The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Obesity is associated with macrophage accumulation in adipose tissue
Open accessAbstract
Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications.To further characterize the changes that occur in adipose tissue with increasing adiposity, we profiled transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (A y ) and obese (Lep ob ).We found that the expression of 1,304 transcripts correlated significantly with body mass.Of the 100 most significantly correlated genes, 30% encoded proteins that are characteristic of macrophages and are positively correlated with body mass.Immunohistochemical analysis of perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue revealed that the percentage of cells expressing the macrophage marker F4/80 (F4/80 + ) was significantly and positively correlated with both adipocyte size and body mass.Similar relationships were found in human subcutaneous adipose tissue stained for the macrophage antigen CD68.Bone marrow transplant studies and quantitation of macrophage number in adipose tissue from macrophage-deficient (Csf1 op/op ) mice suggest that these F4/80 + cells are CSF-1 dependent, bone marrow-derived adipose tissue macrophages.Expression analysis of macrophage and nonmacrophage cell populations isolated from adipose tissue demonstrates that adipose tissue macrophages are responsible for almost all adipose tissue TNF-α expression and significant amounts of iNOS and IL-6 expression.Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Aging is also associated with macrophage infiltration into primarily visceral adipose depots which drives a pro-inflammatory state and further increases adipose dysfunction (40).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As metabolic syndrome is associated with significant macrophage accumulation in adipose tissue,69”
From Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy (2023) · cites this paper as [69]
Experimental — accuracy not yet measuredIn the citing paper
“Activated monocytes that give rise to M1 and M2 macrophages produce even more inflammatory compounds that probably appear in the circulation57.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [57]
In the citing paper
“In adipose tissue from lean subjects, approximately 10% of cells stained positive for macrophages, but in obese subjects, this number increased to up to 50% [38].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [38]
In the citing paper
“In fact, more than 40% of the total adipose tissue cell content from obese rodents and humans was comprised of macrophages compared with approximately 10% in lean counterparts (101).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [101]
In the citing paper
“In addition, macrophages were responsible for the majority of Tnfa expression in adipose tissue and contributed significantly to Il6 and Ikbkb expression (101, 102).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [101]
In the citing paper
“In 2003, the novel discovery that adipose tissue from obese mice and humans is infiltrated with macrophages provided a major mechanistic advance into understanding how obesity propagates inflammation (101, 102).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [101]
In the citing paper
“Moreover, this intermuscular adipose depot is infiltrated with approximately 3 times more macrophages in skeletal muscle from obese compared with lean mice (101).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [101]
In the citing paper
“These include increased production of inflammatory cytokines, 35,36 plasminogen activator inhibitor-1, 37 and other bioactive products 38 -40 ; at the same time the potentially protective adipokine, adiponectin, is reduced.41,42”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [36]
In the citing paper
“Macrophages comprise the largest population of resident immune cells in visceral AT, constituting up to 10% of AT cells in mice (10).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [10]
In the citing paper
“Weisberg et al. demonstrated that subcutaneous AT macrophage infiltration was increased in obese patients, similar to that observed in obese mice (10).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [10]
In the citing paper
“Several detailed studies have also reported a higher macrophage count in visceral AT of insulin-resistant obese patients compared with lean or insulin-sensitive obese counterparts, an effect that was significantly mitigated following bariatric surgery (10,(114)(115)(116).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [10]
In the citing paper
“Several detailed studies have also reported a higher macrophage count in visceral AT of insulin-resistant obese patients compared with lean or insulin-sensitive obese counterparts, an effect that was significantly mitigated following bariatric surgery (10,(114)(115)(116).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [10]
In the citing paper
“The combination of microhypoxia and lipid overload triggers the recruitment of immune cells, such as macrophages in the adipose tissue and their activation ([103](#B103), [129](#B129), [171](#B171)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [171]
In the citing paper
“In 2003, two independent articles in the JCI highlighted the infiltration of macrophages into expanding AT as an important physiological phenomenon (5,6).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [6]
In the citing paper
“Excess body adiposity has been associated with activation of macrophages and associated inflammation in a variety of peripheral tissues including WAT, liver, skeletal muscle and the vasculature and eventually is accompanied by increased circulating plasma levels of pro-inflammatory cytokines (193, 207).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [193]
In the citing paper
“Visceral adipose tissue has an increased number of adipose resident macrophages.”
