The DOI matches its Crossref record; 148 of the 149 references it cites were found in a registry or an index; none of the 198 sources its claims cite is checked for support yet.
Update on Biomarkers for the Detection of Endometriosis
Open accessAbstract
Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7–11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This narrative review concludes that no single biomarker or panel has been validated for noninvasive detection of endometriosis, and laparoscopy remains the diagnostic gold standard. It surveys blood, urine, and endometrial candidates, highlighting promising but largely unvalidated panels and the need for Phase II/III validation.
Key findings
- Laparoscopy remains the gold standard, contributing to a mean latency of 7–11 years from symptom onset to definitive diagnosis; no blood biomarker or panel has been validated for clinical use.
- CA-125 meta-analysis showed 50% sensitivity and 72% specificity for stage I–IV endometriosis, and 60% sensitivity with 80% specificity for stage III–IV disease; CA-125 is not specific because it is also elevated in ovarian cancer.
- Several candidate panels report high accuracy but remain unvalidated, e.g. CA-125 + CA-19-9 + survivin mRNA had 87% sensitivity and a 10% false-positive rate; CA-125 + CCR1 mRNA + MCP-1 had 92.2% sensitivity and 81.6% specificity; a 4-marker panel (CA-125, VEGF, Annexin V, glycodelin/sICAM-1) showed 74–94% sensitivity and 55–75% specificity after initial validation.
- Endometrial nerve fiber detection by PGP9.5 showed 98% sensitivity and 83% specificity in a double-blind pipelle study, but a clinical laboratory adoption detected nerve fibers in 9/45 (22%) histologically confirmed endometriosis cases and 6/21 (29%) women without endometriosis, raising specificity concerns.
Methods
- Narrative review of the current status of endometriosis biomarkers in plasma, urine, and endometrium, framed by the four phases of biomarker development (Phase I preclinical discovery through Phase IV commercialization).
- Synthesizes published studies and reported diagnostic performance metrics; no new primary data, systematic search strategy, or meta-analysis is described.
- Main analysis is qualitative synthesis of candidate biomarkers, including glycoproteins, cytokines, oxidative stress markers, cell adhesion/invasion factors, angiogenesis markers, hormones, autoantibodies, miRNAs, proteomics, metabolomics, cell-free DNA, cell populations, urine markers, and endometrial markers.
Limitations
- Stated in the paper: most endometriosis biomarker studies remain at Phase I, only a few reach Phase II, and Phase III/IV has not been reached; no noninvasive test is commercially available or validated.
- Stated in the paper: common limitations include small sample size, suboptimal specimen characterization (e.g., no breakdown by menstrual phase or lesion phenotype), inconsistent sample handling/storage, and lack of reproducibility; proteomic technologies are costly, time-consuming, and need better standardization.
- Evident from the text: as a narrative review, it does not use a systematic search or formal quality appraisal, and it relies on heterogeneous studies with differing assays, sample types, cycle phases, and populations, which limits comparability of reported sensitivities and specificities.
Model-written summary. Check it against the paper before relying on it.
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In the paper
“CA-125 combined with interleukin-8 (IL-8) and tumor necrosis factors-α (TNF-α) in the secretory phase had a sensitivity of 89.7% and specificity of 71.1% in a study performed by Mihalyi and coworkers [36].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [36] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“In addition to this lack of specificity, the sensitivity to detect all endometriosis stages is low [31].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [31] source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Product development by industry, which has not yet been done successfully for noninvasive endometriosis biomarkers.”
§ Update on Biomarkers for the Detection of Endometriosis > 2. Diagnostic Test for Endometriosis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression.”
- Also stated in: § 1. Background · boosted
“Delayed diagnosis and treatment has significant consequences, as endometriosis is more advanced in women whose diagnostic laparoscopy is delayed, supporting progression of disease over time [13].”
§ Update on Biomarkers for the Detection of Endometriosis > Abstract
What the sources say
- Not checked yetcites [13] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § 1. Background · boosted
None of the sources cited for this claim have been checked yet.
In the paper
“Despite extensive research, no single biomarker nor a panel of biomarkers in peripheral blood has been validated as a diagnostic test for endometriosis [17, 20].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“A panel of CA-125, chemokine receptor (CCR) type-1 mRNA, and monocyte chemoattractant protein- (MCP) 1 showed a sensitivity of 92.2% and specificity of 81.6% to detect endometriosis [40].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [40] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“A clinically reliable test for endometriosis can be expected to have a profound impact on reduction of health care and individual costs by [18]reducing time to diagnosis and the time wasted to see numerous health care professionals;subsequently reducing the time before individualized specialist care is invoked;subsequently reducing expensive hit-and-miss treatments;subsequently reducing expensive”
§ Update on Biomarkers for the Detection of Endometriosis > 2. Diagnostic Test for Endometriosis
What the sources say
- Not checked yetcites [18] 2014
- Not checked yetcites [25] 2008
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“longitudinal placebo-controlled trials with second look laparoscopy have demonstrated that 71–83% of untreated lesions will progress or remain stable over a 12-month period [14].”
§ Update on Biomarkers for the Detection of Endometriosis > 1. Background
What the sources say
- Not checked yetcites [14] 1994, Fertility and Sterility source
Strength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, all these results remain to be validated.”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“According to a meta-analysis by Mol et al., the sensitivity for stage I–IV endometriosis was 50% and specificity was 72%.”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [31] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- It may state two separate claims as one. 43
- Probably not a substantial claim. 8
- The quote only partly states this claim. 1
In the paper
“A recent study showed a significant increase of CA-125 (P = 0.001), CA-19-9 (P = 0.015), and CA-15-3 (P = 0.017) in endometriosis cases (n = 50) versus controls (n = 35) [42].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [42] source
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“However, CA-125 is not specific for endometriosis, being a tumor marker elevated in ovarian cancer [37, 38].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Overall, most endometriosis biomarker studies have remained at the level of Phase I [23] and only a few have made it to Phase II studies.”
§ Update on Biomarkers for the Detection of Endometriosis > 2. Diagnostic Test for Endometriosis
What the sources say
- Not checked yetcites [23] source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Although there is consensus in the World Endometriosis Society that the development of a reliable noninvasive test is one of the top research priorities in endometriosis [11, 21]”
§ Update on Biomarkers for the Detection of Endometriosis > 2. Diagnostic Test for Endometriosis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“endometriosis is more advanced in women whose diagnostic laparoscopy is delayed, supporting progression of disease over time [13].”
