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Oxytocin increases trust in humans
Open accessAbstract
Trust pervades human societies. Trust is indispensable in friendship, love, families and organizations, and plays a key role in economic exchange and politics. In the absence of trust among trading partners, market transactions break down. In the absence of trust in a country's institutions and leaders, political legitimacy breaks down. Much recent evidence indicates that trust contributes to economic, political and social success. Little is known, however, about the biological basis of trust among humans. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions. We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. On the contrary, oxytocin specifically affects an individual's willingness to accept social risks arising through interpersonal interactions. These results concur with animal research suggesting an essential role for oxytocin as a biological basis of prosocial approach behaviour.
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In the citing paper
“Oxytocin is also involved in nursing behavior, trust, and “mind-reading” (Domes et al. 2007; Kosfeld et al. 2005)”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Kosfeld et al. 2005
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Neuroimaging studies in humans have largely substantiated this view.”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [43]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In persons without known developmental or psychiatric disorders, the use of intranasal oxytocin increases social affiliation, social memory, and empathy.2–5”
From Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder (2021) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In humans, intranasal administration of OT was found to increase bonding-related behavior, including gaze to eye region (Guastella et al., 2008), interpersonal trust and empathy (Hurlemann et al., 2010; Kosfeld et al., 2005), and social cognition (Kirsch et al., 2005).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Kosfeld et al., 2005
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A few recent studies show that it is possible to alter preferences and personality through experiments that change the brain's chemistry.”
From Personality Psychology and Economics (2011) · cites this paper as Kosfeld, Heinrichs, Zak et al. [2005]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Oxytocin is crucially involved in human affiliation and trust[ 23 , 24 , 25 ]”
From Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions (2021) · cites this paper as [23]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Much of the interest in intranasal oxytocin followed a report that it enhanced trust (96)”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [96]
The cited source says what the claim attributes to it.
In the citing paper
“Because all studies on trust so far (e.g.(1,4)) resorted to monetary paradigm”
From Is there a Publication Bias in Behavioural Intranasal Oxytocin Research on Humans? Opening the File Drawer of One Laboratory (2016) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“Oxytocin, however, does not make subjects more generous, suggesting that trust is not simply altruism.”
From Personality Psychology and Economics (2011) · cites this paper as Kosfeld, Heinrichs, Zak et al. [2005]
The cited source says what the claim attributes to it.
In the citing paper
“Similarly, nasal sprays of oxytocin increase trust (distinct from altruism or ability to assess probabilities) in a game-theoretic experiment (Kosfeld, Heinrichs, Zak et al. [2005]).”
From Personality Psychology and Economics (2011) · cites this paper as Kosfeld, Heinrichs, Zak et al. [2005]
The cited source says what the claim attributes to it.
In the citing paper
“MDMA’s ability to enhance social bonding is thought to be driven by its stimulation of oxytocin release (84), which increases prosocial feelings (85), greater trust in interpersonal interactions (86), and openness to social reward and connectedness (87).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [86]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“This effect is amplified for mothers who exhibit a secure attachment style compared to those who are insecurely attached, and correlates with oxytocin levels in the blood [43].”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [43]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“This is not due to deficits in general learning and memory or olfaction since they do habituate to non-social odors [78].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [78]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“However, OTKO males fail to habituate after repeated exposures to the same mouse [78].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [78]
Experimental — accuracy not yet measuredIn the citing paper
“The first studies to report intranasal OT effects in humans were done in males only, showing a role for OT in trust and in the processing of socially relevant information”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Kosfeld et al., 2005
In the citing paper
“Administration of oxytocin in humans is associated with changes in social-approach behaviors, such as trust (2) and personal proximity (3).”
