Cited by 153Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

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Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

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Orsini, Caitlin A., Moorman, David E., Young, Jared W., Setlow, Barry, Floresco, Stan B.·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.04.009PMC PMC7913606

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Abstract

Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit decision-making. Recent studies with animal models have made considerable advances in our understanding of how different prefrontal, striatal, limbic and monoaminergic circuits interact to promote efficient risk/reward decision-making, and how dysfunction in these circuits underlies aberrant decision-making observed in numerous psychiatric disorders. This review will highlight recent findings from studies exploring these questions using a variety of behavioral assays, as well as molecular, pharmacological, neurophysiological, and translational approaches. We begin with a discussion of how neural systems related to decision subcomponents may interact to generate more complex decisions involving risk and uncertainty. This is followed by an overview of interactions between prefrontal-amygdala-dopamine and habenular circuits in regulating choice between certain and uncertain rewards and how different modes of dopamine transmission may contribute to these processes. These data will be compared with results from other studies investigating the contribution of some of these systems to guiding decision-making related to rewards vs. punishment. Lastly, we provide a brief summary of impairments in risk-related decision-making associated with psychiatric disorders, highlighting recent translational studies in laboratory animals.

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Fundamental contribution by the basolateral amygdala to different forms of decision making
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Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans
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Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats
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Optogenetic inhibition of cocaine seeking in rats
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Prefrontal Cortical Contribution to Risk-Based Decision Making
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Role of ventral medial prefrontal cortex in incubation of cocaine craving
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Aversive Stimuli Differentially Modulate Real-Time Dopamine Transmission Dynamics within the Nucleus Accumbens Core and Shell
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Glutamate neurons within the midbrain dopamine regions
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Synaptic Activity Unmasks Dopamine D2 Receptor Modulation of a Specific Class of Layer V Pyramidal Neurons in Prefrontal Cortex
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Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling
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A Class of GABAergic Neurons in the Prefrontal Cortex Sends Long-Range Projections to the Nucleus Accumbens and Elicits Acute Avoidance Behavior
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Optogenetic dissection of medial prefrontal cortex circuitry
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The Basal Ganglia’s Contributions to Perceptual Decision Making
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Neural structures underlying set-shifting: Roles of medial prefrontal cortex and anterior cingulate cortex
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Decision Making: The Neuroethological Turn
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The medial prefrontal cortex as a part of the brain reward system
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Impulsivity and Risk Taking in Bipolar Disorder and Schizophrenia
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Prefrontal and monoaminergic contributions to stop-signal task performance in rats
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The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?
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Risk taking and the adolescent reward system: A potential common link to substance abuse
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Impairment in risk-sensitive decision-making in older suicide attempters with depression.
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The infralimbic cortex regulates the consolidation of extinction after cocaine self-administrationPreprint
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Morphological and Physiological Characterization of Pyramidal Neuron Subtypes in Rat Medial Prefrontal Cortex
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Prefrontal cortex plasticity mechanisms in drug seeking and relapse
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Neural Correlates of Emotional Reactivity in Sensation Seeking
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Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus
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Phasic Nucleus Accumbens Dopamine Release Encodes Effort- and Delay-Related Costs
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What electrical microstimulation has revealed about the neural basis of cognition
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“Stimulation of these key regions can bias decisions depending on the area influenced (Salzman et al., 1990; Cohen and Newsome, 2004).”
Background
Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making
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Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers
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Disconnection of the basolateral amygdala complex and nucleus accumbens impairs appetitive Pavlovian second-order conditioned responses.
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Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making
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Disconnection of the basolateral amygdala complex and nucleus accumbens impairs appetitive pavlovian second-order conditioned responses
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Lesions of the Basolateral Amygdala and Orbitofrontal Cortex Differentially Affect Acquisition and Performance of a Rodent Gambling Task
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Dopaminergic Modulation of Risky Decision-Making
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Trait-Related Decision-Making Impairment in the Three Phases of Bipolar Disorder
Adida, M., Jollant, F., Clark, L., Besnier, N., Guillaume, S., Kaladjian, A., Mazzola‐Pomietto, P., Jeanningros, R., Goodwin, G. M., Azorin, J., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.018 · Cited by 156
Cognitive modeling analysis of decision-making processes in cocaine abusers
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Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell.
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A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions
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Encoding of Aversion by Dopamine and the Nucleus Accumbens
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Animal models of prefrontal-executive function
