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The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis

·1990·American Journal of Psychiatry

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Abstract

Sixty-one papers involving over 1,700 subjects have documented that over half of depressed patients experience an antidepressant response to sleep deprivation. Eighty-three percent of unmedicated depressed patients who had an antidepressant response to sleep deprivation relapsed after one night of sleep. Short naps can also activate severe relapses. The authors suggest that these phenomenological observations concerning relapse with a night of sleep or with naps after successful sleep deprivation would be compatible with the existence of a sleep-associated depressogenic process.

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Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1990-01-01
Volume: 147
Issue: 1
Pages: 14-21
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.147.1.14
OpenAlex: W1942495330
Cited by: 618
References: 2
FWCI: 22.42
Type: journal article
Language: en
Open access: closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis

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