Cited by 465

The DOI matches its Crossref record; 371 of the 371 references it cites were found in a registry or an index.

Dendritic Cells: Immune Regulators in Health and Disease

Lipscomb, Mary F., Masten, Barbara J.·2002·Physiological Reviews

DOI 10.1152/physrev.00023.2001

Open this paper in CoChat — free account

Abstract

Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although DCs are a moderately diverse set of cells, they all have potent antigen-presenting capacity for stimulating naive, memory, and effector T cells. DCs are members of the innate immune system in that they can respond to dangers in the host environment by immediately generating protective cytokines. Most important, immature DCs respond to danger signals in the microenvironment by maturing, i.e., differentiating, and acquiring the capacity to direct the development of primary immune responses appropriate to the type of danger perceived. The powerful adjuvant activity that DCs possess in stimulating specific CD4 and CD8 T cell responses has made them targets in vaccine development strategies for the prevention and treatment of infections, allograft reactions, allergic and autoimmune diseases, and cancer. This review addresses the origins and migration of DCs to their sites of activity, their basic biology as antigen-presenting cells, their roles in important human diseases and, finally, selected strategies being pursued to harness their potent antigen-stimulating activity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1152/physrev.00023.2001

Cites

371 of 371 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,336
Functional analysis
Rudin, W. (1973) · Cited by 13,740
Immunobiology of Dendritic Cells
Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y.-J., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,634
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,820
Chemokines
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,859
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,738
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,102
Toll-like receptors in the induction of the innate immune response
Aderem, A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,064
Chemokines and leukocyte traffic
Baggiolini, M. (1998) · Nature · doi:10.1038/33340 · Cited by 2,709
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., & Cohn, Z. A. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.137.5.1142 · Cited by 2,424
CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs
Förster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,367
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes
Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266
CTLA-4 can function as a negative regulator of T cell activation
Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B., & Bluestone, J. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90071-x · Cited by 2,222
Chemokines
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909 · Cited by 1,984
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., & Alber, G. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.2.747 · Cited by 1,983
Interleukin-10
Moore, K. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.165 · Cited by 1,884
Proliferating dendritic cell progenitors in human blood.
Romani, N., Gruner, S., Brang, D., Kämpgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., & Schuler, G. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.1.83 · Cited by 1,840
Innate Immunity
Medzhitov, R., & Janeway, C. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,825
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., & Colonna, M. (1999) · Nature Medicine · doi:10.1038/11360 · Cited by 1,737
Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses
Geijtenbeek, T. B. H., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Adema, G. J., van Kooyk, Y., & Figdor, C. G. (2000) · Cell · doi:10.1016/s0092-8674(00)80693-5 · Cited by 1,700
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
Ohashi, K., Burkart, V., Flohé, S., & Kolb, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.558 · Cited by 1,606
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,602
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
Caux, C., Dezutter-Dambuyant, C., Schmitt, D., & Banchereau, J. (1992) · Nature · doi:10.1038/360258a0 · Cited by 1,554
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
Hart, D. N. J. (1997) · Blood · doi:10.1182/blood.v90.9.3245 · Cited by 1,483
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482
Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites
Dieu, M.-C., Vanbervliet, B., Vicari, A., Bridon, J.-M., Oldham, E., Aït-Yahia, S., Brière, F., Zlotnik, A., Lebecque, S., & Caux, C. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.373 · Cited by 1,425
Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo
den Haan, J. M. M., Lehar, S. M., & Bevan, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1685 · Cited by 1,328
Activation of human dendritic cells through CD40 cross-linking.
Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Van Kooten, C., Durand, I., & Banchereau, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.4.1263 · Cited by 1,317
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
Basu, S., Binder, R. J., Suto, R., Anderson, K. M., & Srivastava, P. K. (2000) · International Immunology · doi:10.1093/intimm/12.11.1539 · Cited by 1,305
The Inverse Association Between Tuberculin Responses and Atopic Disorder
Shirakawa, T., Enomoto, T., Shimazu, S.-I., & Hopkin, J. M. (1997) · Science · doi:10.1126/science.275.5296.77 · Cited by 1,287
Induction of tolerance by IL-10-treated dendritic cells
Steinbrink, K., Wölfl, M., Jonuleit, H., Knop, J., & Enk, A. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.10.4772 · Cited by 1,246
ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor
Cosman, D., Müllberg, J., Sutherland, C. L., Chin, W., Armitage, R., Fanslow, W., Kubin, M., & Chalupny, N. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00095-4 · Cited by 1,232
Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma
Thurner, B., Haendle, I., Röder, C., Dieckmann, D., Keikavoussi, P., Jonuleit, H., Bender, A., Maczek, C., Schreiner, D., von den Driesch, P., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1669 · Cited by 1,226
Danger signals: SOS to the immune system
Gallucci, S., & Matzinger, P. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00191-6 · Cited by 1,204
The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
Grouard, G., Rissoan, M.-C., Filgueira, L., Durand, I., Banchereau, J., & Liu, Y.-J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.6.1101 · Cited by 1,189
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S., & Lanzavecchia, A. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199809)28:09<2760::aid-immu2760>3.0.co;2-n · Cited by 1,183
Treatment of High-Risk Acute Leukemia with T-Cell–Depleted Stem Cells from Related Donors with One Fully Mismatched HLA Haplotype
Aversa, F., Tabilio, A., Velardi, A., Cunningham, I., Terenzi, A., Falzetti, F., Ruggeri, L., Barbabietola, G., Aristei, C., Latini, P., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810223391702 · Cited by 1,168
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000) · Nature Immunology · doi:10.1038/79758 · Cited by 1,143
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
Cella, M., Engering, A., Pinet, V., Pieters, J., & Lanzavecchia, A. (1997) · Nature · doi:10.1038/42030 · Cited by 1,123
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.
Maraskovsky, E., Brasel, K., Teepe, M., Roux, E. R., Lyman, S. D., Shortman, K., & McKenna, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.5.1953 · Cited by 1,115
CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.
Zhou, L. J., & Tedder, T. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2588 · Cited by 1,067
Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells
Muzio, M., Bosisio, D., Polentarutti, N., D’amico, G., Stoppacciaro, A., Mancinelli, R., van’t Veer, C., Penton-Rol, G., Ruco, L. P., Allavena, P., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5998 · Cited by 1,060
Cell migration, chimerism, and graft acceptance
Starzl, T. E., Murase, N., Ildstad, S., Ricordi, C., Demetris, A. J., & Trucco, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91840-5 · Cited by 1,051
Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells
Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (1997) · Science · doi:10.1126/science.277.5334.2005 · Cited by 1,050
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., Lustig, D. S., & Cohn, Z. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.6.1431 · Cited by 1,050
The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses
Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.593 · Cited by 1,041
Chemokines and Cell Migration in Secondary Lymphoid Organs
Cyster, J. G. (1999) · Science · doi:10.1126/science.286.5447.2098 · Cited by 1,031
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Chapoval, A. I., Ni, J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H., Sica, G. L., Zhu, G., Tamada, K., et al. (2001) · Nature Immunology · doi:10.1038/85339 · Cited by 1,015
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
Pamer, E., & Cresswell, P. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.323 · Cited by 1,008
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., & Williams, L. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.258 · Cited by 1,001
Distinct dendritic cell subsets differentially regulate the class of immune response invivo
Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E., & Maliszewski, C. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1036 · Cited by 991
CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo
Maldonado-López, R., De Smedt, T., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K., Leo, O., Urbain, J., & Moser, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.587 · Cited by 984
ICOS co-stimulatory receptor is essential for T-cell activation and function
Dong, C., Juedes, A. E., Temann, U.-A., Shresta, S., Allison, J. P., Ruddle, N. H., & Flavell, R. A. (2001) · Nature · doi:10.1038/35051100 · Cited by 936
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
Kaliński, P., Hilkens, C. M. U., Wierenga, E. A., & Kapsenberg, M. L. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01547-9 · Cited by 933
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.