§ Update on Biomarkers for the Detection of Endometriosis > 1. Background
What the sources say
- Not checked yetcites [13] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Since the extensive review of May et al., 2010, research in endometriosis biomarkers has accomplished the successful validation of biomarkers in an independent sample dataset [24], but still no test for endometriosis is commercially available.”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers
What the sources say
- Not checked yetcites [24] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Blood is an interesting potential source of biomarkers because it allows repeated measurements, is easily obtained, and is highly suitable for high-throughput measurements [29].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers
What the sources say
- Not checked yetcites [29] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In summary, a non- or semi-invasive test would not only reduce the cost associated with endometriosis but also improve the quality of life of women with endometriosis by allowing early diagnosis.”
§ Update on Biomarkers for the Detection of Endometriosis > 2. Diagnostic Test for Endometriosis
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Ozhan et al. stated that a panel consisting of CA-125, syntaxin-5, and laminin-1 had 90% sensitivity, 70% specificity, and 88.7% accuracy to distinguish endometriosis patients (n = 60) from controls (n = 20) [41].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [41] source
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“This delay in diagnosis is due, in part, to presumptive treatment of pain with oral contraceptives (OCPs) and nonsteroidal anti-inflammatory drugs (NSAIDs), as well as reluctance of physicians to refer women to gynecologists for definitive diagnosis, reluctance of women to confront their own pain for fear of a cancer diagnosis, and dismissal of pain, especially dysmenorrhea, as a “normal” event [”
§ Update on Biomarkers for the Detection of Endometriosis > 1. Background
What the sources say
- Not checked yetcites [12] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Another ovarian tumor marker, CA-19-9, has been shown to be elevated in endometriosis and has a comparable or lower sensitivity than CA-125 for the detection of endometriosis [23].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [23] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“CA-125 has been measured simultaneously with urocortin [34], chlamydia antibody [35], CD23 [39], and inflammatory cytokines [32]. However, none of these combinations provided a sufficiently high sensitivity or specificity for endometriosis and results remained unvalidated.”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“In a study conducted by Signorile and Baldi, Zinc (Zn)-alpha2-glycoprotein was identified by mass spectrometry (endometriosis cases n = 5, controls n = 5) as a possible biomarker for endometriosis and confirmed by ELISA to be differentially expressed (P = 0.019) in an additional cohort of endometriosis patients (n = 120) and healthy controls (n = 20) [45].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [45] source
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“A different study assessing glycodelin A found a significant increase in serum of women with endometrioma (n = 57) compared with control women undergoing sterilization or having benign ovarian cysts (n = 42) and demonstrated the potential use of glycodelin A as a biomarker for ovarian endometriosis with a sensitivity of 82.1% and a sensitivity of 78.4% [47].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [47] source
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Follistatin, an inhibitor of activin, has been shown to be increased in endometriosis patients [23], especially in a subgroup of patients with ovarian endometrioma, and showed good sensitivity and specificity [43].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In a study by the same group, the inflammatory biomarker YKL-40 was significantly elevated (P < 0.001) in patients with endometriosis (n = 53) compared with patients without endometriosis (n = 35) and a positive correlation with disease severity was detected [53].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.2. Immunological Markers and Inflammatory Cytokines
What the sources say
- Not checked yetcites [53] source
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In peripheral blood, IL-8, MCP-1, and RANTES showed potential as a biomarker, being significantly increased in endometriosis cases versus controls in, respectively, 46.1%, 50%, and 75% of the assessed studies [54].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.2. Immunological Markers and Inflammatory Cytokines
What the sources say
- Not checked yetcites [54] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Reported sensitivity was 69.4% and specificity was 100% [45].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.1. Glycoproteins
What the sources say
- Not checked yetcites [45] source
Strength:plain· not yet calibratedn = 120Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In a study by Vodolazkaia et al., univariate analysis showed the differential expression of several cytokines and chemokines in 232 women with endometriosis and 121 controls [24]. However, no cytokines or chemokines were included in the final proposed panel of biomarkers after multivariate analysis [24].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.2. Immunological Markers and Inflammatory Cytokines
What the sources say
- Not checked yetcites [24] source
Strength:plain· not yet calibratedn = 232Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In a study by Chen et al., PEDF was significantly decreased in women with endometriosis (n = 43) compared with women without endometriosis (n = 28), independent of the phase of the cycle and correlated with pain symptoms [71].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.5. Angiogenesis
What the sources say
- Not checked yetcites [71] source
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Contrasting evidence exists on prolactin, leptin, luteinizing hormone (LH), and adiponectin levels in endometriosis patients versus controls, showing either no difference, an increase (prolactin, leptin LH) or a decrease (adiponectin) [23, 75, 76].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.6. Hormones
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Elevations of fibroblast growth factor-2 (FGF-2), angiogenin, and soluble Flt-I (VEGFR-1) in serum of women with endometriosis have all been recorded [23].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.5. Angiogenesis
What the sources say
- Not checked yetcites [23] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Additionally, serum anti-PDIK1L [77] and anti-syntaxin 5 autoantibodies [78] were reported elevated in endometriosis patients.”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.7. Autoantibodies
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Hepatocyte growth factor (HGF) was suggested to be elevated in women with endometriosis [72], although this was not confirmed in an additional study [23, 73].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.5. Angiogenesis
What the sources say
Strength:hedged· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Additionally, the potential use of circulating angiogenic cells as biomarkers for endometriosis has been examined, but no difference between endometriosis patients and controls could be detected [98].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.12. Cell Populations
What the sources say
- Not checked yetcites [98] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These studies have shown promising results; however, proteomics technologies are costly and time-consuming [23], and there is a need for better standardization and reproducibility of proteomic technologies before they can be used reliably in clinical research projects [17].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.9. Proteomics
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Reduced plasma levels of miR-17-5p, miR-20a, and miR-22 [86] and elevated plasma levels of miR-16, miR-191, and miR-195 [87] have been found in women with endometriosis compared with women without endometriosis.”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.8. miRNA
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Both total immunoglobulin levels and antiendometrial antibodies have been investigated as potential biomarkers for endometriosis of which the latter showed the most promising results, being more commonly present in endometriosis patients than in controls [23].”
§ Update on Biomarkers for the Detection of Endometriosis > 3. Blood Biomarkers > 3.7. Autoantibodies
What the sources say
- Not checked yetcites [23] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Though legitimizing urine as a diagnostic medium, this finding also suggests potential for reduced specificity, and it will be important to assess the ability of a urinary assay to differentiate endometriosis from other inflammatory conditions.”
§ Update on Biomarkers for the Detection of Endometriosis > 4. Urine Biomarkers
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one. The quote only partly states this claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This finding highlights both the prospect for miRNA dysregulation in the pathogenesis of endometrial disorders and the importance of accounting for menstrual cycle phase in the interpretation of miRNA profiles in biomarker discovery protocols.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Relative to blood, urine evidences a significantly narrower dynamic range of proteins, thereby allowing more rapid preparation of specimens for proteomic interrogation.”