From Epigenetic modification of OXT and human sociability (2016) · cites this paper as [2]
In the citing paper
“exogenous OT increases trusting behavior in an economic game (Kosfeld et al., 2005)”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Kosfeld et al., 2005
In the citing paper
“Oxytocin inhaling was found to increase trust (18)”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [18]
In the citing paper
“Generally, in healthy subjects pro-social feelings, including generosity and trust (6–8), social communication and emotional recognition (9,10), self-perception (11), and social interactions with offspring are altered by OT(12).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [6]
In the citing paper
“as well as with standardized testing, self-report or expert ratings (Kosfeld et al., 2005).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Kosfeld et al., 2005
In the citing paper
“Previous studies have employed simulated social games (Andari et al., 2010; Kosfeld et al., 2005), and static social photographs (Guastella et al., 2008) to evaluate the effects of OT on social behaviors.”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Kosfeld et al., 2005
In the citing paper
“Intriguingly, intranasal application of OT has been shown to increase trusting behavior in humans [20], [21], identification of others' affective states [22] and amygdala responses to emotional faces [23].”
From The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task (2009) · cites this paper as [21]
In the citing paper
“only scales related to social behavior were altered by the administration of intranasal oxytocin relative to a placebo, with the exception of openness to experiences.”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Kosfeld et al., 2005
In the citing paper
“While most studies examine the effects of oxytocin 45 minutes after administration (Ditzen et al., 2009; Kosfeld et al., 2005)”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Kosfeld et al., 2005
In the citing paper
“More recently, studies in humans have demonstrated that OXT administration increases pro-social behaviors like trust, empathy, and willingness to take social risks (Kosfeld et al, 2005), whereas dampening psychophysiological responses to stressors (Ditzen et al, 2009).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Kosfeld et al, 2005
In the citing paper
“we have demonstrated that emotion discrimination abilities in mice are dependent on the OXT system”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [35]
In the citing paper
“OXT has been associated with social cognitive functions, such as emotion recognition [8-10, 33-36, 38, 39].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [35]
In the citing paper
“trust (22)”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [22]
In the citing paper
“Intranasal administration of oxytocin attenuates anticipatory anxiety, subjective stress, and hypothalamic-pituitary-adrenal (HPA) axis activation to a psychosocial laboratory stress task and increases trust (de Oliveira et al., 2011; Heinrichs et al., 2003; Kosfeld et al., 2005).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Kosfeld et al., 2005
In the citing paper
“Researchers have found that OT increases cooperation and trust in others, but also envy and gloating during the experience of loss and defensive responses and punishment for the out-group during threatening conditions (De Dreu et al. 2010; Kosfeld et al. 2005; Shamay-Tsoory et al. 2009).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Kosfeld et al. 2005
In the citing paper
“Researchers found that IN-OT increases cooperation and social trust in others (Kosfeld et al. 2005), increases envy and schadenfreude in situations of loss (Shamay-Tsoory et al. 2009), enhances mind-reading capacities (Domes et al. 2007b), increases memory for faces (Rimmele et al. 2009), and improves emotion recognition (Schulze et al. 2011).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Kosfeld et al. 2005
In the citing paper
“Both published case studies 67 and anecdotal evidence 68 suggest off-label prescriptions of oxytocin are already a common practice by treating clinicians, despite concerns about pediatric use outside of a clinical trial setting.69”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [67]
In the citing paper
“This question has sparked more than a decade of research ever since the first report that administering a single dose of intranasal OT (compared to placebo) increases the willingness to trust in a dyadic economic game with real monetary stakes 8 .”
From A registered replication study on oxytocin and trust (2020) · cites this paper as [8]
In the citing paper
“In an influential paper, Kosfeld et al. (2005) showed that intranasal administration of Oxytocin (OT) increases the transfers made by investors in the trust game -suggesting that OT increases trust in strangers.”
From A registered replication study on oxytocin and trust (2020) · cites this paper as Kosfeld et al. (2005)
In the citing paper
“The Kosfeld et al. study 8 already suggested this: OT increased trusting decisions in the trust game, but did not augment risk-taking in an identically framed risk game played against a computer.”
