(84)90164-1 · Cited by 390
The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Trial
Goldfine, A. B., Fonseca, V., Jablonski, K. A., Pyle, L., Staten, M. A., Shoelson, S. E., & for the TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team* (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-6-201003160-00004 · Cited by 388
The expression of adipogenic genes is decreased in obesity and diabetes mellitus
Nadler, S. T., Stoehr, J. P., Schueler, K. L., Tanimoto, G., Yandell, B. S., & Attie, A. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11371 · Cited by 386
Apovian, C. M., Bigornia, S., Mott, M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M., Hess, D., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 386
Raichur, S., Wang, S. T., Chan, P. W., Li, Y., Ching, J., Chaurasia, B., Dogra, S., Öhman, M. K., Takeda, K., Sugii, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.007 · Cited by 385
Prieur, X., Mok, C. Y. L., Velagapudi, V. R., Núñez, V., Fuentes, L., Montaner, D., Ishikawa, K., Camacho, A., Barbarroja, N., O’Rahilly, S., et al. (2011) · Diabetes · doi:10.2337/db10-0705 · Cited by 381
Aron-Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., Basdevant, A., Aissat, A., Guerre-Millo, M., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0925 · Cited by 378
Overview of Animal Models of Obesity
Lutz, T. A., & Woods, S. C. (2012) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0561s58 · Cited by 375
Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages
Bourlier, V., Zakaroff-Girard, A., Miranville, A., De Barros, S., Maumus, M., Sengenes, C., Galitzky, J., Lafontan, M., Karpe, F., Frayn, K. N., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.724096 · Cited by 373
Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity
Muir, L. A., Neeley, C. K., Meyer, K. A., Baker, N. A., Brosius, A. M., Washabaugh, A. R., Varban, O. A., Finks, J. F., Zamarron, B. F., Flesher, C. G., et al. (2016) · Obesity · doi:10.1002/oby.21377 · Cited by 367
Paolisso, G., Tataranni, P. A., Foley, J. E., Bogardus, C., Howard, B. V., & Ravussin, E. (1995) · Diabetologia · doi:10.1007/bf00422371 · Cited by 367
Shan, B., Wang, X., Wu, Y., Xu, C., Xia, Z., Dai, J., Shao, M., Zhao, F., He, S., Yang, L., et al. (2017) · Nature Immunology · doi:10.1038/ni.3709 · Cited by 367
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357
Huber, J., Kiefer, F. W., Zeyda, M., Ludvik, B., Silberhumer, G. R., Prager, G., Zlabinger, G. J., & Stulnig, T. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2630 · Cited by 356
Poggi, M., Bastelica, D., Gual, P., Iglesias, M. A., Gremeaux, T., Knauf, C., Peiretti, F., Verdier, M., Juhan-Vague, I., Tanti, J. F., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0654-8 · Cited by 355
Yang, R.-Z., Lee, M.-J., Hu, H., Pollin, T. I., Ryan, A. S., Nicklas, B. J., Snitker, S., Horenstein, R. B., Hull, K., Goldberg, N. H., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030287 · Cited by 355
Kim, D. D., & Basu, A. (2016) · Value in Health · doi:10.1016/j.jval.2016.02.008 · Cited by 353
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B. (2008) · Diabetes Care · doi:10.2337/dc07-1338 · Cited by 352
Adiponectin receptors: A review of their structure, function and how they work
Yamauchi, T., Iwabu, M., Okada-Iwabu, M., & Kadowaki, T. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.003 · Cited by 351
Diabetes-Obesity Syndromes in Mice
Coleman, D. L. (1982) · Diabetes · doi:10.2337/diab.31.1.s1 · Cited by 350
The “Big Bang” in obese fat: events initiating obesity-induced adipose tissue inflammation
Wensveen, F. M., Valentić, S., Šestan, M., Turk Wensveen, T., & Polić, B. (2015) · European Journal of Immunology · doi:10.1002/eji.201545502 · Cited by 348