§ Update on Biomarkers for the Detection of Endometriosis > 4. Urine Biomarkers
What the sources say
- Not checked yetcites [105] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“A systematic review of over 200 potential endometrial biomarkers, including hormones and their receptors (n = 29), cytokines (n = 25), factors identified through proteomics (n = 8), and histology (n = 10) revealed sensitivity and specificity (reported in only 32 articles) ranging from 0 to 100% [113].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers
What the sources say
- Not checked yetcites [113] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“First, the endometrium evidences remarkable sex steroid-driven cyclic variation and regenerative capacity.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers
What the sources say
- Not checked yetcites [109] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Additionally, the urine proteome is relatively stable for up to six hours at room temperature and for over 17 years stored at −70°C [105].”
§ Update on Biomarkers for the Detection of Endometriosis > 4. Urine Biomarkers
What the sources say
- Not checked yetcites [105] source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“MicroRNAs (miRNAs) evidence differential expression in the endometrium of women with versus without endometriosis and therefore offer potential as an endometriosis biomarker.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Interestingly, the dysregulation of miRNAs was cycle phase independent, though the relatively small sample size limited definitive correlation.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
What the sources say
- Not checked yetcites [121] source
Strength:plain· not yet calibratedn = 7Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Nerve fibers were first detected in peritoneal endometriotic lesions and these were thought to contribute to associated dysmenorrhea [137].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.4. Neuronal Marker
What the sources say
- Not checked yetcites [137] source
Strength:plain· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Functional endometrial layer nerve fibers assessed by PGP9.5 immunostaining were detected in 9 of 45 (22%) of histologically confirmed cases of endometriosis and in 6 of 21 (29%) of women without endometriosis.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.4. Neuronal Marker
What the sources say
- Not checked yetcites [143] source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“This group further compared miRNA expression in women with mild and severe endometriosis and found increased endometrial expression of miR-21 and DICER in the more advanced stage of the disease [126].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
What the sources say
- Not checked yetcites [126] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These studies highlight molecular pathways that may be associated with the development of endometriosis as well as the changes in expression signature that exist in ectopically located endometrial tissue.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR-542-3p/COX2 [128], miR-126/CRK [129] and miR23a/NR5A1 [130].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
What the sources say
Strength:boosted· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“The specificity of endometrial nerve fiber density was further challenged by the finding of similar endometrial innervation and neuronal growth fibers in women with adenomyosis, with expression reported to be more correlated with pelvic pain than diagnosis [144].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.4. Neuronal Marker
What the sources say
- Not checked yetcites [144] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The adoption of validated, internationally agreed upon standard operating procedures (SOPs) for tissue sample collection, processing and storage, and standardized phenotypic and other patient data collection, are crucial to optimise sample quality, reduce variability, and enable cross-centre studies [17, 113, 148].”
§ Update on Biomarkers for the Detection of Endometriosis > 6. Standard Operating Procedures
What the sources say
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“A more recent study revealed 156 miRNAs differentially expressed between endometriotic tissue and normal endometrium, including twelve miRNAs known to be involved in fibrinolysis and angiogenesis [124].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
What the sources say
- Not checked yetcites [124] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Many centres worldwide have been collecting blood or other body fluids such as peritoneal fluid, endometrial fluid, and menstrual fluid, as well as tissue samples—in particular ectopic and eutopic endometrium—from women with and without endometriosis, for a variety of research purposes [145–147].”
§ Update on Biomarkers for the Detection of Endometriosis > 6. Standard Operating Procedures
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“In a study of sharp curettage and full thickness hysterectomy specimens, PGP9.5 immunostained nerve fibers were detected in the functional endometrial layer from all women with surgically confirmed endometriosis but none of the specimens from unaffected controls, and this finding was cycle phase independent [139].”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.4. Neuronal Marker
What the sources say
- Not checked yetcites [139] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“To date, the utility of miRNAs as biomarkers for endometriosis has not been specifically tested.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✗ Based: failsProbably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Notably, the reports of miR-23a expression in eutopic endometrium from women with and without endometriosis showed opposite directions of dysregulation, with one study involving proliferative endometrial specimens and the other including only early to midsecretory samples.”
§ Update on Biomarkers for the Detection of Endometriosis > 5. Endometrial Biomarkers > 5.2. MicroRNAs
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Recently, the World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) has developed a consensus on standardisation and harmonisation of phenotypic surgical/clinical data and biologic sample collection methods in endometriosis research [146, 147, 149, 150].”
§ Update on Biomarkers for the Detection of Endometriosis > 6. Standard Operating Procedures
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
MALDI-TOF does not allow direct identification of peptides or proteins that are differentially synthesized or secreted.
“Importantly, MALDI-TOF does not allow direct identification of peptides or proteins that are differentially synthesized or secreted, which is fundamental to further validation and clinical assay development, although protein pattern recognition holds promise for the future.”
The paper relies on this without support.
SELDI-TOF MS methodology provides differential proteomic profiles in the form of mass/charge (m/z) peaks without attendant characterization of the peptides or proteins.
“Importantly, the SELDI-TOF MS methodology provides differential proteomic profiles in the form of mass/charge (m/z) peaks without attendant characterization of the peptides or proteins.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The studies showed that a panel of cytokines, rather than a single biomarker, improve sensitivity and specificity values, with some panels showing the ability to discriminate between different stages of disease.”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [71]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Reported panel accuracy does not match sensitivity, specificity, and group sizes
MajorWith 60 patients and 20 controls, 90% sensitivity gives 54 correct patient classifications and 70% specificity gives 14 correct control classifications. Overall accuracy is therefore 68/80, or 85%, not 88.7%. The check repeats 90 three times to represent the 3:1 patient-to-control ratio.
Reported 88.7 · recomputed 85
“Ozhan et al. stated that a panel consisting of CA-125, syntaxin-5, and laminin-1 had 90% sensitivity, 70% specificity, and 88.7% accuracy to distinguish endometriosis patients (n = 60) from controls (n = 20) [41].”
Nine of 45 cases is 20%, not 22%
MinorThe stated count gives 9/45 = 20%. The nearby figure of 6/21 = 29% is consistent with rounding.
Reported 22 · recomputed 20
“Functional endometrial layer nerve fibers assessed by PGP9.5 immunostaining were detected in 9 of 45 (22%) of histologically confirmed cases of endometriosis and in 6 of 21 (29%) of women without endometriosis.”
Two different sensitivities are given for glycodelin A
MinorThe sentence assigns two different sensitivity values to glycodelin A for the same stated diagnostic use, without distinguishing the measures.