From The Vasculature in Prediabetes (2018) · cites this paper as [81]
In the citing paper
“Increased recruitment of pro-inflammatory macrophages to muscle167 and adipose81 results in transforming growth factor β (TGFβ)-mediated fibrosis.168”
From The Vasculature in Prediabetes (2018) · cites this paper as [81]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 15,068
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Flagged first, then by citations
Research works printed but not linked: 5
- 10.1210/jc.83.3.847 · DOI
- 10.1210/jc.82.5.1313 · DOI · Paper page
- 10.1210/en.136.5.2143 · DOI
- Torres, 1999, Invest. Ophthalmol. Vis. Sci., 40, 3194
- Schneider, 1981, Am. J. Physiol., 240, E358
Cited by
Sorted by citations
Items 1,001–1,100 of 1,236
The intestinal microbiota and obesity
Kallus, S. J., & Brandt, L. J. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823711fd · Cited by 210
Adipokines, diabetes and atherosclerosis: an inflammatory association
Freitas‐Lima, L. C., Braga, V. A., de França-Silva, M. D. S., Cruz, J. C., Santos, S. H. S., Monteiro, M. M. D. O., & Balarini, C. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00304 · Cited by 218
Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys
Kavanagh, K., Jones, K. L., Sawyer, J., Kelley, K., Carr, J. J., Wagner, J. D., & Rudel, L. L. (2007) · Obesity · doi:10.1038/oby.2007.200 · Cited by 208
Li, R.-Y., Qin, Q., Yang, H.-C., Wang, Y.-Y., Mi, Y.-X., Yin, Y.-S., Wang, M., Yu, C.-J., & Tang, Y. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00542-y · Cited by 204
Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function
Stadler, J. T., & Marsche, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238985 · Cited by 200
QUINN, L., STRAITBODEY, L., ANDERSON, B., ARGILES, J., & HAVEL, P. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.02.005 · Cited by 199
Immunologic and endocrine functions of adipose tissue: implications for kidney disease
Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200
Altintas, M. M., Azad, A., Nayer, B., Contreras, G., Zaias, J., Faul, C., Reiser, J., & Nayer, A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011338 · Cited by 198
Paniagua, J. A. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.483 · Cited by 197
Central regulation of stress-evoked peripheral immune responses
Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00729-2 · Cited by 207
On phagocytes and macular degeneration
Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.002 · Cited by 185
Varma, V., Yao-Borengasser, A., Bodles, A. M., Rasouli, N., Phanavanh, B., Nolen, G. T., Kern, E. M., Nagarajan, R., Spencer, H. J., Lee, M.-J., et al. (2008) · Diabetes · doi:10.2337/db07-0840 · Cited by 194
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194
Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
Aigner, E., Theurl, I., Theurl, M., Lederer, D., Haufe, H., Dietze, O., Strasser, M., Datz, C., & Weiss, G. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1374 · Cited by 190
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188
Adipose tissue and metabolic syndrome: too much, too little or neither
Grundy, S. M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12519 · Cited by 187
Mechanisms of endothelial dysfunction in obesity.
