Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Wnt proteins are lipid-modified and can act as stem cell growth factors

Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159

Nanotubular Highways for Intercellular Organelle Transport

Rustom, A., Saffrich, R., Markovic, I., Walther, P., & Gerdes, H.-H. (2004) · Science · doi:10.1126/science.1093133 · Cited by 2,038

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491

Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404296 · Cited by 1,340

Extracellular vesicles for drug delivery.

Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,319

Exosomes: secreted vesicles and intercellular communications

Théry, C. (2011) · F1000 Biology Reports · doi:10.3410/b3-15 · Cited by 989

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Muralidharan-Chari, V., Clancy, J., Plou, C., Romao, M., Chavrier, P., Raposo, G., & D'Souza-Schorey, C. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.059 · Cited by 912

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704

Secreted microRNAs: a new form of intercellular communication

Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 690

Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice

Zhu, Y.-G., Feng, X.-M., Abbott, J., Fang, X.-H., Hao, Q., Monsel, A., Qu, J.-M., Matthay, M. A., & Lee, J. W. (2014) · Stem Cells · doi:10.1002/stem.1504 · Cited by 688

Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs

Collino, F., Deregibus, M. C., Bruno, S., Sterpone, L., Aghemo, G., Viltono, L., Tetta, C., & Camussi, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011803 · Cited by 608

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · doi:10.20944/preprints201810.0507.v1 · Cited by 605

Exosomes for drug delivery—A novel application for the mesenchymal stem cell

Lai, R. C., Yeo, R. W. Y., Tan, K. H., & Lim, S. K. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.08.008 · Cited by 546

Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles.

Regev-Rudzki, N., Wilson, D. W., Carvalho, T. G., Sisquella, X., Coleman, B. M., Rug, M., Bursac, D., Angrisano, F., Gee, M., Hill, A. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.029 · Cited by 545

Extracellular Membrane Vesicles as a Mechanism of Cell-to-Cell Communication: Advantages and Disadvantages

Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483

Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles

Yuan, A., Farber, E. L., Rapoport, A. L., Tejada, D., Deniskin, R., Akhmedov, N. B., & Farber, D. B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004722 · Cited by 416

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

Bellingham, S. A., Guo, B. B., Coleman, B. M., & Hill, A. F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00124 · Cited by 412

Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, I. L., Corteling, R., Bracewell, D., & Wall, I. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.006 · Cited by 396

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

Todkar, K., Chikhi, L., Desjardins, V., El-Mortada, F., Pépin, G., & Germain, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21984-w · Cited by 382

Regulation of exosome production and cargo sorting

Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

Paolicelli, R. C., Bergamini, G., & Rajendran, L. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.003 · Cited by 338

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337

Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?

Gangoda, L., Boukouris, S., Liem, M., Kalra, H., & Mathivanan, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400234 · Cited by 301

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020171 · Cited by 301

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

Huan, J., Hornick, N. I., Shurtleff, M. J., Skinner, A. M., Goloviznina, N. A., Roberts, C. T., & Kurre, P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2184 · Cited by 259

A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery

Hung, M. E., & Leonard, J. N. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31027 · Cited by 251

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

Statello, L., Maugeri, M., Garre, E., Nawaz, M., Wahlgren, J., Papadimitriou, A., Lundqvist, C., Lindfors, L., Collén, A., Sunnerhagen, P., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195969 · Cited by 242

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Xu, J.-F., Yang, G.-H., Pan, X.-H., Zhang, S.-J., Zhao, C., Qiu, B.-S., Gu, H.-F., Hong, J.-F., Cao, L., Chen, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114627 · Cited by 235

Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors

Wysoczynski, M., & Ratajczak, M. Z. (2009) · International Journal of Cancer · doi:10.1002/ijc.24479 · Cited by 216

The role of extracellular vesicles in neurodegenerative diseases

Quek, C., & Hill, A. F. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.090 · Cited by 213

Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases

Monsel, A., Zhu, Y.-G., Gudapati, V., Lim, H., & Lee, J. W. (2016) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1170804 · Cited by 200

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

Shi, M., Sheng, L., Stewart, T., Zabetian, C. P., & Zhang, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.005 · Cited by 181

Role of Alix in miRNA packaging during extracellular vesicle biogenesis

IAVELLO, A., FRECH, V. S. L., GAI, C., DEREGIBUS, M. C., QUESENBERRY, P. J., & CAMUSSI, G. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2488 · Cited by 175

MicroRNAs as biomarkers for CNS disease

Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 171

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

Rankin-Turner, S., Vader, P., O'Driscoll, L., Giebel, B., Heaney, L. M., & Davies, O. G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.012 · Cited by 161

In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts

Le Bihan, M.-C., Bigot, A., Jensen, S. S., Dennis, J. L., Rogowska-Wrzesinska, A., Lainé, J., Gache, V., Furling, D., Jensen, O. N., Voit, T., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.09.008 · Cited by 153

Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA

Németh, A., Orgovan, N., Sódar, B. W., Osteikoetxea, X., Pálóczi, K., Szabó-Taylor, K. É., Vukman, K. V., Kittel, Á., Turiák, L., Wiener, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08392-1 · Cited by 146