“a sensitivity of 82.1%”
“a sensitivity of 78.4%”
Citations
Cites
2 retracted
Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam063 · Cited by 261 · cited 1×
“In contrast to studies comparing miRNA expression in eutopic versus ectopic endometrium, relatively few studies have compared miRNA expression in eutopic endometrium from women with and without surgically confirmed endometriosis [120, 125, 126].”
RetractedThe Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs
Toloubeydokhti, T., Pan, Q., Luo, X., Bukulmez, O., & Chegini, N. (2008) · Reproductive Sciences · doi:10.1177/1933719108324132 · Cited by 83 · cited 1×
“Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR542-3p/COX2 [128], miR-126/CRK [129] andmiR23a/NR5A1 [130].”
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · cited 1×
“For example, most miRNA are able to regulate several hundred transcripts and several miRNA often regulate the same mRNA target [82].”
miRBase: tools for microRNA genomics
Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,432 · cited 1×
“With over 2200 distinct miRNAs identified to date, miRNA regulatory mechanisms are redundant, overlapping, and complex [81].”
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166
Self-citationSampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Self-citationEskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617
Nnoaham, K. E., Hummelshoj, L., Webster, P., d’Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., Jenkinson, C., Kennedy, S. H., & Zondervan, K. T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.090 · Cited by 1,584 · cited 2×
“Endometriosis is a major cause of disability and significantly compromised quality of life in women and adolescents [3].”
Self-citationSimoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070 · cited 1×
“A worldwide study of costs caused by endometriosis indicates that the average annual total costs per woman are 9579 euros, of which 66% is caused by costs for productivity loss, while medication counts for only 10% of the total yearly costs [26].”
Self-citation
Flagged first, then by citations
1 of the 149 references couldn’t be matched to a known paper.
Research works printed but not linked: 10
- 1927, American Journal of Obstetrics & Gynecology, 14, 442
- 2014, Biomarkers of endometriosis, 321
- 10.1093/humupd/dmq009 · DOI · Paper page
- 2008, Health economics of endometriosis, 1
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- 2003, Di Yi Jun Yi Da Xue Xue Bao, 23, 757
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- 2014, Biomarkers of endometriosis
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Cited by
Sorted by citations
Clinical diagnosis of endometriosis: a call to action
Agarwal, S. K., Chapron, C., Giudice, L. C., Laufer, M. R., Leyland, N., Missmer, S. A., Singh, S. S., & Taylor, H. S. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.12.039 · Cited by 843
Self-citationBlood biomarkers for the non-invasive diagnosis of endometriosis
Nisenblat, V., Bossuyt, P. M., Shaikh, R., Farquhar, C. M., Jordan, V., Scheffers, C. S., Mol, B. W., JOHNSON, N. P., & Hull, M. L. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012179 · Cited by 401
Fertile ground: human endometrial programming and lessons in health and disease
Evans, J., Salamonsen, L. A., Winship, A., Menkhorst, E. M., Nie, G., Gargett, C. E., & Dimitriadis, E. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.116 · Cited by 378
Biomarkers in endometriosis: Challenges and opportunities
Ahn, S. H., Singh, V., & Tayade, C. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.009 · Cited by 242
Combination of the non-invasive tests for the diagnosis of endometriosis
Nisenblat, V., Prentice, L., Bossuyt, P. M., Farquhar, C. M., Hull, M. L., & JOHNSON, N. P. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012281 · Cited by 231
Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
Anastasiu, C. V., Moga, M., Neculau, A. E., Bălan, A., Scârneciu, I., Dragomir, R. M., Dull, A.-M., & Chicea, L.-M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051750 · Cited by 202
“Under these circumstances, a considerable diagnostic delay is explicable [6,7], leading to 8–12 years of belated appropriate treatment [8].”
BackgroundEndometrial biomarkers for the non-invasive diagnosis of endometriosis
Gupta, D., Hull, M. L., Fraser, I. S., Miller, L., Bossuyt, P. M., JOHNSON, N. P., & Nisenblat, V. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012165 · Cited by 179
Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro
Harp, D., Driss, A., Mehrabi, S., Chowdhury, I., Xu, W., Liu, D., Garcia-Barrio, M. T., Taylor, R. N., Gold, B., Jefferson, S., et al. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2358-1 · Cited by 131
“Patients with endometriosis often have delayed (6– 11 years) diagnosis because symptoms are variable and often mimic other gynecological diseases (Fassbender et al. 2015; Leone Roberti Maggiore et al. 2016; Nogales et al. 1993).”
Plasma miRNAs as biomarkers for endometriosis
Vanhie, A., Dolores Saavedra, O., Peterse, D., Beckers, A., Cuéllar, A., Fassbender, A., Meuleman, C., Mestdagh, P., & D’Hooghe, T. M. (2019) · Human Reproduction · doi:10.1093/humrep/dez116 · Cited by 126
“Since a diagnostic laparoscopy is often considered in these patients, they represent a relevant patient group for which a non-invasive diagnostic test for endometriosis would be useful (Vodolazkaia et al. , 2012, Fassbender et al. , 2015).”
Self-citationRekker, K., Saare, M., Roost, A. M., Kaart, T., Sõritsa, D., Karro, H., Sõritsa, A., Simón, C., Salumets, A., & Peters, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.06.029 · Cited by 118
“To propose some marker as diagnostic tool for endometriosis, several requirements should be fulfilled, including a retrospective validation and a prospective validation phase; unfortunately, most endometriosis biomarker studies have remained at the discovery phase (47).”
MethodPeritoneal fluid cytokines related to endometriosis in patients evaluated for infertility
Jørgensen, H., Hill, A. S., Beste, M. T., Kumar, M. P., Chiswick, E. L., Fedorcsák, P., Isaacson, K., Lauffenburger, D. A., Griffith, L. G., & Qvigstad, E. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.03.013 · Cited by 120
“In spite of decades of research in this field, we have no predictable markers for the disease intensity and long-term outcome (10), nor do we understand why the presence of ectopic endometrium is symptomatic in some women and not in others.”
BackgroundImmunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target
Agostinis, C., Balduit, A., Mangogna, A., Zito, G., Romano, F., Ricci, G., Kishore, U., & Bulla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599117 · Cited by 123
“In addition to estradiol, a potential factor for the upregulation of C3 expression by endometrial cells was the peritoneal fluid rich in pro-inflammatory factors (113); TNF-a and IL-1b levels appeared to be increased in the peritoneal fluid of patients with EM, and higher levels of TNF-a seemed to be associated with m…”
BackgroundSerum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis
Zhang, L., Li, H., Yuan, M., Li, D., Chang, S., & Wang, G. (2020) · Disease Markers · doi:10.1155/2020/2456340 · Cited by 115
“The signs and symptoms of patients suffering from endometriosis include pelvic pain, dysmenorrhea, and infertility [2].”