From A registered replication study on oxytocin and trust (2020) · cites this paper as [8]
In the citing paper
“reports that oxytocin increases trust14”
In the citing paper
“Several human studies showed that intranasal oxytocin can facilitate trust and prosocial behavior [40,41].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [40]
In the citing paper
“intranasal oxytocin administration has been shown to reliably modulate neuropsychological functions in a series of studies (2–5) in the absence of relevant side effects (16).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [5]
In the citing paper
“Research in humans has almost exclusively focused on the role of oxytocin in the regulation of prosocial behavior, including trust, attachment, and sexual behavior (2–5), largely ignoring potential effects of the neuropeptide on ingestive behavior and metabolism.”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [5]
In the citing paper
“Oxytocin, the hypothalamic neuropeptide important for social cognition and behavior, has been shown to promote prosocial approach, such as trust and cooperative behaviors (16, 21, 22, but also see ref. 23)”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [16]
In the citing paper
“Trust signals prosocial approach to others (16) and is an important determinant to establish and maintain interpersonal relationships (17).”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [16]
In the citing paper
“The amount of investment indicated trust in others (16).”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [16]
In the citing paper
“Oxytocin, the hypothalamic neuropeptide important for social cognition and behavior, has been shown to promote prosocial approach, such as trust and cooperative behaviors (16, 21, 22, but also see ref. 23)”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [16]
In the citing paper
“seminal work by Kosfeld et al. (2005) showed that intranasally administered OT can increase trust among human individuals.”
From Long-term oxytocin administration enhances the experience of attachment (2017) · cites this paper as Kosfeld et al. (2005)
In the citing paper
“using a social trust game with monetary stakes, Kosfeld et al. (2005) showed that a single-dose of OT significantly increased the readiness to bear social risks arising through interpersonal interactions.”
From Long-term oxytocin administration enhances the experience of attachment (2017) · cites this paper as Kosfeld et al. (2005)
In the citing paper
“oxytocin administration exerts no significant behavioral change in strangers who share no pre-existing bonding relationship (Barraza et al., 2011; De Dreu, 2012b; Kosfeld et al., 2005; Zak et al., 2007)”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Kosfeld et al., 2005
In the citing paper
“The positive effects of OT on social cognition may only be observed when the tasks demand a binding relationship in which reward contingencies are congruent between two players, where they form a partnership by becoming stake holders of common interest (Barraza et al., 2011; Kosfeld et al., 2005; Zak et al., 2007).”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Kosfeld et al., 2005
In the citing paper
“thereby promoting in-group trust (Kosfeld et al, 2005)”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Kosfeld et al, 2005
In the citing paper
“These studies have shown that intranasally delivered oxytocin can increase trust or generosity in economic games (Kosfeld et al., 2005, Zak et al., 2007)”
From Oxytocin decreases aversion to angry faces in an associative learning task (2010) · cites this paper as Kosfeld et al., 2005
In the citing paper
“While OT can facilitate appetitive approach behaviors, such as interpersonal trust and generosity (Kosfeld et al., 2005; Zak et al., 2007), pair bonding and maternal behavior (Strathearn et al., 2009; Scheele et al., 2012) and emotional empathy and face recognition (Hurlemann et al., 2010; Marsh et al., 2010)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Kosfeld et al., 2005
In the citing paper
“There is no doubt that oxytocin is implicated in the development of trust (10, 18), empathy, and prosociality (11), but these tendencies appear limited to individuals belonging to one's in-group (16, 17).”
From Oxytocin promotes human ethnocentrism (2011) · cites this paper as [18]
In the citing paper
“Indeed, intranasal administration of oxytocin in humans promotes trust and cooperation (11, 16–19), although such effects may be limited to in-group members and do not extend toward out-groups (16, 17).”
From Oxytocin promotes human ethnocentrism (2011) · cites this paper as [18]
In the citing paper
“To conform with prior research showing that effects of oxytocin peak after ∼30–40 min (10, 16, 18), after 38–42 min, the computer switched to the experimental task (lasting 15–20 min).”
