Cited by 151Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

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Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

Quintana, Daniel S., Alvares, Gail A., Hickie, Ian B., Guastella, Adam J.·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2014.12.011

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Abstract

Accumulating evidence demonstrates the important role of oxytocin (OT) in the modulation of social cognition and behavior. This has led many to suggest that the intranasal administration of OT may benefit psychiatric disorders characterized by social dysfunction, such as autism spectrum disorders and schizophrenia. Here, we review nasal anatomy and OT pathways to central and peripheral destinations, along with the impact of OT delivery to these destinations on social behavior and cognition. The primary goal of this review is to describe how these identified pathways may contribute to mechanisms of OT action on social cognition and behavior (that is, modulation of social information processing, anxiolytic effects, increases in approach-behaviors). We propose a two-level model involving three pathways to account for responses observed in both social cognition and behavior after intranasal OT administration and suggest avenues for future research to advance this research field.

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Authors: Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J.
Affiliations: The University of Sydney (AU)
Corresponding author: Quintana, Daniel S.
ORCID: Quintana, Daniel S.
Alvares, Gail A.
Hickie, Ian B.
Guastella, Adam J.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-02
Volume: 49
Pages: 182-192
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2014.12.011
OpenAlex: W2051491987
Cited by: 149
References: 143
Citations by year: 2026: 7 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 19 · 2020: 12 · 2019: 12 · 2018: 25 · 2017: 27 · 2016: 17 · 2015: 11
FWCI: 2.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Australian Research Council (LP110100513)
National Health and Medical Research Council (10436644, 1061922)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, intranasal administration, delivery routes, social cognition, social behavior, nasal anatomy, social information processing, anxiolytic effects, approach behavior, autism spectrum disorder, schizophrenia, two-level model
MeSH terms: Administration, Intranasal, Animals, Cognition, Humans, Models, Biological, Nose, Oxytocin, Psychotropic Drugs, Social Behavior

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Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

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