Avogaro, A., & de Kreutzenberg, S. V. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.04.020 · Cited by 188
Han, C. Y., Umemoto, T., Omer, M., Den Hartigh, L. J., Chiba, T., LeBoeuf, R., Buller, C. L., Sweet, I. R., Pennathur, S., Abel, E. D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304998 · Cited by 187
White, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185
Waters, D. L., & Baumgartner, R. N. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.007 · Cited by 185
Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
Zaragosi, L.-E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., et al. (2010) · Diabetes · doi:10.2337/db10-0013 · Cited by 184
Dahlman, I., Forsgren, M., Sjögren, A., Nordström, E. A., Kaaman, M., Näslund, E., Attersand, A., & Arner, P. (2006) · Diabetes · doi:10.2337/db05-1421 · Cited by 184
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183
Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
Spielman, L. J., Little, J. P., & Klegeris, A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.004 · Cited by 182
Disruption of CXC Motif Chemokine Ligand-14 in Mice Ameliorates Obesity-induced Insulin Resistance
Nara, N., Nakayama, Y., Okamoto, S., Tamura, H., Kiyono, M., Muraoka, M., Tanaka, K., Taya, C., Shitara, H., Ishii, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700412200 · Cited by 176
Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice
Morinaga, H., Mayoral, R., Heinrichsdorff, J., Osborn, O., Franck, N., Hah, N., Walenta, E., Bandyopadhyay, G., Pessentheiner, A. R., Chi, T. J., et al. (2015) · Diabetes · doi:10.2337/db14-1238 · Cited by 175
Tsatsoulis, A., Mantzaris, M. D., Bellou, S., & Andrikoula, M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.004 · Cited by 174
Ott, B., Skurk, T., Hastreiter, L., Lagkouvardos, I., Fischer, S., Büttner, J., Kellerer, T., Clavel, T., Rychlik, M., Haller, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12109-9 · Cited by 170
The Inflammasome in Atherosclerosis and Type 2 Diabetes
Masters, S. L., Latz, E., & O’Neill, L. A. J. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001902 · Cited by 169
Barrea, L., Marzullo, P., Muscogiuri, G., Di Somma, C., Scacchi, M., Orio, F., Aimaretti, G., Colao, A., & Savastano, S. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000136 · Cited by 171
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170
Cellular heterogeneity in adipose tissues
Corvera, S. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-095446 · Cited by 171
Physical Activity and Cancer Prevention: Pathways and Targets for Intervention
Rogers, C. J., Colbert, L. H., Greiner, J. W., Perkins, S. N., & Hursting, S. D. (2008) · Sports Medicine · doi:10.2165/00007256-200838040-00002 · Cited by 170
Pathophysiology of NASH: perspectives for a targeted treatment
Marra, F., & Lotersztajn, S. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990344 · Cited by 163
Dobrian, A. D., Ma, Q., Lindsay, J. W., Leone, K. A., Ma, K., Coben, J., Galkina, E. V., & Nadler, J. L. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00463.2010 · Cited by 166
Vila, I. K., Badin, P.-M., Marques, M.-A., Monbrun, L., Lefort, C., Mir, L., Louche, K., Bourlier, V., Roussel, B., Gui, P., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.062 · Cited by 165
Inflammatory markers and bariatric surgery: a meta-analysis
Rao, S. R. (2012) · Inflammation Research · doi:10.1007/s00011-012-0473-3 · Cited by 162
Herová, M., Schmid, M., Gemperle, C., & Hersberger, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402166 · Cited by 157
Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue
Han, C. Y. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.4.272 · Cited by 159
The role of interleukin-18 in the metabolic syndrome
Trøseid, M., Seljeflot, I., & Arnesen, H. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-11 · Cited by 155
Puig, K. L., Floden, A. M., Adhikari, R., Golovko, M. Y., & Combs, C. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030378 · Cited by 152
Plomgaard, P., Nielsen, A. R., Fischer, C. P., Mortensen, O. H., Broholm, C., Penkowa, M., Krogh-Madsen, R., Erikstrup, C., Lindegaard, B., Petersen, A. M. W., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0834-6 · Cited by 152
