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Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
Open accessAbstract
The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian oscillations of clock gene expression and neuronal firing. However, SCN rhythmicity depends on sufficient membrane depolarization and levels of intracellular calcium and cAMP. In the intact SCN, cellular oscillations are synchronized and reinforced by rhythmic synaptic input from other cells, resulting in a reproducible topographic pattern of distinct phases and amplitudes specified by SCN circuit organization. The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision. Thus, even though individual SCN neurons can be cell-autonomous circadian oscillators, neuronal network properties are integral to normal function of the SCN.
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“Moreover, dissociated SCN cells also remain rhythmic in culture, showing that rhythmicity is a cellular property (27).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [27]
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Metadata
- Authors
- Welsh, D. K., Takahashi, J. S., & Kay, S. A.
- Affiliations
- University of California San Diego (US)
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2010-03-17
- Volume
- 72
- Issue
- 1
- Pages
- 551-577
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- PMC
- PMC3758475
- OpenAlex
- W2108130957
- Cited by
- 1,216
- References
- 213
- Citations by year
- 2026: 58 · 2025: 60 · 2024: 75 · 2023: 84 · 2022: 93 · 2021: 92 · 2020: 67 · 2019: 65 · 2018: 72 · 2017: 69 · 2016: 86 · 2015: 87 · 2014: 72 · 2013: 70 · 2012: 79
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05)
- National Institute of Mental Health (R01 MH51573, P50 MH-074924, R01MH082945, R01MH051573, R01MH078024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- suprachiasmatic nucleus, circadian pacemaker, neuronal network synchronization, clock gene expression, circadian rhythm, intracellular calcium, cyclic AMP, synaptic input, light input, phase distribution, neuronal firing
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Drosophila, Hormones, Humans, Light, Nerve Net, Neurons, Suprachiasmatic Nucleus, Photoperiod
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