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Macrophage Diversity Enhances Tumor Progression and Metastasis

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Qian, Bin-Zhi, Pollard, Jeffrey W.·2010·Cell
DOI 10.1016/j.cell.2010.03.014
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Abstract

There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation they create an inflammatory environment that is mutagenic and which promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration, invasion, and suppress anti-tumor immunity. At metastatic sites macrophages prepare the target tissue for arrival of tumor cells and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.

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Cited by

Metadata

Authors
Qian, B.-Z., & Pollard, J. W.
Venue
Cell
Publisher
Elsevier BV
Published
2010-04
Volume
141
Issue
1
Pages
39-51
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2010.03.014
OpenAlex
W2058648826
Cited by
5,188
References
22
FWCI
80.44
Type
journal article
Language
en
Open access
bronze
Licence

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