BackgroundWang, W.-T., Sun, Y.-M., Huang, W., He, B., Zhao, Y.-N., & Chen, Y.-Q. (2016) · Scientific Reports · doi:10.1038/srep23343 · Cited by 97
The gut microbiota: a puppet master in the pathogenesis of endometriosis?
Laschke, M. W., & Menger, M. D. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.02.036 · Cited by 95
Papari, E., Noruzinia, M., Kashani, L., & Foster, W. G. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.01.026 · Cited by 89
Urinary biomarkers for the non-invasive diagnosis of endometriosis
Liu, E., Nisenblat, V., Farquhar, C. M., Fraser, I. S., Bossuyt, P. M., JOHNSON, N. P., & Hull, M. L. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012019 · Cited by 91
Polymorphisms and endometriosis: A systematic review and meta-analyses
Méar, L., Herr, M., Fauconnier, A., Pineau, C., & Vialard, F. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz034 · Cited by 85
Bakhtiarizadeh, M. R., Hosseinpour, B., Shahhoseini, M., Korte, A., & Gifani, P. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00453 · Cited by 78
Diagnostic accuracy of serum miR‐122 and miR‐199a in women with endometriosis
Maged, A. M., Deeb, W. S., Amir, A. E., Zaki, S. S., Elsawah, H., Almohamady, M., Metwally, A. A., & Katta, M. A. (2017) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12392 · Cited by 76
New biomarkers in endometriosis
(2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.12.002 · Cited by 72
Morelli, M. A. C., Iuliano, A., Schettini, S. C. A., Petruzzi, D., Ferri, A., Colucci, P., Viggiani, L., Cuviello, F., & Ostuni, A. (2019) · Metabolomics · doi:10.1007/s11306-019-1481-x · Cited by 70
Hirsch, M., Duffy, J. M., Deguara, C. S., Davis, C., & Khan, K. S. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.12.002 · Cited by 73
“Evaluation of noninvasive diagnostic biomarkers has not identified an accurate non-invasive test for the detection of endometriosis [2,3].”
BackgroundJiang, J., Jiang, Z., & Xue, M. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1554034 · Cited by 66
“Therefore, the development of a less-invasive method for diagnosing endometriosis may improve management [3].”
MethodRelevant human tissue resources and laboratory models for use in endometriosis research
Greaves, E., Critchley, H., Horne, A. W., & Saunders, P. T. K. (2017) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13119 · Cited by 62
“As yet there are no validated clinical biomarkers of endometriosis (2), so the reference standard for diagnosis of the condition is the macroscopic visualization of lesions during laparoscopy.”
BackgroundPateisky, P., Pils, D., Szabo, L., Kuessel, L., Husslein, H., Schmitz, A. A. P., Wenzl, R. J., & Yotova, I. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.05.007 · Cited by 61
Serum miR-17, IL-4, and IL-6 levels for diagnosis of endometriosis
Wang, F., Wang, H., Jin, D., & Zhang, Y. (2018) · Medicine · doi:10.1097/md.0000000000010853 · Cited by 62
“Laparoscopic visual examination and pathological diagnosis are the gold standard for the diagnosis of endometriosis.([4]) However, previous studies have revealed that these examinations could show a considerable delay in diagnosing endometriosis which may worsen the endometriosis lesions.”
BackgroundMarí‐Alexandre, J., Barceló‐Molina, M., Belmonte-López, E., García-Oms, J., Estellés, A., Braza‐Boïls, A., & Gilabert–Estellés, J. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.11.036 · Cited by 58
Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review
Михалева, Л. М., Davydov, A. I., Игоревна, П. О., Вячеславовна, М. Е., Nikolenko, V. N., Неганова, М. Е., Klochkov, S. G., Somasundaram, S. G., Kirkland, C. E., & Aliev, G. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01363-5 · Cited by 60
Altered Immunity in Endometriosis: What Came First?
Králíčková, M., Fiala, L., Lošan, P., Tomeš, P., & Větvička, V. (2018) · Immunological Investigations · doi:10.1080/08820139.2018.1467926 · Cited by 54
“Therefore, despite extensive research, no consensus exists on the use of cytokines in diagnosis; for review see Fassbender et al. (2015).”
BackgroundO, D. F., Flores, I., Waelkens, E., & D’Hooghe, T. M. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.04.001 · Cited by 55
“Peripheral blood is a useful source of biomarkers, as it is easily obtained andminimally invasive [10].”
BackgroundSelf-citationMicroRNA-142-3p suppresses endometriosis by regulating KLF9-mediated autophagy in vitro and in vivo
Ma, L., Li, Z., Li, W., Ai, J., & Chen, X. (2019) · RNA Biology · doi:10.1080/15476286.2019.1657352 · Cited by 51
“Histopathological diagnosis and laparoscopic visual examination are the gold standard methods for the diagnosis of endometriosis [6], which may be developed into endometrioid and ovarian cancer [7,8].”
MethodKimber-Trojnar, Ż., Pilszyk, A., Niebrzydowska-Tatus, M., Pilszyk, Z., Ruszała, M., & Leszczyńska‐Gorzelak, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132762 · Cited by 54
Giamougiannis, P., Morais, C. L. M., Rodriguez, B., et al. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03472-8 · Cited by 48
“Previous studies have revealed some urinary biomarkers (mainly enzymes and peptides) with good discriminatory ability, using methods that included mass spectrometry but not vibrational spectroscopy [67, 68].”
MethodVicente-Muñoz, S., Morcillo, I., Puchades‐Carrasco, L., Payá, V., Pellicer, A., & Pineda‐Lucena, A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.09.014 · Cited by 47
Gajbhiye, R., Bendigeri, T., Arun, G., Bhusane, K., Begum, S., Warty, N. R., Sawant, R., Padte, K., Humane, A. C., DasMahapatra, P., et al. (2016) · Reproductive Sciences · doi:10.1177/1933719116657190 · Cited by 44
“The majority of these markers were not useful for the detection of minimal–mild endometriosis (rAFS stage I-II), and few of these markers showed contradictory data with respect to sensitivity and specificity when studied by different researches.(20,21) Thus, accurate and reliable biomarker for the diagnosis of endomet…”
BackgroundAdamyan, L. V., Starodubtseva, N. L., Borisova, A. V., Stepanian, A. A., Chagovets, V., Salimova, D., Wang, Z., Kononikhin, A. S., Popov, I. A., Bugrova, A. E., et al. (2017) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2017.08.658 · Cited by 43
Novel diagnostic options for endometriosis – Based on the glycome and microbiome
Kovács, Z., Glover, L. E., Reidy, F., MacSharry, J. A., & Saldova, R. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.01.015 · Cited by 45
Pant, A., Moar, K., Arora, T. K., & Maurya, P. K. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117563 · Cited by 46
Javadi, M., Rad, J. S., Farashah, M. S. G., & Roshangar, L. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00556-9 · Cited by 41
“The symptoms of EMs are pelvic pain, dysmenorrhea, and infertility [114].”
