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Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.
Open accessAbstract
There is increasing evidence for an important role of adverse early experience on the development of major psychiatric disorders in adulthood. Corticotropin-releasing factor (CRF), an endogenous neuropeptide, is the primary physiological regulator of the mammalian stress response. Grown nonhuman primates who were exposed as infants to adverse early rearing conditions were studied to determine if long-term alterations of CRF neuronal systems had occurred following the early stressor. In comparison to monkeys reared by mothers foraging under predictable conditions, infant monkeys raised by mothers foraging under unpredictable conditions exhibited persistently elevated cerebrospinal fluid (CSF) concentrations of CRF. Because hyperactivity of CRF-releasing neurons has been implicated in the pathophysiology of certain human affective and anxiety disorders, the present finding provides a potential neurobiological mechanism by which early-life stressors may contribute to adult psychopathology.
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“For example, offspring of macaque females exposed to unpredictable foraging demands have elevated serotonin metabolites and CRH (Coplan et al., 1996;Sanchez, 2006).”
From Allostatic load and biological anthropology (2017) · cites this paper as Coplan et al., 1996
In the citing paper
“chronic activation of this system, particularly by continued psychosocial stressors, is implicated in the progression of multiple disease states and psychopathologies61.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [61]
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Self-citation
Metadata
- Authors
- Coplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M., & Nemeroff, C. B.
- Affiliations
- Columbia University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-02-20
- Volume
- 93
- Issue
- 4
- Pages
- 1619-1623
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC39991
- OpenAlex
- W2062636872
- Cited by
- 649
- References
- 27
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 15 · 2020: 26 · 2019: 8 · 2018: 9 · 2017: 20 · 2016: 18 · 2015: 19 · 2014: 28 · 2013: 21 · 2012: 26
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh042545-08, 5r01mh015965-19)
- National Institute of Mental Health (MH 42545, R01MH042088, MH42088, MH15965)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- corticotropin-releasing factor, early life stress, non-human primates, infant monkeys, cerebrospinal fluid, stress response, anxiety disorders, mood disorders, neuroendocrine regulation, psychopathology
- MeSH terms
- Animals, Anxiety Disorders, Appetitive Behavior, Cerebrospinal Fluid Proteins, Corticotropin-Releasing Hormone, Female, Hydrocortisone, Macaca radiata, Male, Maternal Behavior, Stress, Psychological, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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