The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Oxytocin Increases Gaze to the Eye Region of Human Faces
Abstract
Background In nonhuman mammals, oxytocin has a critical role in peer recognition and social approach behavior. In humans, oxytocin has been found to enhance trust and the ability to interpret the emotions of others. It has been suggested that oxytocin may enhance facial processing by increasing focus on the eye region of human faces.Methods In a double-blind, randomized, placebo-controlled, between-subject design, we tracked the eye movements of 52 healthy male volunteers who were presented with 24 neutral human faces after intranasal administration of 24 IU oxytocin or placebo.Results Participants given oxytocin showed an increased number of fixations and total gaze time toward the eye region compared with placebo participants.Conclusions Oxytocin increases gaze specifically toward the eye region of human faces. This may be one mechanism by which oxytocin enhances emotion recognition, interpersonal communication, and social approach behavior in humans. Findings suggest a possible role for oxytocin in the treatment of disorders characterized by eye-gaze avoidance and facial processing deficits.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In humans, intranasal administration of OT was found to increase bonding-related behavior, including gaze to eye region (Guastella et al., 2008), interpersonal trust and empathy (Hurlemann et al., 2010; Kosfeld et al., 2005), and social cognition (Kirsch et al., 2005).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Guastella et al., 2008
In the citing paper
“Furthermore, OXT is known to increase gaze directed at the eyes of others (Guastella et al., 2008)”
From Oxytocin Modulates Social Distance between Males and Females (2012) · cites this paper as Guastella et al., 2008
In the citing paper
“Conversely, giving either an OT-antagonist or a vasopressin antagonist blocked OT-induced partner preferences [54].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [54]
In the citing paper
“IN-OXT has also been shown in an increasing number of studies to change social visual attention in non-clinical populations of humans77–81.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [80]
In the citing paper
“OXT has been shown to increase gaze toward the eye-region of neutral faces (Guastella, Mitchell, & Dadds, 2008)”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Guastella, Mitchell, & Dadds, 2008
In the citing paper
“Such findings have led to the suggestion that OXT might improve prosocial behavior by increasing attention to socially relevant cues (Guastella et al., 2008).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Guastella et al., 2008
In the citing paper
“The acute effects of intranasal OT that we found here resemble those found in many human studies, consisting of an increase in pro-social behavior and engagement (specifically time spent in contact in males)(13,15,64–66).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [64]
In the citing paper
“Similar doses of OT have been administered to subjects in previous studies of social functioning (Andari et al., 2010; Feifel et al., 2010; Guastella et al., 2008; Hollander et al., 2007; Ditzen et al., 2009).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Guastella et al., 2008
In the citing paper
“Previous studies have employed simulated social games (Andari et al., 2010; Kosfeld et al., 2005), and static social photographs (Guastella et al., 2008) to evaluate the effects of OT on social behaviors.”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Guastella et al., 2008
In the citing paper
“While the mechanism by which oxytocin facilitates prosocial behavior is unknown, a common view is that oxytocin alters how social signals in the external environment are processed, encoded, and/or interpreted (Bartz et al., 2010a; Ellenbogen, Linnen, Grumet, Cardoso, & Joober, 2012; Guastella, Mitchell, & Dadds, 2008; Marsh, Yu, Pine, & Blair, 2010; Theodoridou, Rowe, Penton-Voak, & Rogers, 2009).”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Guastella, Mitchell, & Dadds, 2008
In the citing paper
“improving social and emotion recognition (Domes et al, 2007b;Guastella et al, 2008;Rimmele et al, 2009)”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Guastella et al, 2008
In the citing paper
“Research on humans has shown beneficial effects of intranasal oxytocin on performance on tests assessing social cognition2 and gaze to the eye region3.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [3]
In the citing paper
“These results are also consistent with a growing body of research indicating that intranasal oxytocin administration modulates emotion processing2,3,53,54”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [3]
In the citing paper
“IN-OT increases gaze time or visual fixation toward the eye region and the face (Auyeung et al. 2015; Domes et al. 2013; Guastella et al. 2008).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Guastella et al. 2008
In the citing paper
“For instance, oxytocin has been shown to enhance memory for happy faces relative to angry and neutral faces (Guastella et al., 2008).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Guastella et al., 2008
In the citing paper
“No significant differential improvements were observed on changes in parent or experimenter reports of symptoms, or on observed behaviours during interactions.However, it remains unclear whether a lack of effect in this study may be due to the complicated study design.”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [51]
In the citing paper
“Guided by other pharmaceutical trials, four randomized placebo-controlled trials of children and adolescents have employed dosages stratified by weight or age.38,49,51,54”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [51]
