Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886

Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions.

Lalazar, A., Weisgraber, K. H., Rall, S. C., Giladi, H., Innerarity, T. L., Levanon, A. Z., Boyles, J. K., Amit, B., Gorecki, M., & Mahley, R. W. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68957-4 · Cited by 209

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice

Hofmann, S. L., Russell, D. W., Brown, M. S., Goldstein, J. L., & Hammer, R. E. (1988) · Science · doi:10.1126/science.3344433 · Cited by 117

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994

Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

Hobbs, H. H., Brown, M. S., & Goldstein, J. L. (1992) · Human Mutation · doi:10.1002/humu.1380010602 · Cited by 921

Apolipoprotein E: Structure-Function Relationships

Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

Chen, W. J., Goldstein, J. L., & Brown, M. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39742-x · Cited by 731

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

Lillis, A. P., Van Duyn, L. B., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 669

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

Strickland, D. K., Ashcom, J. D., Williams, S., Burgess, W. H., Migliorini, M., & Argraves, W. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38172-9 · Cited by 558

THE LDL RECEPTOR LOCUS IN FAMILIAL HYPERCHOLESTEROLEMIA: Mutational Analysis of a Membrane Protein

Hobbs, H. H., Russell, D. W., Brown, M. S., & Goldstein, J. L. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.001025 · Cited by 553

Relaxin family peptides and their receptors

Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534

Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein

Teng, B., Burant, C. F., & Davidson, N. O. (1993) · Science · doi:10.1126/science.8511591 · Cited by 536

Hepatic uptake of chylomicron remnants

Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499

LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

Herz, J., Clouthier, D. E., & Hammer, R. E. (1992) · Cell · doi:10.1016/0092-8674(92)90511-a · Cited by 497

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

Herz, J., Goldstein, J. L., Strickland, D. K., Ho, Y. K., & Brown, M. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54845-6 · Cited by 482

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein.

Beisiegel, U., Weber, W., & Bengtsson-Olivecrona, G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8342 · Cited by 468

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Rohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455

Lipoprotein receptors in the nervous system

Herz, J., & Bock, H. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135342 · Cited by 457

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes

Mahley, R. W., Huang, Y., & Rall, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32417-2 · Cited by 447

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

Trommsdorff, M., Borg, J.-P., Margolis, B., & Herz, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33556 · Cited by 453

Post-transcriptional Regulation of Low Density Lipoprotein Receptor Protein by Proprotein Convertase Subtilisin/Kexin Type 9a in Mouse Liver

Park, S. W., Moon, Y.-A., & Horton, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410077200 · Cited by 452

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., & Herz, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000955200 · Cited by 450

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87014-4 · Cited by 445

Human Apolipoprotein E Receptor 2

Kim, D.-H., Iijima, H., Goto, K., Sakai, J., Ishii, H., Kim, H.-J., Suzuki, H., Kondo, H., Saeki, S., & Yamamoto, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8373 · Cited by 384

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

Kang, D. E., Pietrzik, C. U., Baum, L., Chevallier, N., Merriam, D. E., Kounnas, M. Z., Wagner, S. L., Troncoso, J. C., Kawas, C. H., Katzman, R., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11013 · Cited by 354

Apolipoprotein J: structure and tissue distribution

De Silva, H. V., Harmony, J. A. K., Stuart, W. D., Gil, C. M., & Robbins, J. (1990) · Biochemistry · doi:10.1021/bi00474a025 · Cited by 353

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G., & Schwartz, A. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9480 · Cited by 349

Apolipoprotein E: from atherosclerosis to Alzheimerʼs disease and beyond

Mahley, R. W., & Huang, Y. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00003 · Cited by 308

Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies

Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075796 · Cited by 297

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

Williams, S. E., Ashcom, J. D., Argraves, W. S., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50384-2 · Cited by 285

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

Kanekiyo, T., & Bu, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00093 · Cited by 281

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

Willnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., & Herz, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00623.x · Cited by 276

39 kDa receptor‐associated protein is an ER resident protein and molecular chaperone for LDL receptor‐related protein.

