The DOI matches its Crossref record; 239 of the 239 references it cites were found in a registry or an index.
Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
Abstract
Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of nanoparticles plays a key role in controlling their in vivo transport behaviors due to the existence of various physiological size thresholds within the body and size-dependent nano-bio interactions. Encouraged by the evolving discoveries of nanoparticle-size-dependent biological effects, we believe that it is necessary to systematically summarize the size-scaling laws of nanoparticle transport in vivo . In this review, we summarized the size effect of nanoparticles on their in vivo transport along their journey in the body: begin with the administration of nanoparticles via different delivery routes, followed by the targeting of nanoparticles to intended tissues including tumors and other organs, and eventually clearance of nanoparticles through the liver or kidneys. We outlined the tools for investigating the in vivo transport of nanoparticles as well. Finally, we discussed how we may leverage the size-dependent transport to tackle some of the key challenges in nanomedicine translation and also raised important size-related questions that remain to be answered in the future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218
Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Cedervall, T., Lynch, I., Lindman, S., Berggård, T., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608582104 · Cited by 3,281
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,180
Biomolecular coronas provide the biological identity of nanosized materials
Monopoli, M. P., Åberg, C., Salvati, A., & Dawson, K. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.207 · Cited by 3,017
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 2,823
He, C., Hu, Y., Yin, L., Tang, C., & Yin, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.065 · Cited by 2,607
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Cheng, Q., Wei, T., Farbiak, L., Johnson, L. T., Dilliard, S. A., & Siegwart, D. J. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0669-6 · Cited by 2,383
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,815
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
Arvanitis, C. D., Ferraro, G. B., & Jain, R. K. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0205-x · Cited by 1,792
Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255691.76142.4a · Cited by 1,750
The entry of nanoparticles into solid tumours
Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732
Protein-nanoparticle interactions
Lynch, I., & Dawson, K. A. (2008) · Nano Today · doi:10.1016/s1748-0132(08)70014-8 · Cited by 1,727
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
De Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.037 · Cited by 1,615
Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C., & Chan, W. C. W. (2009) · Nano Letters · doi:10.1021/nl900031y · Cited by 1,513
The gastrointestinal mucus system in health and disease
Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.35 · Cited by 1,438
Protein−Nanoparticle Interactions: Opportunities and Challenges
Mahmoudi, M., Lynch, I., Ejtehadi, M. R., Monopoli, M. P., Bombelli, F. B., & Laurent, S. (2011) · Chemical Reviews · doi:10.1021/cr100440g · Cited by 1,426
Anatomical basis of tolerance and immunity to intestinal antigens
Mowat, A. M. (2003) · Nature Reviews Immunology · doi:10.1038/nri1057 · Cited by 1,415
Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
Zhang, Y.-N., Poon, W., Tavares, A. J., McGilvray, I. D., & Chan, W. C. W. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.020 · Cited by 1,349
Nanoparticles target distinct dendritic cell populations according to their size
Manolova, V., Flace, A., Bauer, M., Schwarz, K., Saudan, P., & Bachmann, M. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200737984 · Cited by 1,289
Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255690.03436.ae · Cited by 1,257
The intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
Biju, V. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60273g · Cited by 1,186
Targeted drug delivery strategies for precision medicines
Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,183
Physical Principles of Nanoparticle Cellular Endocytosis
Zhang, S., Gao, H., & Bao, G. (2015) · ACS Nano · doi:10.1021/acsnano.5b03184 · Cited by 1,103
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101