Xia, J. Y., Holland, W. L., Kusminski, C. M., Sun, K., Sharma, A. X., Pearson, M. J., Sifuentes, A. J., McDonald, J. G., Gordillo, R., & Scherer, P. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.007 · Cited by 348
Anti-inflammatory and immunomodulatory effects of statins
Blanco-Colio, L. M., Tuñón, J., Martín-Ventura, J. L., & Egido, J. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00744.x · Cited by 347
Rong, J. X., Qiu, Y., Hansen, M. K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Mattie, M. D., Higashiyama, H., Asano, S., et al. (2007) · Diabetes · doi:10.2337/db06-1135 · Cited by 335
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334
Furuhashi, M., Fucho, R., Görgün, C. Z., Tuncman, G., Cao, H., & Hotamisligil, G. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34750 · Cited by 332
Davies, L. C., Rosas, M., Jenkins, S. J., Liao, C.-T., Scurr, M. J., Brombacher, F., Fraser, D. J., Allen, J. E., Jones, S. A., & Taylor, P. R. (2013) · Nature Communications · doi:10.1038/ncomms2877 · Cited by 332
Toll-like receptors: linking inflammation to metabolism
Könner, A. C., & Brüning, J. C. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 331
Immunological Functions of the Omentum
Meza-Perez, S., & Randall, T. D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.03.002 · Cited by 326
The Costs of Obesity in the Workplace
Finkelstein, E. A., DiBonaventura, M. D., Burgess, S. M., & Hale, B. C. (2010) · Journal of Occupational & Environmental Medicine · doi:10.1097/jom.0b013e3181f274d2 · Cited by 325
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324
Stanley, T. L., Zanni, M. V., Johnsen, S., Rasheed, S., Makimura, H., Lee, H., Khor, V. K., Ahima, R. S., & Grinspoon, S. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1170 · Cited by 321
Aging and adipose tissue: potential interventions for diabetes and regenerative medicine
Palmer, A. K., & Kirkland, J. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.013 · Cited by 321
Chronic adipose tissue inflammation: all immune cells on the stage
Cildir, G., Akıncılar, S. C., & Tergaonkar, V. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.001 · Cited by 317
Cederberg, H., Stančáková, A., Yaluri, N., Modi, S., Kuusisto, J., & Laakso, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3528-5 · Cited by 316
Adipokines and the Peripheral and Neural Control of Energy Balance
Ahima, R. S., & Lazar, M. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0529 · Cited by 315
Cooperation between brain and islet in glucose homeostasis and diabetes
Schwartz, M. W., Seeley, R. J., Tschöp, M. H., Woods, S. C., Morton, G. J., Myers, M. G., & D’Alessio, D. (2013) · Nature · doi:10.1038/nature12709 · Cited by 314
High Adiponectin Concentrations Are Associated with the Metabolically Healthy Obese Phenotype
Aguilar-Salinas, C. A., García, E. G., Robles, L., Riaño, D., Ruiz-Gomez, D. G., García-Ulloa, A. C., Melgarejo, M. A., Zamora, M., Guillen-Pineda, L. E., Mehta, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2724 · Cited by 310
Angiogenic Role of LYVE-1–Positive Macrophages in Adipose Tissue
Cho, C.-H., Jun Koh, Y., Han, J., Sung, H.-K., Jong Lee, H., Morisada, T., Schwendener, R. A., Brekken, R. A., Kang, G., Oike, Y., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000259564.92792.93 · Cited by 309
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 307
Ninghayu, C., Wijaya, A., & As'ad, S. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.113 · Cited by 305
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., et al. (2013) · Nature Communications · doi:10.1038/ncomms2537 · Cited by 301
Regulation of Triglyceride Metabolism.IV. Hormonal regulation of lipolysis in adipose tissue
Jaworski, K., Sarkadi-Nagy, E., Duncan, R. E., Ahmadian, M., & Sul, H. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00554.2006 · Cited by 300