Bu, G., Geuze, H. J., Strous, G. J., & Schwartz, A. L. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07221.x · Cited by 274

Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain

May, P., Reddy, Y. K., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201979200 · Cited by 260

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

Zhuo, M., Holtzman, D. M., Li, Y., Osaka, H., DeMaro, J., Jacquin, M., & Bu, G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00542.2000 · Cited by 258

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

Russell, D. W., Brown, M. S., & Goldstein, J. L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88240-4 · Cited by 253

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway.

Sehayek, E., & Eisenberg, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55263-7 · Cited by 249

Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice

May, P., Rohlmann, A., Bock, H. H., Zurhove, K., Marth, J. D., Schomburg, E. D., Noebels, J. L., Beffert, U., Sweatt, J. D., Weeber, E. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8872-8883.2004 · Cited by 236

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K. (1995) · Annals of Neurology · doi:10.1002/ana.410370212 · Cited by 232

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

Willnow, T. E., Armstrong, S. A., Hammer, R. E., & Herz, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4537 · Cited by 228

Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase

Mulder, M., Lombardi, P., Jansen, H., van Berkel, T. J., Frants, R. R., & Havekes, L. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98359-6 · Cited by 214

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

Ramanathan, A., Nelson, A. R., Sagare, A. P., & Zlokovic, B. V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00136 · Cited by 205

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons

Bu, G., Maksymovitch, E. A., Nerbonne, J. M., & Schwartz, A. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32340-2 · Cited by 185

Lipoprotein receptors: new roles for ancient proteins

Willnow, T. E., Nykjaer, A., & Herz, J. (1999) · Nature Cell Biology · doi:10.1038/14109 · Cited by 181

A β 42 and A β 40: similarities and differences

Qiu, T., Liu, Q., Chen, Y., Zhao, Y., & Li, Y. (2015) · Journal of Peptide Science · doi:10.1002/psc.2789 · Cited by 180

Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene Family

Brown, S. D., Twells, R. C. J., Hey, P. J., Cox, R. D., Levy, E. R., Soderman, A. R., Metzker, M. L., Caskey, C. T., Todd, J. A., & Hess, J. F. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9061 · Cited by 176

LDL Receptor–Related Protein-1

Gonias, S. L., & Campana, W. M. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.08.029 · Cited by 175

Hemoglobin and Heme Scavenger Receptors

Nielsen, M. J., Møller, H. J., & Moestrup, S. K. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2792 · Cited by 172

Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse

Osono, Y., Woollett, L. A., Herz, J., & Dietschy, J. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117760 · Cited by 169

Modular Assembly of Genes and the Evolution of New Functions

Patthy, L. (2003) · Genetica · doi:10.1023/a:1024182432483 · Cited by 166

The endocytic receptor protein LRP also mediates neuronal calcium signaling via N -methyl- d -aspartate receptors

Bacskai, B. J., Xia, M. Q., Strickland, D. K., Rebeck, G. W., & Hyman, B. T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200238297 · Cited by 163

More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration

Lane-Donovan, C., Philips, G. T., & Herz, J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.005 · Cited by 158

Transmembrane and cytoplasmic domains of syndecan mediate a multi-step endocytic pathway involving detergent-insoluble membrane rafts

FUKI, I. V., MEYER, M. E., & WILLIAMS, K. J. (2000) · Biochemical Journal · doi:10.1042/bj3510607 · Cited by 151

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

Kounnas, M. Z., Argraves, W. S., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36811-5 · Cited by 151

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

Battey, F. D., Gåfvels, M. E., FitzGerald, D. J., Argraves, W. S., Chappell, D. A., Strauss, J. F., & Strickland, D. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31648-4 · Cited by 150

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity

Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A., & Crutcher, K. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07100.1999 · Cited by 148

Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects.

Demant, T., Bedford, D., Packard, C. J., & Shepherd, J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115459 · Cited by 145

Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase

May, P., Bock, H. H., Nimpf, J., & Herz, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305858200 · Cited by 142

The Second and Fourth Cluster of Class A Cysteine-rich Repeats of the Low Density Lipoprotein Receptor-related Protein Share Ligand-binding Properties

Neels, J. G., van den Berg, B. M. M., Lookene, A., Olivecrona, G., Pannekoek, H., & van Zonneveld, A.-J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31305 · Cited by 142

Receptor-associated Protein Is a Folding Chaperone for Low Density Lipoprotein Receptor-related Protein

Bu, G., & Rennke, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22218 · Cited by 138

