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Cited by 8,914

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Open access
Shrestha, Shikshya, Offer, Steven M.·2016·Medical Epigenetics
DOI 10.1159/000444713
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Abstract

The GABAergic neurotransmission is a highly conserved system that has been attributed to various regulatory events. There has been a notable number of studies on the importance of GABAergic neurotransmission, both excitatory and inhibitory, in neurogenesis and central nervous system development including its control of neuronal cell proliferation and migration, synaptogenesis, dendrite formation and branching, and new neuronal cell integration in the adult brain. There has been remarkable progress in understanding the epigenetic regulations of GABAergic genes and their aberrant expressions in various neurological disorders such as autism spectrum disorder, Rett's syndrome, schizophrenia and PWS. The roles of histone modifications, chromatin looping and gene methylation have been implicated in altered regulations of key genes in the GABAergic pathway. Taken together, they affect the functioning of GABAergic neurotransmission and disrupt various events in brain development. Here, we focus on the role of GABAergic neurotransmission in brain development and on how various genetic and epigenetic events regulate the GABAergic genes in pre- and postnatal brain. We also discuss how these regulatory mechanisms contribute to the pathogenesis of neurological disorders and, therefore, can be used in the development of potential epigenetic therapy for these diseases.

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Cited by

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Metadata

Authors
Shrestha, S., & Offer, S. M.
Venue
Medical Epigenetics
Publisher
S. Karger AG
Published
2016-03-24
Volume
4
Issue
1
Pages
1-19
ISSN
1664-5561 (ISSN-L)
DOI
10.1159/000444713
OpenAlex
W2320983896
Cited by
8,914
References
69
FWCI
507.72
Type
journal article
Language
en
Open access
diamond
Licence

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.