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Cited by 947

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content

Goodpaster, Bret H., Kelley, David E., Thaete, F. Leland, He, Jing, Ross, Robert·2000·Journal of Applied Physiology
DOI 10.1152/jappl.2000.89.1.104
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Abstract

The purpose of this investigation was to validate that in vivo measurement of skeletal muscle attenuation (MA) with computed tomography (CT) is associated with muscle lipid content. Single-slice CT scans performed on phantoms of varying lipid concentrations revealed good concordance between attenuation and lipid concentration ( r 2= 0.995); increasing the phantom's lipid concentration by 1 g/100 ml decreased its attenuation by ∼1 Hounsfield unit (HU). The test-retest coefficient of variation for two CT scans performed in six volunteers was 0.51% for the midthigh and 0.85% for the midcalf, indicating that the methodological variability is low. Lean subjects had significantly higher ( P < 0.01) MA values (49.2 ± 2.8 HU) than did obese nondiabetic (39.3 ± 7.5 HU) and obese Type 2 diabetic (33.9 ± 4.1 HU) subjects, whereas obese Type 2 diabetic subjects had lower MA values that were not different from obese nondiabetic subjects. There was also good concordance between MA in midthigh and midcalf ( r = 0.60, P < 0.01), psoas ( r = 0.65, P < 0.01), and erector spinae ( r = 0.77, P < 0.01) in subsets of volunteers. In 45 men and women who ranged from lean to obese (body mass index = 18.5 to 35.9 kg/m 2), including 10 patients with Type 2 diabetes mellitus, reduced MA was associated with increased muscle fiber lipid content determined with histological oil red O staining ( P = −0.43, P < 0.01). In a subset of these volunteers ( n = 19), triglyceride content in percutaneous biopsy specimens from vastus lateralis was also associated with MA ( r = −0.58, P = 0.019). We conclude that the attenuation of skeletal muscle in vivo determined by CT is related to its lipid content and that this noninvasive method may provide additional information regarding the association between muscle composition and muscle function.

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Metadata

Authors
Goodpaster, B. H., Kelley, D. E., Thaete, F. L., He, J., & Ross, R.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2000-07-01
Volume
89
Issue
1
Pages
104-110
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.2000.89.1.104
OpenAlex
W2127400865
Cited by
947
References
11
FWCI
4.54
Type
journal article
Language
en
Open access
closed

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