Caux, C., Vanbervliet, B., Massacrier, C., Dezutter-Dambuyant, C., de Saint-Vis, B., Jacquet, C., Yoneda, K., Imamura, S., Schmitt, D., & Banchereau, J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.2.695 · Cited by 920
CD1 Recognition by Mouse NK1 + T Lymphocytes
Bendelac, A., Lantz, O., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995) · Science · doi:10.1126/science.7538697 · Cited by 914
The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells
Iezzi, G., Karjalainen, K., & Lanzavecchia, A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80461-6 · Cited by 908
CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin
Basu, S., Binder, R. J., Ramalingam, T., & Srivastava, P. K. (2001) · Immunity · doi:10.1016/s1074-7613(01)00111-x · Cited by 900
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
Kadowaki, N., Antonenko, S., Lau, J. Y.-N., & Liu, Y.-J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.219 · Cited by 849
Control of Homeostasis of CD8 + Memory T Cells by Opposing Cytokines
Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J., & Marrack, P. (2000) · Science · doi:10.1126/science.288.5466.675 · Cited by 816
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., & Cohn, Z. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.2.380 · Cited by 814
CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen
Vremec, D., Pooley, J., Hochrein, H., Wu, L., & Shortman, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.2978 · Cited by 811
Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance
Starzl, T. E., Demetris, A. J., Trucco, M., Murase, N., Ricordi, C., Ildstad, S., Ramos, H., Todo, S., Tzakis, A., Fung, J. J., et al. (1993) · Hepatology · doi:10.1002/hep.1840170629 · Cited by 810
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M., & Muller, W. A. (1998) · Science · doi:10.1126/science.282.5388.480 · Cited by 809
Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells
Lanzavecchia, A., & Sallusto, F. (2000) · Science · doi:10.1126/science.290.5489.92 · Cited by 796
Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
Cella, M., Facchetti, F., Lanzavecchia, A., & Colonna, M. (2000) · Nature Immunology · doi:10.1038/79747 · Cited by 793
T-cell co-stimulation through B7RP-1 and ICOS
Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U., Guo, J., Horan, T., Shih, G., Zhang, M., Coccia, M. A., Kohno, T., et al. (1999) · Nature · doi:10.1038/45582 · Cited by 777
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
De Smedt, T., Pajak, B., Muraille, E., Lespagnard, L., Heinen, E., De Baetselier, P., Urbain, J., Leo, O., & Moser, M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.4.1413 · Cited by 762
A fresh look at tumor immunosurveillance and immunotherapy
Smyth, M. J., Godfrey, D. I., & Trapani, J. A. (2001) · Nature Immunology · doi:10.1038/86297 · Cited by 745
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
Li, Y., Li, X. C., Zheng, X. X., Wells, A. D., Turka, L. A., & Strom, T. B. (1999) · Nature Medicine · doi:10.1038/15256 · Cited by 745
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
Werts, C., Tapping, R. I., Mathison, J. C., Chuang, T.-H., Kravchenko, V., Saint Girons, I., Haake, D. A., Godowski, P. J., Hayashi, F., Ozinsky, A., et al. (2001) · Nature Immunology · doi:10.1038/86354 · Cited by 733
Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.
Miller, M. D., & Krangel, M. S. (1992) · PubMed · Cited by 731
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I., & Lanzavecchia, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.821 · Cited by 709
Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells
Heufler, C., Koch, F., Stanzl, U., Topar, G., Wysocka, M., Trinchieri, G., Enk, A., Steinman, R. M., Romani, N., & Schuler, G. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260323 · Cited by 700
A Novel Immunoglobulin Superfamily Receptor for Cellular and Viral MHC Class I Molecules
Cosman, D., Fanger, N., Borges, L., Kubin, M., Chin, W., Peterson, L., & Hsu, M.-L. (1997) · Immunity · doi:10.1016/s1074-7613(00)80529-4 · Cited by 695
The Th1–Th2 hypothesis of HIV infection: new insights
Clerici, M., & Shearer, G. M. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90220-8 · Cited by 685
Distinct patterns and kinetics of chemokine production regulate dendritic cell function
Sallusto, F., Palermo, B., Lenig, D., Miettinen, M., Matikainen, S., Julkunen, I., Forster, R., Burgstahler, R., Lipp, M., & Lanzavecchia, A. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199905)29:05<1617::aid-immu1617>3.0.co;2-3 · Cited by 681
Dendritic Cells in Cancer Immunotherapy
Fong, L., & Engleman, E. G. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.245 · Cited by 680
ICOS is essential for effective T-helper-cell responses
Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, S. K., Jordana, M., Wakeham, A., Boucher, L.-M., Bouchard, D., Chan, V. S. F., Duncan, G., et al. (2001) · Nature · doi:10.1038/35051113 · Cited by 675
CD91: a receptor for heat shock protein gp96
Binder, R. J., Han, D. K., & Srivastava, P. K. (2000) · Nature Immunology · doi:10.1038/77835 · Cited by 671
Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
van der Pouw Kraan, T. C., Boeije, L. C., Smeenk, R. J., Wijdenes, J., & Aarden, L. A. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.2.775 · Cited by 666
Cytotoxic T-cell memory without antigen
Lau, L. L., Jamieson, B. D., Somasundaram, T., & Ahmed, R. (1994) · Nature · doi:10.1038/369648a0 · Cited by 656
ICOS is critical for CD40-mediated antibody class switching
McAdam, A. J., Greenwald, R. J., Levin, M. A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G. J., & Sharpe, A. H. (2001) · Nature · doi:10.1038/35051107 · Cited by 647
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
Scarlatti, G., Tresoldi, E., Björndal, Å., Fredriksson, R., Colognesi, C., Kui Deng, H., Malnati, M. S., Plebani, A., Siccardi, A. G., Littman, D. R., et al. (1997) · Nature Medicine · doi:10.1038/nm1197-1259 · Cited by 633
Toll signaling pathways in the innate immune response
Anderson, K. V. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00045-x · Cited by 632
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.