Sonavane, G., Tomoda, K., & Makino, K. (2008) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2008.07.004 · Cited by 1,100
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Wong, C., Stylianopoulos, T., Cui, J., Martin, J., Chauhan, V. P., Jiang, W., Popović, Z., Jain, R. K., Bawendi, M. G., & Fukumura, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018382108 · Cited by 1,062
Ernsting, M. J., Murakami, M., Roy, A., & Li, S.-D. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.013 · Cited by 1,012
Mechanism of hard-nanomaterial clearance by the liver
Tsoi, K. M., MacParland, S. A., Ma, X.-Z., Spetzler, V. N., Echeverri, J., Ouyang, B., Fadel, S. M., Sykes, E. A., Goldaracena, N., Kaths, J. M., et al. (2016) · Nature Materials · doi:10.1038/nmat4718 · Cited by 1,010
Modern methods for delivery of drugs across the blood–brain barrier
Chen, Y., & Liu, L. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,006
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
Liver: An organ with predominant innate immunity
Gao, B., Jeong, W.-I., & Tian, Z. (2008) · Hepatology · doi:10.1002/hep.22034 · Cited by 952
Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size
Desai, M. P., Labhasetwar, V., Amidon, G. L., & Levy, R. J. (1996) · Pharmaceutical Research · doi:10.1023/a:1016085108889 · Cited by 941
Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers
Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., & Chilkoti, A. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj070 · Cited by 920
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles
Yu, M., & Zheng, J. (2015) · ACS Nano · doi:10.1021/acsnano.5b01320 · Cited by 886
Huang, K., Ma, H., Liu, J., Huo, S., Kumar, A., Wei, T., Zhang, X., Jin, S., Gan, Y., Wang, P. C., et al. (2012) · ACS Nano · doi:10.1021/nn301282m · Cited by 840
Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
Zhou, Q., Shao, S., Wang, J., Xu, C., Xiang, J., Piao, Y., Zhou, Z., Yu, Q., Tang, J., Liu, X., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0485-z · Cited by 819
Strategies for advancing cancer nanomedicine
Chauhan, V. P., & Jain, R. K. (2013) · Nature Materials · doi:10.1038/nmat3792 · Cited by 812
Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles
Cedervall, T., Lynch, I., Foy, M., Berggård, T., Donnelly, S. C., Cagney, G., Linse, S., & Dawson, K. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700465 · Cited by 777
Alameh, M.-G., Tombácz, I., Bettini, E., Lederer, K., Ndeupen, S., Sittplangkoon, C., Wilmore, J. R., Gaudette, B. T., Soliman, O. Y., Pine, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.001 · Cited by 775
The Evolution of the Protein Corona around Nanoparticles: A Test Study
Lundqvist, M., Stigler, J., Cedervall, T., Berggård, T., Flanagan, M. B., Lynch, I., Elia, G., & Dawson, K. (2011) · ACS Nano · doi:10.1021/nn202458g · Cited by 752
Soluble Polymer Carriers for the Treatment of Cancer: The Importance of Molecular Architecture
Fox, M. E., Szoka, F. C., & Fréchet, J. M. J. (2009) · Accounts of Chemical Research · doi:10.1021/ar900035f · Cited by 748
Yamaoka, T., Tabata, Y., & Ikada, Y. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830432 · Cited by 748
Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R., & Mahajan, A. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.30 · Cited by 721
Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
Huang, J., Li, J., Lyu, Y., Miao, Q., & Pu, K. (2019) · Nature Materials · doi:10.1038/s41563-019-0378-4 · Cited by 721
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
Oberli, M. A., Reichmuth, A. M., Dorkin, J. R., Mitchell, M. J., Fenton, O. S., Jaklenec, A., Anderson, D. G., Langer, R., & Blankschtein, D. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b03329 · Cited by 719
The nanoparticle biomolecule corona: lessons learned – challenge accepted?
Docter, D., Westmeier, D., Markiewicz, M., Stolte, S., Knauer, S. K., & Stauber, R. H. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00217f · Cited by 693
Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection
Lei, Z., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202007040 · Cited by 683
Dobrovolskaia, M. A., Patri, A. K., Zheng, J., Clogston, J. D., Ayub, N., Aggarwal, P., Neun, B. W., Hall, J. B., & McNeil, S. E. (2009) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2008.08.001 · Cited by 679
Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors
Dai, Q., Wilhelm, S., Ding, D., Syed, A. M., Sindhwani, S., Zhang, Y., Chen, Y. Y., MacMillan, P., & Chan, W. C. W. (2018) · ACS Nano · doi:10.1021/acsnano.8b03900 · Cited by 658
