C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19-induced Damage to the Nervous System

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175

Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein

Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · doi:10.1101/2020.02.19.956581 · Cited by 8,586

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

Structural basis of receptor recognition by SARS-CoV-2

Shang, J., Ye, G., Shi, K., Wan, Y., Luo, C., Aihara, H., Geng, Q., Auerbach, A., & Li, F. (2020) · Nature · doi:10.1038/s41586-020-2179-y · Cited by 3,661

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Ou, X., Liu, Y., Lei, X., Li, P., Mi, D., Ren, L., Guo, L., Guo, R., Chen, T., Hu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15562-9 · Cited by 3,097

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Dorsey, E. R., Elbaz, A., Nichols, E., Abbasi, N., Abd-Allah, F., Abdelalim, A., Adsuar, J. C., Ansha, M. G., Brayne, C., Choi, J.-Y. J., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30295-3 · Cited by 2,816

A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong

Lee, N. L. S., Hui, D. S. C., Wu, A. K. L., Chan, P. K. S., Cameron, P. A., Joynt, G. M., Ahuja, A. T., Yung, M. Y., Leung, C. B., To, K. F., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030685 · Cited by 2,638

Alzheimer's disease

Lane, C. A., Hardy, J., & Schott, J. M. (2018) · European Journal of Neurology · doi:10.1111/ene.13439 · Cited by 2,616

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Feigin, V. L., Abajobir, A. A., Abate, K. H., Abd-Allah, F., Abdulle, A. M., Abera, S. F., Abyu, G. Y., Ahmed, M. B., Aichour, A. N., Aichour, I., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30299-5 · Cited by 2,275

Neurological associations of COVID-19

Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., & Solomon, T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30221-0 · Cited by 2,156

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954

The Science of Stroke: Mechanisms in Search of Treatments

Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Cantuti-Castelvetri, L., Ojha, R., Pedro, L. D., Djannatian, M., Franz, J., Kuivanen, S., van der Meer, F., Kallio, K., Kaya, T., Anastasina, M., et al. (2020) · Science · doi:10.1126/science.abd2985 · Cited by 1,925

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

Montalban, X., Hauser, S. L., Kappos, L., Arnold, D. L., Bar-Or, A., Comi, G., de Seze, J., Giovannoni, G., Hartung, H.-P., Hemmer, B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606468 · Cited by 1,905

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,667

Pathology of Neurodegenerative Diseases

Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,659

Control of microglial neurotoxicity by the fractalkine receptor

Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531

1,026 Experimental treatments in acute stroke

O’Collins, V. E., Macleod, M. R., Donnan, G. A., Horky, L. L., van der Worp, H. B., & Howells, D. W. (2006) · Annals of Neurology · doi:10.1002/ana.20741 · Cited by 1,453

What contributes to quality of life in patients with Parkinson's disease?

Schrag, A. E. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.3.308 · Cited by 1,420

Neuropilin-1 is a host factor for SARS-CoV-2 infection

Daly, J. L., Simonetti, B., Klein, K., Chen, K.-E., Williamson, M. K., Antón-Plágaro, C., Shoemark, D. K., Simón-Gracia, L., Bauer, M., Hollandi, R., et al. (2020) · Science · doi:10.1126/science.abd3072 · Cited by 1,251

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity

Browne, P., Chandraratna, D., Angood, C., Tremlett, H., Baker, C., Taylor, B. V., & Thompson, A. J. (2014) · Neurology · doi:10.1212/wnl.0000000000000768 · Cited by 1,223

Aging in COVID-19: Vulnerability, immunity and intervention

Chen, Y., Klein, S. L., Garibaldi, B. T., Li, H., Wu, C., Osevala, N. M., Li, T., Margolick, J. B., Pawelec, G., & Leng, S. X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101205 · Cited by 1,007

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

Allen, C., & Bayraktutan, U. (2009) · International Journal of Stroke · doi:10.1111/j.1747-4949.2009.00387.x · Cited by 985

Inflammation and Stroke: An Overview

Anrather, J., & Iadecola, C. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0483-x · Cited by 966

Milk proteins as vehicles for bioactives

Livney, Y. D. (2009) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2009.11.002 · Cited by 948

Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases

Dawson, J. H. (1988) · Science · doi:10.1126/science.3358128 · Cited by 930

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

Ishihara, K., & Hirano, T. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00027-8 · Cited by 807

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease

Rocha, E. M., Miranda, B. D., & Sanders, L. H. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.004 · Cited by 797

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

Buckner, J. H. (2010) · Nature reviews. Immunology · doi:10.1038/nri2889 · Cited by 790

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Trist, B. G., Hare, D. J., & Double, K. L. (2019) · Aging Cell · doi:10.1111/acel.13031 · Cited by 778

