Cited by 5,501Regulation of Appetite and ObesitySleep and Wakefulness ResearchNeuropeptides and Animal Physiology

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Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

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Sakurai, Takeshi, Amemiya, Akira, Ishii, Makoto, Matsuzaki, Ichiyo, Chemelli, Richard M, Tanaka, Hirokazu, Williams, S.Clay, Richardson, James A, Kozlowski, Gerald P, Wilson, Shelagh, Arch, Jonathan R.S, Buckingham, Robin E, Haynes, Andrea C, Carr, Steven A, Annan, Roland S, McNulty, Dean E, Liu, Wu-Schyong, Terrett, Jonathan A, Elshourbagy, Nabil A, Bergsma, Derk J, Yanagisawa, Masashi·1998·Cell

DOI 10.1016/s0092-8674(00)80949-6

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Abstract

The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.

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Authors: Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W.-S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J., & Yanagisawa, M.
Affiliations: Howard Hughes Medical Institute (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Yanagisawa, Masashi
ORCID: Sakurai, Takeshi
Ishii, Makoto
Matsuzaki, Ichiyo
Richardson, James A
Wilson, Shelagh
Carr, Steven A
Annan, Roland S
Terrett, Jonathan A
Yanagisawa, Masashi
Venue: Cell
Publisher: Elsevier BV
Published: 1998-02
Volume: 92
Issue: 4
Pages: 573-585
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80949-6
OpenAlex: W2027740042
Cited by: 5,501
References: 57
Citations by year: 2026: 93 · 2025: 158 · 2024: 169 · 2023: 186 · 2022: 207 · 2021: 197 · 2020: 189 · 2019: 191 · 2018: 239 · 2017: 211 · 2016: 211 · 2015: 239 · 2014: 274 · 2013: 252 · 2012: 242
FWCI: 54.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5645 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: orexin-A, orexin B, orexin receptors, G protein-coupled receptors, hypothalamus, feeding behavior, energy homeostasis, neuropeptides, fasting, dietary intake, central regulation of feeding
MeSH terms: Orexins, Animals, Carrier Proteins, Chromatography, High Pressure Liquid, Fasting, Feeding Behavior, Cricetinae, Humans, Hypothalamus, Kidney, Male, Molecular Sequence Data, Neurons, Neuropeptides, Protein Precursors, Rabbits, RNA, Messenger, CHO Cells, Rats, Wistar, Sequence Homology, Amino Acid, Receptors, Neuropeptide, GTP-Binding Proteins, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Rats, Orexin Receptors

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Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

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