From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
Trevaskis, N. L., Kaminskas, L. M., & Porter, C. J. H. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4608 · Cited by 654
Investigating the optimal size of anticancer nanomedicine
Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411499111 · Cited by 654
Transport and interactions of nanoparticles in the kidneys
Du, B., Yu, M., & Zheng, J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0038-3 · Cited by 649
Self-citationRapid translocation of nanoparticles from the lung airspaces to the body
Choi, H. S., Ashitate, Y., Lee, J. H., Kim, S. H., Matsui, A., Insin, N., Bawendi, M. G., Semmler-Behnke, M., Frangioni, J. V., & Tsuda, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1696 · Cited by 648
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
Benezra, M., Penate-Medina, O., Zanzonico, P. B., Schaer, D., Ow, H., Burns, A., DeStanchina, E., Longo, V., Herz, E., Iyer, S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45600 · Cited by 645
Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency
Sykes, E. A., Chen, J., Zheng, G., & Chan, W. C. W. (2014) · ACS Nano · doi:10.1021/nn500299p · Cited by 635
Recent advances in magnetic nanoparticle-based multi-modal imaging
Shin, T.-H., Choi, Y., Kim, S., & Cheon, J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00345d · Cited by 602
Liu, J., Yu, M., Zhou, C., Yang, S., Ning, X., & Zheng, J. (2013) · Journal of the American Chemical Society · doi:10.1021/ja401612x · Cited by 597
Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometre regime
Du, B., Jiang, X., Das, A., Zhou, Q., Yu, M., Jin, R., & Zheng, J. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.170 · Cited by 587
Self-citationHirn, S., Semmler-Behnke, M., Schleh, C., Wenk, A., Lipka, J., Schäffler, M., Takenaka, S., Möller, W., Schmid, G., Simon, U., et al. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.12.029 · Cited by 583
Elimination Pathways of Nanoparticles
Poon, W., Zhang, Y.-N., Ouyang, B., Kingston, B. R., Wu, J. L. Y., Wilhelm, S., & Chan, W. C. W. (2019) · ACS Nano · doi:10.1021/acsnano.9b01383 · Cited by 575
Weber, S., Zimmer, A., & Pardeike, J. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.08.013 · Cited by 568
Near-infrared luminescence high-contrast in vivo biomedical imaging
Chen, Y., Wang, S., & Zhang, F. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-022-00002-8 · Cited by 566
Composition and functional role of the mucus layers in the intestine
Johansson, M. E. V., Ambort, D., Pelaseyed, T., Schütte, A., Gustafsson, J. K., Ermund, A., Subramani, D. B., Holmén-Larsson, J. M., Thomsson, K. A., Bergström, J. H., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0822-3 · Cited by 556
Kumar, R., Roy, I., Ohulchanskky, T. Y., Vathy, L. A., Bergey, E. J., Sajjad, M., & Prasad, P. N. (2010) · ACS Nano · doi:10.1021/nn901146y · Cited by 548
Jin, H., Heller, D. A., Sharma, R., & Strano, M. S. (2009) · ACS Nano · doi:10.1021/nn800532m · Cited by 544
A framework for designing delivery systems
Poon, W., Kingston, B. R., Ouyang, B., Ngo, W., & Chan, W. C. W. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0759-5 · Cited by 524
Mi, P., Kokuryo, D., Cabral, H., Wu, H., Terada, Y., Saga, T., Aoki, I., Nishiyama, N., & Kataoka, K. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.72 · Cited by 512
Qiu, M., Tang, Y., Chen, J., Muriph, R., Ye, Z., Huang, C., Evans, J., Henske, E. P., & Xu, Q. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116271119 · Cited by 504
Targeting kidney mesangium by nanoparticles of defined size
Choi, C. H. J., Zuckerman, J. E., Webster, P., & Davis, M. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103573108 · Cited by 502
Luminescent Gold Nanoparticles with Efficient Renal Clearance
Zhou, C., Long, M., Qin, Y., Sun, X., & Zheng, J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007321 · Cited by 490
Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging
Zhou, Z., Yang, L., Gao, J., & Chen, X. (2019) · Advanced Materials · doi:10.1002/adma.201804567 · Cited by 488
Size‐Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting
Kang, H., Rho, S., Stiles, W. R., Hu, S., Baek, Y., Hwang, D. W., Kashiwagi, S., Kim, M. S., & Choi, H. S. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901223 · Cited by 480
Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine
Burns, A. A., Vider, J., Ow, H., Herz, E., Penate-Medina, O., Baumgart, M., Larson, S. M., Wiesner, U., & Bradbury, M. (2009) · Nano Letters · doi:10.1021/nl803405h · Cited by 474