Oxidative damage in multiple sclerosis lesions

Haider, L., Fischer, M. T., Frischer, J., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C., Witztum, J., & Lassmann, H. (2011) · Brain : a journal of neurology · doi:10.1093/brain/awr128 · Cited by 754

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

Parker, A., Fonseca, S., & Carding, S. R. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1638722 · Cited by 736

Nanoparticles for direct nose-to-brain delivery of drugs

Mistry, A., Stolnik, S., & Illum, L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.019 · Cited by 734

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

Romay, C., Gonzalez, R., Ledón, N., Remírez, D., & Rimbau, V. (2003) · Current Protein and Peptide Science · doi:10.2174/1389203033487216 · Cited by 718

Altered Microbiomes Distinguish Alzheimer’s Disease from Amnestic Mild Cognitive Impairment and Health in a Chinese Cohort

Liu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669

The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: An overview

Wu, Q., Liu, L., Miron, A., Klímová, B., Wan, D., & Kuča, K. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1744-5 · Cited by 655

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643

A new penumbra: transitioning from injury into repair after stroke

Lo, E. H. (2008) · Nature Medicine · doi:10.1038/nm1735 · Cited by 611

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587

Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: United States, 2007.

Nahin, R. L., Barnes, P. M., Stussman, B. J., & Bloom, B. E. (2009) · PubMed · Cited by 583

Neurological manifestations and complications of COVID-19: A literature review

Ahmad, I., & Rathore, F. A. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.05.017 · Cited by 565

Frequent neurologic manifestations and encephalopathy‐associated morbidity in Covid‐19 patients

Liotta, E. M., Batra, A., Clark, J. R., Shlobin, N. A., Hoffman, S. C., Orban, Z. S., & Koralnik, I. J. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51210 · Cited by 541

-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Ma, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1071-09.2009 · Cited by 536

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4528 · Cited by 533 · cited 2×

Nutritional and therapeutic potential of spirulina

Khan, Z., Bhadouria, P., & Bisen, P. (2005) · Current Pharmaceutical Biotechnology · doi:10.2174/138920105774370607 · Cited by 524

SARS‐CoV‐2 targets neurons of 3D human brain organoids

Ramani, A., Müller, L., Ostermann, P. N., Gabriel, E., Abida‐Islam, P., Müller‐Schiffmann, A., Mariappan, A., Goureau, O., Gruell, H., Walker, A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020106230 · Cited by 518

Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae

Romay, C., Armesto, J., Remirez, D., González, R., Ledon, N., & García, I. (1998) · Inflammation Research · doi:10.1007/s000110050256 · Cited by 511

Hyaluronan in Peritumoral Stroma and Malignant Cells Associates with Breast Cancer Spreading and Predicts Survival

Auvinen, P., Tammi, R., Parkkinen, J. J., Tammi, M., Ågren, U. M., Johansson, R. T., Hirvikoski, P. P., Eskelinen, M. J., & Kosma, V. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64757-8 · Cited by 494

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

Bastide, M. F., Meissner, W. G., Picconi, B., Fasano, S., Fernagut, P., Feyder, M. T., Francardo, V., Alcacer, C., Ding, Y., Brambilla, R., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.002 · Cited by 492

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

Rose, C. F., Amodio, P., Bajaj, J. S., Dhiman, R. K., Montagnese, S., Taylor-Robinson, S. D., Vilstrup, H., & Jalan, R. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.013 · Cited by 489

Global Stroke Statistics

Thrift, A. G., Cadilhac, D. A.-M., Thayabaranathan, T., Howard, G., Howard, V. J., Rothwell, P. M., & Donnan, G. A. (2013) · International Journal of Stroke · doi:10.1111/ijs.12245 · Cited by 487

Determinants of dopaminergic neuron loss in Parkinson's disease

Surmeier, D. J. (2018) · FEBS Journal · doi:10.1111/febs.14607 · Cited by 483

Effector T cell plasticity: flexibility in the face of changing circumstances

Murphy, K. M., & Stockinger, B. (2010) · Nature Immunology · doi:10.1038/ni.1899 · Cited by 482

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants

Jung, K.-A., & Kwak, M. (2010) · Molecules · doi:10.3390/molecules15107266 · Cited by 478

Classification of Stroke Subtypes

Amarenco, P., Bogousslavsky, J., Caplan, L. R., Donnan, G. A., & Hennerici, M. G. (2009) · Cerebrovascular Diseases · doi:10.1159/000210432 · Cited by 475

Current understanding of metal ions in the pathogenesis of Alzheimer’s disease

Wang, L., Yin, Y.-L., Liu, X.-Z., Shen, P., Zheng, Y.-G., Lan, X.-R., Lu, C.-B., & Wang, J.-Z. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00189-z · Cited by 454

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449

Antioxidant activity of different fractions of Spirulina platensis protean extract