Schnoor, M., Cullen, P., Lorkowski, J., Stolle, K., Robenek, H., Troyer, D., Rauterberg, J., & Lorkowski, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5707 · Cited by 298
Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance
Jia, L., Vianna, C. R., Fukuda, M., Berglund, E. D., Liu, C., Tao, C., Sun, K., Liu, T., Harper, M. J., Lee, C. E., et al. (2014) · Nature Communications · doi:10.1038/ncomms4878 · Cited by 294
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 294
Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes
Cavelti-Weder, C., Babians-Brunner, A., Keller, C., Stahel, M. A., Kurz-Levin, M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, T., Dinarello, C. A., & Donath, M. Y. (2012) · Diabetes Care · doi:10.2337/dc11-2219 · Cited by 294
Sahai, A., Malladi, P., Pan, X., Paul, R., Melin-Aldana, H., Green, R. M., & Whitington, P. F. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00199.2004 · Cited by 290
Role of Glucose Effectiveness in the Determination of Glucose Tolerance
Best, J. D., Kahn, S. E., Ader, M., Watanabe, R. M., Ni, T. C., & Bergman, R. N. (1996) · Diabetes Care · doi:10.2337/diacare.19.9.1018 · Cited by 290
Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance
Spencer, M., Unal, R., Zhu, B., Rasouli, N., McGehee, R. E., Peterson, C. A., & Kern, P. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1567 · Cited by 290
Dominguez, H., Storgaard, H., Rask-Madsen, C., Steffen Hermann, T., Ihlemann, N., Baunbjerg Nielsen, D., Spohr, C., Kober, L., Vaag, A., & Torp-Pedersen, C. (2005) · Journal of Vascular Research · doi:10.1159/000088261 · Cited by 286
Villaret, A., Galitzky, J., Decaunes, P., Estève, D., Marques, M.-A., Sengenès, C., Chiotasso, P., Tchkonia, T., Lafontan, M., Kirkland, J. L., et al. (2010) · Diabetes · doi:10.2337/db10-0398 · Cited by 282
Fabbrini, E., Cella, M., Mccartney, S. A., Fuchs, A., Abumrad, N. A., Pietka, T. A., Chen, Z., Finck, B. N., Han, D. H., Magkos, F., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.010 · Cited by 280
Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K., & Kammoun, H. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00470 · Cited by 277
Heni, M., Machann, J., Staiger, H., Schwenzer, N. F., Peter, A., Schick, F., Claussen, C. D., Stefan, N., Häring, H., & Fritsche, A. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1073 · Cited by 277
Wong, V. W.-S., Wong, G. L.-H., Yeung, D. K.-W., Abrigo, J. M., Kong, A. P.-S., Chan, R. S.-M., Chim, A. M.-L., Shen, J., Ho, C.-S., Woo, J., et al. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.1 · Cited by 275
Ventre, J., Doebber, T., Wu, M., MacNaul, K., Stevens, K., Pasparakis, M., Kollias, G., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275
Koster, A., Ding, J., Stenholm, S., Caserotti, P., Houston, D. K., Nicklas, B. J., You, T., Lee, J. S., Visser, M., Newman, A. B., et al. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr070 · Cited by 274
Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review
Rheinheimer, J., de Souza, B. M., Cardoso, N. S., Bauer, A. C., & Crispim, D. (2017) · Metabolism · doi:10.1016/j.metabol.2017.06.002 · Cited by 273
Obesity accelerates T cell senescence in murine visceral adipose tissue
Shirakawa, K., Yan, X., Shinmura, K., Endo, J., Kataoka, M., Katsumata, Y., Yamamoto, T., Anzai, A., Isobe, S., Yoshida, N., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88606 · Cited by 271
The Inflammasome Puts Obesity in the Danger Zone
Stienstra, R., Tack, C. J., Kanneganti, T.-D., Joosten, L. A. B., & Netea, M. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.011 · Cited by 271
Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects
Sharma, N. K., Das, S. K., Mondal, A. K., Hackney, O. G., Chu, W. S., Kern, P. A., Rasouli, N., Spencer, H. J., Yao-Borengasser, A., & Elbein, S. C. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1001 · Cited by 271