Chudasama, Y. (2011) · Behavioral Neuroscience · doi:10.1037/a0023766 · Cited by 149 · cited 1×
“Broadly speaking, the mPFC in rodents is widely considered to subserve a variety of executive functions that are engaged during decisionmaking (Cardinal, 2006; St Onge and Floresco, 2010; Euston et al., 2012; Chudasama, 2011).”
Background
Risk-Prone Individuals Prefer the Wrong Options on a Rat Version of the Iowa Gambling Task
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Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task
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Delay Activity in Rodent Frontal Cortex During a Simple Reaction Time Task
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Dopamine D1and NMDA Receptors Mediate Potentiation of Basolateral Amygdala-Evoked Firing of Nucleus Accumbens Neurons
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The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder
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Phasic Nucleus Accumbens Dopamine Encodes Risk-Based Decision-Making Behavior
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Risky Decisions and Their Consequences: Neural Processing by Boys with Antisocial Substance Disorder
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Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA (“Ecstasy”)
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Safety Encoding in the Basal Amygdala
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The role of medial prefrontal cortex in extinction and reinstatement of alcohol‐seeking in rats
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Reason, emotion and decision-making: risk and reward computation with feeling
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Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making
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Heterogeneity of strategy use in the Iowa gambling task: A comparison of win-stay/lose-shift and reinforcement learning models
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Alterations in Reward, Fear and Safety Cue Discrimination after Inactivation of the Rat Prelimbic and Infralimbic Cortices
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A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature
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Amygdala Neurons Differentially Encode Motivation and Reinforcement
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“, 2013) and during response execution and inhibition (Tye and Janak, 2007; Tye et al., 2010).”
Background
Dorsomedial Prefrontal Cortex Contribution to Behavioral and Nucleus Accumbens Neuronal Responses to Incentive Cues
Ishikawa, A., Ambroggi, F., Nicola, S. M., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0253-08.2008 · Cited by 129
Activation of Prefrontal Cortical Parvalbumin Interneurons Facilitates Extinction of Reward-Seeking Behavior
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The Plasticity of Extinction: Contribution of the Prefrontal Cortex in Treating Addiction through Inhibitory Learning
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Functional Specialization of the Primate Frontal Cortex during Decision Making: Figure 1.
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Differential tonic influence of lateral habenula on prefrontal cortex and nucleus accumbens dopamine release
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Differential effects of dopaminergic manipulations on risky choice
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Dissociable Roles for the Basolateral Amygdala and Orbitofrontal Cortex in Decision-Making under Risk of Punishment
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Decision‐making Impairments in Women with Binge Eating Disorder in Comparison with Obese and Normal Weight Women
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Functional neuroanatomy of the prefrontal cortex: autonomic interactions
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Executive functions among individuals with methamphetamine or alcohol as drugs of choice: Preliminary observations
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Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects
Lobo, D. S. S., de Souza, R. P., Tong, R. P., Casey, D. M., Hodgins, D. C., Smith, G. J., Williams, R. J., Schopflocher, D., Wood, R., el‐Guebaly, N., et al. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.04.008 · Cited by 117
Selective involvement by the medial orbitofrontal cortex in biasing risky, but not impulsive, choice
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Altered risk-related processing in substance users: Imbalance of pain and gain
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Effects of quinolinic acid-induced lesions of the orbital prefrontal cortex on inter-temporal choice: a quantitative analysis
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Impaired decision-making and brain shrinkage in alcoholism
Berre, A. L., Rauchs, G., Joie, R. L., Mézenge, F., Boudehent, C., Vabret, F., Segobin, S. H., Viader, F., Allain, P., Eustache, F., et al. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2012.10.002 · Cited by 115
Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex
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Adolescent Risk Taking, Cocaine Self-Administration, and Striatal Dopamine Signaling
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Differences in impulsivity and sexual risk behavior among inner-city crack/cocaine users and heroin users
Lejuez, C. W., Bornovalova, M. A., Daughters, S. B., & Curtin, J. J. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.08.013 · Cited by 114
Contributions of the amygdala and medial prefrontal cortex to incentive cue responding
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Increased risk-taking decision-making but not altered response to punishment in stimulant-using young adults.
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The Iowa Gambling Task in depression – what have we learned about sub-optimal decision-making strategies?
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Authors: Orsini, C. A., Moorman, D. E., Young, J. W., Setlow, B., & Floresco, S. B.
Affiliations: University of Florida Health (US)
University of Massachusetts Amherst (US)
University of California San Diego (US)
University of British Columbia (CA)
Corresponding author: Floresco, Stan B.
ORCID: Orsini, Caitlin A.
Moorman, David E.
Young, Jared W.
Setlow, Barry
Floresco, Stan B.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-11
Volume: 58
Pages: 147-167
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.04.009
PMC: PMC7913606
OpenAlex: W2214549810
Cited by: 153
References: 267
Citations by year: 2026: 6 · 2025: 10 · 2024: 25 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 13 · 2019: 11 · 2018: 15 · 2017: 21 · 2016: 17 · 2015: 7
FWCI: 1.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: McKnight Brain Institute
National Institutes of Health (R21-DA032005, R01-DA024671, R01-MH104344)
Canadian Institutes of Health Research (MOP 89861)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: cost-benefit decision making, reward uncertainty, habenula, dopamine signaling, striatal circuits, limbic circuits, mental illness, animal models
MeSH terms: Animals, Brain, Decision Making, Humans, Risk-Taking, Translational Research, Biomedical

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Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

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