Piñero Estrada, J. (2001) · Il Farmaco · doi:10.1016/s0014-827x(01)01084-9 · Cited by 447

Heme oxygenase–1, oxidation, inflammation, and atherosclerosis

Araujo, J. A., Zhang, M., & Yin, F. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00119 · Cited by 443

NADPH oxidase in brain injury and neurodegenerative disorders

Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

Quintana, F. J., Murugaiyan, G., Farez, M., Mitsdoerffer, M., Tukpah, A.-M. C., Burns, E. J., & Weiner, H. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009201107 · Cited by 430

The epidemiology of the dementias: an update

Qiu, C., Ronchi, D. D., & Fratiglioni, L. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32816ebc7b · Cited by 418

Human and economic burden of stroke

Carlo, A. D. (2008) · Age and Ageing · doi:10.1093/ageing/afn282 · Cited by 409

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

Yang, X., Yu, D., Xue, L., Li, H., & Du, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.07.001 · Cited by 407 · cited 1×

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

Kanberg, N., Ashton, N. J., Andersson, L., Yilmaz, A., Lindh, M., Nilsson, S., Price, R. W., Blennow, K., Zetterberg, H., & Gisslén, M. (2020) · Neurology · doi:10.1212/wnl.0000000000010111 · Cited by 373

Natural products for human health: an historical overview of the drug discovery approaches

Bernardini, S., Tiezzi, A., Masci, V. L., & Ovidi, E. (2017) · Natural Product Research · doi:10.1080/14786419.2017.1356838 · Cited by 372

The Role of Oxidative Stress in Parkinson’s Disease

Chang, K., & Chen, C. (2020) · Antioxidants · doi:10.3390/antiox9070597 · Cited by 369

Neurological Involvement in COVID-19 and Potential Mechanisms: A Review

Aghagoli, G., Gallo Marin, B., Katchur, N. J., Chaves-Sell, F., Asaad, W. F., & Murphy, S. A. (2021) · Neurocritical Care · doi:10.1007/s12028-020-01049-4 · Cited by 357

Acute ischemic stroke therapy overview

Catanese, L., Tarsia, J., & Fisher, M. (2017) · Circulation Research · doi:10.1161/circresaha.116.309278 · Cited by 341

Elucidation of the molecular structures of components of the phycobilisome: reconstructing a giant

Adir, N. (2005) · Photosynthesis Research · doi:10.1007/s11120-004-2143-y · Cited by 340

Burden of illness in Parkinson's disease

Huse, D. M., Schulman, K. L., Orsini, L. S., Castelli‐Haley, J., Kennedy, S., & Lenhart, G. M. (2005) · Movement Disorders · doi:10.1002/mds.20609 · Cited by 335

High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer.

Anttila, M., Tammi, R., Tammi, M., Syrjänen, K. J., Saarikoski, S., & Kosma, V. (2000) · PubMed · Cited by 327

Activation of the Ah Receptor Signal Transduction Pathway by Bilirubin and Biliverdin

Phelan, D., Winter, G. M., Rogers, W. J., Lam, J., & Denison, M. S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0814 · Cited by 318

The hallmarks of P arkinson's disease

Antony, P. M. A., Diederich, N. J., Krüger, R., & Balling, R. (2013) · FEBS Journal · doi:10.1111/febs.12335 · Cited by 317

Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site

Jaimes, J. A., Millet, J. K., & Whittaker, G. R. (2020) · iScience · doi:10.1016/j.isci.2020.101212 · Cited by 317

Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation

Chora, Â. F., da Fontoura, P. P., Cunha, A., Pais, T. F., Cardoso, S., Ho, P. P.-K., Lee, L. Y., Sobel, R. A., Steinman, L., & Soares, M. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28844 · Cited by 307

Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS

Fancy, S. P. J., Zhao, C., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.015 · Cited by 302

Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease

Akhtar, A., & Sah, S. P. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104707 · Cited by 297

Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

Charvin, D., Medori, R., Hauser, R. A., & Rascol, O. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.136 · Cited by 294

The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway

Farkhondeh, T., Llorens, S., Pourbagher‐Shahri, A. M., Ashrafizadeh, M., & Samarghandian, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110234 · Cited by 279

Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: Protection against oxidative damage to DNA

Bhat, V. B., & Madyastha, K. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5195 · Cited by 277

Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats

Lanone, S., Bloc, S., Foresti, R., Almolki, A., Taillé, C., Callebert, J., Conti, M., Goven, D., Aubier, M., Dureuil, B., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2368fje · Cited by 261

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.