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

Sutaria, D. S., Badawi, M., Phelps, M. A., & Schmittgen, T. D. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2123-5 · Cited by 140

The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise

Vechetti, I. J., Valentino, T., Mobley, C. B., & McCarthy, J. J. (2021) · The Journal of Physiology · doi:10.1113/jp278929 · Cited by 141

MicroRNAs are shaping the hematopoietic landscape

Bissels, U., Bosio, A., & Wagner, W. (2012) · Haematologica · doi:10.3324/haematol.2011.051730 · Cited by 129

Mesenchymal stem cell-derived exosome: A tumor regulator and carrier for targeted tumor therapy

Zhang, F., Guo, J., Zhang, Z., Qian, Y., Wang, G., Duan, M., Zhao, H., Yang, Z., & Jiang, X. (2022) · Cancer Letters · doi:10.1016/j.canlet.2021.11.015 · Cited by 127

Clinical applications for exosomes: Are we there yet?

Perocheau, D., Touramanidou, L., Gurung, S., Gissen, P., & Baruteau, J. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15432 · Cited by 123

Sources and Functions of Extracellular Small RNAs in Human Circulation

Fritz, J. V., Heintz-Buschart, A., Ghosal, A., Wampach, L., Etheridge, A., Galas, D., & Wilmes, P. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050711 · Cited by 121

The ribonome: a dominant force in co‐ordinating gene expression

Mansfield, K. D., & Keene, J. D. (2009) · Biology of the Cell · doi:10.1042/bc20080055 · Cited by 102

Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine

Tao, S., Guo, S., & Zhang, C. (2018) · Advanced Science · doi:10.1002/advs.201700449 · Cited by 100

Extracellular vesicles as new players in angiogenesis

Kholia, S., Ranghino, A., Garnieri, P., Lopatina, T., Deregibus, M. C., Rispoli, P., Brizzi, M. F., & Camussi, G. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.03.005 · Cited by 97

Revisiting extracellular RNA release, processing, and function

Tosar, J. P., Witwer, K., & Cayota, A. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.12.008 · Cited by 91

Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials

Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K. (2022) · Small · doi:10.1002/smll.202104783 · Cited by 81

A novel population of extracellular vesicles smaller than exosomes promotes cell proliferation

Lee, S.-S., Won, J.-H., Lim, G. J., Han, J., Lee, J. Y., Cho, K.-O., & Bae, Y.-K. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0401-z · Cited by 79

Information transfer by exosomes: A new frontier in hematologic malignancies

Boyiadzis, M., & Whiteside, T. L. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.01.004 · Cited by 79

Extracellular vesicles in renal tissue damage and regeneration

Bruno, S., Porta, S., & Bussolati, B. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.06.058 · Cited by 74

A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

Zhang, N., Sun, N., & Deng, C. (2020) · Chemical Communications · doi:10.1039/d0cc06147f · Cited by 69

Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx mice

Matsuzaka, Y., Tanihata, J., Komaki, H., Ishiyama, A., Oya, Y., Rüegg, U., Takeda, S.-I., & Hashido, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167811 · Cited by 68

Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics

Roerig, J., & Schulz‐Siegmund, M. (2023) · Small · doi:10.1002/smll.202301763 · Cited by 67

Extracellular vesicles released by oxidatively injured or intact C2C12 myotubes promote distinct responses converging toward myogenesis

Guescini, M., Maggio, S., Ceccaroli, P., Battistelli, M., Annibalini, G., Piccoli, G., Sestili, P., & Stocchi, V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112488 · Cited by 59

Recent Advances on Extracellular Vesicles in Central Nervous System Diseases

Jin, T., Gu, J., Li, Z., Xu, Z., & Gui, Y. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s288415 · Cited by 44

Techniques for increasing the yield of stem cell-derived exosomes: What factors may be involved?

Feng, Z.-Y., Zhang, Q.-Y., Tan, J., & Xie, H.-Q. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-1997-2 · Cited by 40

Icotinib-resistant HCC827 cells produce exosomes with mRNA MET oncogenes and mediate the migration and invasion of NSCLC

Yu, Y., Abudula, M., Li, C., Chen, Z., Zhang, Y., & Chen, Y. (2019) · Respiratory Research · doi:10.1186/s12931-019-1202-z · Cited by 33

Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis

Ojeda-Hernández, D. D., Hernández-Sapiéns, M. A., Reza-Zaldívar, E. E., Canales-Aguirre, A., Matías-Guiu, J. A., Matías-Guiu, J., Mateos-Díaz, J. C., Gómez-Pinedo, U., & Sancho-Bielsa, F. (2022) · Life · doi:10.3390/life12091417 · Cited by 25

EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities

Heydari, Z., Peshkova, M., Gonen, Z. B., Coretchi, I., Eken, A., Yay, A. H., Dogan, M. E., Gokce, N., Akalin, H., Kosheleva, N., et al. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02276-2 · Cited by 18