Süss, G., & Shortman, K. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.4.1789 · Cited by 631
Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove
Zeng, Z.-H., Castaño, A. R., Segelke, B. W., Stura, E. A., Peterson, P. A., & Wilson, I. A. (1997) · Science · doi:10.1126/science.277.5324.339 · Cited by 630
Asthma and Immunoglobulin E Antibodies After Respiratory Syncytial Virus Bronchiolitis: A Prospective Cohort Study With Matched Controls
Sigurs, N., Bjarnason, R., Sigurbergsson, F., Kjellman, B., & Björkstén, B. (1995) · Pediatrics · doi:10.1542/peds.95.4.500 · Cited by 630
Vitamin D3 Affects Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells
Piemonti, L., Monti, P., Sironi, M., Fraticelli, P., Leone, B. E., Dal Cin, E., Allavena, P., & Di Carlo, V. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4443 · Cited by 623
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V. (1993) · Nature · doi:10.1038/361359a0 · Cited by 615 · cited 1×
“It is now known that antigens can escape by poorly understood mechanisms from endocytic pathways, undergo proteosome-dependent degradation, and subsequently enter the ER via the TAP pathway to be presented in the binding groove of MHC class I molecules as is true for endogenous proteins (258, 270).”
Background
Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells
Visintin, A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S. K., & Segal, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.249 · Cited by 612
Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.
Sozzani, S., Allavena, P., D’Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., & Mantovani, A. (1998) · PubMed · Cited by 605
IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
Kaliński, P., Hilkens, C. M., Snijders, A., Snijdewint, F. G., & Kapsenberg, M. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.28 · Cited by 602
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.
O’Doherty, U., Peng, M., Gezelter, S., Swiggard, W. J., Betjes, M. G. H., Bhardwaj, N., & Steinman, R. M. (1994) · PubMed Central · Cited by 601
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
Wells, A. D., Li, X. C., Li, Y., Walsh, M. C., Zheng, X. X., Wu, Z., Nuñez, G., Tang, A., Sayegh, M., Hancock, W. W., et al. (1999) · Nature Medicine · doi:10.1038/15260 · Cited by 596
Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine
Iwasaki, A., & Kelsall, B. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1381 · Cited by 578
Effect of interleukin‐10 on dendritic cell maturation and function
de Smedt, T., van Mechelen, M., De Becker, G., Urbain, J., Leo, O., & Moser, M. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270526 · Cited by 565
CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal
Schulz, O., Edwards, A. D., Schito, M., Aliberti, J., Manickasingham, S., Sher, A., & Reis e Sousa, C. (2000) · Immunity · doi:10.1016/s1074-7613(00)00045-5 · Cited by 561
Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions
Corinti, S., Albanesi, C., la Sala, A., Pastore, S., & Girolomoni, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4312 · Cited by 555
Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.
Larsen, C. P., Morris, P. J., & Austyn, J. M. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.1.307 · Cited by 553
Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
Brossart, P., Wirths, S., Stuhler, G., Reichardt, V. L., Kanz, L., & Brugger, W. (2000) · Blood · doi:10.1182/blood.v96.9.3102 · Cited by 552
Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
Rodriguez, A., Regnault, A., Kleijmeer, M., Ricciardi-Castagnoli, P., & Amigorena, S. (1999) · Nature Cell Biology · doi:10.1038/14058 · Cited by 552
In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells
Ingulli, E., Mondino, A., Khoruts, A., & Jenkins, M. K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.12.2133 · Cited by 546
Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression
Sallusto, F., & Lanzavecchia, A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17717.x · Cited by 523
A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells
Adema, G. J., Hartgers, F., Verstraten, R., de Vries, E., Marland, G., Menon, S., Foster, J., Xu, Y., Nooyen, P., McClanahan, T., et al. (1997) · Nature · doi:10.1038/42716 · Cited by 523
Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro.