Okuda, Y., Sakoda, S., Bernard, C. C. A., Fujimura, H., Saeki, Y., Kishimoto, T., & Yanagihara, T. (1998) · International Immunology · doi:10.1093/intimm/10.5.703 · Cited by 244

Neuropathologic Alterations in Mild Cognitive Impairment: A Review

Markesbery, W. R. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1220 · Cited by 236

Bilirubin Possesses Powerful Immunomodulatory Activity and Suppresses Experimental Autoimmune Encephalomyelitis

Liu, Y., Li, P., Lu, J., Xiong, W., Oger, J., Tetzlaff, W., & Cynader, M. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1887 · Cited by 228

Multiple sclerosis animal models: a clinical and histopathological perspective

Kipp, M., Nyamoya, S., Hochstrasser, T., & Amor, S. (2017) · Brain Pathology · doi:10.1111/bpa.12454 · Cited by 226

NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA).

Gutiérrez-Salmeán, G., Castillo, L., & Chamorro, G. (2015) · PubMed · doi:10.3305/nh.2015.32.1.9001 · Cited by 224

Olig gene function in CNS development and disease

Ligon, K. L., Fancy, S. P. J., Franklin, R. J. M., & Rowitch, D. H. (2006) · Glia · doi:10.1002/glia.20273 · Cited by 223

Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?

Jansen, T., & Daiber, A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00030 · Cited by 218

Alzheimer’s disease as an inflammatory disease

Bolós, M., Perea, J. R., & Avila, J. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2016-0029 · Cited by 216

Antioxidant activities of phycocyanobilin prepared from Spirulina platensis

Hirata, T., Tanaka, M., Ooike, M., Tsunomura, T., & Sakaguchi, M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008175217194 · Cited by 216

C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages

Reddy, M. C., Subhashini, J., Mahipal, S. V. K., Bhat, V. B., Reddy, P. S., Kiranmai, G., Madyastha, K. M., & Reddanna, P. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00586-2 · Cited by 208

Iron-chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulinaplatensis

Bermejo‐Bescós, P., Piñero, E., & Villar, Á. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.02.021 · Cited by 204

Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis

Shindler, K. S., Ventura, E. S., Dutt, M., Elliott, P. J., Fitzgerald, D. C., & Rostami, A. M. (2010) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0b013e3181f7f833 · Cited by 203

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

Zeng, X., Geng, W.-S., Jia, J., Chen, L., & Zhang, P.-P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00109 · Cited by 203

Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress

Zheng, J., Inoguchi, T., Sasaki, S., Maeda, Y., McCarty, M. F., Fujii, M., Ikeda, N., Kobayashi, K., Sonoda, N., & Takayanagi, R. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00648.2011 · Cited by 201

Peroxynitrite formation within the central nervous system in active multiple sclerosis

Cross, A. H., Manning, P. T., Keeling, R. M., Schmidt, R. E., & Misko, T. P. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00078-2 · Cited by 201

Clinical Potential of Spirulina as a Source of Phycocyanobilin

McCarty, M. F. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2007.621 · Cited by 199

Nutraceuticals - shedding light on the grey area between pharmaceuticals and food

Santini, A., & Novellino, E. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1464911 · Cited by 199

Biliprotein maturation: the chromophore attachment

Scheer, H., & Zhao, K. ‐. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06160.x · Cited by 198

Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation

Romay, C., Ledón, N., & González, R. (1998) · Inflammation Research · doi:10.1007/s000110050338 · Cited by 195

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 193

d-glutamate and Gut Microbiota in Alzheimer’s Disease

Chang, C.-H., Lin, C.-H., & Lane, H.-Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082676 · Cited by 191

Epidemiology of neurological diseases in older adults

Dumurgier, J., & Tzourio, C. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.01.356 · Cited by 183

Future directions of acute ischaemic stroke therapy

Fisher, M., & Saver, J. L. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00054-x · Cited by 180

Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds

Koníčková, R., Vaňková, K., Vaníková, J., Vanova, K. H., Lucie Muchova, A., Subhanová, I., Zadinová, M., Zelenka, J., Dvořák, A., Kolář, M., et al. (2014) · Annals of Hepatology · doi:10.1016/s1665-2681(19)30891-9 · Cited by 180

Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin

Kapitulnik, J., & Maines, M. D. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.12.003 · Cited by 178

United States Pharmacopeia Safety Evaluation of Spirulina

Marles, R. J., Barrett, M. L., Barnes, J., Chavez, M. L., Gardiner, P., Ko, R., Mahady, G. B., Dog, T. L., Sarma, N. D., Giancaspro, G. I., et al. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408391003721719 · Cited by 177

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

Fonseca-Kelly, Z., Nassrallah, M., Uribe, J., Khan, R. S., Dine, K. E., Dutt, M., & Shindler, K. S. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00084 · Cited by 168

Evidence for the production of peroxynitrite in inflammatory CNS demyelination

Cross, A. H., Manning, P. T., Stern, M. K., & Misko, T. P. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00145-8 · Cited by 163

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

McCarty, M. F., & DiNicolantonio, J. J. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.02.007 · Cited by 163

