Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 654

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

Anisman, Hymie, Zaharia, Marilee D., Meaney, Michael J., Merali, Zul·1998·International Journal of Developmental Neuroscience
DOI 10.1016/s0736-5748(98)00025-2
Open this paper in CoChat — free account

Abstract

Early‐life stimulation (e.g. brief handling) attenuates the behavioral and neuroendocrine responses to stressors encountered in adulthood, particularly with respect to activation of hypothalamic‐pituitary‐adrenal (HPA) activity. In contrast, if neonates were subjected to a more severe stressor, such as protracted separation from the dam or exposure to an endotoxin, then the adult response to a stressor was exaggerated. These early‐life experiences program HPA functioning, including negative feedback derived from stimulation of hippocampal glucocorticoid receptors, and corticotropin‐releasing hormone (CRH) and arginine vasopressin (AVP) coexpression in PVN neurons, to modify the response to subsequent stressor experiences. The persistent variations of HPA activity observed in handled/stimulated animals may stem from alterations in dam–pup interactions (e.g. increased arched‐back feeding, licking, grooming). In addition genetic makeup is critical in determining stress reactivity. For instance, BALB/cByJ mice are more reactive to stressors than C57BL/6ByJ mice, exhibiting greater HPA hormonal alterations and behavioral disturbances. BALB/cByJ also fail to acquire a spatial learning response in a Morris water‐maze paradigm, which has been shown to be correlated with hippocampal cell loss associated with aging. Early‐life handling of BALB/cByJ mice prevented these performance deficits and attenuated the hypersecretion of ACTH and corticosterone elicited by stressors. The stressor reactivity may have been related to maternal and genetic factors. When BALB/cByJ mice were raised by a C57BL/6ByJ dam, the excessive stress‐elicited HPA activity was reduced, as were the behavioral impairments. However, cross‐fostering the more resilient C57BL/6ByJ mice to a BALB/cByJ dam failed to elicit the behavioral disturbances. It is suggested that genetic factors may influence dam–pup interactive styles and may thus proactively influence the response to subsequent stressors among vulnerable animals. In contrast, in relatively hardy animals the early‐life manipulations may have less obvious effects.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0736-5748(98)00025-2