In the citing paper
“A succession of studies reported modest improvements in social cognition after use of nasal oxytocin spray in both neurotypical16, 17, 18 and psychiatric19, 20, 21 populations”
In the citing paper
“Following intranasal OT (Syntocinon spray, Novartis), humans spend more time visually inspecting the eye region of faces compared to placebo (i.e., all inactive ingredients except for the peptide) (Gamer et al., 2010; Guastella et al., 2008).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Guastella et al., 2008
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891
A secure base: parent-child attachment and healthy human development
(1989) · Choice Reviews Online · doi:10.5860/choice.26-4750 · Cited by 4,886
Baron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00715 · Cited by 4,555
Baron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Klin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.809 · Cited by 2,120
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Research works printed but not linked: 1
- Gobbini, 2000, The effect of personal familiarity on the neural response to faces, Soc Neurosci Abstracts, 26, 974
Cited by
Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962
Self-citationPromoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
Beetz, A., Uvnäs-Moberg, K., Julius, H., & Kotrschal, K. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00234 · Cited by 904
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 805
Adult attachment predicts maternal brain and oxytocin response to infant cues.
Strathearn, L., Fonagy, P., Amico, J., & Montague, P. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.103 · Cited by 773
The Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585
Music and social bonding: “self-other†merging and neurohormonal mechanisms
Tarr, B., Launay, J., & Dunbar, R. I. M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01096 · Cited by 548
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479
Survival of the Friendliest: Homo sapiens Evolved via Selection for Prosociality
Hare, B. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044201 · Cited by 444
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
Oxytocin Makes a Face in Memory Familiar
Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4260-08.2009 · Cited by 402
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366
Self-citationOxytocin, motivation and the role of dopamine
Love, T. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.06.011 · Cited by 369
The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis
LoParo, D., & Waldman, I. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.77 · Cited by 343
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.022 · Cited by 343
Yatawara, C. J., Einfeld, S. L., Hickie, I. B., Davenport, T. A., & Guastella, A. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.162 · Cited by 344
Self-citationOxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 359
Self-citationOxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352
Self-citationAnagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336
Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies
Walum, H., Waldman, I. D., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.016 · Cited by 347
Dopaminergic-neuropeptide interactions in the social brain
Skuse, D. H., & Gallagher, L. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.09.007 · Cited by 340
Declerck, C. H., Boone, C., & Kiyonari, T. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.01.006 · Cited by 331
Ross, H. E., Freeman, S. M., Spiegel, L. L., Ren, X., Terwilliger, E. F., & Young, L. J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5039-08.2009 · Cited by 322
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.019 · Cited by 318
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 333
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307
Oxytocin Modulates Social Distance between Males and Females
Scheele, D., Striepens, N., Güntürkün, O., Deutschländer, S., Maier, W., Kendrick, K. M., & Hurlemann, R. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2755-12.2012 · Cited by 301
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283
Oxytocin enhances the experience of attachment security
Buchheim, A., Heinrichs, M., George, C., Pokorny, D., Koops, E., Henningsen, P., O’Connor, M.-F., & Gündel, H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.002 · Cited by 277
Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Riebold, M., Laiba, E., Bachner-Melman, R., Maril, A., Bornstein, G., Knafo, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005535 · Cited by 278
Valstad, M., Alvares, G. A., Egknud, M., Matziorinis, A. M., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.017 · Cited by 277
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273
Maternal neglect: oxytocin, dopamine and the neurobiology of attachment
Strathearn, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02228.x · Cited by 268
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265
Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial
Dadds, M. R., MacDonald, E., Cauchi, A., Williams, K., Levy, F., & Brennan, J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1899-3 · Cited by 250
Self-citationChang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255
Auyeung, B., Lombardo, M. V., Heinrichs, M., Chakrabarti, B., Sule, A., Deakin, J. B., Bethlehem, R. A. I., Dickens, L., Mooney, N., Sipple, J. A. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.146 · Cited by 234
Dumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., van Gerven, J. M. A., Buitelaar, J. K., & Verkes, R. J. (2009) · Social Neuroscience · doi:10.1080/17470910802649470 · Cited by 238
Oxytocin and human social behavior.