BackgroundRocha, A. L., Vieira, E. L., Ferreira, M. C., Maia, L. M., Teixeira, A. L., & Reis, F. M. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0327 · Cited by 41
Cellular Origins of Endometriosis: Towards Novel Diagnostics and Therapeutics
Filby, C. E., Rombauts, L. J. F., Montgomery, G. W., Giudice, L. C., & Gargett, C. E. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1713429 · Cited by 40
Self-citationMicroRNA expression pattern differs depending on endometriosis lesion type†
Haikalis, M. E., Wessels, J. M., Leyland, N. A., Agarwal, S. K., & Foster, W. G. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy019 · Cited by 41
Overall Adiposity, Adipose Tissue Distribution, and Endometriosis: A Systematic Review
Backonja, U., Buck Louis, G. M., & Lauver, D. R. (2016) · Nursing Research · doi:10.1097/nnr.0000000000000146 · Cited by 39
How to Use CA-125 More Effectively in the Diagnosis of Deep Endometriosis
Oliveira, M. A. P., Raymundo, T. S., Soares, L. C., Pereira, T. R., & Evangelista, A. V. (2017) · BioMed Research International · doi:10.1155/2017/9857196 · Cited by 38
“Other serummarkers such as CA19-9, interleukins 6, 8, and 10, and tumor necrosis factor alpha have also already been studied [12, 13].”
BackgroundBouaziz, J., Mashiach, R., Cohen, S., Kedem, A., Baron, A., Zajicek, M., Feldman, I., Seidman, D. S., & Soriano, D. (2018) · BioMed Research International · doi:10.1155/2018/6217812 · Cited by 41
“0) were as follows: (i) Cyclin-dependent kinase inhibitor 2B (CDKN2B), whose rs1537377 polymorphism showed significant associations with endometriosis [25], was found in other studies [5, 26] to play a key role in the pathogenesis.”
BackgroundExosomes and their cargo are important regulators of cell function in endometriosis
Freger, S., Leonardi, M., & Foster, L. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.05.022 · Cited by 41
Gater, A., Taylor, F. C., Seitz, C., Gerlinger, C., Wichmann, K., & Haberland, C. (2020) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-020-0177-3 · Cited by 39
“In the absence of established sensitive and specific biomarkers, the key symptoms and impacts associated with endometriosis can only be measured by direct reports from women themselves [19].”
BackgroundPal, A., Biswas, S., Kare, S. P. O., Biswas, P., Jana, S. K., Das, S., & Chaudhury, K. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130460 · Cited by 37
The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19‐9 in the Detection of Endometriosis
Rokhgireh, S., Mehdizadehkashi, A., Chaichian, S., Delbandi, A., Allahqoli, L., Ahmadi-Pishkuhi, M., Khodaverdi, S., & Alkatout, İ. (2020) · BioMed Research International · doi:10.1155/2020/5208279 · Cited by 36
“In the present study, although the diagnostic power of urinary enolase-Cr was lower than that of serum CA-125 for the detection of endometriosis, when combined with serum CA-125 and CA19-9, the AUC was increased to 0.675 (95% CI 0.573-0.710).”
BackgroundInfluentialAgostinis, C., Zorzet, S., Balduit, A., Zito, G., Mangogna, A., Macor, P., Romano, F., Toffoli, M., Belmonte, B., Morello, G., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693118 · Cited by 32
“A potential candidate for the upregulation of C3 expression by endometrial cells is the PF rich in pro-inflammatory factors (39).”
BackgroundFauconnier, A., Drioueche, H., Huchon, C., Cheyron, J. D., Indersie, É., Candau, Y., Panel, P., & Fritel, X. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.07.1205 · Cited by 35
New paradigms in the diagnosis and management of endometriosis
Kavoussi, S. K., Lim, C. S., Skinner, B. D., Lebovic, D. I., & As‐Sanie, S. (2016) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000288 · Cited by 33
“Investigations of biomarkers have included those of serum, peritoneal fluid, uterine fluid, urine, and endometrial tissues [18].”
BackgroundOncological markers CA-125, CA 19-9 and endometriosis
Fiala, L., Bob, P., & Raboch, J. (2018) · Medicine · doi:10.1097/md.0000000000013759 · Cited by 32
“[11] Some studies show that CA-19-9 may be demonstrably elevated in endometriosis and exhibit the same or decreased sensitivity as CA-125.”
BackgroundInfluentialRevisiting the Risk Factors for Endometriosis: A Machine Learning Approach
Blass, I., Sahar, T., Shraibman, A., Ofer, D., Rappoport, N., & Linial, M. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071114 · Cited by 33
“Despite extensive efforts to identify biomarkers (e.g., miRNA, peptides, metabolites) and to establish non-invasive indicators [47], diagnostic tests based on biomarkers from peripheral blood have not been validated [48].”
Non-invasive diagnosis of endometriosis: Immunologic and genetic markers
Mahini, S. M., Younesi, M., Mortazavi, G., Samare‐Najaf, M., Azadbakht, M. K., & Jamali, N. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.11.013 · Cited by 32
Gajbhiye, R., McKinnon, B. D., Mortlock, S., Mueller, M. D., & Montgomery, G. W. (2018) · Reproductive Sciences · doi:10.1177/1933719118768688 · Cited by 31
Rafi, U., Ahmad, S., Bokhari, S. S., Iqbal, M. A., Zia, A., Khan, M. A., & Roohi, N. (2021) · Mediators of Inflammation · doi:10.1155/2021/3425560 · Cited by 30
“CRP could be an additional potential biomarker in endometriosis [24].”
Muruganandan, S., Fan, X., Dhal, S., et al. (2020) · Biomolecules · doi:10.3390/biom10010136 · Cited by 30
“Likewise, the rapid and effective diagnosis of endometriosis is also limited due to clinically unavailable biomarkers that would sensitively and specifically detect the disease state [42].”
BackgroundMéar, L., Com, E., Fathallah, K., Laetitia Guillot, D., Lavigne, R., Guével, B., Fauconnier, A., Vialard, F., & Pineau, C. (2022) · Diagnostics · doi:10.3390/diagnostics12020419 · Cited by 30
“Moreover, endometrial biopsies are minimally invasive compared to laparoscopy surgery, although not particularly pleasant or comfortable for women [16,21].”