Steinman, R. M., Kaplan, G., Witmer, M. D., & Cohn, Z. A. (1979) · The Journal of experimental medicine · doi:10.1084/jem.149.1.1 · Cited by 519
Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells
Hahn, G., Jores, R., & Mocarski, E. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3937 · Cited by 509
Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties
Sozzani, S., Allavena, P., D’Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., & Mantovani, A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.3.1083 · Cited by 507
Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction
Vieira, P. L., de Jong, E. C., Wierenga, E. A., Kapsenberg, M. L., & Kaliński, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4507 · Cited by 502
DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking
Geijtenbeek, T. B. H., Krooshoop, D. J. E. B., Bleijs, D. A., van Vliet, S. J., van Duijnhoven, G. C. F., Grabovsky, V., Alon, R., Figdor, C. G., & van Kooyk, Y. (2000) · Nature Immunology · doi:10.1038/79815 · Cited by 499
CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue
Cook, D. N., Prosser, D. M., Forster, R., Zhang, J., Kuklin, N. A., Abbondanzo, S. J., Niu, X.-D., Chen, S.-C., Manfra, D. J., Wiekowski, M. T., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80201-0 · Cited by 498
Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans
d'Ostiani, C. F., Del Sero, G., Bacci, A., Montagnoli, C., Spreca, A., Mencacci, A., Ricciardi-Castagnoli, P., & Romani, L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1661 · Cited by 493
Dendritic Cell Vaccines for Cancer Immunotherapy
Timmerman, M., & Levy, M. (1999) · Annual Review of Medicine · doi:10.1146/annurev.med.50.1.507 · Cited by 485
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
Turley, S. J., Inaba, K., Garrett, W. S., Ebersold, M., Unternaehrer, J., Steinman, R. M., & Mellman, I. (2000) · Science · doi:10.1126/science.288.5465.522 · Cited by 477
A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells
Borkowski, T. A., Letterio, J. J., Farr, A. G., & Udey, M. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2417 · Cited by 474
Epstein-Barr Virus–induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells
Ngo, V. N., Lucy Tang, H., & Cyster, J. G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.181 · Cited by 470
Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity
Stumbles, P. A., Thomas, J. A., Pimm, C. L., Lee, P. T., Venaille, T. J., Proksch, S., & Holt, P. G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2019 · Cited by 465
Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response
Wykes, M., Pombo, A., Jenkins, C., & MacPherson, G. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.3.1313 · Cited by 462
B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα
Swallow, M. M., Wallin, J. J., & Sha, W. C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80117-x · Cited by 453
Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo
Brocker, T., Riedinger, M., & Karjalainen, K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.541 · Cited by 442
Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.
D’Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., & Sinigaglia, F. (1998) · PubMed · Cited by 438
RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells
Wu, L., D’Amico, A., Winkel, K. D., Suter, M., Lo, D., & Shortman, K. (1998) · Immunity · doi:10.1016/s1074-7613(00)80649-4 · Cited by 438
Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice
Pulendran, B., Lingappa, J., Kennedy, M. K., Smith, J., Teepe, M., Rudensky, A., Maliszewski, C. R., & Maraskovsky, E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2222 · Cited by 436
CD34+ Hematopoietic Progenitors From Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to Granulocyte-Macrophage Colony-Stimulating Factor Plus Tumor Necrosis Factor α: II. Functional Analysis
Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Durand, I., Cella, M., Lanzavecchia, A., & Banchereau, J. (1997) · Blood · doi:10.1182/blood.v90.4.1458 · Cited by 424
Measles Virus Suppresses Cell-mediated Immunity by Interfering with the Survival and Functions of Dendritic and T Cells
Fugier-Vivier, I., Servet-Delprat, C., Rivailler, P., Rissoan, M.-C., Liu, Y.-J., & Rabourdin-Combe, C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.813 · Cited by 424
High-level IL-12 production by human dendritic cells requires two signals
Snijders, A. (1998) · International Immunology · doi:10.1093/intimm/10.11.1593 · Cited by 420
The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations
Kamath, A. T., Pooley, J., O’Keeffe, M. A., Vremec, D., Zhan, Y., Lew, A. M., D’Amico, A., Wu, L., Tough, D. F., & Shortman, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.12.6762 · Cited by 419
Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation
Bachmann, M. F., McKall-Faienza, K., Schmits, R., Bouchard, D., Beach, J., Speiser, D. E., Mak, T. W., & Ohashi, P. S. (1997) · Immunity · doi:10.1016/s1074-7613(00)80376-3 · Cited by 418
Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors
Schuler, G., & Steinman, R. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1183 · Cited by 416
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.