Campbell, A. (2010) · Personality and Social Psychology Review · doi:10.1177/1088868310363594 · Cited by 232
The Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228
Self-citationLischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218
Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience
Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00083 · Cited by 207
Skuse, D. H., Lori, A., Cubells, J. F., Lee, I., Conneely, K. N., Puura, K., Lehtimäki, T., Binder, E. B., & Young, L. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302985111 · Cited by 207
Chronic and acute intranasal oxytocin produce divergent social effects in mice
Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199
Yamasue, H., Okada, T., Munesue, T., Kuroda, M., Fujioka, T., Uno, Y., Matsumoto, K., Kuwabara, H., Mori, D., Okamoto, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0097-2 · Cited by 185
Intranasal oxytocin blocks alcohol withdrawal in human subjects
Pedersen, C. A., Smedley, K. L., Leserman, J., Jarskog, L. F., Rau, S. W., Kampov‐Polevoi, A., Casey, R. L., Fender, T., & Garbutt, J. C. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01958.x · Cited by 196
Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.2 · Cited by 193
DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli
Jack, A., Connelly, J. J., & Morris, J. P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00280 · Cited by 192
From mind perception to mental connection: synchrony as a mechanism for social understanding.
Wheatley, T., Kang, O., Parkinson, C., & Looser, C. E. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00450.x · Cited by 178
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism
Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187
The effect of intranasal administration of oxytocin on fear recognition
Fischer-Shofty, M., Shamay-Tsoory, S. G., Harari, H., & Levkovitz, Y. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.09.003 · Cited by 184
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
Munesue, T., Yokoyama, S., Nakamura, K., Anitha, A., Yamada, K., Hayashi, K., Asaka, T., Liu, H.-X., Jin, D., Koizumi, K., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.004 · Cited by 177
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176
McGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171
Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9071-2 · Cited by 170
A socio-relational framework of sex differences in the expression of emotion
Vigil, J. M. (2009) · Behavioral and Brain Sciences · doi:10.1017/s0140525x09991075 · Cited by 173
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169
Sharing secrets: oxytocin and trust in schizophrenia
Kéri, S., Kiss, I., & Kelemen, O. (2009) · Social Neuroscience · doi:10.1080/17470910802319710 · Cited by 167
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162
Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31032 · Cited by 163
Keebaugh, A. C., & Young, L. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.018 · Cited by 154
Domes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160
Kemp, A. H., Quintana, D. S., Kuhnert, R.-L., Griffiths, K., Hickie, I. B., & Guastella, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044014 · Cited by 158
Self-citationEllingsen, D.-M., Wessberg, J., Chelnokova, O., Olausson, H., Laeng, B., & Leknes, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.017 · Cited by 153
Oxytocin and the maternal brain
LENG, G., MEDDLE, S., & DOUGLAS, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.07.001 · Cited by 158
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155
Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis
Keech, B., Crowe, S., & Hocking, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.022 · Cited by 145
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss062 · Cited by 151
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149
Self-citationOxytocin-Augmented Social Cognitive Skills Training in Schizophrenia
Davis, M. C., Green, M. F., Lee, J., Horan, W. P., Senturk, D., Clarke, A. D., & Marder, S. R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.68 · Cited by 149
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
Carson, D. S., Cornish, J. L., Guastella, A. J., Hunt, G. E., & McGregor, I. S. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.018 · Cited by 146
Self-citation
Metadata
- Authors
- Guastella, A. J., Mitchell, P. B., & Dadds, M. R.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Guastella, Adam J.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 63
- Issue
- 1
- Pages
- 3-5
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2025147744
- Cited by
- 798
- References
- 23
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 12 · 2023: 24 · 2022: 27 · 2021: 39 · 2020: 32 · 2019: 36 · 2018: 59 · 2017: 52 · 2016: 58 · 2015: 61 · 2014: 67 · 2013: 81 · 2012: 63
- FWCI
- 46.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, eye movements, fixation, gaze time, emotion recognition, social approach behavior, intranasal administration, interpersonal communication
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Attention, Double-Blind Method, Emotions, Face, Facial Expression, Fixation, Ocular, Humans, Male, Oxytocin, Pattern Recognition, Visual, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