From Oxytocin promotes human ethnocentrism (2011) · cites this paper as [18]
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Citations
Cites
Riggins, F. J., & Mitra, S. (1990) · Choice Reviews Online · doi:10.5860/choice.27-6637 · Cited by 16,590
A Theory of Fairness, Competition, and Cooperation
Fehr, E., & Schmidt, K. M. (1999) · The Quarterly Journal of Economics · doi:10.1162/003355399556151 · Cited by 11,264
z-Tree: Zurich toolbox for ready-made economic experiments
Fischbacher, U. (2007) · Experimental Economics · doi:10.1007/s10683-006-9159-4 · Cited by 9,524
Gamst, F. C. (1991) · Anthropology of Work Review · doi:10.1525/awr.1991.12.3.19 · Cited by 8,036
Does Social Capital Have an Economic Payoff? A Cross-Country Investigation
Knack, S., & Keefer, P. (1997) · The Quarterly Journal of Economics · doi:10.1162/003355300555475 · Cited by 7,484
Risk Aversion and Incentive Effects
Holt, C. A., & Laury, S. K. (2002) · American Economic Review · doi:10.1257/000282802762024700 · Cited by 5,893
Trust, Reciprocity, and Social History
Berg, J., Dickhaut, J., & McCabe, K. (1995) · Games and Economic Behavior · doi:10.1006/game.1995.1027 · Cited by 5,548
(1979) · Medical Entomology and Zoology · Cited by 3,065
Zak, P. J., & Knack, S. (2001) · The Economic Journal · doi:10.1111/1468-0297.00609 · Cited by 2,810
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Flagged first, then by citations
Research works printed but not linked: 1
- Fischbacher, U. z-Tree. Zurich Toolbox for Readymade Economic Experiments (Working Paper No. 21, Institute for Empirical Research in Economics, Univ., Zurich, 1999)
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Ophir, A. G., Gessel, A., Zheng, D.-J., & Phelps, S. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.007 · Cited by 161
Sharing secrets: oxytocin and trust in schizophrenia
Kéri, S., Kiss, I., & Kelemen, O. (2009) · Social Neuroscience · doi:10.1080/17470910802319710 · Cited by 167
The New Statistics for Better Science: Ask How Much, How Uncertain, and What Else Is Known
Calin-Jageman, R. J., & Cumming, G. (2019) · The American Statistician · doi:10.1080/00031305.2018.1518266 · Cited by 183
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166
“In adult humans they have been found to modulate social trust, social cooperation, and social cognition in adult humans (Kosfeld et al., 2005; Guastella et al., 2010; Rilling et al., 2012).”
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Bshary, R., & Bergmüller, R. (2008) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2007.01482.x · Cited by 173
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Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164
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Wu, G., Feder, A., Wegener, G., Bailey, C., Saxena, S., Charney, D. S., & Mathé, A. A. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.628314 · Cited by 163
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Smith, K. B., Oxley, D. R., Hibbing, M. V., Alford, J. R., & Hibbing, J. R. (2011) · Political Psychology · doi:10.1111/j.1467-9221.2010.00821.x · Cited by 174
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Gottman, J. M., & Gottman, J. (2017) · Journal of Family Theory & Review · doi:10.1111/jftr.12182 · Cited by 164
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162
Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31032 · Cited by 163
Keebaugh, A. C., & Young, L. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.018 · Cited by 154
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Kogan, A., Oveis, C., Carr, E. W., Gruber, J., Mauss, I. B., Shallcross, A. J., Impett, E. A., van der Löwe, I., Hui, B. P. H., Cheng, C., et al. (2014) · Journal of Personality and Social Psychology · doi:10.1037/a0037509 · Cited by 176
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Domes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160
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Woensel, M. V., Wauthoz, N., Rosière, R., Amighi, K., Mathieu, V., Lefranc, F., Gool, S. V., & Vleeschouwer, S. D. (2013) · Cancers · doi:10.3390/cancers5031020 · Cited by 162
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Sturgis, P., Read, S., Hatemi, P., Zhu, G., Trull, T. J., Wright, M. J., & Martin, N. G. (2009) · Political Behavior · doi:10.1007/s11109-009-9101-5 · Cited by 164
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Greene, J. D. (2009) · The MIT Press eBooks · doi:10.7551/mitpress/8029.003.0086 · Cited by 164
Keltner, D. J., & Lerner, J. S. (2010) · Wiley eBooks · doi:10.1002/9780470561119.socpsy001009 · Cited by 164
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Biele, G., Rieskamp, J., Krugel, L. K., & Heekeren, H. R. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001089 · Cited by 157
Veenema, A. H. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.002 · Cited by 172
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Chang, S. W. C., Brent, L. J. N., Adams, G. K., Klein, J. T., Pearson, J. M., Watson, K. K., & Platt, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301213110 · Cited by 157
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Krueger, F., & Meyer-Lindenberg, A. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.10.004 · Cited by 162
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155
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Fetissov, S. O., Harro, J., Jaanisk, M., Järv, A., Podar, I., Allik, J., Nilsson, I., Sakthivel, P., Lefvert, A. K., & Hökfelt, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507204102 · Cited by 152
Social closeness increases salivary progesterone in humans
Brown, S. L., Fredrickson, B. L., Wirth, M. M., Poulin, M. J., Meier, E. A., Heaphy, E. D., Cohen, M. D., & Schultheiss, O. C. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.022 · Cited by 157
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151
Maud, C., Ryan, J., McIntosh, J. E., & Olsson, C. A. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1740-9 · Cited by 151
“Further, intranasal OXT increased trust and willingness to accept social risks amongst healthy volunteers involved in an experimental game [11], as well as the reduction of the short-term stress response demonstrated by reduced cortisol release”
BackgroundEstimation for Better Inference in Neuroscience
Calin-Jageman, R. J., & Cumming, G. (2019) · eNeuro · doi:10.1523/eneuro.0205-19.2019 · Cited by 147
Urinary oxytocin as a noninvasive biomarker of positive emotion in dogs
Mitsui, S., Yamamoto, M., Nagasawa, M., Mogi, K., Kikusui, T., Ohtani, N., & Ohta, M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.05.012 · Cited by 147
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
Kully‐Martens, K., Denys, K., Treit, S., Tamana, S. K., & Rasmussen, C. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01661.x · Cited by 172
Voice pitch alters mate-choice-relevant perception in hunter–gatherers
Apicella, C. L., & Feinberg, D. R. (2008) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2008.1542 · Cited by 149
The evolution of trust and trustworthiness
Kumar, A., Capraro, V., & Perc, M. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0491 · Cited by 148
ERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145
Gutnik, L. A., Hakimzada, A. F., Yoskowitz, N. A., & Patel, V. L. (2006) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2006.03.002 · Cited by 147
Effects of intranasal oxytocin on 'compassion focused imagery'
Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., & Gilbert, P. (2011) · Emotion · doi:10.1037/a0023861 · Cited by 147
A heartfelt response: oxytocin effects on response to social stress in men and women
Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.02.010 · Cited by 142
Carson, D. S., Cornish, J. L., Guastella, A. J., Hunt, G. E., & McGregor, I. S. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.018 · Cited by 146
Free Markets and Fettered Consumers
McFadden, D. L. (2006) · American Economic Review · doi:10.1257/000282806776157542 · Cited by 145
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143
Bargaining and trust: the effects of 36‐h total sleep deprivation on socially interactive decisions
Anderson, C., & Dickinson, D. L. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00767.x · Cited by 143
Madden, J. R., & Clutton-Brock, T. H. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1675 · Cited by 144
Effects of MDMA and intranasal oxytocin on social and emotional processing
Kirkpatrick, M. G., Lee, R., Wardle, M. C., Jacob, S., & de Wit, H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.12 · Cited by 143
Oxytocin Modulates Neural Reactivity to Children's Faces as a Function of Social Salience
Wittfoth-Schardt, D., Gründing, J., Wittfoth, M., Lanfermann, H., Heinrichs, M., Domes, G., Buchheim, A., Gündel, H., & Waller, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.47 · Cited by 139
Handlin, L., Nilsson, A., Ejdebäck, M., Hydbring-Sandberg, E., & Uvnäs-Moberg, K. (2012) · Anthrozoös · doi:10.2752/175303712x13316289505468 · Cited by 169
Neuroethics: The Ethical, Legal, and Societal Impact of Neuroscience
Farah, M. J. (2011) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100438 · Cited by 151
The dark side of going abroad: How broad foreign experiences increase immoral behavior.