BackgroundResultInfluentialJi, S., Liu, Y., Li, Y., Zhang, Y., Li, Y., Zhu, Q., Xia, W., Ge, S., & Zhang, J. (2023) · Journal of Proteomics · doi:10.1016/j.jprot.2023.104995 · Cited by 30
Kusum, K., Raj, R., Rai, S., Pranjali, P., Ashish, A., Vicente-Muñoz, S., Chaube, R., & Kumar, D. (2022) · ACS Omega · doi:10.1021/acsomega.2c00332 · Cited by 29
“40 Metabolomics analysis of blood plasma/serum can provide noninvasive biomarkers for diagnostic and therapeutic monitoring and also an emerging approach for gaining better understanding of the pathophysiology of this disease.”
InfluentialAdvances in the diagnosis and management of endometriosis: A comprehensive review
Chen, Y., Waseem, S., & Luo, L. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155813 · Cited by 33
miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis
Maier, I. M., & Maier, A. C. (2021) · Biomedicines · doi:10.3390/biomedicines9111662 · Cited by 27
Endometriosis biomarkers of the disease: an update
Soto, D. E., Rassier, S. L. C., Green, I. C., Burnett, T. L., Khan, Z., & Cope, A. G. (2022) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000798 · Cited by 29
Possibility of using superoxide dismutase and glutathione peroxidase as endometriosis biomarkers
Ekarattanawong, S., Tanprasertkul, C., Somprasit, C., Chamod, P., Tiengtip, R., Bhamarapravatana, K., & Suwannarurk, K. (2017) · International Journal of Women s Health · doi:10.2147/ijwh.s141021 · Cited by 24
“The attempt to use blood biomarkers for endometriosis has been investigated since 1998.(13) However, the lack of specificity and low sensitivity of the studied biomarkers prevented further development.”
Cui, Z., Bhandari, R., Lei, Q., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.656145 · Cited by 24
“Similarly, novel diagnostic biomarkers and therapeutic targets should be identified to improve the early diagnosis and treatment of EM, which can improve the quality of life and cure rates of patients (Fassbender et al., 2015).”
BackgroundAXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis
Ek, M., Roth, B., Engström, G., & Ohlsson, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010189 · Cited by 23
“motif chemokine 5 (CCL5), and YKL-40 [3].”
BackgroundInfluentialGică, N., Panaitescu, A. M., Iancu, G., Botezatu, R., Peltecu, G. C., & Gică, C. (2020) · Ginekologia Polska · doi:10.5603/gp.2020.0039 · Cited by 22
“Present data from the literature is controversial, with some studies demonstrating elevated interleukins, IL-6 and IL8, in patients with endometriosis, while others have reported similar results in the endometriosis group versus control group [3, 4, 11, 13].”
BackgroundResultToll-Like Receptor 2 Expression as a New Hallmark of Advanced Endometriosis
Sobstyl, M., Niedźwiedzka‐Rystwej, P., Grywalska, E., Korona‐Głowniak, I., Sobstyl, A., Bednarek, W., & Roliński, J. (2020) · Cells · doi:10.3390/cells9081813 · Cited by 24
“However, none of them was proven useful in clinical settings [5,6].”
BackgroundSoluble tumor necrosis factor-alpha receptors in the serum of endometriosis patients
Othman, E. R., Hornung, D., Hussein, M., Abdelaal, I. I., Sayed, A. A.-R., Fetih, A. N., & Al-Hendy, A. A. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.02.025 · Cited by 22
“Previous studies examined different endometriosis biomarkers for non-surgical diagnosis [18,27,28].”
BackgroundResultInfluentialEvaluation of Circulating Endometrial Cells as a Biomarker for Endometriosis.
Chen, Y., Zhu, H., Tang, Z., Neoh, K. H., Ouyang, D., Cui, H., Cheng, H.-Y., Ma, R., Ye, X., Han, R. P. S., et al. (2017) · PubMed Central · doi:10.4103/0366-6999.215325 · Cited by 22
“More importantly, the current reported EM biomarkers are mainly molecules such as glycoproteins, cytokines, and RNAs, which may only reflect a single aspect of the disease.[27] As intact cells, CECs contain comprehensive information of genome, transcriptome, and the proteome and could reflect certain histological char…”
BackgroundPlasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women
Maia, L. M., Rocha, A. L., Del Puerto, H. L., Petraglia, F., & Reis, F. M. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1380188 · Cited by 20
“However, because it is an invasive procedure, many patients are undiagnosed, delaying the treatment and contributing for disease progression [13,22].”
BackgroundWoo, J., Ahn, J., Jang, D. S., & Choi, J. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500666 · Cited by 20
Dolińska, W., Draper, H., Othman, L., Thompson, C., Girvan, S., Cunningham, K., Allen, J., Rigby, A. S., Phillips, K., & Guinn, B. (2022) · F&S Reviews · doi:10.1016/j.xfnr.2022.12.001 · Cited by 23
Burghaus, S., Fehm, T. N., Fasching, P. A., Blum, S., Renner, S. P., Baier, F., Brodkorb, T., Fahlbusch, C., Findeklee, S., Häberle, L., et al. (2016) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0042-106895 · Cited by 18
“Possible biomarkers include peripheral biomarkers in blood, such as growth factors, hormones, proteolytic enzymes, glycoproteins, soluble adhesion molecules, immunological cell changes, auto-antibodies, miRNA, circulating cell-free DNA, and cytokines [22], and tissue obtained during surgery.”
Endometriosis: Challenges in Clinical Molecular Diagnostics and Treatment
Chalma, P. R., Díaz-Landy, E. N., Antonio-Véjar, V., Tejedor, J. G. O., Reytor-González, C., Simancas‐Racines, D., & Ordóñez, G. D. B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093979 · Cited by 20
Seckin, B., Ates, M. C., Kirbas, A., & Yesilyurt, H. (2021) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh-2018-0078 · Cited by 18
Khan, W. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.68834 · Cited by 19
Trapero, C., Jover, L., Fernández-Montolí, M.-E., García‐Tejedor, A., Vidal, A., de Aranda, I. G., Ponce, J., Matías‐Guiu, X., & Martı́n-Satué, M. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12794 · Cited by 17
Circulating Endometrial Cells: A New Source of Information on Endometriosis Dynamics
Pospisilova, E., Kiss, I., Souckova, H., Tomes, P., Spicka, J., Matkowski, R., Jedryka, M., Ferrero, S., Bobek, V., & Kolostova, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111938 · Cited by 17
“Endometriosis is a common disease among women of reproductive age and a major contributor to pelvic pain and subfertility causing disability and significantly compromised quality of life [1].”
BackgroundConservative approach to rectosigmoid endometriosis: a cohort study
Egekvist, A. G., Marinovskij, E., Forman, A., Kesmodel, U. S., Riiskjær, M., & Seyer‐Hansen, M. (2017) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.13094 · Cited by 15
“Endometriosis is defined by ectopic presence of endometrium-like tissue (1).”
