Cited by 850Sleep and Work-Related FatigueSleep and Wakefulness ResearchCircadian rhythm and melatonin

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation

Irwin, Michael R.·2006·Archives of Internal Medicine

Open this paper in CoChat — free account

Abstract

BACKGROUND: Inflammation is associated with increased risk of cardiovascular disorders, arthritis, diabetes mellitus, and mortality. The effects of sleep loss on the cellular and genomic mechanisms that contribute to inflammatory cytokine activity are not known. METHODS: In 30 healthy adults, monocyte intracellular proinflammatory cytokine production was repeatedly assessed during the day across 3 baseline periods and after partial sleep deprivation (awake from 11 pm to 3 am). We analyzed the impact of sleep loss on transcription of proinflammatory cytokine genes and used DNA microarray analyses to characterize candidate transcription-control pathways that might mediate the effects of sleep loss on leukocyte gene expression. RESULTS: In the morning after a night of sleep loss, monocyte production of interleukin 6 and tumor necrosis factor alpha was significantly greater compared with morning levels following uninterrupted sleep. In addition, sleep loss induced a more than 3-fold increase in transcription of interleukin 6 messenger RNA and a 2-fold increase in tumor necrosis factor alpha messenger RNA. Bioinformatics analyses suggested that the inflammatory response was mediated by the nuclear factor kappaB inflammatory signaling system as well as through classic hormone and growth factor response pathways. CONCLUSIONS: Sleep loss induces a functional alteration of the monocyte proinflammatory cytokine response. A modest amount of sleep loss also alters molecular processes that drive cellular immune activation and induce inflammatory cytokines; mapping the dynamics of sleep loss on molecular signaling pathways has implications for understanding the role of sleep in altering immune cell physiologic characteristics. Interventions that target sleep might constitute new strategies to constrain inflammation with effects on inflammatory disease risk.

Integrity signals

Registry

Crossref · 10.1001/archinte.166.16.1756

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Epidemiology of insomnia: what we know and what we still need to learn
Ohayon, M. M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0186 · Cited by 3,743
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Mortality Associated With Sleep Duration and Insomnia
Kripke, D. F., Garfinkel, L., Wingard, D. L., Klauber, M. R., & Marler, M. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.131 · Cited by 1,614
Sleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities
Foley, D. J., Monjan, A. A., Brown, S. L., Simonsick, E. M., Wallace, R. B., & Blazer, D. G. (1995) · Sleep · doi:10.1093/sleep/18.6.425 · Cited by 1,610
Sleep and Psychiatric Disorders: A Meta-analysis
Benca, R. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080059010 · Cited by 1,468
GOstat: find statistically overrepresented Gene Ontologies within a group of genes
Beißbarth, T., & Speed, T. P. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth088 · Cited by 1,256
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
Circadian variation in the frequency of sudden cardiac death.
Muller, J. E., Ludmer, P. L., Willich, S. N., Tofler, G. H., Aylmer, G., Klangos, I., & Stone, P. H. (1987) · Circulation · doi:10.1161/01.cir.75.1.131 · Cited by 1,083