Lu, J. G., Quoidbach, J., Gino, F., Chakroff, A., Maddux, W. W., & Galinsky, A. D. (2016) · Journal of Personality and Social Psychology · doi:10.1037/pspa0000068 · Cited by 146
Affective Touch in Human–Robot Interaction: Conveying Emotion to the Nao Robot
Andreasson, R., Alenljung, B., Billing, E., & Lowe, R. J. (2017) · International Journal of Social Robotics · doi:10.1007/s12369-017-0446-3 · Cited by 148
Oxytocin and the Neurobiology of Prosocial Behavior
Marsh, N., Marsh, A. A., Lee, M. R., & Hurlemann, R. (2020) · The Neuroscientist · doi:10.1177/1073858420960111 · Cited by 159
Social attachment and aversion in human moral cognition
Moll, J., & Schulkin, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.12.001 · Cited by 141
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.014 · Cited by 140
Social Conflict: The Emergence and Consequences of Struggle and Negotiation
Dreu, C. K. W. D. (2010) · Wiley eBooks · doi:10.1002/9780470561119.socpsy002027 · Cited by 144
Boccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136
Pierrehumbert, B., Torrisi, R., Laufer, D., Halfon, O., Ansermet, F., & Beck Popovic, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.016 · Cited by 139
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Fonagy, P., BATEMAN, A. W., & Bateman, A. (2011) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1111/j.2044-8341.2010.02005.x · Cited by 141
Hatemi, P., McDermott, R., Eaves, L. J., Kendler, K. S., & Neale, M. C. (2013) · American Journal of Political Science · doi:10.1111/ajps.12016 · Cited by 146
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Kang, J., Scholp, A., & Jiang, J. J. (2018) · Journal of Voice · doi:10.1016/j.jvoice.2017.07.008 · Cited by 139
Oxytocin and experimental therapeutics in autism spectrum disorders
BARTZ, J., & HOLLANDER, E. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00435-4 · Cited by 139
Oxytocin modulates the racial Bias in neural responses to others' suffering
Sheng, F., Liu, Y., Zhou, B., Zhou, W., & Han, S. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2012.11.018 · Cited by 139
To trust or not to trust: the dynamics of social interaction in psychosis
Fett, A.-K. J., Shergill, S. S., Joyce, D. W., Riedl, A. M., Strobel, M., Gromann, P. M., & Krabbendam, L. (2012) · Brain · doi:10.1093/brain/awr359 · Cited by 136
An integrative review of the enjoyment of sadness associated with music
Eerola, T., Vuoskoski, J. K., Peltola, H., Putkinen, V., & Schäfer, K. (2017) · Physics of Life Reviews · doi:10.1016/j.plrev.2017.11.016 · Cited by 147
The neuroethology of friendship
Brent, L. J. N., Chang, S. W. C., Gariépy, J., & Platt, M. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12315 · Cited by 138
Harari-Dahan, O., & Bernstein, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.007 · Cited by 143
Waller, R. E., & Wagner, N. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.005 · Cited by 148
Building trust: Heart rate synchrony and arousal during joint action increased by public goods game
Mitkidis, P., McGraw, J. J., Roepstorff, A., & Wallot, S. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.033 · Cited by 144
Clark, M. S., & Lemay, E. P. (2010) · Wiley eBooks · doi:10.1002/9780470561119.socpsy002025 · Cited by 137
A registered replication study on oxytocin and trust
Declerck, C. H., Boone, C., Pauwels, L., Vogt, B., & Fehr, E. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0878-x · Cited by 137
Self-citationKuroda, K. O., Tachikawa, K., Yoshida, S., Tsuneoka, Y., & Numan, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.008 · Cited by 139
Adult attachment and the brain
Coan, J. A. (2010) · Journal of Social and Personal Relationships · doi:10.1177/0265407509360900 · Cited by 134
Movahedi, A., Bahrami, F., Marandi, S. M., & Abedi, A. (2013) · Research in Autism · doi:10.1016/j.rasd.2013.04.012 · Cited by 141
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Alexander, V., Blinder, C., & Zak, P. J. (2018) · Computers in Human Behavior · doi:10.1016/j.chb.2018.07.026 · Cited by 148
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135
Borderline personality disorder: a dysregulation of the endogenous opioid system?