Huang, J., Bu, L., Xie, J., Chen, K., Cheng, Z., Li, X., & Chen, X. (2010) · ACS Nano · doi:10.1021/nn101643u · Cited by 463
Venturoli, D., & Rippe, B. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00171.2004 · Cited by 461
Material design for lymph node drug delivery
Schudel, A., Francis, D. M., & Thomas, S. N. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0110-7 · Cited by 460
Lipid-Based Delivery Systems and Intestinal Lymphatic Drug Transport: A Mechanistic Update
Trevaskis, N. L., Charman, W. N., & Porter, C. J. H. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.007 · Cited by 442
Targeted delivery of nanoparticles for the treatment of lung diseases
Azarmi, S., Roa, W. H., & Löbenberg, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.006 · Cited by 440
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives
Sun, R., Xiang, J., Zhou, Q., Piao, Y., Tang, J., Shao, S., Zhou, Z., Bae, Y. H., & Shen, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114614 · Cited by 433
Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona
Caracciolo, G., Farokhzad, O. C., & Mahmoudi, M. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.08.011 · Cited by 426
Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots
Huang, X., Zhang, F., Zhu, L., Choi, K. Y., Guo, N., Guo, J., Tackett, K., Anilkumar, P., Liu, G., Quan, Q., et al. (2013) · ACS Nano · doi:10.1021/nn401911k · Cited by 418
Self-citationKopac, T. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.108 · Cited by 418
Molecular imaging and disease theranostics with renal-clearable optical agents
Cheng, P., & Pu, K. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00328-6 · Cited by 413
Abdelaziz, H. M., Gaber, M., Abd-Elwakil, M. M., Mabrouk, M. T., Elgohary, M. M., Kamel, N. M., Kabary, D. M., Freag, M. S., Samaha, M. W., Mortada, S. M., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.036 · Cited by 409
Cells in the Marginal Zone of the Spleen
Kraal, G. (1992) · International Review of Cytology · doi:10.1016/s0074-7696(08)62453-5 · Cited by 401
Entry of nanoparticles into cells: the importance of nanoparticle properties
Zhao, J., & Stenzel, M. H. (2018) · Polymer Chemistry · doi:10.1039/c7py01603d · Cited by 391
Piella, J., Bastús, N. G., & Puntes, V. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00575 · Cited by 382
Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review
Bratosin, D., Mazurier, J., Tissier, J. P., Estaquier, J., Huart, J. J., Ameisen, J. C., Aminoff, D., & Montreuil, J. (1998) · Biochimie · doi:10.1016/s0300-9084(98)80024-2 · Cited by 376
In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape
García-Álvarez, R., Hadjidemetriou, M., Sánchez-Iglesias, A., Liz-Marzán, L. M., & Kostarelos, K. (2018) · Nanoscale · doi:10.1039/c7nr08322j · Cited by 373
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
Zuckerman, J. E., Choi, C. H. J., Han, H., & Davis, M. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200718109 · Cited by 372
Nanotechnology approaches for inhalation treatment of lung diseases
Kuzmov, A., & Minko, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.024 · Cited by 352
Fischer, H. C., Liu, L., Pang, K. S., & Chan, W. C. W. (2006) · Advanced Functional Materials · doi:10.1002/adfm.200500529 · Cited by 347
Schleh, C., Semmler-Behnke, M., Lipka, J., Wenk, A., Hirn, S., Schäffler, M., Schmid, G., Simon, U., & Kreyling, W. G. (2012) · Nanotoxicology · doi:10.3109/17435390.2011.552811 · Cited by 325
Chen, S., Zhong, Y., Fan, W., Xiang, J., Wang, G., Zhou, Q., Wang, J., Geng, Y., Sun, R., Zhang, Z., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00701-4 · Cited by 325
The role of mucus on drug transport and its potential to affect therapeutic outcomes
Murgia, X., Loretz, B., Hartwig, O., Hittinger, M., & Lehr, C.-M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.009 · Cited by 324
Nanoparticles' interactions with vasculature in diseases
Tee, J. K., Yip, L. X., Tan, E. S., Santitewagun, S., Prasath, A., Ke, P. C., Ho, H. K., & Leong, D. T. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00309f · Cited by 314
Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood
Setyawati, M. I., Tay, C. Y., Docter, D., Stauber, R. H., & Leong, D. T. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00499c · Cited by 308
Cho, M., Cho, W.-S., Choi, M., Kim, S. J., Han, B. S., Kim, S. H., Kim, H. O., Sheen, Y. Y., & Jeong, J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.04.017 · Cited by 304