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Zerbinatti, C. V., Wozniak, D. F., Cirrito, J., Cam, J. A., Osaka, H., Bales, K. R., Zhuo, M., Paul, S. M., Holtzman, D. M., & Bu, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305803101 · Cited by 133

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase

Chappell, D. A., Fry, G. L., Waknitz, M. A., Iverius, P. H., Williams, S. E., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35675-8 · Cited by 133

Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by Their Distinct Endocytosis Rates

Li, Y., Lu, W., Marzolo, M. P., & Bu, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101589200 · Cited by 131

Chronic social defeat stress disrupts regulation of lipid synthesis

Chuang, J.-C., Cui, H., Mason, B. L., Mahgoub, M., Bookout, A. L., Yu, H. G., Perello, M., Elmquist, J. K., Repa, J. J., Zigman, J. M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002196 · Cited by 126

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

Marzolo, M.-P., & Bu, G. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.10.005 · Cited by 122

Signaling through LRP1: Protection from atherosclerosis and beyond

Boucher, P., & Herz, J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.09.018 · Cited by 122

Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the Intracellular Adapter Protein Fe65

Kinoshita, A., Whelan, C. M., Smith, C. J., Mikhailenko, I., Rebeck, G. W., Strickland, D. K., & Hyman, B. T. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08354.2001 · Cited by 113

Functional Roles of the Interaction of APP and Lipoprotein Receptors

Pohlkamp, T., Wasser, C. R., & Herz, J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00054 · Cited by 92

Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein

Obermoeller-McCormick, L. M., Li, Y., Osaka, H., FitzGerald, D. J., Schwartz, A. L., & Bu, G. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.5.899 · Cited by 110

Canonical and non-canonical Reelin signaling

Bock, H. H., & May, P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00166 · Cited by 107

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease

Spuch, C., Ortolano, S., & Navarro, C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00269 · Cited by 107

Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Cam (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-8 · Cited by 106

A New Low Density Lipoprotein Receptor Homologue with 8 Ligand Binding Repeats in Brain of Chicken and Mouse

Novak, S., Hiesberger, T., Schneider, W. J., & Nimpf, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11732 · Cited by 105

The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP

Williams, S. E., Inoue, I., Tran, H., Fry, G. L., Pladet, M. W., Iverius, P. H., Lalouel, J. M., Chappell, D. A., & Strickland, D. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37017-5 · Cited by 103

Evidence for a second alpha 2-macroglobulin receptor.

Misra, U. K., Chu, C. T., Gawdi, G., & Pizzo, S. V. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99909-6 · Cited by 102

Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans.

Nenseter, M. S., Rustan, A. C., Lund-Katz, S., Søyland, E., Maelandsmo, G., Phillips, M. C., & Drevon, C. A. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.3.369 · Cited by 99

The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors

Medh, J. D., Fry, G. L., Bowen, S. L., Pladet, M. W., Strickland, D. K., & Chappell, D. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.536 · Cited by 94

Heparan sulphate proteoglycans are involved in the lipoprotein lipase-mediated enhancement of the cellular binding of very low density and low density lipoproteins

Mulder, M., Lombardi, P., Jansen, H., van Berkel, T. J. C., Frants, R. R., & Havekes, L. M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91664-c · Cited by 93

Molecular mechanisms that underlie structural and functional changes atthe postsynaptic membrane duringsynaptic plasticity

Wheal, H. V., Chen, Y., Mitchell, J., Schachner, M., Maerz, W., Wieland, H., van Rossum, D., & Kirsch, J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00026-4 · Cited by 93

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-d-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Nakajima, C., Kulik, A., Frotscher, M., Herz, J., Schäfer, M., Bock, H. H., & May, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444364 · Cited by 85

Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism

Hooper, A. J., van Bockxmeer, F. M., & Burnett, J. R. (2005) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500295113 · Cited by 89

Apolipoprotein E Is Resistant to Intracellular Degradation in Vitro and in Vivo

Rensen, P. C. N., Jong, M. C., van Vark, L. C., van der Boom, H., Hendriks, W. L., van Berkel, T. J. C., Biessen, E. A. L., & Havekes, L. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8564 · Cited by 86

Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

Ebara, T., Conde, K., Kako, Y., Liu, Y., Xu, Y., Ramakrishnan, R., Goldberg, I. J., & Shachter, N. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8283 · Cited by 86

Increased Expression of LDL Receptor-Related Protein 1 during Human Cytomegalovirus Infection Reduces Virion Cholesterol and Infectivity

Gudleski-O'Regan, N., Greco, T. M., Cristea, I. M., & Shenk, T. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.05.012 · Cited by 84

A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling

Koch, S., Strasser, V., Hauser, C., Fasching, D., Brandes, C., Bajari, T. M., Schneider, W. J., & Nimpf, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf599 · Cited by 80

Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia

Jones, C., Hammer, R. E., Li, W.-P., Cohen, J. C., Hobbs, H. H., & Herz, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304855200 · Cited by 80

Genetic Mutations Affecting Human Lipoproteins, Their Receptors, and Their Enzymes

Zannis, V. I., Kardassis, D., & Zanni, E. E. (1993) · Advances in Human Genetics 21 · doi:10.1007/978-1-4615-3010-7_3 · Cited by 78

Apolipoprotein E-1Harrisburg: a new variant of apolipoprotein E dominantly associated with type III hyperlipoproteinemia.

Mann, W. A., Gregg, R. E., Sprecher, D. L., & Brewer, H. B. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90043-x · Cited by 75

The generation and function of soluble apoE receptors in the CNS

Rebeck, G. W., LaDu, M. J., Estus, S., Bu, G., & Weeber, E. J. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-15 · Cited by 66

Heterogeneous lipoprotein (a) size isoforms differ by their interaction with the low density lipoprotein receptor and the low density lipoprotein receptor‐related protein/α2‐macroglobulin receptor

März, W., Beckmann, A., Scharnagl, H., Siekmeier, R., Mondorf, U., Held, I., Schneider, W., Preissner, K. T., Curtiss, L. K., Groß, W., et al. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81087-g · Cited by 67

Adipocyte Low Density Lipoprotein Receptor-related Protein Gene Expression and Function Is Regulated by Peroxisome Proliferator-activated Receptor γ

Gauthier, A., Vassiliou, G., Benoist, F., & McPherson, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212989200 · Cited by 66

Differential Functions of Triplicated Repeats Suggest Two Independent Roles for the Receptor-associated Protein as a Molecular Chaperone

Obermoeller, L. M., Warshawsky, I., Wardell, M. R., & Bu, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10761 · Cited by 64

Expression of α2‐macroglobulin receptor/low density lipoprotein receptor‐related protein is increased in reactive and neoplastic glial cells

Lopes, M. B. S., Bogaev, C. A., Gonias, S. L., & VandenBerg, S. R. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80288-2 · Cited by 64

Role of the Lipid Membrane and Membrane Proteins in Tau Pathology

Bok, E., Leem, E., Lee, B.-R., Lee, J. M., Yoo, C. J., Lee, E. M., & Kim, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.653815 · Cited by 61

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

Yokode, M., Pathak, R., Hammer, R., Brown, M., Goldstein, J., & Anderson, R. (1992) · The Journal of cell biology · doi:10.1083/jcb.117.1.39 · Cited by 62

Mutant Lrp1 Knock-In Mice Generated by Recombinase-Mediated Cassette Exchange Reveal Differential Importance of the NPXY Motifs in the Intracellular Domain of LRP1 for Normal Fetal Development

Roebroek, A. J. M., Reekmans, S., Lauwers, A., Feyaerts, N., Smeijers, L., & Hartmann, D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.605-616.2006 · Cited by 62

Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells

Iadonato, S. P., Bu, G., Maksymovitch, E. A., & Schwartz, A. L. (1993) · Biochemical Journal · doi:10.1042/bj2960867 · Cited by 62

Structural independence of ligand-binding modules five and six of the LDL receptor

North, C. L., & Blacklow, S. C. (1999) · Biochemistry · doi:10.1021/bi9821622 · Cited by 58

Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris

Fernandez-Castaneda, A., Arandjelovic, S., Stiles, T. L., Schlobach, R. K., Mowen, K. A., Gonias, S. L., & Gaultier, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.384693 · Cited by 55

Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in Vivo

Heeren, J., Grewal, T., Jäckle, S., & Beisiegel, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107461200 · Cited by 55