Activation of Aryl Hydrocarbon Receptor by Tcdd Prevents Diabetes in Nod Mice and Increases Foxp3 + T Cells in Pancreatic Lymph Nodes

Kerkvliet, N. I., Steppan, L. B., Vorachek, W. R., Oda, S. K., Farrer, D. G., Wong, C. P., Pham, D., & Mourich, D. V. (2009) · Immunotherapy · doi:10.2217/imt.09.24 · Cited by 161

Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

Quinn, J. F., Bussiere, J. R., Hammond, R., Montine, T. J., Henson, E., Jones, R. E., & Stackman, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.014 · Cited by 161

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV

Örd, M., Faustova, I., & Loog, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-74101-0 · Cited by 159

Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn

Hansen, T. W. R., Wong, R. J., & Stevenson, D. K. (2020) · Physiological Reviews · doi:10.1152/physrev.00004.2019 · Cited by 157

Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems

Hemmati-Dinarvand, M., Saedi, S., Valilo, M., Kalantary‐Charvadeh, A., Sani, M. A., Kargar, R., Safari, H., & Samadi, N. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134296 · Cited by 156

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Wu, P., Zhang, Z., Wang, F., & Chen, J. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.186 · Cited by 152

Infectability of Human BrainSphere Neurons Suggests Neurotropism of SARS-CoV-2*

Bullen, C. K. (2020) · ALTEX · doi:10.14573/altex.2006111 · Cited by 147

Potential health benefits of spirulina microalgae*: A review of the existing literature

Capelli, B., & Cysewski, G. R. (2010) · Nutrafoods · doi:10.1007/bf03223332 · Cited by 147

Crystal Structure of a Light-Harvesting Protein C-Phycocyanin from Spirulina platensis

Padyana, A. K., Bhat, V. B., Madyastha, K. M., Rajashankar, K. R., & Ramakumar, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4663 · Cited by 144

Biliverdin reductase isozymes in metabolism

O’Brien, L., Hosick, P. A., John, K., Stec, D. E., & Hinds, T. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.02.001 · Cited by 142

Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death‐associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by α‐lipoic acid

Karunakaran, S., Diwakar, L., Saeed, U., Agarwal, V., Ramakrishnan, S., Iyengar, S., & Ravindranath, V. (2007) · The FASEB Journal · doi:10.1096/fj.06-7580com · Cited by 140

Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases

Chen, D., Zhang, T., & Lee, T. H. (2020) · Biomolecules · doi:10.3390/biom10081158 · Cited by 140

Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression

Choi, B., Pae, H., Jeong, Y.-R., Kim, Y., & Chung, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.106 · Cited by 138

Genetics of Alzheimer’s Disease

Vilatela, M. E. A., López, M., & Yescas, P. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.10.017 · Cited by 137

Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages

Cherng, S.-C., Cheng, S.-N., Tarn, A., & Chou, T.-C. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.09.009 · Cited by 136

Bilirubin as a signaling molecule

Vı́tek, L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21660 · Cited by 136

Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis

Liu, Y., Zhu, B., Wang, X., Luo, L., Li, P., Paty, D. W., & Cynader, M. S. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00132-2 · Cited by 135

Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice

Wang, Q., Shen, Y., Wang, X., Fu, S., Zhang, X., Zhang, Y., & Wang, R. (2020) · Aging · doi:10.18632/aging.102645 · Cited by 135

Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells

Bermejo-Bescós, P., Piñero-Estrada, E., & Villar del Fresno, Á. M. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.05.004 · Cited by 134

Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease

Zhang, L., Yu, X., Ji, M., Liu, S., Wu, X., Wang, Y., & Liu, R. (2018) · Food & Function · doi:10.1039/c8fo00964c · Cited by 132

Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide

Vasavda, C., Kothari, R., Malla, A. P., Tokhunts, R. A., Lin, A. L., Ji, M., Ricco, C., Xu, R., Saavedra, H. G., Sbodio, J. I., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.07.006 · Cited by 129

Stroke Neurologist’s Perspective on the New Endovascular Trials

Grotta, J. C., & Hacke, W. (2015) · Stroke · doi:10.1161/strokeaha.115.008384 · Cited by 128

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

Barone, E., Di Domenico, F., Mancuso, C., & Butterfield, D. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.018 · Cited by 127

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain

Genoud, S., Roberts, B. R., Gunn, A. P., Halliday, G. M., Lewis, S. J. G., Ball, H. J., Hare, D. J., & Double, K. L. (2017) · Metallomics · doi:10.1039/c7mt00244k · Cited by 126

Phycocyanin is an Antioxidant Protector of Human Erythrocytes Against Lysis by Peroxyl Radicals

Romay, C., & Gonzalez, R. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774093 · Cited by 124

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

Barone, E., Domenico, F. D., Rukhsana Sultana, A., Coccia, R., Mancuso, C., Marzia Perluigi, A., & Butterfield, D. A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.020 · Cited by 124

Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease

Bonfili, L., Cecarini, V., Gogoi, O., Gong, C., Cuccioloni, M., Angeletti, M., Rossi, G., & Eleuteri, A. M. (2020) · FEBS Journal · doi:10.1111/febs.15571 · Cited by 123

Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations

Maramai, S., Benchekroun, M., Gabr, M. T., & Yahiaoui, S. (2020) · BioMed Research International · doi:10.1155/2020/5120230 · Cited by 121

Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductase

Terry, M. J., Maines, M. D., & Lagarias, J. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74286-0 · Cited by 118

Cell Surface Biliverdin Reductase Mediates Biliverdin-induced Anti-inflammatory Effects via Phosphatidylinositol 3-Kinase and Akt

Wegiel, B., Baty, C. J., Gallo, D. J., Csizmadia, E., Scott, J. R., Akhavan, A., Chin, B. Y., Kaczmarek, E., Alam, J., Bach, F. H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027433 · Cited by 114

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

Rouse, M. D., Singh, N. P., Nagarkatti, P. S., & Nagarkatti, M. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12205 · Cited by 112

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline

Koriyama, Y., Nakayama, Y., Matsugo, S., & Kato, S. (2013) · Brain Research · doi:10.1016/j.brainres.2012.12.041 · Cited by 112

Well-tolerated spirulina extract inhibits influenza virus replication and reduces virus-induced mortality

Chen, Y.-H., Chang, G.-K., Kuo, S.-M., Huang, S.-Y., Hu, I.-C., Lo, Y.-L., & Shih, S.-R. (2016) · Scientific Reports · doi:10.1038/srep24253 · Cited by 112

SpirulinaandC-phycocyaninreduce cytotoxicity and inflammation-related genes expression of microglial cells

Chen, J.-C., Liu, K. S., Yang, T.-J., Hwang, J.-H., Chan, Y., & Lee, I. (2012) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000020 · Cited by 109

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

Ohno, N., Chiang, H., Mahad, D., Kidd, G. J., Liu, L., Ransohoff, R. M., Sheng, Z., Komuro, H., & Trapp, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401155111 · Cited by 108

Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress

Fang, J., Yuan, Y., Teng, X., Wen, X., Li, N., Peng, S., Liu, W., Donadeu, F. X., Zhao, S., & Hua, J. (2018) · Aging · doi:10.18632/aging.101602 · Cited by 108

Single-step chromatography for simultaneous purification of C-phycocyanin and allophycocyanin with high purity and recovery from Spirulina (Arthrospira) platensis

Yan, S., Zhu, L., Su, H., Zhang, X., Chen, X., Zhou, B., & Zhang, Y. (2010) · Journal of Applied Phycology · doi:10.1007/s10811-010-9525-7 · Cited by 107

Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice

Ge, L., Liu, L., Liu, H., Liu, S., Xue, H., Wang, X., Yuan, L., Wang, Z., & Liu, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.026 · Cited by 106

Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice

Peng, Y., Hou, C., Yang, Z., Li, C., Jia, L., Liu, J., Tang, Y., Shi, L., Li, Y., Long, J., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600332 · Cited by 103

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

Barone, E., Di Domenico, F., Cassano, T., Arena, A., Tramutola, A., Lavecchia, M. A., Coccia, R., Butterfield, D. A., & Perluigi, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.012 · Cited by 100

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

Hou, L., Bao, X., Zang, C., Yang, H., Sun, F., Che, Y., Wu, X., Li, S., Zhang, D., & Wang, Q. (2018) · Redox Biology · doi:10.1016/j.redox.2017.11.010 · Cited by 98

Heme Oxygenase-1-Mediated CD4+CD25high Regulatory T Cells Suppress Allergic Airway Inflammation

Xia, Z., Zhong, W., Xu, L.-Q., Jian‐Le, S., Shen, Q.-X., Wang, J., Shao, J., Li, Y., & Shan-chang, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5936 · Cited by 97

CNS Myelin Paranodes Require Nkx6-2 Homeoprotein Transcriptional Activity for Normal Structure

Southwood, C., He, C., Garbern, J., Kamholz, J., Arroyo, E., & Gow, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3479-04.2004 · Cited by 94

Anti-oxidant activity of holo- and apo-c-phycocyanin and their protective effects on human erythrocytes

Pleonsil, P., Soogarun, S., & Suwanwong, Y. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.016 · Cited by 93

Injury and repair in the neurovascular unit

Xing, C., Hayakawa, K., Lok, J. M., Arai, K., & Lo, E. H. (2012) · Neurological Research · doi:10.1179/1743132812y.0000000019 · Cited by 93

Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Dadhania, V. P., Trivedi, P. P., Vikram, A., & Tripathi, D. N. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160104142223 · Cited by 93