Show all 44 references

Sorted by citations

Sleep disturbance, sleep duration, and inflammation: A systematic review and meta-analysis of cohort studies and experimental sleep deprivation
Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.014 · Cited by 2,085
Self-citation
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“Following sleep deprivation in the first night half, TNF production in monocytes and TNF mRNA were shown to be increased in the morning (256, 262, 264).”
Background
Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective
Irwin, M. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115205 · Cited by 1,325
“Partial-night sleep deprivation induces an increase in TLR-4-stimulated production of IL-6 and TNF, which is especially prominent in women who show sustained elevations ADRB2 TLR4 Circulation SNS nerve fibers Cardiovascular disease Major depressive disorder Cancer NF-κB Expression of proinflammatory immune response ge…”
BackgroundInfluentialSelf-citation
Reciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910
“Wake–sleep cycles have emerged as prominent regulators of inflammatory biology, with experimental sleep restriction studies showing upregulated leukocyte expression of pro-inflammatory cytokine genes and increased NF-κB activit”
BackgroundSelf-citation
Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments
Buysse, D. J., Yu, L., Moul, D. E., Germain, A., Stover, A., Dodds, N. E., Johnston, K. L., Shablesky-Cade, M. A., & Pilkonis, P. A. (2010) · Sleep · doi:10.1093/sleep/33.6.781 · Cited by 850
Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
Mullington, J. M., Haack, M., Toth, M., Serrador, J. M., & Meier-Ewert, H. K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.003 · Cited by 783
Social regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745
“Bioinformatic analyses of differentially expressing promoters [41,42] test the specific hypotheses that immune cells from high-lonely individuals show in vivo, under basal physiological conditions: 1.”
Background
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676
Self-citation
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624
Self-citation
Sleep habits and susceptibility to the common cold
Cohen, S., Doyle, W. J., Alper, C. M., Janicki-Deverts, D., & Turner, R. B. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.505 · Cited by 605
Sleep Duration and Biomarkers of Inflammation
Patel, S. R., Zhu, X., Storfer-Isser, A., Mehra, R., Jenny, N. S., Tracy, R., & Redline, S. (2009) · Sleep · doi:10.1093/sleep/32.2.200 · Cited by 615
Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes
Reutrakul, S., & Van Cauter, E. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.010 · Cited by 584
Joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society on the recommended amount of sleep for a healthy adult: methodology and discussion
Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., et al. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4950 · Cited by 568
A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552
The Emerging Field of Human Social Genomics
Slavich, G. M., & Cole, S. W. (2013) · Clinical Psychological Science · doi:10.1177/2167702613478594 · Cited by 523
Is depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524
Sleep loss and inflammation
Mullington, J. M., Simpson, N. S., Meier-Ewert, H. K., & Haack, M. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.014 · Cited by 519
Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances: A Randomized Clinical Trial
Black, D. S., O’Reilly, G. A., Olmstead, R., Breen, E. C., & Irwin, M. R. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.8081 · Cited by 491
Self-citation
To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers
O’Connor, M.-F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., Hoyt, M. A., Martin, J. L., Robles, T. F., Sloan, E. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.005 · Cited by 500
Self-citation
Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation
Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499
Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
van Leeuwen, W. M. A., Lehto, M., Karisola, P., Lindholm, H., Luukkonen, R., Sallinen, M., Härmä, M., Porkka-Heiskanen, T., & Alenius, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004589 · Cited by 483
Sleep Loss Activates Cellular Inflammatory Signaling
Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., Martinez-Maza, O., & Cole, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.004 · Cited by 467
Self-citation
Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery
Faraut, B., Boudjeltia, K. Z., Vanhamme, L., & Kerkhofs, M. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.05.001 · Cited by 418
Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?
Danese, A., & J Lewis, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.198 · Cited by 393
Short sleep duration and cardiometabolic risk: from pathophysiology to clinical evidence
Tobaldini, E., Fiorelli, E. M., Solbiati, M., Costantino, G., Nobili, L., & Montano, N. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0109-6 · Cited by 357
Sleep deprivation during pregnancy and maternal and fetal outcomes: is there a relationship?
Chang, J. J., Pien, G. W., Duntley, S. P., & Macones, G. A. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.05.001 · Cited by 339
The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults
Frey, D. J., Fleshner, M., & Wright, K. P. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.003 · Cited by 330
New neurons in the adult brain: the role of sleep and consequences of sleep loss
Meerlo, P., Mistlberger, R. E., Jacobs, B. L., Craig Heller, H., & McGinty, D. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.004 · Cited by 318
Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes
Reutrakul, S., & Van Cauter, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12355 · Cited by 321
Habitual sleep duration associated with self-reported and objectively determined cardiometabolic risk factors
Grandner, M. A., Chakravorty, S., Perlis, M. L., Oliver, L., & Gurubhagavatula, I. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.09.012 · Cited by 300