Inaba, K., Inaba, M., Deguchi, M., Hagi, K., Yasumizu, R., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.3038 · Cited by 416
Antigen Presentation in Extracellular Matrix
Gunzer, M., Schäfer, A., Borgmann, S., Grabbe, S., Zänker, K. S., Bröcker, E.-B., Kämpgen, E., & Friedl, P. (2000) · Immunity · doi:10.1016/s1074-7613(00)00032-7 · Cited by 414
Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction
Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M., & Delespesse, G. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250442 · Cited by 414
The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli
Inaba, K., Turley, S., Iyoda, T., Yamaide, F., Shimoyama, S., e Sousa, C. R., Germain, R. N., Mellman, I., & Steinman, R. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.927 · Cited by 414
The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function
Coyle, A. J., & Gutierrez-Ramos, J.-C. (2001) · Nature Immunology · doi:10.1038/85251 · Cited by 413
Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)
Fanger, N. A., Maliszewski, C. R., Schooley, K., & Griffith, T. S. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.8.1155 · Cited by 413
Brain Dendritic Cells and Macrophages/Microglia in Central Nervous System Inflammation
Fischer, H.-G., & Reichmann, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2717 · Cited by 411
Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells
Iwasaki, A., & Kelsall, B. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4884 · Cited by 409
Flt3-Ligand and Granulocyte Colony-Stimulating Factor Mobilize Distinct Human Dendritic Cell Subsets In Vivo
Pulendran, B., Banchereau, J., Burkeholder, S., Kraus, E., Guinet, E., Chalouni, C., Caron, D., Maliszewski, C., Davoust, J., Fay, J., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.566 · Cited by 408
In vivo generation of human dendritic cell subsets by Flt3 ligand
Maraskovsky, E., Daro, E., Roux, E., Teepe, M., Maliszewski, C. R., Hoek, J., Caron, D., Lebsack, M. E., & McKenna, H. J. (2000) · Blood · doi:10.1182/blood.v96.3.878 · Cited by 407
Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.
Wu, L., Li, C. L., & Shortman, K. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.903 · Cited by 400
Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia
Erb, K. J., Holloway, J. W., Sobeck, A., Moll, H., & Le Gros, G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.561 · Cited by 399
Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor
Traver, D., Akashi, K., Manz, M., Merad, M., Miyamoto, T., Engleman, E. G., & Weissman, I. L. (2000) · Science · doi:10.1126/science.290.5499.2152 · Cited by 393
Oligosaccharides of Hyaluronan Are Potent Activators of Dendritic Cells
Termeer, C. C., Hennies, J., Voith, U., Ahrens, T., M. Weiss, J., Prehm, P., & Simon, J. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1863 · Cited by 388
Dendritic Cells Are Required for the Development of Chronic Eosinophilic Airway Inflammation in Response to Inhaled Antigen in Sensitized Mice
Lambrecht, B. N., Salomon, B., Klatzmann, D., & Pauwels, R. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.4090 · Cited by 383
Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.
McWilliam, A. S., Nelson, D., Thomas, J. A., & Holt, P. G. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1331 · Cited by 383
The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor
Singh-Jasuja, H., Scherer, H. U., Hilf, N., Arnold-Schild, D., Rammensee, H.-G., Toes, R. E. M., & Schild, H. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(2000)30:18<2211::aid-immu2211>3.0.co;2-h · Cited by 380
From TCR Engagement to T Cell Activation
Lanzavecchia, A., Iezzi, G., & Viola, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80952-6 · Cited by 380
An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules
Morris, P., Shaman, J. A., Attaya, M., Amaya, M., Goodman, S., Bergman, C., Monaco, J. J., & Mellins, E. (1994) · Nature · doi:10.1038/368551a0 · Cited by 379
Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors
Dieu-Nosjean, M.-C., Massacrier, C., Homey, B., Vanbervliet, B., Pin, J.-J., Vicari, A., Lebecque, S., Dezutter-Dambuyant, C., Schmitt, D., Zlotnik, A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.705 · Cited by 378
Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
Sozzani, S., Luini, W., Borsatti, A., Polentarutti, N., Zhou, D., Piemonti, L., D’Amico, G., Power, C. A., Wells, T. N., Gobbi, M., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1993 · Cited by 377
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
Kaisho, T., & Akira, S. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01811-1 · Cited by 375
Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells
D’Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., & Sinigaglia, F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5111 · Cited by 372
Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation
Kaliński, P., Schuitemaker, J. H. N., Hilkens, C. M. U., & Kapsenberg, M. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.2804 · Cited by 371
Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
Sallusto, F., Kremmer, E., Palermo, B., Hoy, A., Ponath, P., Qin, S., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06<2037::aid-immu2037>3.0.co;2-v · Cited by 370
T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo
Cottrez, F., Hurst, S. D., Coffman, R. L., & Groux, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4848 · Cited by 366
COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II+, CD80dim, CD86-) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS12
Fu, F., Li, Y., Qian, S., Lu, L., Chambers, F., Starzl, T. E., Fung, J. J., & Thomson, A. W. (1996) · Transplantation · doi:10.1097/00007890-199609150-00021 · Cited by 364
Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2
Hertz, C. J., Kiertscher, S. M., Godowski, P. J., Bouis, D. A., Norgard, M. V., Roth, M. D., & Modlin, R. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2444 · Cited by 356
CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
Aliberti, J., Reis e Sousa, C., Schito, M., Hieny, S., Wells, T., Huffnagle, G. B., & Sher, A. (2000) · Nature Immunology · doi:10.1038/76957 · Cited by 349
Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.