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 11 references

Research works printed but not linked: 94

  1. 10.1016/0197-4580(89)90062-6 · DOI
  2. Anisman H., 1993, Rev., 4, 147
  3. Bhatnagar S., 1995, Neuroendocrinology, 7, 107
  4. 10.1210/endo-92-6-1775 · DOI
  5. Cabib S., 1993, Brain Research, 604, 2332, 10.1016/0006-8993(93)90374-V · DOI
  6. 10.1016/S0306-4522(96)00668-9 · DOI
  7. 10.1016/0006-8993(93)90079-3 · DOI · Paper page
  8. 10.1002/dev.420270505 · DOI
  9. Clausing P., 1997, Brain Res., 82, 179
  10. Conrad C.D., 1993, J. Neurosci, 13, 2582, 10.1523/JNEUROSCI.13-06-02582.1993 · DOI
  11. 10.1016/0006-8993(87)90498-7 · DOI · Paper page
  12. DAmore A., 1991, Peptides, 12, 1291, 10.1016/0196-9781(91)90209-8 · DOI
  13. De Goeji D.C.E., 1992, Endocrinology, 131, 847
  14. De Goeji D.C.E., 1992, Brain Res, 577, 165, 10.1016/0006-8993(92)90552-K · DOI
  15. 10.1016/0306-4530(87)90040-0 · DOI · Paper page
  16. De Kloet E.R., 1991, Brain, 12, 95
  17. 10.1037/h0042567 · DOI · Paper page
  18. Dinan T.G., 1994, J., 164, 365
  19. Escorihuela R.M., 1994, Brain Res, 61, 169
  20. Fernandez‐Teruel A., 1991, Physiol., 50, 563
  21. 10.1007/BF02245303 · DOI
  22. 10.1016/0091-3057(94)00419-J · DOI
  23. Francis D.D., 1995, Physiol., 58, 57
  24. Giles E.E., 1996, Neurol, 15, 114
  25. Gonzalez A.S., 1990, Physiol., 47, 735
  26. 10.1006/brbi.1996.0022 · DOI
  27. 10.1016/0091-3057(92)90519-L · DOI
  28. 10.1210/endo-106-3-991 · DOI
  29. 10.1038/2121371a0 · DOI
  30. Heim C., 1997, J., 33, 185
  31. Hennessy M.B., 1997, Rev, 21, 11
  32. 10.1097/00006842-199307000-00004 · DOI · Paper page
  33. 10.1016/0006-8993(91)91580-T · DOI
  34. 10.1016/0092-8674(87)90152-8 · DOI · Paper page
  35. 10.1002/dev.420170302 · DOI
  36. Kuhn C., 1990, J., 23, 395
  37. Ladd C.O., 1996, Endocrinology, 137, 1212, 10.1210/endo.137.4.8625891 · DOI · Paper page
  38. 10.1016/S0079-6123(08)60215-0 · DOI
  39. 10.1126/science.715460 · DOI · Paper page
  40. Lee M.H., 1976, W, 7, 489
  41. Lee M.H., 1974, A, 22, 679
  42. Levine S., 1975, Society, Stress and Disease, 43
  43. 10.1016/S0079-6123(08)61521-6 · DOI
  44. Levine S., 1967, Physiol., 2, 55
  45. Maes M., 1995, Biol. Psych, 19, 11
  46. Manuck S.B., 1986, A., 6, 2
  47. 10.1016/0165-3806(85)90183-X · DOI
  48. 10.1159/000111395 · DOI · Paper page
  49. 10.1006/smns.1994.1032 · DOI
  50. 10.1016/0197-4580(91)90036-J · DOI · Paper page
  51. Meaney M.J., 1991, In, 16, 85
  52. Meaney M.J., 1991, Biochem., 39, 265
  53. 10.1159/000125287 · DOI · Paper page
  54. 10.1016/0165-3806(90)90204-C · DOI · Paper page
  55. Mitchell J.B., 1990, J. Neurosci, 10, 1745, 10.1523/JNEUROSCI.10-06-01745.1990 · DOI
  56. Munck A., 1984, Physiol, 5, 25
  57. Musi B., 1993, In, 95, 43
  58. Nemeroff C.B., 1993, In, 19, 1
  59. Nunez J.F., 1996, Physiol., 60, 1355
  60. Patacchioli F.R., 1990, Brain Res, 37, 185
  61. Pieretti S., 1991, A., 105, 215
  62. 10.1016/0306-4530(93)90042-J · DOI
  63. Renner M. J., 1987, Enriched and Impoverished Environments : Effects on Brain and Behavior, 10.1007/978-1-4612-4766-1 · DOI
  64. 10.1037/0003-066X.39.4.365 · DOI
  65. 10.1038/scientificamerican0272-22 · DOI · Paper page
  66. Sapolsky R. M., 1992, Stress, the Aging Brain and the Mechanisms of Neuron Death., MIT Press
  67. 10.1016/0166-2236(87)90065-8 · DOI
  68. 10.1210/edrv-7-3-284 · DOI · Paper page
  69. 10.1523/JNEUROSCI.05-05-01222.1985 · DOI · Paper page
  70. 10.1073/pnas.81.19.6174 · DOI · Paper page
  71. 10.1016/0165-3806(88)90162-9 · DOI
  72. Schmidt E.D., 1996, A., 8, 703
  73. Schwegler H., 1988, W., 18, 153
  74. 10.1016/0091-3057(93)90538-5 · DOI
  75. Shanks N., 1988, A, 102, 895
  76. Shanks N., 1994, Brain Res, 63, 25
  77. 10.1016/0091-3057(91)90591-O · DOI
  78. 10.1016/0091-3057(90)90249-H · DOI
  79. 10.1002/dev.420100303 · DOI
  80. Smyth J.W., 1994, Dev. Brain Res., 80, 183, 10.1016/0165-3806(94)90103-1 · DOI · Paper page
  81. 10.1002/dev.420230505 · DOI
  82. 10.1111/j.1749-6632.1993.tb49921.x · DOI
  83. Upchurch M., 1988, J., 18, 55
  84. 10.1016/0169-328X(93)90151-E · doi:10.1016/0169-328x(93)90151-e
  85. 10.1523/JNEUROSCI.17-07-02626.1997 · DOI · Paper page
  86. 10.1523/JNEUROSCI.13-03-01097.1993 · DOI · Paper page
  87. Wakshlak A., 1990, Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress, Physiol Behav., 48, 298, 10.1016/0031-9384(90)90315-U · DOI
  88. Walker C.D., 1995, A, 56, 169
  89. Walker C.D., 1995, Am. J. Physiol, 1281, 1288
  90. Warren D.A., 1991, Psychobiology, 19, 127, 10.3758/BF03327182 · DOI
  91. Windle R.J., 1997, Neuroendocrinology, 9, 407, 10.1046/j.1365-2826.1997.00587.x · DOI · Paper page
  92. 10.1016/0006-8993(87)90436-7 · DOI
  93. 10.1007/s002130050130 · DOI · Paper page
  94. Zaharia M.D., 1994, A, 20, 1769

Cited by

Metadata

Authors
Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z.
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
1998-06
Volume
16
Issue
3-4
Pages
149-164
ISSN
  • 0736-5748 (ISSN-L)
  • 1873-474X
DOI
10.1016/s0736-5748(98)00025-2
OpenAlex
W2059134061
Cited by
654
References
11
FWCI
11.24
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 204 d)
Funders
Ontario Health Foundation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.