Selective Filtering of Particles by the Extracellular Matrix: An Electrostatic Bandpass
Lieleg, O., Baumgärtel, R. M., & Bausch, A. R. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.07.009 · Cited by 304
Radiolabelling of nanomaterials for medical imaging and therapy
Pellico, J., Gawne, P. J., & T. M. de Rosales, R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00384k · Cited by 304
Suzuki, Y., & Ishihara, H. (2021) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2021.100424 · Cited by 298
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
Lamson, N. G., Berger, A., Fein, K. C., & Whitehead, K. A. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0465-5 · Cited by 296
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
Han, X., Lu, Y., Xie, J., Zhang, E., Zhu, H., Du, H., Wang, K., Song, B., Yang, C., Shi, Y., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0693-6 · Cited by 296
Size-dependent tissue kinetics of PEG-coated gold nanoparticles
Cho, W.-S., Cho, M., Jeong, J., Choi, M., Han, B. S., Shin, H.-S., Hong, J., Chung, B. H., Jeong, J., & Cho, M.-H. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.02.013 · Cited by 281
Tailoring nanoparticle designs to target cancer based on tumor pathophysiology
Sykes, E. A., Dai, Q., Sarsons, C. D., Chen, J., Rocheleau, J. V., Hwang, D. M., Zheng, G., Cramb, D. T., Rinker, K. D., & Chan, W. C. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521265113 · Cited by 281
Ruge, C. A., Kirch, J., & Lehr, C.-M. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70072-9 · Cited by 280
Liu, J., Yu, M., Ning, X., Zhou, C., Yang, S., & Zheng, J. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201304465 · Cited by 276
Zi, Y., Yang, K., He, J., Wu, Z., Liu, J., & Zhang, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114449 · Cited by 268
Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation
Zhang, L., Cao, Z., Li, Y., Ella-Menye, J.-R., Bai, T., & Jiang, S. (2012) · ACS Nano · doi:10.1021/nn301159a · Cited by 260
Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258
Why nanoparticles prefer liver macrophage cell uptake in vivo
Ngo, W., Ahmed, S., Blackadar, C., Bussin, B., Ji, Q., Mladjenovic, S. M., Sepahi, Z., & Chan, W. C. W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114238 · Cited by 256
The blood clearance kinetics and pathway of polymeric micelles in cancer drug delivery
Sun, X., Wang, G., Zhang, H., Hu, S., Liu, X., Tang, J., & Shen, Y. (2018) · ACS Nano · doi:10.1021/acsnano.8b02830 · Cited by 253
Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles
Lima, T., Bernfur, K., Vilanova, M., & Cedervall, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-57943-6 · Cited by 250
Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro
Metz, S., Bonaterra, G., Rudelius, M., Settles, M., Rummeny, E., & Daldrup-Link, H. (2004) · European Radiology · doi:10.1007/s00330-004-2405-2 · Cited by 246
Tailoring the component of protein corona via simple chemistry
Lu, X., Xu, P., Ding, H.-M., Yu, Y.-S., Huo, D., & Ma, Y.-Q. (2019) · Nature Communications · doi:10.1038/s41467-019-12470-5 · Cited by 246
New Insights into the Molecular Control of the Lymphatic Vascular System and its Role in Disease
Cueni, L. N., & Detmar, M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700464 · Cited by 245
Shilo, M., Sharon, A., Baranes, K., Motiei, M., Lellouche, J.-P. M., & Popovtzer, R. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0075-7 · Cited by 237
Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery
Liu, Q., Guan, J., Qin, L., Zhang, X., & Mao, S. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2019.09.023 · Cited by 229
(2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.1171 · Cited by 219
Near‐Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics
Zhou, C., Hao, G., Thomas, P., Liu, J., Yu, M., Sun, S., Öz, O. K., Sun, X., & Zheng, J. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201203031 · Cited by 214
Angelova, A., Garamus, V. M., Angelov, B., Tian, Z., Li, Y., & Zou, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.04.006 · Cited by 211
Formation, characterization, and fate of inhaled drug nanoparticles
Zhang, J., Wu, L., Chan, H.-K., & Watanabe, W. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.11.002 · Cited by 210
Ohta, S., Kikuchi, E., Ishijima, A., Azuma, T., Sakuma, I., & Ito, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-75253-9 · Cited by 207
Zhang, Y.-N., Lazarovits, J., Poon, W., Ouyang, B., Nguyen, L. N. M., Kingston, B. R., & Chan, W. C. W. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02834 · Cited by 198