THE GLUCOSE FATTY ACID CYCLE IN OBESITY AND MATURITY ONSET DIABETES MELLITUS
Randle, P. J., Garland, P. B., Newsholmet, E. A., & Hales, C. N. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb34800.x · Cited by 267
Moschen, A. R., Molnar, C., Geiger, S., Graziadei, I., Ebenbichler, C. F., Weiss, H., Kaser, S., Kaser, A., & Tilg, H. (2010) · Gut · doi:10.1136/gut.2010.214577 · Cited by 267
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., et al. (2016) · Diabetes · doi:10.2337/db15-0291 · Cited by 267
Illán-Gómez, F., Gonzálvez-Ortega, M., Orea-Soler, I., Alcaraz-Tafalla, M. S., Aragón-Alonso, A., Pascual-Díaz, M., Pérez-Paredes, M., & Lozano-Almela, M. L. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0643-y · Cited by 265
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin
Piya, M. K., McTernan, P. G., & Kumar, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0498 · Cited by 264
Takaya, K., Ogawa, Y., Isse, N., Okazaki, T., Satoh, N., Masuzaki, H., Mori, K., Tamura, N., Hosoda, K., & Nakao, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1133 · Cited by 263
Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation
Nijhuis, J., Rensen, S. S., Slaats, Y., van Dielen, F. M. H., Buurman, W. A., & Greve, J. W. M. (2009) · Obesity · doi:10.1038/oby.2009.113 · Cited by 262
Fisher, F. F. M., Trujillo, M. E., Hanif, W., Barnett, A. H., McTernan, P. G., Scherer, P. E., & Kumar, S. (2005) · Diabetologia · doi:10.1007/s00125-005-1758-7 · Cited by 262
A thrifty variant in CREBRF strongly influences body mass index in Samoans
Minster, R. L., Hawley, N. L., Su, C.-T., Sun, G., Kershaw, E. E., Cheng, H., Buhule, O. D., Lin, J., Reupena, M. S., Viali, S., et al. (2016) · Nature Genetics · doi:10.1038/ng.3620 · Cited by 262
Miyazaki, M., Man, W. C., & Ntambi, J. M. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.9.2260 · Cited by 261
Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling
Erridge, C., & Samani, N. J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.194050 · Cited by 260
Lynch, L., O'Shea, D., Winter, D. C., Geoghegan, J., Doherty, D. G., & O'Farrelly, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939349 · Cited by 257
Nishimoto, S., Fukuda, D., Higashikuni, Y., Tanaka, K., Hirata, Y., Murata, C., Kim-Kaneyama, J.-R., Sato, F., Bando, M., Yagi, S., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501332 · Cited by 254
Salicylate (Salsalate) in Patients With Type 2 Diabetes: A Randomized Trial
Goldfine, A. B., Fonseca, V., Jablonski, K. A., Chen, Y.-D. I., Tipton, L., Staten, M. A., & Shoelson, S. E. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-1-201307020-00003 · Cited by 251
Genetic Architecture of Insulin Resistance in the Mouse
Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.002 · Cited by 249
Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse
Zheng, Y., Eilertsen, K. J., Ge, L., Zhang, L., Sundberg, J. P., Prouty, S. M., Stenn, K. S., & Parimoo, S. (1999) · Nature Genetics · doi:10.1038/15446 · Cited by 249
Immune modulatory effects of statins
Zeiser, R. (2018) · Immunology · doi:10.1111/imm.12902 · Cited by 249
Hoenicke, L., & Zender, L. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs124 · Cited by 248
Uysal, K. T., Wiesbrock, S. M., & Hotamisligil, G. S. (1998) · Endocrinology · doi:10.1210/endo.139.12.6337 · Cited by 247
Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism
Chaurasia, B., Kaddai, V. A., Lancaster, G. I., Henstridge, D. C., Sriram, S., Galam, D. L. A., Gopalan, V., Prakash, K. N. B., Velan, S. S., Bulchand, S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.002 · Cited by 247
Fujisaka, S., Usui, I., Ikutani, M., Aminuddin, A., Takikawa, A., Tsuneyama, K., Mahmood, A., Goda, N., Nagai, Y., Takatsu, K., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2885-1 · Cited by 239
