Cited by 556Neuroendocrine regulation and behaviorAttachment and Relationship DynamicsHuman-Animal Interaction Studies

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A neurobiological basis of social attachment.

Thomas R. Insel·1997·American Journal of Psychiatry

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Abstract

OBJECTIVE: Although an inability to form normal social attachments characterizes many forms of psychopathology, there has been little study of the neural basis of social bond formation. The primary purpose of this article is to describe a novel approach to the neurobiology of attachment. METHOD: The author reviews animal research on two closely related neuropeptides, oxytocin and vasopressin, implicated in the central mediation of attachment behaviors. These neuropeptides appear to be important for the initiation of pair bonds and parental behaviors as well as the infant's response to social separation. RESULTS: Both cellular and molecular studies have begun to reveal the mechanisms by which oxytocin and vasopressin neural pathways are regulated, leading to a preliminary understanding of how these hormones act within the brain to influence complex social behaviors. CONCLUSIONS: Although their function in the human brain has yet to be demonstrated, the available evidence suggests that oxytocin and vasopressin may prove to be important in the pathophysiology of clinical disorders, such as autism, characterized by an inability to form normal social attachments.

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Attachment and Loss. Vol. 1. Attachment
Rever, G. W. (1972) · Psychosomatic Medicine · doi:10.1097/00006842-197211000-00011 · Cited by 8,446
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
Monogamy in Mammals
Kleiman, D. G. (1977) · The Quarterly Review of Biology · doi:10.1086/409721 · Cited by 1,436
Prenatal maternal speech influences newborns' perception of speech sounds
DeCasper, A. J., & Spence, M. J. (1986) · Infant Behavior and Development · doi:10.1016/0163-6383(86)90025-1 · Cited by 1,145
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Physiology of Reproduction.
(1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-4-654_2 · Cited by 720
Physiological substrates of mammalian monogamy: The prairie vole model
Sue Carter, C., Courtney Devries, A., & Getz, L. L. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00070-h · Cited by 615

Show all 82 references

Research works printed but not linked: 9

Kraemer G, 1992, Behavioral Brain Sci, 15, 494
Hinde RA, 1983, Mass
Archer R, 1974, Handbook of Physiology, vol 4, 119
Sofroniew MV, 1981, McGaugh JL, 327
Dewsbury DA, 1987, American Zoology: Nebraska Symposium on Motivation, vol 35, 1
Jannett FJ, 1980, Biologist, 62, 3
Fisher H, 1992, The Anatomy of Love
Numan M, 1994, The Physiology of Reproduction, 221
Smotherman WP, 1991, Developmental Psychobiology: New Concepts and Changing Methods, 148

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Authors: Insel, T. R.
Affiliations: Emory University (US)
Corresponding author: Thomas R. Insel
ORCID: Thomas R. Insel
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1997-06-01
Volume: 154
Issue: 6
Pages: 726-735
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.154.6.726
OpenAlex: W1717145785
Cited by: 553
References: 82
Citations by year: 2026: 4 · 2025: 8 · 2024: 20 · 2023: 19 · 2022: 7 · 2021: 21 · 2020: 8 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 10 · 2015: 18 · 2014: 20 · 2013: 21 · 2012: 30
FWCI: 4.36
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
Keywords: social attachment, neurobiology of attachment, oxytocin, vasopressin, pair bonding, parental behavior, social separation, autism spectrum disorder, neuropeptides
MeSH terms: Animals, Arginine Vasopressin, Behavior, Animal, Arvicolinae, Female, Humans, Male, Maternal Behavior, Oxytocin, Pair Bond, Sexual Behavior, Animal, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin

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A neurobiological basis of social attachment.

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