Holt, P. G., Haining, S., Nelson, D. J., & Sedgwick, J. D. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.1.256 · Cited by 347 · cited 1×
“DCs in the airway epithelium express an immature phenotype and exhibit a rapid turnover (142, 233).”
Background
Direct and indirect recognition: the role of MHC antigens in graft rejection
Gould, D. S., & Auchincloss, H. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01394-2 · Cited by 347
Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin
CERIO, R., GRIFFITHS, C. E. M., COOPER, K. D., NICKOLOFF, B. J., & HEADINGTON, J. T. (1989) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1989.tb15509.x · Cited by 346
Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generatedin vitro from CD34+ hematopoietic progenitor cells
Mackensen, A., Herbst, B., Chen, J.-L., K�hler, G., Noppen, C., Herr, W., Spagnoli, G. C., Cerundolo, V., & Lindemann, A. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000501)86:3<385::aid-ijc13>3.0.co;2-t · Cited by 345
Dendritic Cells Injected Via Different Routes Induce Immunity in Cancer Patients
Fong, L., Brockstedt, D., Benike, C., Wu, L., & Engleman, E. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.4254 · Cited by 343
Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells
Ohteki, T., Fukao, T., Suzue, K., Maki, C., Ito, M., Nakamura, M., & Koyasu, S. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1981 · Cited by 332
A CD1a+/CD11c+ Subset of Human Blood Dendritic Cells Is a Direct Precursor of Langerhans Cells
Ito, T., Inaba, M., Inaba, K., Toki, J., Sogo, S., Iguchi, T., Adachi, Y., Yamaguchi, K., Amakawa, R., Valladeau, J., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1409 · Cited by 332
Chemokines and the Homing of Dendritic Cells to the T Cell Areas of Lymphoid Organs
Cyster, J. G. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.447 · Cited by 327
The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.
Auchincloss, H., Lee, R., Shea, S., Markowitz, J. S., Grusby, M. J., & Glimcher, L. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3373 · Cited by 325
A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells
Whelan, M., Harnett, M. M., Houston, K. M., Patel, V., Harnett, W., & Rigley, K. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6453 · Cited by 324
Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1
Spits, H., Couwenberg, F., Bakker, A. Q., Weijer, K., & Uittenbogaart, C. H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1775 · Cited by 322
Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL
Harshyne, L. A., Watkins, S. C., Gambotto, A., & Barratt-Boyes, S. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3717 · Cited by 321
OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection
Kopf, M., Ruedl, C., Schmitz, N., Gallimore, A., Lefrang, K., Ecabert, B., Odermatt, B., & Bachmann, M. F. (1999) · Immunity · doi:10.1016/s1074-7613(00)80144-2 · Cited by 321
Secondary Lymphoid-tissue Chemokine Is a Functional Ligand for the CC Chemokine Receptor CCR7
Yoshida, R., Nagira, M., Kitaura, M., Imagawa, N., Imai, T., & Yoshie, O. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7118 · Cited by 321
Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions
Chen, A. I., McAdam, A. J., Buhlmann, J. E., Scott, S., Lupher, M. L., Greenfield, E. A., Baum, P. R., Fanslow, W. C., Calderhead, D. M., Freeman, G. J., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80143-0 · Cited by 321
TRANCE, a TNF Family Member, Is Differentially Expressed on T Cell Subsets and Induces Cytokine Production in Dendritic Cells
Josien, R., Wong, B. R., Li, H.-L., Steinman, R. M., & Choi, Y. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2562 · Cited by 317
Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines
Sozzani, S., Sallusto, F., Luini, W., Zhou, D., Piemonti, L., Allavena, P., Van Damme, J., Valitutti, S., Lanzavecchia, A., & Mantovani, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3292 · Cited by 315
Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production
Ho, L.-J., Wang, J.-J., Shaio, M.-F., Kao, C.-L., Chang, D.-M., Han, S.-W., & Lai, J.-H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1499 · Cited by 314
Modelling T-cell memory by genetic marking of memory T cells in vivo
Jacob, J., & Baltimore, D. (1999) · Nature · doi:10.1038/21208 · Cited by 308
Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells
Tang, H. L., & Cyster, J. G. (1999) · Science · doi:10.1126/science.284.5415.819 · Cited by 308
Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction
Qian, S., Lu, L., Fu, F., Li, Y., Li, W., Starzl, T. E., Fung, J. J., & Thomson, A. W. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4654 · Cited by 302
Dendritic cells capable of stimulating T cells in germinal centres
Grouard, G., Durand, I., Filgueira, L., Banchereau, J., & Liu, Y.-J. (1996) · Nature · doi:10.1038/384364a0 · Cited by 299
T cell receptor antagonists and partial agonists
Jameson, S. C., & Bevan, M. J. (1995) · Immunity · doi:10.1016/1074-7613(95)90074-8 · Cited by 298
The endocytic activity of dendritic cells.