Goren, I., Müller, E., Schiefelbein, D., Christen, U., Pfeilschifter, J., Mühl, H., & Frank, S. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700842 · Cited by 151
Kirk, E. A., Sagawa, Z. K., McDonald, T. O., O'Brien, K. D., & Heinecke, J. W. (2008) · Diabetes · doi:10.2337/db07-1061 · Cited by 149
Brain Adipocytokine Action and Metabolic Regulation
Ahima, R. S., Qi, Y., Singhal, N. S., Jackson, M. B., & Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-s018 · Cited by 150
Angiogenesis, adipokines and breast cancer
Vona-Davis, L., & Rose, D. P. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.05.007 · Cited by 148
Arner, P., Arner, E., Hammarstedt, A., & Smith, U. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018284 · Cited by 146
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149
Hypothalamic inflammation and energy homeostasis: Resolving the paradox
Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.002 · Cited by 144
MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation
Ying, W., Tseng, A., Chang, R. C.-A., Morin, A., Brehm, T., Triff, K., Nair, V., Zhuang, G., Song, H., Kanameni, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81656 · Cited by 144
Impact of visceral adipose tissue on liver metabolism
Lafontan, M., & Girard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.04.001 · Cited by 143
Gut Microbiota in Obesity and Undernutrition
de Clercq, N. C., Groen, A. K., Romijn, J. A., & Nieuwdorp, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012914 · Cited by 140
Bauernfeind, F., Niepmann, S., Knolle, P. A., & Hornung, V. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501336 · Cited by 137
Jung, T. W., Park, H. S., Choi, G. H., Kim, D., & Lee, T. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0431-7 · Cited by 137
The Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137
Melby, C., Paris, H., Foright, R., & Peth, J. (2017) · Nutrients · doi:10.3390/nu9050468 · Cited by 136
Calcium and 1,25‐Dihydroxyvitamin D3 Regulation of Adipokine Expression
Sun, X., & Zemel, M. B. (2007) · Obesity · doi:10.1038/oby.2007.540 · Cited by 137
The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
Skurk, T., Kolb, H., Müller-Scholze, S., Röhrig, K., Hauner, H., & Herder, C. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01897 · Cited by 135
Orellana-Gavaldà, J. M., Herrero, L., Malandrino, M. I., Pañeda, A., Sol Rodríguez-Peña, M., Petry, H., Asins, G., Van Deventer, S., Hegardt, F. G., & Serra, D. (2011) · Hepatology · doi:10.1002/hep.24140 · Cited by 135
Evidence of proatherogenic inflammation in polycystic ovary syndrome
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.022 · Cited by 135
Rodriguez, A., Catalan, V., Gomez-Ambrosi, J., & Fruhbeck, G. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781039599 · Cited by 133
Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?
Bing, C. (2015) · Adipocyte · doi:10.4161/21623945.2014.979661 · Cited by 127
Johnson, A. R., Qin, Y., Cozzo, A. J., Freemerman, A. J., Huang, M. J., Zhao, L., Sampey, B. P., Milner, J. J., Beck, M. A., Damania, B., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.005 · Cited by 130
Vasudevan, A. R., Wu, H., Xydakis, A. M., Jones, P. H., Smith, E. O., Sweeney, J. F., Corry, D. B., & Ballantyne, C. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1280 · Cited by 132
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling
Ying, W., Wollam, J., Ofrecio, J. M., Bandyopadhyay, G., El Ouarrat, D., Lee, Y. S., Oh, D. Y., Li, P., Osborn, O., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90350 · Cited by 128
Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome
Fujita, T. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.149062 · Cited by 130
Bettiga, A., Fiorio, F., Di Marco, F., Trevisani, F., Romani, A., Porrini, E., Salonia, A., Montorsi, F., & Vago, R. (2019) · Nutrients · doi:10.3390/nu11081748 · Cited by 127
Higami, Y., Barger, J. L., Page, G. P., Allison, D. B., Smith, S. R., Prolla, T. A., & Weindruch, R. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.2.343 · Cited by 126
Fonken, L. K., Lieberman, R. A., Weil, Z. M., & Nelson, R. J. (2013) · Endocrinology · doi:10.1210/en.2013-1121 · Cited by 125
Double diabetes: a distinct high-risk group?
Kietsiriroje, N., Pearson, S., Campbell, M., Ariëns, R. A. S., & Ajjan, R. A. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13848 · Cited by 123
Alam, M. A., Uddin, R., Subhan, N., Rahman, M. M., Jain, P., & Reza, H. M. (2015) · Journal of Lipids · doi:10.1155/2015/496169 · Cited by 123
“Furthermore, inflammatory cells such as macrophages infiltration are also increased in adipose tissues [12].”
BackgroundOkuno, Y., Fukuhara, A., Hashimoto, E., Kobayashi, H., Kobayashi, S., Otsuki, M., & Shimomura, I. (2018) · Diabetes · doi:10.2337/db17-1032 · Cited by 124
Obesity: A neuroimmunometabolic perspective
Larabee, C. M., Neely, O. C., & Domingos, A. I. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0283-6 · Cited by 123
Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism
Tanianskii, D. A., Jarzebska, N., Birkenfeld, A. L., O’Sullivan, J. F., & Rodionov, R. N. (2019) · Nutrients · doi:10.3390/nu11030524 · Cited by 121
Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction
Thakker, G. D., Frangogiannis, N. G., Bujak, M., Zymek, P., Gaubatz, J. W., Reddy, A. K., Taffet, G., Michael, L. H., Entman, M. L., & Ballantyne, C. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00322.2006 · Cited by 121
Increased Glucose Uptake in Visceral Versus Subcutaneous Adipose Tissue Revealed by PET Imaging
Christen, T., Sheikine, Y., Rocha, V. Z., Hurwitz, S., Goldfine, A. B., Di Carli, M., & Libby, P. (2010) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2010.06.004 · Cited by 120
Rydén, M., & Arner, P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01854.x · Cited by 118
Modulation of glucose metabolism by the renin-angiotensin-aldosterone system
Favre, G. A., Esnault, V. L. M., & Van Obberghen, E. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00391.2014 · Cited by 114
Conjugated linoleic acid and inflammatory cell signalling
Reynolds, C. M., & Roche, H. M. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.021 · Cited by 118
Brain inflammation and hypertension: the chicken or the egg?
Winklewski, P. J., Radkowski, M., Wszedybyl-Winklewska, M., & Demkow, U. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0306-8 · Cited by 116
Murabayashi, N., Sugiyama, T., Zhang, L., Kamimoto, Y., Umekawa, T., Ma, N., & Sagawa, N. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.02.003 · Cited by 114
A Switch in Hepatic Cortisol Metabolism across the Spectrum of Non Alcoholic Fatty Liver Disease
Ahmed, A., Rabbitt, E., Brady, T., Brown, C., Guest, P., Bujalska, I. J., Doig, C., Newsome, P. N., Hubscher, S., Elias, E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029531 · Cited by 115
Kogelman, L. J. A., Cirera, S., Zhernakova, D. V., Fredholm, M., Franke, L., & Kadarmideen, H. N. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-57 · Cited by 106
Lee, Y., Ka, S.-O., Cha, H.-N., Chae, Y.-N., Kim, M.-K., Park, S.-Y., Bae, E. J., & Park, B.-H. (2017) · Diabetes · doi:10.2337/db16-1446 · Cited by 114
Fatty acids and the metabolic syndrome
Roche, H. M. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004405 · Cited by 113
Lackey, D. E., Burk, D. H., Ali, M. R., Mostaedi, R., Smith, W. H., Park, J., Scherer, P. E., Seay, S. A., McCoin, C. S., Bonaldo, P., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00476.2013 · Cited by 111
Zhang, X., Lam, K. S. L., Ye, H., Chung, S. K., Zhou, M., Wang, Y., & Xu, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135509 · Cited by 112
Guo, C., Huang, T., Chen, A., Chen, X., Wang, L., Shen, F., & Gu, X. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20165826 · Cited by 112
Effects of exercise on adipokines and the metabolic syndrome
You, T., & Nicklas, B. J. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0003-4 · Cited by 112
Yamada, H., Yoshida, M., Nakano, Y., Suganami, T., Satoh, N., Mita, T., Azuma, K., Itoh, M., Yamamoto, Y., Kamei, Y., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.171736 · Cited by 112
Cai, J., Pires, K. M., Ferhat, M., Chaurasia, B., Buffolo, M. A., Smalling, R., Sargsyan, A., Atkinson, D. L., Summers, S. A., Graham, T. E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.040 · Cited by 107
“, 2011) but also contributes to insulin resistance (Weisberg et al., 2003).”