Drenckhahn, D., & Wagner, J. (1986) · The Journal of cell biology · doi:10.1083/jcb.102.5.1738 · Cited by 195
Glutathione-mediated biotransformation in the liver modulates nanoparticle transport
Jiang, X., Du, B., & Zheng, J. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0499-6 · Cited by 190
Self-citationNanoparticle coronas take shape
Monopoli, M. P., Bombelli, F. B., & Dawson, K. A. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.267 · Cited by 190
Inhalation of nanoparticle-based drug for lung cancer treatment: Advantages and challenges
Lee, W.-H., Loo, C.-Y., Traini, D., & Young, P. M. (2015) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2015.08.009 · Cited by 189
Nakamura, T., Kawai, M., Sato, Y., Maeki, M., Tokeshi, M., & Harashima, H. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b01182 · Cited by 186
Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium
Williams, R. M., Shah, J., Ng, B. D., Minton, D. R., Gudas, L. J., Park, C. Y., & Heller, D. A. (2015) · Nano Letters · doi:10.1021/nl504610d · Cited by 185
Applications and challenges of ultra-small particle size nanoparticles in tumor therapy
Xu, J., Song, M., Fang, Z., Zheng, L., Huang, X., & Liu, K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.028 · Cited by 185
Targeting of Hepatic Macrophages by Therapeutic Nanoparticles
Colino, C. I., Lanao, J. M., & Gutierrez-Millan, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00218 · Cited by 184
Nano- and micro-based inhaled drug delivery systems for targeting alveolar macrophages
Lee, W.-H., Loo, C.-Y., Traini, D., & Young, P. M. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1039509 · Cited by 179
Noninvasive Staging of Kidney Dysfunction Enabled by Renal‐Clearable Luminescent Gold Nanoparticles
Yu, M., Zhou, J., Du, B., Ning, X., Authement, C., Gandee, L., Kapur, P., Hsieh, J., & Zheng, J. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201511148 · Cited by 174
Self-citationDiagnostic imaging and therapeutic application of nanoparticles targeting the liver
Wang, H., Thorling, C. A., Liang, X., Bridle, K. R., Grice, J. E., Zhu, Y., Crawford, D. H. G., Xu, Z. P., Liu, X., & Roberts, M. S. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01611d · Cited by 173
The exit of nanoparticles from solid tumours
Nguyen, L. N. M., Lin, Z. P., Sindhwani, S., MacMillan, P., Mladjenovic, S. M., Stordy, B., Ngo, W., & Chan, W. C. W. (2023) · Nature Materials · doi:10.1038/s41563-023-01630-0 · Cited by 172
Lee, C., Kwon, W., Beack, S., Lee, D., Park, Y., Kim, H., Hahn, S. K., Rhee, S.-W., & Kim, C. (2016) · Theranostics · doi:10.7150/thno.16923 · Cited by 165
Linnankoski, J., Mäkelä, J., Palmgren, J., Mauriala, T., Vedin, C., Ungell, A., Lazorova, L., Artursson, P., Urtti, A., & Yliperttula, M. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21961 · Cited by 164
Sakulkhu, U., Mahmoudi, M., Maurizi, L., Coullerez, G., Hofmann-Amtenbrink, M., Vries, M., Motazacker, M., Rezaee, F., & Hofmann, H. (2015) · Biomaterials Science · doi:10.1039/c4bm00264d · Cited by 163
Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours
Wang, Q., Liang, Q., Dou, J., Zhou, H., Zeng, C., Pan, H., Shen, Y., Li, Q., Liu, Y., Leong, D. T., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01498-w · Cited by 162
Fluoro‐Photoacoustic Polymeric Renal Reporter for Real‐Time Dual Imaging of Acute Kidney Injury
Cheng, P., Chen, W., Li, S., He, S., Miao, Q., & Pu, K. (2020) · Advanced Materials · doi:10.1002/adma.201908530 · Cited by 161
Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments
Pinals, R. L., Yang, D., Rosenberg, D. J., Chaudhary, T., Crothers, A. R., Iavarone, A. T., Hammel, M., & Landry, M. P. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202008175 · Cited by 160
Protein Nanoparticle Charge and Hydrophobicity Govern Protein Corona and Macrophage Uptake
Pustulka, S. M., Ling, K., Pish, S. L., & Champion, J. A. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12341 · Cited by 160
Lunov, O., Zablotskii, V., Syrovets, T., Röcker, C., Tron, K., Nienhaus, G. U., & Simmet, T. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.111 · Cited by 159
Stepien, G., Moros, M., Pérez-Hernández, M., Monge, M., Gutiérrez, L., Fratila, R. M., las Heras, M. D., Menao Guillén, S., Puente Lanzarote, J. J., Solans, C., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18648 · Cited by 158
Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2019) · Nanoscale · doi:10.1039/c8nr09855g · Cited by 158