Steinman, R. M., & Swanson, J. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.283 · Cited by 297
Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.
Reis e Sousa, C., & Germain, R. N. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.841 · Cited by 296
Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells
Bauer, M., Redecke, V., Ellwart, J. W., Scherer, B., Kremer, J.-P., Wagner, H., & Lipford, G. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5000 · Cited by 293
The role of dendritic cells in the induction and regulation of immunity to microbial infection
Reis e Sousa, C., Sher, A., & Kaye, P. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80066-1 · Cited by 293
Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype
Hilkens, C. M. U., Kalinski, P., de Boer, M., & Kapsenberg, M. L. (1997) · Blood · doi:10.1182/blood.v90.5.1920 · Cited by 292
Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection
Gorak, P. M. A., Engwerda, C. R., & Kaye, P. M. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199802)28:02<687::aid-immu687>3.0.co;2-n · Cited by 277
Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells
Buelens, C., Willems, F., Delvaux, A., Piérard, G., Delville, J., Velu, T., & Goldman, M. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250940 · Cited by 274
BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2
Lu, L., McCaslin, D., Starzl, T. E., & Thomson, A. W. (1995) · Transplantation · doi:10.1097/00007890-199560120-00028 · Cited by 271
Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments
Chiu, Y.-H., Jayawardena, J., Weiss, A., Lee, D., Park, S.-H., Dautry-Varsat, A., & Bendelac, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.103 · Cited by 269
Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines
Dieu-Nosjean, M.-C., Vicari, A., Lebecque, S., & Caux, C. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.2.252 · Cited by 266
Modulating the immune response with dendritic cells and their growth factors
Pulendran, B., Banchereau, J., Maraskovsky, E., & Maliszewski, C. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01794-4 · Cited by 263
DNA vaccination: antigen presentation and the induction of immunity
Shedlock, D. J., & Weiner, D. B. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.6.793 · Cited by 259
Heterogeneity of Mouse Spleen Dendritic Cells: In Vivo Phagocytic Activity, Expression of Macrophage Markers, and Subpopulation Turnover
Leenen, P. J. M., Radošević, K., Voerman, J. S. A., Salomon, B., van Rooijen, N., Klatzmann, D., & van Ewijk, W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.5.2166 · Cited by 256
Dendritic Cell Development in Culture from Thymic Precursor Cells in the Absence of Granulocyte/Macrophage Colony-stimulating Factor
Saunders, D., Lucas, K., Ismaili, J., Wu, L., Maraskovsky, E., Dunn, A., & Shortman, K. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2185 · Cited by 252
Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease
Ludewig, B., Ochsenbein, A. F., Odermatt, B., Paulin, D., Hengartner, H., & Zinkernagel, R. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.5.795 · Cited by 252

Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
Smith, I. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.463-496.2003 · Cited by 1,154
Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.013 · Cited by 1,030
Immunoregulatory functions of surfactant proteins
Wright, J. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1528 · Cited by 964
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
Mu, C.-Y., Huang, J.-A., Chen, Y., Chen, C., & Zhang, X.-G. (2011) · Medical Oncology · doi:10.1007/s12032-010-9515-2 · Cited by 577

See all 465

Authors: Lipscomb, M. F., & Masten, B. J.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2002-01-01
Volume: 82
Issue: 1
Pages: 97-130
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00023.2001
OpenAlex: W2115422483
Cited by: 465
References: 371
FWCI: 1.31
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Dendritic Cells: Immune Regulators in Health and Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources