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Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Open accessAbstract
Social adaptation requires specific cognitive and emotional competences. Individuals with high-functioning autism or with Asperger syndrome cannot understand or engage in social situations despite preserved intellectual abilities. Recently, it has been suggested that oxytocin, a hormone known to promote mother-infant bonds, may be implicated in the social deficit of autism. We investigated the behavioral effects of oxytocin in 13 subjects with autism. In a simulated ball game where participants interacted with fictitious partners, we found that after oxytocin inhalation, patients exhibited stronger interactions with the most socially cooperative partner and reported enhanced feelings of trust and preference. Also, during free viewing of pictures of faces, oxytocin selectively increased patients' gazing time on the socially informative region of the face, namely the eyes. Thus, under oxytocin, patients respond more strongly to others and exhibit more appropriate social behavior and affect, suggesting a therapeutic potential of oxytocin through its action on a core dimension of autism.
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In the citing paper
“Animal model research points to a strong relationship between socially monogamous attachment behaviors and the expression of oxytocin within the brain—along with that of an affiliated peptide, vasopressin, and a suite of auxiliary hormones and neurotransmitters including dopamine.”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [37]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Several trials have shown that a single dose of intranasal oxytocin enhanced performance on measures of social cognition10,11 or motivation,12–14 as compared with placebo, in persons with autism spectrum disorder.”
From Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder (2021) · cites this paper as [13]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Infusing oxytocin into the brains of the females, and vasopressin into the brains of the males, significantly enhanced pair-bonding even in the absence of actual mating.”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [37]
Experimental — accuracy not yet measuredIn the citing paper
“Indeed, IN-OT has been shown to acutely increase gaze to the eye region of human faces in autistic populations (65,66), although the benefit of chronic or developmental OT exposure is only beginning to be explored (67,68).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [65]
In the citing paper
“within the ASD literature there is evidence that improved facial emotion recognition is due, in part, to participants spending more time looking at the eye area of faces (e.g., Andari et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Andari et al., 2010
In the citing paper
“Nevertheless, our results are consistent with evidence from ASD literature suggesting that OXT increases attention to socially relevant stimuli, and specifically for the eye-region (e.g., Andari et al., 2010).”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Andari et al., 2010
In the citing paper
“A second study [16] also found significantly elevated plasma OT concentrations at 10 minutes post-administration.”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [16]
In the citing paper
“It appears that the enhanced prosocial effects of intranasally administered OT are especially pronounced for individuals suffering from socio-emotional deficits, as is the case for individuals with Asperger syndrome (Andari et al., 2010) or high alexithymia (Luminet et al., 2011).”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Andari et al., 2010
In the citing paper
“In individuals with autism, intranasal OT was shown to increase emotion recognition (13) and to increase feelings of trust and willingness to interact socially (16).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [16]
In the citing paper
“OT administration has been shown to improve social decision-making (Andari et al., 2010; Hollander et al., 2007)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“promote visual scanning of faces (Andari et al., 2010)”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“Similar doses of OT have been administered to subjects in previous studies of social functioning (Andari et al., 2010; Feifel et al., 2010; Guastella et al., 2008; Hollander et al., 2007; Ditzen et al., 2009).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“Previous studies have employed simulated social games (Andari et al., 2010; Kosfeld et al., 2005), and static social photographs (Guastella et al., 2008) to evaluate the effects of OT on social behaviors.”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Andari et al., 2010
In the citing paper
“Other research suggests that the effect of oxytocin on cooperative behavior depends on characteristics of the individual (Andari et al. 2010; Bartz et al. 2010a; Bartz et al. 2011).”
From Acute intranasal oxytocin improves positive self-perceptions of personality (2012) · cites this paper as Andari et al. 2010
In the citing paper
“For example, oxytocin has been shown to increase gazing time on the eye region33, and to improve performance on the Reading the Mind in the Eyes Task in adults and adolescents with ASD48,49.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [33]
In the citing paper
“Moreover, in subjects diagnosed with autism, a single intranasal administration of OXT might be able to improve, at least temporarily, emotion recognition abilities in the Reading the Mind in the Eyes test and the patients' ability to process socially relevant cues in a computer-based game (Andari et al, 2010;Green and Hollander, 2010;Guastella et al, 2010).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Andari et al, 2010
In the citing paper
“While most randomized clinical trials have found some oxytocin effects on ASD symptoms33,50–52 and brain function50–52,80,81, not all trials have reported effects82.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [33]
In the citing paper
“Studies in our lab and others have found that OT plasma concentration is significantly lower in patients with ASD than in healthy subjects (Andari et al. 2010; Modahl et al. 1998).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Andari et al. 2010
In the citing paper
“In terms of exogenous effects of OT, we showed that intranasal administration (24 IU) of OT to adults with ASD (men between 18 and 45 years old) enhanced their attention to faces and improved the social recognition of implicit cues within an interactive social game in a within subject placebo-controlled study (Andari et al. 2010).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Andari et al. 2010
In the citing paper
“Intranasal OT also increases attention to the eyes in individuals with social deficits. Individuals with autism, for example, spend more time attending to the eye region of faces following intranasal OT compared to placebo (Andari et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Andari et al., 2010
In the citing paper
“two studies have found lower average levels of blood plasma concentrations of oxytocin in individuals with ASD relative to controls [166,167]”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [166]
In the citing paper
“increases cooperative behaviors, trust, and attention to socially informative stimuli (for example, eyes) [166]”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [166]
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“A large portion of the human studies focused on the effect of OT on allocating attention to salient social stimuli, such as the eyes (Andari et al., 2010; Auyeung et al., 2015; Guastella et al., 2008), but these studies address only one component of social interactions, that of social perception.”
Sniff and mimic–Intranasal oxytocin increases facial mimicry in a sample of men
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“…and schizophrenia (Caldwell et al., 2009; Guastella et al., 2009b; Bartz et al., 2010; Feifel et al., 2010; Rubin et al., 2010; Luminet et al., 2011; Pedersen et al., 2011; Hall et al., 2012) as it has already been shown in autism spectrum disorders (Andari et al., 2010; Guastella et al., 2010).”
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Metadata
- Authors
- Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre de Neuroscience Cognitive, Unité Mixte de Recherche 5229, Centre National de la Recherche Scientifique, 69675 Bron, France; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-02-16
- Volume
- 107
- Issue
- 9
- Pages
- 4389-4394
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2840168
- OpenAlex
- W2034453108
- Cited by
- 941
- References
- 32
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 25 · 2023: 44 · 2022: 37 · 2021: 44 · 2020: 91 · 2019: 48 · 2018: 51 · 2017: 72 · 2016: 68 · 2015: 81 · 2014: 100 · 2013: 89 · 2012: 74
- FWCI
- 109.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation FondaMental
- Fondation Orange
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- oxytocin, autism spectrum disorder, Asperger syndrome, social behavior, social cognition, trust, gaze behavior, face processing, social interaction, social dysfunction
- MeSH terms
- Administration, Inhalation, Adolescent, Adult, Autistic Disorder, Emotions, Female, Humans, Male, Oxytocin, Social Behavior, Young Adult
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