Esser, N., L’homme, L., De Roover, A., Kohnen, L., Scheen, A. J., Moutschen, M., Piette, J., Legrand-Poels, S., & Paquot, N. (2013) · Diabetologia · doi:10.1007/s00125-013-3023-9 · Cited by 239
Swarbrick, M. M., & Havel, P. J. (2008) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2007.0029 · Cited by 238
Tataranni, P. A., & Ortega, E. (2005) · Diabetes · doi:10.2337/diabetes.54.4.917 · Cited by 238
Local proliferation of macrophages in adipose tissue during obesity-induced inflammation
Haase, J., Weyer, U., Immig, K., Klöting, N., Blüher, M., Eilers, J., Bechmann, I., & Gericke, M. (2014) · Diabetologia · doi:10.1007/s00125-013-3139-y · Cited by 236
Tsigos, C., Kyrou, I., Chala, E., Tsapogas, P., Stavridis, J. C., Raptis, S. A., & Katsilambros, N. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90277-9 · Cited by 233
Koliwad, S. K., Streeper, R. S., Monetti, M., Cornelissen, I., Chan, L., Terayama, K., Naylor, S., Rao, M., Hubbard, B., & Farese, R. V. (2010) · Journal of Clinical Investigation · doi:10.1172/jci36066 · Cited by 233
Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., Schön, M. R., Shang, E., Lohmann, T., Dreßler, M., et al. (2012) · Metabolism · doi:10.1016/j.metabol.2011.10.008 · Cited by 233
Duffaut, C., Zakaroff-Girard, A., Bourlier, V., Decaunes, P., Maumus, M., Chiotasso, P., Sengenès, C., Lafontan, M., Galitzky, J., & Bouloumié, A. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.192583 · Cited by 232
Shi, Y., & Cheng, D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90949.2008 · Cited by 232
Physical inactivity and obesity underlie the insulin resistance of aging
Amati, F., Dubé, J. J., Coen, P. M., Stefanovic-Racic, M., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes Care · doi:10.2337/dc09-0267 · Cited by 230
Contribution of visceral fat mass to the insulin resistance of aging
Cefalu, W. T., Wang, Z. Q., Werbel, S., Bell-Farrow, A., Crouse, J. R., Hinson, W. H., Terry, J. G., & Anderson, R. (1995) · Metabolism · doi:10.1016/0026-0495(95)90251-1 · Cited by 228
Suganami, T., Mieda, T., Itoh, M., Shimoda, Y., Kamei, Y., & Ogawa, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.190 · Cited by 227
Kodama, S., Horikawa, C., Fujihara, K., Heianza, Y., Hirasawa, R., Yachi, Y., Sugawara, A., Tanaka, S., Shimano, H., Iida, K. T., et al. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws172 · Cited by 226
Adipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size
Yin, X., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S., & Jensen, M. D. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3042 · Cited by 225
Hardy, O. T., Perugini, R. A., Nicoloro, S. M., Gallagher-Dorval, K., Puri, V., Straubhaar, J., & Czech, M. P. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.05.013 · Cited by 223
A decade of progress in adipose tissue macrophage biology
Hill, A. A., Reid Bolus, W., & Hasty, A. H. (2014) · Immunological Reviews · doi:10.1111/imr.12216 · Cited by 222
Ehses, J. A., Meier, D. T., Wueest, S., Rytka, J., Boller, S., Wielinga, P. Y., Schraenen, A., Lemaire, K., Debray, S., Van Lommel, L., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1747-3 · Cited by 222
Lipodystrophy: metabolic insights from a rare disorder
Huang-Doran, I., Sleigh, A., Rochford, J. J., O'Rahilly, S., & Savage, D. B. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0272 · Cited by 215
Stromsdorfer, K. L., Yamaguchi, S., Yoon, M. J., Moseley, A. C., Franczyk, M. P., Kelly, S. C., Qi, N., Imai, S.-I., & Yoshino, J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.027 · Cited by 213
Paquot, N. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.3.1316 · Cited by 212
Natural killer T cells in adipose tissue prevent insulin resistance
Schipper, H. S., Rakhshandehroo, M., van de Graaf, S. F. J., Venken, K., Koppen, A., Stienstra, R., Prop, S., Meerding, J., Hamers, N., Besra, G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62739 · Cited by 212