BackgroundAntônio, L. G. L., Meola, J., Silva, A. C. J. D. S. R. E., Nogueira, A. A., dos Reis, F. J. C., Poli‐Neto, O. B., & Silva, J. C. R. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054434 · Cited by 16
“Although obtaining endometrial tissue presents an invasive aspect, the advantage of its use is that it can be accessed by biopsy without the need for anesthesia [32].”
BackgroundRocha, A. L. L., Vieira, É. L. M., Maia, L. M. A., Teixeira, A. L., & dos Reis, F. M. (2016) · Gynecologic and Obstetric Investigation · doi:10.1159/000443956 · Cited by 17
Margatho, D., Carvalho, N. M., Eloy, L., & Bahamondes, L. G. (2018) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625187.2018.1531117 · Cited by 17
“Due to the fact that surgery is an invasive diagnostic tool, several biomarkers have recently been proposed as non-invasive diagnostic tools for endometriosis [2,4,5]; however, none of the biomarkers proposed, thus far, have a high enough sensitivity and specificity to properly diagnose the disease [6].”
BackgroundA short anogenital distance on MRI is a marker of endometriosis
Crestani, A., Abdel Wahab, C., Arfi, A., Ploteau, S., Kolanska, K., Breban, M., Bendifallah, S., Ferrier, C., & Darai, E. (2021) · Human Reproduction Open · doi:10.1093/hropen/hoab003 · Cited by 15
“For decades, numerous potential non-invasive diagnostic biomarkers (blood, urine, endometrial) have been explored (Fassbender et al., 2015) though none have been shown to be effective to date (Liu et al.”
BackgroundFibronectin Molecular Status in Plasma of Women with Endometriosis and Fertility Disorders
Lis-Kuberka, J., Kubik, P., Chrobak, A., Pajak, J., Chełmońska‐Soyta, A., & Orczyk‐Pawiłowicz, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111410 · Cited by 15
“In recent years, the rapid development of civilization diseases has contributed to a significant increase in incidents of fertility problems in women [1,2].”
BackgroundTSH receptor antibodies (TRAb) – A potential new biomarker for endometriosis
Svensson, A., Roth, B., Kronvall, L., & Ohlsson, B. (2022) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2022.09.013 · Cited by 15
Biomarkers of Pelvic Endometriosis
Monteiro, C. D. S., Carneiro, M. M., & dos Reis, F. M. (2017) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0037-1601398 · Cited by 18
Endometriosis through an immunological lens: a pathophysiology based in immune dysregulation
McCallion, A., Sisnett, D. J., Zutautas, K. B., Hayati, D., Spiess, K. G., Aleksieva, S., Lingegowda, H., Koti, M., & Tayade, C. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00062 · Cited by 16
“Since surgery is invasive and expensive, other tests including imaging and biomarkers [glycoproteins, growth factors, microRNAs (miRNAs), and long noncoding RNAs (lncRNAs)] have been evaluated for their non-invasive diagnostic potential [225, 226].”
BackgroundMarí‐Alexandre, J., García-Oms, J., Agababyan, C., Belda-Montesinos, R., Royo-Bolea, S., Varo-Gómez, B., Díaz-Sierra, C., González-Cantó, E., & Gilabert–Estellés, J. (2020) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2020.1795827 · Cited by 14
Vargas, E., Aghajanova, L., Gemzell‐Danielsson, K., Altmäe, S., & Esteban, F. J. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2019.11.003 · Cited by 13
Kaya‐Sezginer, E., Kırlangıç, O. F., Tanrıverdi, M. D. E., Topçu, H. O., & Gür, S. (2021) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2021.52284 · Cited by 16
Kaspute, G., Bareikiene, E., Prentice, U., Uzielienè, I., Ramašauskaitė, D., & Ivaškienė, T. (2024) · Medicina · doi:10.3390/medicina60111866 · Cited by 15
CYFRA 21-1 and Placental Growth Factor as Screening Markers for Endometriosis
Cho, H. Y., & Kyung, M. S. (2019) · Medical Science Monitor · doi:10.12659/msm.912787 · Cited by 12
“In addition, complications associated with general anesthesia as well as the high cost of surgery should not be ignored [12].”
BackgroundInfluentialEndometriose Aspectos clínicos do diagnóstico ao tratamento
Silva, J. C. R. E., Valério, F. P., Herren, H., Troncon, J. K., Garcia, R. B., & Poli‐Neto, O. B. (2021) · Femina · doi:10.61622/0100-7254493202101 · Cited by 14
“(20) O diagnóstico cirúrgico tem muitas desvantagens, quando comparado com um diagnóstico minimamente invasivo, tais como riscos inerentes ao próprio procedimento (dano ao órgão, hemorragia, infecções e formação de aderência), complicações anestésicas e alto custo financeiro associado ao paciente e ao sistema de saúde…”
InfluentialThe Role of Exosomes in Diseases Related to Infertility
Jiayu, H., Zhang, H., & Gao, Y. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190123162842 · Cited by 11
Diagnostic Value of Circulating MicroRNAs for Endometriosis: a Meta-analysis
Zhou, L., Chen, Y., Gao, J., Shankar, S., & Zhang, G. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00024-5 · Cited by 10
Konrad, L., Hackethal, A., Oehmke, F., Berkes, E., Engel, J. B., & Tinneberg, H. (2016) · Reproductive Sciences · doi:10.1177/1933719116641756 · Cited by 11
Histotyping and grading of endometriosis and its association with clinico-pathological parameters
Litson, J., Agnes, R., & Ravikumar, G. (2022) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2022.2146997 · Cited by 9
“Despite many studies on biomarkers for endometriosis, no single or panel of clinically useful biomarkers are identified to date (Fassbender et al. 2015).”
Background
Metadata
- Authors
- Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Madigan Army Medical Center (US)
- Department of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium
- University of California, San Francisco (US)
- Corresponding author
- D’Hooghe, Thomas
- Giudice, Linda
- Venue
- BioMed Research International
- Publisher
- Hindawi Limited
- Published
- 2015
- Volume
- 2015
- Pages
- 1-14
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4512573
- OpenAlex
- W1935876281
- Semantic Scholar
- 49184ea27e4695119ebaa60bce32622318c29b7e
- Cited by
- 195
- References
- 149
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 26 · 2021: 25 · 2020: 27 · 2019: 23 · 2018: 18 · 2017: 18 · 2016: 22 · 2015: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD055764)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, biomarkers, early diagnosis, plasma biomarkers, urinary biomarkers, endometrium, infertility, pelvic pain, delayed diagnosis
- MeSH terms
- Endometriosis, Endometrium, Female, Humans, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Early Diagnosis
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