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2014 Alzheimer's disease facts and figures
Open accessAbstract
This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society. It also examines the impact of AD on women compared with men. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are age 65 years or older. By mid‐century, fueled in large part by the baby boom generation, the number of people living with AD in the United States is projected to grow by about 9 million. Today, someone in the country develops AD every 67 seconds. By 2050, one new case of AD is expected to develop every 33 seconds, or nearly a million new cases per year, and the total estimated prevalence is expected to be 13.8 million. In 2010, official death certificates recorded 83,494 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death in Americans aged 65 years or older. Between 2000 and 2010, the proportion of deaths resulting from heart disease, stroke, and prostate cancer decreased 16%, 23%, and 8%, respectively, whereas the proportion resulting from AD increased 68%. The actual number of deaths to which AD contributes (or deaths with AD) is likely much larger than the number of deaths from AD recorded on death certificates. In 2014, an estimated 700,000 older Americans will die with AD, and many of them will die from complications caused by AD. In 2013, more than 15 million family members and other unpaid caregivers provided an estimated 17.7 billion hours of care to people with AD and other dementias, a contribution valued at more than $220 billion. Average per‐person Medicare payments for services to beneficiaries aged 65 years and older with AD and other dementias are more than two and a half times as great as payments for all beneficiaries without these conditions, and Medicaid payments are 19 times as great. Total payments in 2014 for health care, long‐term care, and hospice services for people aged 65 years and older with dementia are expected to be $214 billion. AD takes a stronger toll on women than men. More women than men develop the disease, and women are more likely than men to be informal caregivers for someone with AD or another dementia. As caregiving responsibilities become more time consuming and burdensome or extend for prolonged durations, women assume an even greater share of the caregiving burden. For every man who spends 21 to more than 60 hours per week as a caregiver, there are 2.1 women. For every man who lives with the care recipient and provides around‐the‐clock care, there are 2.5 women. In addition, for every man who has provided caregiving assistance for more than 5 years, there are 2.3 women.
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“The most common cause of late onset dementia is Alzheimer’s disease (AD) [1], comprising between 60 and 80% of cases.”
A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
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A Pilot Randomized Trial of a Companion Robot for People With Dementia Living in the Community
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US Prevalence And Predictors Of Informal Caregiving For Dementia
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The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease
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Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
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Impact of the Baltimore Experience Corps Trial on cortical and hippocampal volumes
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Sex and gender differences in the causes of dementia: A narrative review
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The present and future of pharmacotherapy of Alzheimer's disease: a comprehensive review
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Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease
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Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
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Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies
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Upstream regulators and downstream effectors of NF-κB in Alzheimer’s disease
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Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease
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Alzheimer's in 3D culture: Challenges and perspectives
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The Proteasome and Oxidative Stress in Alzheimer's Disease
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Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans
Levine, D. A., Galecki, A. T., Langa, K. M., Unverzagt, F. W., Kabeto, M. U., Giordani, B., Cushman, M., McClure, L. A., Safford, M. M., & Wadley, V. G. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12062 · Cited by 91
Testing Family-Centered, Function-Focused Care in Hospitalized Persons with Dementia
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Worries About Getting Alzheimer’s: Who’s Concerned?
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The puzzle of sex, gender and Alzheimer’s disease: Why are women more often affected than men?
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Memantine ER/Donepezil: A Review in Alzheimer’s Disease
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A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation
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“Previously approved inhibitors of N-methyl-D-aspartate receptors and of acetylcholine esterase only ameliorate symptoms (Alzheimer ’ s Association, 2014).”
Health Care Utilization Among Elderly Medicare Beneficiaries With Coexisting Dementia and Cancer
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Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer’s disease
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Luteinizing hormone and the aging brain
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Spotlight on Age: An Overlooked Construct in Medical Sociology
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Metadata
- Authors
- Alzheimer's Association
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-03
- Volume
- 10
- Issue
- 2
- Pages
- e47-92
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W4211135065
- Cited by
- 1,020
- References
- 97
- FWCI
- 128.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.