THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S·1974·Genetics

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Abstract

Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C.elegans are large.

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Crossref · 10.1093/genetics/77.1.71

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(1987) · Europe PMC (PubMed Central) · Cited by 168
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Wicks, S. R., Roehrig, C. J., & Rankin, C. H. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-12-04017.1996 · Cited by 156
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Farach-Carson, M. C., Warren, C. R., Harrington, D. A., & Carson, D. D. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.08.004 · Cited by 155
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Gouw, J. W., Krijgsveld, J., & Heck, A. J. R. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r900001-mcp200 · Cited by 151
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Kocabas, A., Shen, C.-H., Guo, Z. V., & Ramanathan, S. (2012) · Nature · doi:10.1038/nature11431 · Cited by 150
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Stevens, D. R., Wu, Z.-X., Matti, U., Junge, H. J., Schirra, C., Becherer, U., Wojcik, S. M., Brose, N., & Rettig, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.055 · Cited by 149
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Siegfried, K. R., & Kimble, J. (2002) · Development · doi:10.1242/dev.129.2.443 · Cited by 136
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van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H.-E., Du, D., Thijssen, K. L., Wiersma, M., Burggraaff, R., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.020 · Cited by 133
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Berri, S., Boyle, J. H., Tassieri, M., Hope, I. A., & Cohen, N. (2009) · HFSP Journal · doi:10.2976/1.3082260 · Cited by 132
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Faumont, S., Rondeau, G., Thiele, T. R., Lawton, K. J., McCormick, K. E., Sottile, M., Griesbeck, O., Heckscher, E. S., Roberts, W. M., Doe, C. Q., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024666 · Cited by 128
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Narayan, V., Ly, T., Pourkarimi, E., Murillo, A. B., Gartner, A., Lamond, A. I., & Kenyon, C. (2016) · Cell Systems · doi:10.1016/j.cels.2016.06.011 · Cited by 127
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Shin, T. H., Yasuda, J., Rocheleau, C. E., Lin, R., Soto, M., Bei, Y., Davis, R. J., & Mello, C. C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80375-5 · Cited by 123
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Hallam, S. J., Goncharov, A., McEwen, J., Baran, R., & Jin, Y. (2002) · Nature Neuroscience · doi:10.1038/nn959 · Cited by 118
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Edwards, S. L., Charlie, N. K., Richmond, J. E., Hegermann, J., Eimer, S., & Miller, K. G. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902095 · Cited by 83
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Van Auken, K., Weaver, D. C., Edgar, L. G., & Wood, W. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4499 · Cited by 89
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Norris, A., Tammineni, P., Wang, S., Gerdes, J., Murr, A., Kwan, K. Y., Cai, Q., & Grant, B. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612730114 · Cited by 90
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Dennis, S., Sheth, U., Feldman, J. L., English, K. A., & Priess, J. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002591 · Cited by 88
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Honda, Y., Higashibata, A., Matsunaga, Y., Yonezawa, Y., Kawano, T., Higashitani, A., Kuriyama, K., Shimazu, T., Tanaka, M., Szewczyk, N. J., et al. (2012) · Scientific Reports · doi:10.1038/srep00487 · Cited by 87
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Karbowski, J., Schindelman, G., Cronin, C. J., Seah, A., & Sternberg, P. W. (2008) · Journal of Computational Neuroscience · doi:10.1007/s10827-007-0054-6 · Cited by 87
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Munno, D. W., & Syed, N. I. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045062 · Cited by 86
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Johari, S., Nock, V., Alkaisi, M. M., & Wang, W. (2013) · Lab on a Chip · doi:10.1039/c3lc41403e · Cited by 86
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Pedersen, M. E., Snieckute, G., Kagias, K., Nehammer, C., Multhaupt, H. A. B., Couchman, J. R., & Pocock, R. (2013) · Science · doi:10.1126/science.1242528 · Cited by 80
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Zhang, J., Li, X., Olmedo, M., Holdorf, A. D., Shang, Y., Artal-Sanz, M., Yilmaz, L. S., & Walhout, A. J. M. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.07.010 · Cited by 77
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Dominguez-Meijide, A., Parrales, V., Vasili, E., González-Lizárraga, F., König, A., Lázaro, D. F., Lannuzel, A., Haik, S., Del Bel, E., Chehín, R., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105256 · Cited by 81
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Bishop, J. D., Han, Z., & Schumacher, J. M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0682 · Cited by 72
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Deo, R., Kushwah, M. S., Kamerkar, S. C., Kadam, N. Y., Dar, S., Babu, K., Srivastava, A., & Pucadyil, T. J. (2018) · Nature Communications · doi:10.1038/s41467-018-07586-z · Cited by 77
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Edwards, S. L., Yu, S.-C., Hoover, C. M., Phillips, B. C., Richmond, J. E., & Miller, K. G. (2013) · Genetics · doi:10.1534/genetics.112.147348 · Cited by 76
RAB-10-GTPase–mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate
Shi, A., Liu, O., Koenig, S., Banerjee, R., Chen, C. C.-H., Eimer, S., & Grant, B. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205278109 · Cited by 76
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Authors: Brenner, S.
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1974-05-01
Volume: 77
Issue: 1
Pages: 71-94
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/77.1.71
OpenAlex: W1944127002
Cited by: 15,081
References: 0
FWCI: 8.31
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

THE GENETICS OF CAENORHABDITIS ELEGANS

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