Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 6,664

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Human Adipose Tissue Is a Source of Multipotent Stem Cells

Open access
Zuk, Patricia A., Zhu, Min, Ashjian, Peter, De Ugarte, Daniel A., Huang, Jerry I., Mizuno, Hiroshi, Alfonso, Zeni C., Fraser, John K., Benhaim, Prosper, Hedrick, Marc H.·2002·Molecular Biology of the Cell
DOI 10.1091/mbc.e02-02-0105
Open this paper in CoChat — free account

Abstract

Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within the adipose stromal compartment. This cell population, termed processed lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and, like MSCs, differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages. To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches. PLA cells expressed multiple CD marker antigens similar to those observed on MSCs. Mesodermal lineage induction of PLA cells and clones resulted in the expression of multiple lineage-specific genes and proteins. Furthermore, biochemical analysis also confirmed lineage-specific activity. In addition to mesodermal capacity, PLA cells and clones differentiated into putative neurogenic cells, exhibiting a neuronal-like morphology and expressing several proteins consistent with the neuronal phenotype. Finally, PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1091/mbc.e02-02-0105

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 68

  1. Ailhaud G., 1992, Annu. Rev. Nutr., 12, 207, 10.1146/annurev.nu.12.070192.001231 · DOI · Paper page
  2. Atchley W.R., 1994, Proc. Natl. Acad. Sci. USA, 91, 11522, 10.1073/pnas.91.24.11522 · DOI
  3. Benayahu D., 1989, J. Cell Physiol., 140, 1, 10.1002/jcp.1041400102 · DOI
  4. Bennett J.H., 1991, J. Cell Sci., 99, 131, 10.1242/jcs.99.1.131 · DOI · Paper page
  5. Benson M.D., 2000, J. Biol. Chem., 275, 13907, 10.1074/jbc.275.18.13907 · DOI
  6. Beresford J.N., 1986, Endocrinology, 119, 1776, 10.1210/endo-119-4-1776 · DOI · Paper page
  7. Bernlohr D.A., 1985, Biochem. Biophys. Res. Commun., 132, 850, 10.1016/0006-291X(85)91209-4 · DOI
  8. Bjornson C.R.R., 1999, Science, 283, 534, 10.1126/science.283.5401.534 · DOI · Paper page
  9. Bruder S.P., 1997, J. Cell Biochem., 64, 278, 10.1002/(SICI)1097-4644(199702)64:2<278::AID-JCB11>3.0.CO;2-F · DOI
  10. Bruder S.P., 1998, J. Orthop. Res., 16, 155, 10.1002/jor.1100160202 · DOI · Paper page
  11. Chen X., 1997, Biochim. Biophys. Acta, 1359, 136, 10.1016/S0167-4889(97)00083-9 · DOI
  12. Conget P.A., 1999, J. Cell Physiol., 181, 67, 10.1002/(SICI)1097-4652(199910)181:1<67::AID-JCP7>3.0.CO;2-C · DOI
  13. Cooper M.S., 1999, J. Endocrinol., 163, 159, 10.1677/joe.0.1630159 · DOI
  14. Deng W., 2001, Biochem. Biophys. Res. Commun., 282, 148, 10.1006/bbrc.2001.4570 · DOI · Paper page
  15. Dennis J.E., 2002, Cells Tissues Organs, 170, 73, 10.1159/000046182 · DOI · Paper page
  16. Dennis J.E., 1999, J. Bone Miner. Res., 14, 700, 10.1359/jbmr.1999.14.5.700 · DOI · Paper page
  17. Evans M., 1981, Nature, 292, 154, 10.1038/292154a0 · DOI · Paper page
  18. Farndale R.W., 1986, Biochim. Biophys. Acta, 883, 173, 10.1016/0304-4165(86)90306-5 · DOI · Paper page
  19. Ferrari G., 1998, Science, 279, 1528, 10.1126/science.279.5356.1528 · DOI · Paper page
  20. Friedenstein A.J., 1990, Bone and Mineral Research, 7, 243, 10.1016/B978-0-444-81371-8.50012-1 · DOI · Paper page
  21. Galli R., 2000, Nat. Neurosci., 3, 986, 10.1038/79924 · DOI · Paper page
  22. Galotto M., 1994, J. Bone Miner. Res., 9, 1239, 10.1002/jbmr.5650090814 · DOI
  23. Green H., 1974, Cell, 3, 127, 10.1016/0092-8674(74)90116-0 · DOI · Paper page
  24. Grigoradis A., 1988, J. Cell Biol., 106, 2139, 10.1083/jcb.106.6.2139 · DOI · Paper page
  25. Gronthos S., 1994, Blood, 84, 4164, 10.1182/blood.V84.12.4164.bloodjournal84124164 · DOI · Paper page
  26. Hall P.A., 1989, Development, 106, 619, 10.1242/dev.106.4.619 · DOI · Paper page
  27. Hauner H., 1987, J. Clin. Endocrinol. Metabol., 64, 832, 10.1210/jcem-64-4-832 · DOI · Paper page
  28. Haynesworth S.E., 1992, Bone, 13, 69, 10.1016/8756-3282(92)90363-2 · DOI · Paper page