Yamaoka, T., Tabata, Y., & Ikada, Y. (1995) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1995.tb05835.x · Cited by 157
Chono, S., Tanino, T., Seki, T., & Morimoto, K. (2006) · Journal of drug targeting · doi:10.1080/10611860600834375 · Cited by 157
Huang, J., Lyu, Y., Li, J., Cheng, P., Jiang, Y., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910137 · Cited by 157
Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery
Kang, H., Gravier, J., Bao, K., Wada, H., Lee, J. H., Baek, Y., Fakhri, G. E., Gioux, S., Rubin, B. P., Coll, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201601101 · Cited by 156
Li, H., Jin, K., Luo, M., Wang, X., Zhu, X., Liu, X., Jiang, T., Zhang, Q., Wang, S., & Pang, Z. (2019) · Cells · doi:10.3390/cells8080881 · Cited by 154
Huang, J., Huang, J., Cheng, P., Jiang, Y., & Pu, K. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003628 · Cited by 152
Nanoparticle contrast agents for X‐ray imaging applications
Hsu, J. C., Nieves, L. M., Betzer, O., Sadan, T., Noël, P. B., Popovtzer, R., & Cormode, D. P. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1642 · Cited by 149
Guo, S., Liang, Y., Liu, L., Yin, M., Wang, A., Sun, K., Li, Y., & Shi, Y. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00770-2 · Cited by 148
Bandi, S. P., Kumbhar, Y. S., & Venuganti, V. V. K. (2020) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-04785-y · Cited by 147
The influence of small intestinal mucus structure on particle transport ex vivo
Bajka, B. H., Rigby, N. M., Cross, K. L., Macierzanka, A., & Mackie, A. R. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.038 · Cited by 144
Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition
Murgia, X., Pawelzyk, P., Schaefer, U. F., Wagner, C., Willenbacher, N., & Lehr, C.-M. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00164 · Cited by 144
Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules
Lawrence, M. G., Altenburg, M. K., Sanford, R. B., Willett, J., Bleasdale, B., Ballou, B. T., Wilder, J., Li, F., Miner, J. H., Berg, U., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616457114 · Cited by 144
Yıldız, H., McKelvey, C. A., Marsac, P. J., & Carrier, R. L. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1086359 · Cited by 143
Moghimi, S. M. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00043-7 · Cited by 142
Tang, S., Peng, C., Xu, J., Du, B., Wang, Q., Vinluan, R. D., Yu, M., Kim, M. J., & Zheng, J. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201609043 · Cited by 142
Self-citationMucus Penetration of Surface-Engineered Nanoparticles in Various pH Microenvironments
Guo, Y., Ma, Y., Chen, X., Li, M., Ma, X., Cheng, G., Xue, C., Zuo, Y. Y., & Sun, B. (2023) · ACS Nano · doi:10.1021/acsnano.2c11147 · Cited by 142
Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors
Kingston, B. R., Lin, Z. P., Ouyang, B., MacMillan, P., Ngai, J., Syed, A. M., Sindhwani, S., & Chan, W. C. W. (2021) · ACS Nano · doi:10.1021/acsnano.1c04510 · Cited by 141
Proximal Tubular Secretory Clearance
Wang, K., & Kestenbaum, B. R. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12001017 · Cited by 139
Pearce, S., Aljawadi, A., Kishida, K., Yu, S., Hu, M. D., Fritzky, L., Edelblum, K. L., Gao, N., & Ferraris, R. P. (2018) · BMC Biology · doi:10.1186/s12915-018-0481-z · Cited by 139
Physical and chemical profiles of nanoparticles for lymphatic targeting
Ke, X., Howard, G. P., Tang, H., Cheng, B., Saung, M. T., Santos, J. L., & Mao, H. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.09.005 · Cited by 139
Obst, K., Yealland, G., Balzus, B., Miceli, E., Dimde, M., Weise, C., Eravci, M., Bodmeier, R. A., Haag, R., Calderón, M., et al. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00158 · Cited by 137
Howard, G. P., Verma, G., Ke, X., Thayer, W. M., Hamerly, T., Baxter, V. K., Lee, J. E., Dinglasan, R. R., & Mao, H. (2019) · Nano Research · doi:10.1007/s12274-019-2301-3 · Cited by 133
Jackson, M. A., Werfel, T. A., Curvino, E. J., Yu, F. Z., Kavanaugh, T. E., Sarett, S. M., Dockery, M. D., Kilchrist, K. V., Jackson, A. N., Giorgio, T. D., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01110 · Cited by 132
PET Imaging and Biodistribution of Silicon Quantum Dots in Mice
Tu, C., Ma, X., House, A. E., Kauzlarich, S. M., & Louie, A. Y. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml1002844 · Cited by 131
Phosphatidylserine Lipid Nanoparticles Promote Systemic RNA Delivery to Secondary Lymphoid Organs
