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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Open accessAbstract
To maintain immune homeostasis, the intestinal immune system has evolved redundant regulatory strategies. In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3+ T reg cell. Therefore, we hypothesized that the gut environment preferentially supports extrathymic T reg cell development. We show that peripheral conversion of CD4+ T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) after oral exposure to antigen and in a lymphopenic environment. Dendritic cells (DCs) purified from the lamina propria (Lp; LpDCs) of the small intestine were found to promote a high level of T reg cell conversion relative to lymphoid organ–derived DCs. This enhanced conversion by LpDCs was dependent on TGF-β and retinoic acid (RA), which is a vitamin A metabolite highly expressed in GALT. Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
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Metadata
- Authors
- Sun, C.-M., Hall, J. A., Blank, R. B., Bouladoux, N., Oukka, M., Mora, J. R., & Belkaid, Y.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-07-09
- Volume
- 204
- Issue
- 8
- Pages
- 1775-1785
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2144836936
- Cited by
- 1,881
- References
- 1
- FWCI
- 48.48
- Type
- journal article
- Language
- en
- Open access
- green
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