Bandelow, B., Schmahl, C., Falkai, P., & Wedekind, D. (2010) · Psychological Review · doi:10.1037/a0018095 · Cited by 135
van Iersel, L., Brokke, K. E., Adan, R. A. H., Bulthuis, L. C. M., van den Akker, E. L. T., & van Santen, H. M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00017 · Cited by 146
Emotional face processing in schizophrenia
Morris, R. W., Weickert, C. S., & Loughland, C. M. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328324f895 · Cited by 139
Hierarchical prediction errors in midbrain and septum during social learning
Diaconescu, A. O., Mathys, C. D., Weber, L. A. E., Kasper, L., Mauer, J., & Stephan, K. E. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw171 · Cited by 138
Lane, A., Luminet, O., Nave, G., & Mikolajczak, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12384 · Cited by 129
Oxytocin facilitates accurate perception of competition in men and kinship in women
Fischer-Shofty, M., Levkovitz, Y., & Shamay-Tsoory, S. G. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr100 · Cited by 132
Uzefovsky, F., Shalev, I., Israel, S., Edelman, S., Raz, Y., Mankuta, D., Knafo-Noam, A., & Ebstein, R. P. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.11.007 · Cited by 131
Lukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 141
The past, present and future of social neuroscience: A European perspective
Singer, T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.109 · Cited by 141
Music, biological evolution, and the brain
Patel, A. D. (2010) · Cited by 132
Status and distrust: The relevance of inequality and betrayal aversion
Hong, K., & Bohnet, I. (2006) · Journal of Economic Psychology · doi:10.1016/j.joep.2006.06.003 · Cited by 135
Frontotemporal Lobar Degeneration: Epidemiology, Pathology, Diagnosis and Management
Seltman, R. E., & Matthews, B. R. (2012) · CNS Drugs · doi:10.2165/11640070-000000000-00000 · Cited by 132
Oxytocin blunts social vigilance in the rhesus macaque
Ebitz, R. B., Watson, K. K., & Platt, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305230110 · Cited by 132
Oxytocin modulation of neural circuits for social behavior
Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130
How and why humans trust: A meta-analysis and elaborated model
Hancock, P. A., Kessler, T. T., Kaplan, A. D., Stowers, K. L., Brill, J. C., Billings, D. R., Schaefer, K. E., & Szalma, J. L. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1081086 · Cited by 168
Metadata
- Authors
- Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E.
- Affiliations
- University of Zurich (CH)
- Claremont Graduate University (US)
- Corresponding author
- Heinrichs, Markus
- Fehr, Ernst
- Venue
- Nature
- Published
- 2005-06
- Volume
- 435
- Issue
- 7042
- Pages
- 673-676
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2138559331
- Cited by
- 3,690
- References
- 31
- Citations by year
- 2026: 78 · 2025: 92 · 2024: 111 · 2023: 128 · 2022: 134 · 2021: 209 · 2020: 205 · 2019: 233 · 2018: 184 · 2017: 186 · 2016: 208 · 2015: 232 · 2014: 260 · 2013: 238 · 2012: 236
- FWCI
- 148.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Research Bank (Australian Catholic University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- John D. and Catherine T. MacArthur Foundation
- Cogito Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Universität Zürich
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Experimental Behavioral Economics Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- oxytocin, trust, social risk, prosocial behavior, social attachment, neuropeptides, intranasal administration, interpersonal interaction, risk-taking
- MeSH terms
- Administration, Intranasal, Adult, Games, Experimental, Humans, Investments, Male, Oxytocin, Surveys and Questionnaires, Risk, Social Behavior, Trust
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