  29. Jabs E.W., 1993, Cell, 75, 443, 10.1016/0092-8674(93)90379-5 · DOI · Paper page
  30. Jaiswal N., 1997, J. Cell. Biochem., 64, 295, 10.1002/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I · DOI
  31. Johnson E.E., 1988, Clin. Orthop., 236, 249, 10.1097/00003086-198811000-00034 · DOI
  32. Johnstone B., 1998, Exp. Cell Res., 238, 265, 10.1006/excr.1997.3858 · DOI · Paper page
  33. Jonasson L., 1984, Atherosclerosis, 51, 313, 10.1016/0021-9150(84)90179-5 · DOI
  34. Kuri-Harcuch W., 1978, Biol. Chem., 252, 2158, 10.1016/S0021-9258(18)71879-6 · DOI
  35. Lassar A., 1994, Curr. Opin. Cell Biol., 6, 432, 10.1016/0955-0674(94)90037-X · DOI
  36. Leboy P.S., 1991, J. Cell Physiol., 146, 370, 10.1002/jcp.1041460306 · DOI · Paper page
  37. Legasse E., 2000, Nutr. Med., 6, 1229
  38. Lendahl U., 1990, Cell, 60, 585, 10.1016/0092-8674(90)90662-X · DOI · Paper page
  39. Lennon D.P., 1996, In Vitro Cell Dev. Biol., 32, 602, 10.1007/BF02724045 · DOI · Paper page
  40. Levesque J.B., 2001, Blood., 98, 1289, 10.1182/blood.V98.5.1289 · DOI · Paper page
  41. Lieberman J.R., 1998, J. Orthop. Res., 16, 330, 10.1002/jor.1100160309 · DOI · Paper page
  42. Lucas P.A., 1992, In Vitro Cell Biol., 28, 154A, 10.1007/BF02631084 · DOI
  43. Majeska R.J., 1982, J. Biol. Chem., 257, 3362, 10.1016/S0021-9258(18)34781-1 · DOI · Paper page
  44. Malaval L., 1994, J. Cell Physiol., 158, 555, 10.1002/jcp.1041580322 · DOI · Paper page
  45. Mizuno H., 2001, Plastic Reconstr. Surg., 109, 199, 10.1097/00006534-200201000-00030 · DOI · Paper page
  46. Muraglia A., 2000, J. Cell Sci., 113, 1161, 10.1242/jcs.113.7.1161 · DOI · Paper page
  47. Newberry E.P., 1998, Biochemistry, 37, 16360, 10.1021/bi981878u · DOI
  48. Ogeuch O., 2000, J. Clin. Endo. Meta., 85, 1997, 10.1210/jcem.85.5.6591 · DOI
  49. Osdoby P., 1979, Dev. Biol., 73, 84, 10.1016/0012-1606(79)90140-4 · DOI
  50. Owen T.A., 1990, J. Cell Physiol., 143, 420, 10.1002/jcp.1041430304 · DOI · Paper page
  51. Reddi A.H., 1982, Prog. Clin. Biol. Res., 110, 261
  52. Rikard D.J., 1994, Dev. Biol., 161, 218, 10.1006/dbio.1994.1022 · DOI · Paper page
  53. Ryoo H.M., 1997, Mol. Endocrinol., 11, 1681, 10.1210/mend.11.11.0011 · DOI · Paper page
  54. Sanchez-Ramos J., 2000, Exp. Neurol., 164, 247, 10.1006/exnr.2000.7389 · DOI · Paper page
  55. Satomura K., 2000, J. Cell Biochem., 78, 391, 10.1002/1097-4644(20000901)78:3<391::AID-JCB5>3.0.CO;2-E · DOI
  56. Shamblott M.J., 1998, Proc. Natl. Acad. Sci. USA, 95, 13726, 10.1073/pnas.95.23.13726 · DOI · Paper page
  57. Tachetti C., 1987, J. Cell Biol., 106, 999, 10.1083/jcb.105.2.999 · DOI
  58. Tanner J.W., 1992, Biochem. J., 182, 99, 10.1042/bj2820099 · DOI
  59. Toma J.G., 2001, Nat. Cell Biol., 3, 778, 10.1038/ncb0901-778 · DOI · Paper page
  60. Totonoz P., 1994, Genes Dev., 8, 1224, 10.1101/gad.8.10.1224 · DOI · Paper page
  61. Wakitani S., 1995, Muscle Nerve, 18, 1417, 10.1002/mus.880181212 · DOI · Paper page
  62. Wang E.A., 1990, Proc. Natl. Acad. Sci. USA, 87, 2220, 10.1073/pnas.87.6.2220 · DOI · Paper page
  63. Westin S., 1988, Nature, 395, 199, 10.1038/26040 · DOI · Paper page
  64. Wise L.S., 1979, J. Biol. Chem., 254, 273, 10.1016/S0021-9258(17)37913-9 · DOI · Paper page
  65. Woodbury D., 2000, J. Neurosci. Res., 61, 364, 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C · DOI
  66. Yoo J.U., 1998, J. Bone Joint Surg. Am., 80, 1745, 10.2106/00004623-199812000-00004 · DOI · Paper page
  67. Young H.E., 1995, Dev. Dyn., 202, 137, 10.1002/aja.1002020205 · DOI
  68. Zuk P.A., 2001, Tissue Eng., 7, 211, 10.1089/107632701300062859 · DOI · Paper page

Cited by

Metadata

Authors
Zuk, P. A., Zhu, M., Ashjian, P., De Ugarte, D. A., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H.
Venue
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Published
2002-12
Volume
13
Issue
12
Pages
4279-4295
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
DOI
10.1091/mbc.e02-02-0105
OpenAlex
W2107503723
Cited by
6,664
References
5
FWCI
27.90
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.