C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils

Pentón‐Rol, G., Marín‐Prida, J., Andreu, G. L. P., Martı́nez-Sánchez, G., Acosta-Medina, E. F., Valdivia, A., Lagumersindez-Denis, N., Jiménez, E. R., Llopiz, A., López-Saura, P. A., et al. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.05.016 · Cited by 92

Popular functional foods and herbs for the management of type-2-diabetes mellitus: A comprehensive review with special reference to clinical trials and its proposed mechanism

Venkatakrishnan, K., Chiu, H., & Wang, C. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.039 · Cited by 91

A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson's Disease

Pabon, M. M., Jernberg, J. N., Morganti, J., Contreras, J., Hudson, C. E., Klein, R. L., & Bickford, P. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045256 · Cited by 90

Oxygen Radical Absorbance Capacity of Phycocyanin and Phycocyanobilin from the Food Supplement Aphanizomenon flos-aquae

Benedetti, S., Benvenuti, F., Scoglio, S., & Canestrari, F. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0257 · Cited by 88

Neurotoxicity by microglia: Mechanisms and potential therapeutic strategy

Takeuchi, H. (2010) · Clinical and Experimental Neuroimmunology · doi:10.1111/j.1759-1961.2009.00001.x · Cited by 88

Spirulina platensis and phycocyanobilin activate atheroprotective heme oxygenase-1: a possible implication for atherogenesis

Strasky, Z., Zemankova, L., Nemeckova, I., Rathouska, J., Wong, R. J., Muchova, L., Subhanova, I., Vanikova, J., Vanova, K., Vitek, L., et al. (2013) · Food & Function · doi:10.1039/c3fo60230c · Cited by 87

G ilbert's syndrome and the risk of death: A population‐based cohort study

Horsfall, L., Nazareth, I., Pereira, S. P., et al. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12279 · Cited by 86

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

Barone, E., Tramutola, A., Triani, F., Calcagnini, S., Di Domenico, F., Ripoli, C., Gaetani, S., Grassi, C., Butterfield, D. A., Cassano, T., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1231-5 · Cited by 86

The role of nutraceuticals as a complementary therapy against various neurodegenerative diseases: A mini-review

Chiu, H., Venkatakrishnan, K., & Wang, C. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.03.008 · Cited by 86

Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina

Minic, S. L., Stanic-Vucinic, D., Mihailovic, J., Krstic, M., Nikolic, M. R., & Cirkovic Velickovic, T. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.03.043 · Cited by 83

Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?

Neyrinck, A. M., Taminiau, B., Walgrave, H., Daube, G., Cani, P. D., Bindels, L. B., & Delzenne, N. M. (2017) · Nutrients · doi:10.3390/nu9060633 · Cited by 81

Bilirubin and brain: A pharmacological approach

Mancuso, C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.013 · Cited by 77

Disease-Modifying Treatment in Progressive Multiple Sclerosis

Ciotti, J. R., & Cross, A. H. (2018) · Current Treatment Options in Neurology · doi:10.1007/s11940-018-0496-3 · Cited by 77

Strong Stromal Hyaluronan Expression Is Associated with PSA Recurrence in Local Prostate Cancer

Aaltomaa, S. H., Lipponen, P., Tammi, R., Tammi, M., Viitanen, J., Kankkunen, J.-P., & Kosma, V. M. (2002) · Urologia Internationalis · doi:10.1159/000066123 · Cited by 75

Lactulose: An indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production

Chen, X., Zuo, Q., Hai, Y., & Sun, X. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.09.026 · Cited by 75

Assessment of C-phycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model

Min, S. K., Park, J. S., Luo, L., Kwon, Y. S., Lee, H. C., Jung Shim, H., Kim, I.-D., Lee, J.-K., & Shin, H. S. (2015) · Scientific Reports · doi:10.1038/srep14418 · Cited by 74

Beneficial effects of oral administration of C-Phycocyanin and Phycocyanobilin in rodent models of experimental autoimmune encephalomyelitis

Cervantes-Llanos, M., Lagumersindez-Denis, N., Marín-Prida, J., Pavón-Fuentes, N., Falcon-Cama, V., Piniella-Matamoros, B., Camacho-Rodríguez, H., Fernández-Massó, J. R., Valenzuela-Silva, C., Raíces-Cruz, I., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.032 · Cited by 73

Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain

Butterfield, D. A., Barone, E., Domenico, F. D., Cenini, G., Rukhsana Sultana, A., Murphy, M. P., Mancuso, C., & Head, E. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001118 · Cited by 69

Twenty-Year History of the Evolution of Stroke Thrombolysis With Intravenous Alteplase to Reduce Long-Term Disability

Campbell, B. C. V., Meretoja, A., Donnan, G. A., & Davis, S. M. (2015) · Stroke · doi:10.1161/strokeaha.114.007564 · Cited by 67