BackgroundFatty Acids - Induced Lipotoxicity and Inflammation
Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762729 · Cited by 111
Lee, G., Kim, Y. Y., Jang, H., Han, J. S., Nahmgoong, H., Park, Y. J., Han, S. M., Cho, C., Lim, S., Noh, J.-R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.010 · Cited by 111
Adipose tissue inflammation in aging
Mau, T., & Yung, R. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.014 · Cited by 110
Ageing, adipose tissue, fatty acids and inflammation
Pararasa, C., Bailey, C. J., & Griffiths, H. R. (2015) · Biogerontology · doi:10.1007/s10522-014-9536-x · Cited by 110
Zhu, S., Zhang, B., Jiang, X., Li, Z., Zhao, S., Cui, L., & Chen, Z.-J. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.09.013 · Cited by 109
B‐1a lymphocytes attenuate insulin resistance
Shen, L., Chng, M. H. Y., Alonso, M. N., Yuan, R., Winer, D. A., & Engleman, E. G. (2015) · Diabetes · doi:10.2337/db14-0554 · Cited by 109
High-fat diet causes psychiatric disorders in mice by increasing Proteobacteria population
Jeong, M.-Y., Jang, H.-M., & Kim, D.-H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.006 · Cited by 110
O’Hara, A., Lim, F.-L., Mazzatti, D. J., & Trayhurn, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0693-8 · Cited by 108
Inflammation in subcutaneous adipose tissue: relationship to adipose cell size
McLaughlin, T., Deng, A., Yee, G., Lamendola, C., Reaven, G., Tsao, P. S., Cushman, S. W., & Sherman, A. (2010) · Diabetologia · doi:10.1007/s00125-009-1496-3 · Cited by 105
Metadata
- Authors
- Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Ferrante, Anthony W.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-12-15
- Volume
- 112
- Issue
- 12
- Pages
- 1796-1808
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC296995
- OpenAlex
- W2008869160
- Cited by
- 10,041
- References
- 99
- Citations by year
- 2026: 265 · 2025: 337 · 2024: 420 · 2023: 373 · 2022: 460 · 2021: 504 · 2020: 524 · 2019: 494 · 2018: 536 · 2017: 537 · 2016: 530 · 2015: 558 · 2014: 575 · 2013: 683 · 2012: 554
- FWCI
- 130.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Clinical Investigation (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russell Berrie Foundation
- National Institutes of Health (K08 DK)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064773, R01DK052431, K08DK059960, R01DK066525)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, adipose tissue macrophages, macrophage accumulation, perigonadal adipose tissue, F4/80, CD68, bone marrow-derived macrophages, adipose tissue inflammation, TNF-α, inducible nitric oxide synthase, interleukin-6, adipocyte size, body mass, subcutaneous adipose tissue
- MeSH terms
- CD68 Molecule, Adipose Tissue, Animals, Body Weight, Cell Separation, Female, Flow Cytometry, Humans, Immunohistochemistry, Liver, Macrophages, Male, Mice, Inbred C57BL, Obesity, RNA, Messenger, Time Factors, Tumor Necrosis Factor-alpha, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Interleukin-6, Immunophenotyping, Leukocyte Common Antigens, Nitric Oxide Synthase, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Mice, Nitric Oxide Synthase Type II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