Structural insights into adiponectin receptors suggest ceramidase activity
Vasiliauskaité-Brooks, I., Sounier, R., Rochaix, P., Bellot, G., Fortier, M., Hoh, F., De Colibus, L., Bechara, C., Saied, E. M., Arenz, C., et al. (2017) · Nature · doi:10.1038/nature21714 · Cited by 212
The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity
O'Connell, J., Lynch, L., Cawood, T. J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., O'Farrelly, C., & O'Shea, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009997 · Cited by 211
Recent advances in obesity-induced inflammation and insulin resistance
Tateya, S., Kim, F., & Tamori, Y. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00093 · Cited by 211
Hereditary Diabetes in Genetically Obese Mice
Mayer, J., Bates, M. W., & Dickie, M. M. (1951) · Science · doi:10.1126/science.113.2948.746 · Cited by 209
Araneta, M. R. G., & Barrett‐Connor, E. (2005) · Obesity Research · doi:10.1038/oby.2005.176 · Cited by 207
Vázquez, L. A., Pazos, F., Berrazueta, J. R., Fernández-Escalante, C., García-Unzueta, M. T., Freijanes, J., & Amado, J. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032059 · Cited by 205
Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes
Albert, J. S., Yerges-Armstrong, L. M., Horenstein, R. B., Pollin, T. I., Sreenivasan, U. T., Chai, S., Blaner, W. S., Snitker, S., O'Connell, J. R., Gong, D.-W., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315496 · Cited by 199
McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Oliver, E., Claessens, M., Mills, K. H. G., & Roche, H. M. (2011) · Diabetes · doi:10.2337/db10-1278 · Cited by 199
Altintas, M. M., Azad, A., Nayer, B., Contreras, G., Zaias, J., Faul, C., Reiser, J., & Nayer, A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011338 · Cited by 198
Innate sensors of pathogen and stress: Linking inflammation to obesity
Jin, C., & Flavell, R. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.022 · Cited by 196
Obesity genetics in mouse and human: back and forth, and back again
Yazdi, F. T., Clee, S. M., & Meyre, D. (2015) · PeerJ · doi:10.7717/peerj.856 · Cited by 196
The Portal Theory Supported by Venous Drainage–Selective Fat Transplantation
Rytka, J. M., Wueest, S., Schoenle, E. J., & Konrad, D. (2011) · Diabetes · doi:10.2337/db10-0697 · Cited by 194
Kappes, A., & Löffler, G. (2000) · Hormone and Metabolic Research · doi:10.1055/s-2007-978684 · Cited by 193
Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women
Mittendorfer, B., Magkos, F., Fabbrini, E., Mohammed, B. S., & Klein, S. (2009) · Obesity · doi:10.1038/oby.2009.224 · Cited by 192
Robblee, M. M., Kim, C. C., Abate, J. P., Valdearcos, M., Sandlund, K. L. M., Shenoy, M. K., Volmer, R., Iwawaki, T., & Koliwad, S. K. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.053 · Cited by 192
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
Ingalls, A. M., Dickie, M. M., & Snell, G. D. (1996) · Obesity Research · doi:10.1002/j.1550-8528.1996.tb00519.x · Cited by 191
Lipoxins: nature's way to resolve inflammation
Sharma-walia, N., & Chandrasekharan, J. (2015) · Journal of Inflammation Research · doi:10.2147/jir.s90380 · Cited by 190
Wu, L., Parekh, V. V., Gabriel, C. L., Bracy, D. P., Marks-Shulman, P. A., Tamboli, R. A., Kim, S., Mendez-Fernandez, Y. V., Besra, G. S., Lomenick, J. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200498109 · Cited by 190
Normal weight individuals who develop Type 2 diabetes: the personal fat threshold
Taylor, R., & Holman, R. R. (2015) · Clinical Science · doi:10.1042/cs20140553 · Cited by 190
Landgraf, K., Rockstroh, D., Wagner, I. V., Weise, S., Tauscher, R., Schwartze, J. T., Löffler, D., Bühligen, U., Wojan, M., Till, H., et al. (2015) · Diabetes · doi:10.2337/db14-0744 · Cited by 190