Biozzi mice: Of mice and human neurological diseases

Amor, S., Smith, P. A., Hart, B. A. ‘., & Baker, D. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.04.010 · Cited by 67

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Cho (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000350 · Cited by 66

Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism

Fan, H., Tang, X., Song, Y., Liu, P., & Chen, Y. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s251173 · Cited by 66

A systematic review and meta-analysis of the COVID-19 associated liver injury

Wong, Y. J., Tan, M. T. K., Zheng, Q., Li, J. W., Kumar, R., Fock, K. M., Teo, E. K., & Ang, T. L. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.08.064 · Cited by 66

SARS-CoV-2, an Underestimated Pathogen of the Nervous System

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Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis : Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation

Jensen, G. S., Drapeau, C., Lenninger, M. R., & Benson, K. F. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2015.0143 · Cited by 63

Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson’s Disease Are Related to Its Anti-Inflammatory Effects

Lima, F. A. V., Joventino, I. P., Joventino, F. P., de Almeida, A. C., Neves, K. R. T., do Carmo, M. R. S., Leal, L. K. A. M., de Andrade, G. M., & Viana, G. S. D. B. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2379-5 · Cited by 63

Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in mice

Chamorro, G., Garduño‐Siciliano, L., Barrón, B. L., Madrigal-Bujaidar, E., Cruz‐Vega, D. E., & Pagès, N. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.08.039 · Cited by 62

Diet Supplementation with Hydroxytyrosol Ameliorates Brain Pathology and Restores Cognitive Functions in a Mouse Model of Amyloid-β Deposition

Nardiello, P., Pantano, D., Lapucci, A., Stefani, M., & Casamenti, F. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171124 · Cited by 62

Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats

Marín-Prida, J., Pavón-Fuentes, N., Llópiz-Arzuaga, A., Fernández-Massó, J. R., Delgado-Roche, L., Mendoza-Marí, Y., Santana, S. P., Cruz-Ramírez, A., Valenzuela-Silva, C., Nazábal-Gálvez, M., et al. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.021 · Cited by 61 · cited 16×

C-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells

Pentón-Rol, G., Martínez-Sánchez, G., Cervantes-Llanos, M., Lagumersindez-Denis, N., Acosta-Medina, E. F., Falcón-Cama, V., Alonso-Ramírez, R., Valenzuela-Silva, C., Rodríguez-Jiménez, E., Llópiz-Arzuaga, A., et al. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.10.001 · Cited by 61

A new way to estimate neurologic disease prevalence in the United States

Nelson, L. M., Wallin, M. T., Marrie, R. A., Culpepper, W. J., Langer-Gould, A. M., Campbell, J., Buka, S. L., Tremlett, H. L., Cutter, G., Kaye, W., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007044 · Cited by 61

Neuroprotective effect of Spirulina in cerebral ischemia–reperfusion injury in rats

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Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

Hua, P., Yu, Z., Xiong, Y. C., Liu, B., & Zhao, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124023 · Cited by 59

Phycocyanin Ameliorates Radiation‐Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF‐κB Pathway

Lu, L., Li, W., Sun, C., Kang, S., Li, J., Luo, X., Su, Q., Liu, B., & Qin, S. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1744 · Cited by 59

Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature

Gentscheva, G., Nikolova, K., Panayotova, V., Peycheva, K., Makedonski, L., Slavov, P., Radusheva, P., Petrova, P., & Yotkovska, I. (2023) · Life · doi:10.3390/life13030845 · Cited by 106

Antiinflammatory Activities of Curcumin and Spirulina: Focus on Their Role against COVID-19

Perna, A., Hay, E., Sellitto, C., Del Genio, E., De Falco, M., Guerra, G., De Luca, A., De Blasiis, P., & Lucariello, A. (2023) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2173354 · Cited by 12

Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductase

Terry, M. J., Maines, M. D., & Lagarias, J. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74286-0 · Cited by 118

Biosynthesis of the chromophore of phycobiliproteins. A study of mesohaem and mesobiliverdin as possible intermediates and further evidence for an algal haem oxygenase

Brown, S. B., & Holroyd, J. A. (1984) · Biochemical Journal · doi:10.1042/bj2170265 · Cited by 13

Recombinant Expression of a Fluorescent Phycocyanin Holo-α-subunit from Arthrospira platensis in Escherichia coli

Jun, Y. (2011) · Cited by 2

Biosynthesis of Open‐Chain Tetrapyrroles in Plants, Algae, and Cyanobacteria

Beale, S. I. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514535.ch9 · Cited by 25

First computational step towards the understanding of the antioxidant activity of the Phycocyanobilin:Ferredoxin Oxidoreductase in complex with biliverdin IXα

Cerón‐Carrasco, J. P., Jacquemin, D., & Laurent, A. D. (2015) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2015.10.018 · Cited by 3