Luozhong, S., Yuan, Z., Sarmiento, T., Chen, Y., Gu, W., McCurdy, C., Gao, W., Li, R., Wilkens, S., & Jiang, S. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c03234 · Cited by 131
Polymeric nanoparticles in development for treatment of pulmonary infectious diseases
Lim, Y. H., Tiemann, K. M., Hunstad, D. A., Elsabahy, M., & Wooley, K. L. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1401 · Cited by 128
X-ray-Based Techniques to Study the Nano–Bio Interface
Sánchez-Cano, C., Álvarez‐Puebla, R. A., Abendroth, J. M., Beck, T., Blick, R. H., Cao, Y., Caruso, F., Chakraborty, I., Chapman, H. N., Chen, C., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c09563 · Cited by 128
Self-citationThe role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles
García-Díaz, M., Birch, D., Wan, F., & Nielsen, H. M. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.11.002 · Cited by 124
Ashby, J., Pan, S., & Zhong, W. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am503909q · Cited by 120
Lymphatic targeting by albumin-hitchhiking: Applications and optimisation
Abdallah, M., Müllertz, O. O., Styles, I. K., Mörsdorf, A., Quinn, J. F., Whittaker, M. R., & Trevaskis, N. L. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.046 · Cited by 119
Engineering Strategies for Lymph Node Targeted Immune Activation
Chen, Y., Koker, S. D., & Geest, B. G. D. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00260 · Cited by 118
Effect of PLGA NP size on efficiency to target traumatic brain injury
Cruz, L. J., Stammes, M. A., Que, I., van Beek, E. R., Blankevoort, V., Snoeks, T. J. A., Chan, A. B., Kaijzel, E. L., & Löwik, C. W. G. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.029 · Cited by 115
Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles
Peng, C., Xu, J., Yu, M., Ning, X., Huang, Y., Du, B., Hernandez, E., Kapur, P., Hsieh, J., & Zheng, J. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903256 · Cited by 112
Self-citationSize-Dependent Translocation of Nanoemulsions via Oral Delivery
Xia, F., Fan, W., Jiang, S., Ma, Y., Lü, Y., Qi, J., Ahmad, E., Dong, X., Zhao, W., & Wu, W. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b04916 · Cited by 109
Transcytosis-enabled active extravasation of tumor nanomedicine
Zhou, Q., Li, J., Xiang, J., Shao, S., Zhou, Z., Tang, J., & Shen, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114480 · Cited by 109
Pang, Z., Yan, W., Yang, J., Li, Q., Guo, Y., Zhou, D., & Jiang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c03752 · Cited by 107
Self-citationReineke, J., Cho, D., Dingle, Y. L., Morello, A. P., Jacob, J. S., Thanos, C. G., & Mathiowitz, E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305882110 · Cited by 104
Yan, D., Li, T., Yang, Y., Niu, N., Wang, D., Ge, J., Wang, L., Zhang, R., Wang, D., & Tang, B. Z. (2022) · Advanced Materials · doi:10.1002/adma.202206643 · Cited by 104
Johnston, B. D., Kreyling, W. G., Pfeiffer, C., Schäffler, M., Sarioglu, H., Ristig, S., Hirn, S., Haberl, N., Thalhammer, S., Hauck, S. M., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201701956 · Cited by 100
Huang, Y., Yu, M., & Zheng, J. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01366-7 · Cited by 100
Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies
Wang, Y., Wang, J., Zhu, D., Wang, Y., Qing, G., Zhang, Y., Liu, X., & Liang, X. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.007 · Cited by 93
Cai, X., Bandla, A., Mao, D., Feng, G., Qin, W., Liao, L., Thakor, N. V., Tang, B. Z., & Liu, B. (2016) · Advanced Materials · doi:10.1002/adma.201601191 · Cited by 92
Exploring Primary Liver Macrophages for Studying Quantum Dot Interactions with Biological Systems
Fischer, H. C., Hauck, T. S., Gómez-Aristizábal, A., & Chan, W. C. W. (2010) · Advanced Materials · doi:10.1002/adma.200904231 · Cited by 91
Three-Dimensional Optical Mapping of Nanoparticle Distribution in Intact Tissues
Sindhwani, S., Syed, A. M., Wilhelm, S., Glancy, D., Chen, Y. Y., Dobosz, M., & Chan, W. C. W. (2016) · ACS Nano · doi:10.1021/acsnano.6b01879 · Cited by 91
Cited by
Li, M., Gao, Z., Lv, H., Sekhar, K. P. C., Song, A., Jiang, X., Hao, J., & Cui, J. (2025) · ACS Nano · doi:10.1021/acsnano.5c03978 · Cited by 31
Self-citation
Metadata
- Authors
- Xu, M., Qi, Y., Liu, G., Song, Y., Jiang, X., & Du, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-11-03
- Volume
- 17
- Issue
- 21
- Pages
- 20825-20849
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4388290259
- Cited by
- 632
- References
- 239
- FWCI
- 34.79
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.