Lim, Y.-M., Lim, H., Hur, K. Y., Quan, W., Lee, H.-Y., Cheon, H., Ryu, D., Koo, S.-H., Kim, H. L., Kim, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms5934 · Cited by 189
Fat Accretion and Growth in the Rat
Zucker, T. F., & Zucker, L. M. (1963) · The Journal of Nutrition · doi:10.1093/jn/80.1.6 · Cited by 185
Xu, J., Yeh, C.-H., Chen, S., He, L., Sensi, S. L., Canzoniero, L. M. T., Choi, D. W., & Hsu, C. Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16521 · Cited by 183
Reid, J., Macdougall, A. I., & Andrews, M. M. (1957) · BMJ · doi:10.1136/bmj.2.5053.1071 · Cited by 182
Epigenetics in Adipose Tissue, Obesity, Weight Loss, and Diabetes
Martínez, J. A., Milagro, F. I., Claycombe, K. J., & Schalinske, K. L. (2014) · Advances in Nutrition · doi:10.3945/an.113.004705 · Cited by 182
Katakura, T., Miyazaki, M., Kobayashi, M., Herndon, D. N., & Suzuki, F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1407 · Cited by 181
Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age
Coon, P. J. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.4.1125 · Cited by 179
Age Related Shift in Visceral Fat.
Hunter, G. R., Gower, B. A., & Kane, B. (2010) · PubMed · Cited by 178
MECHANISMS IN ENDOCRINOLOGY: Are metabolically healthy obese individuals really healthy?
Blüher, M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0540 · Cited by 177
Inflammation and macrophage modulation in adipose tissues: Adipose tissue macrophage modulation
Vieira-Potter, V. J. (2014) · Cellular Microbiology · doi:10.1111/cmi.12336 · Cited by 176
Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells
O’Rourke, R. W., White, A. E., Metcalf, M. D., Olivas, A. S., Mitra, P., Larison, W. G., Cheang, E. C., Varlamov, O., Corless, C. L., Roberts, C. T., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2103-y · Cited by 175
Macrophages and Adipocytes in Human Obesity
Capel, F., Klimčáková, E., Viguerie, N., Roussel, B., Vítková, M., Kováčiková, M., Polák, J., Kováčová, Z., Galitzky, J., Maoret, J.-J., et al. (2009) · Diabetes · doi:10.2337/db09-0033 · Cited by 175
Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
García, M. C., Wernstedt, I., Berndtsson, A., Enge, M., Bell, M., Hultgren, O., Horn, M., Ahrén, B., Enerback, S., Ohlsson, C., et al. (2006) · Diabetes · doi:10.2337/db05-1304 · Cited by 175
Spite, M., Hellmann, J., Tang, Y., Mathis, S. P., Kosuri, M., Bhatnagar, A., Jala, V. R., & Haribabu, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100196 · Cited by 175
Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice
O'Rourke, R. W., White, A. E., Metcalf, M. D., Winters, B. R., Diggs, B. S., Zhu, X., & Marks, D. L. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.018 · Cited by 174
Biology of Obesity: Lessons from Animal Models of Obesity
Kanasaki, K., & Koya, D. (2011) · BioMed Research International · doi:10.1155/2011/197636 · Cited by 174
Cited by
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
Chronic Low Grade Inflammation in Pathogenesis of PCOS
Rudnicka, E., Suchta, K., Grymowicz, M., Calik-Ksepka, A., Smolarczyk, K., Duszewska, A. M., Smolarczyk, R., & Meczekalski, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073789 · Cited by 680
Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343
Saponaro, C., Sabatini, S., Gaggini, M., Carli, F., Rosso, C., Positano, V., Armandi, A., Caviglia, G. P., Faletti, R., Bugianesi, E., et al. (2022) · Liver International · doi:10.1111/liv.15377 · Cited by 116
Metadata
- Authors
- Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M.
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2018-12-13
- Volume
- 9
- Issue
- 1
- Pages
- 1-58
- ISSN
- 2040-4603 (ISSN-L)
- OpenAlex
- W2905533535
- Cited by
- 373
- References
- 570
- Type
- other
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.