“Sleep loss is associated with a proinflammatory state [96], with noted elevations in a number of proinflammatory biomarkers such as IL-6 [97–103] and tumor necrosis factor [36,97,98, 100,104–106].”
Cognitive Behavioral Therapy vs. Tai Chi for Late Life Insomnia and Inflammatory Risk: A Randomized Controlled Comparative Efficacy Trial
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Breen, E. C., Witarama, T., Yokomizo, M., Lavretsky, H., Carroll, J. E., Motivala, S. J., et al. (2014) · Sleep · doi:10.5665/sleep.4008 · Cited by 303
Self-citation
Stress, Sleep and Recovery in Elite Soccer: A Critical Review of the Literature
Nédélec, M., Halson, S., Abaidia, A.-E., Ahmaidi, S., & Dupont, G. (2015) · Sports Medicine · doi:10.1007/s40279-015-0358-z · Cited by 291
Sleep loss activates cellular markers of inflammation: Sex differences
Irwin, M. R., Carrillo, C., & Olmstead, R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.06.001 · Cited by 287
Self-citation
Hidden wounds? inflammatory links between childhood trauma and psychopathology
Danese, A., & Baldwin, J. R. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044208 · Cited by 286
Sleep Loss Exacerbates Fatigue, Depression, and Pain in Rheumatoid Arthritis
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., FitzGerald, J. D., Ranganath, V. K., & Nicassio, P. M. (2012) · Sleep · doi:10.5665/sleep.1742 · Cited by 279
Self-citation
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253
Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context
Ruiz-Núñez, B., Pruimboom, L., Dijck-Brouwer, D. A. J., & Muskiet, F. A. J. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.02.009 · Cited by 246
Sleep duration, cardiovascular disease, and proinflammatory biomarkers
Grandner, M., Sands-Lincoln, Pak, & Garland (2013) · Nature and Science of Sleep · doi:10.2147/nss.s31063 · Cited by 246
Hypertension and sleep: Overview of a tight relationship
Pepin, J.-L., Borel, A.-L., Tamisier, R., Baguet, J.-P., Levy, P., & Dauvilliers, Y. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.03.003 · Cited by 245
Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late-Life Insomnia: A Randomized Controlled Trial
Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., Arevalo, J. M. G., Ma, J., Nicassio, P., Bootzin, R., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.010 · Cited by 227
Self-citation
Depression, social support, and beta-adrenergic transcription control in human ovarian cancer
Lutgendorf, S. K., DeGeest, K., Sung, C. Y., Arevalo, J. M., Penedo, F., Lucci, J., Goodheart, M., Lubaroff, D., Farley, D. M., Sood, A. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.04.155 · Cited by 215
Sleep and Antibody Response to Hepatitis B Vaccination
Prather, A. A., Hall, M., Fury, J. M., Ross, D. C., Muldoon, M. F., Cohen, S., & Marsland, A. L. (2012) · SLEEP · doi:10.5665/sleep.1990 · Cited by 207
A prospective study of sleep duration and pneumonia risk in women
Patel, S. R., Malhotra, A., Gao, X., Hu, F. B., Neuman, M. I., & Fawzi, W. W. (2012) · Sleep · doi:10.5665/sleep.1594 · Cited by 195
Cross-sectional versus Prospective Associations of Sleep Duration with Changes in Relative Weight and Body Fat Distribution
Stranges, S., Cappuccio, F. P., Kandala, N.-B., Miller, M. A., Taggart, F. M., Kumari, M., Ferrie, J. E., Shipley, M. J., Brunner, E. J., & Marmot, M. G. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm302 · Cited by 196
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity
Lucassen, E. A., Rother, K. I., & Cizza, G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06655.x · Cited by 191
Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men
Chennaoui, M., Sauvet, F., Drogou, C., Van Beers, P., Langrume, C., Guillard, M., Gourby, B., Bourrilhon, C., Florence, G., & Gomez-Merino, D. (2011) · Cytokine · doi:10.1016/j.cyto.2011.06.002 · Cited by 186
Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior
Raison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183
Sleep duration, insomnia, and markers of systemic inflammation: Results from the Netherlands Study of Depression and Anxiety (NESDA)
Prather, A. A., Vogelzangs, N., & Penninx, B. W. J. H. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.018 · Cited by 181
Inflammation, Sanitation, and Consternation: Loss of Contact With Coevolved, Tolerogenic Microorganisms and the Pathophysiology and Treatment of Major Depression
Raison, C. L., Lowry, C. A., & Rook, G. A. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.161 · Cited by 169
Social influences on clinical outcomes of patients with ovarian cancer
Lutgendorf, S. K., De Geest, K., Bender, D., Ahmed, A., Goodheart, M. J., Dahmoush, L., Zimmerman, M. B., Penedo, F. J., Lucci, J. A., Ganjei-Azar, P., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.4411 · Cited by 177
Sleep disturbance, inflammation and depression risk in cancer survivors
Irwin, M. R., Olmstead, R. E., Ganz, P. A., & Haque, R. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.002 · Cited by 173
Self-citation
Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study
Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.008 · Cited by 173
Self-citation
Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance
Pejovic, S., Basta, M., Vgontzas, A. N., Kritikou, I., Shaffer, M. L., Tsaoussoglou, M., Stiffler, D., Stefanakis, Z., Bixler, E. O., & Chrousos, G. P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2013 · Cited by 166
REM Sleep Deprivation in Rats Results in Inflammation and Interleukin-17 Elevation
Yehuda, S., Sredni, B., Carasso, R. L., & Kenigsbuch-Sredni, D. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0080 · Cited by 158
Association between Sleep Duration and Mortality Is Mediated by Markers of Inflammation and Health in Older Adults: The Health, Aging and Body Composition Study
Hall, M. H., Smagula, S. F., Boudreau, R. M., Ayonayon, H. N., Goldman, S. E., Harris, T. B., Naydeck, B. L., Rubin, S. M., Samuelsson, L., Satterfield, S., et al. (2015) · Sleep · doi:10.5665/sleep.4394 · Cited by 155
Sexual Minority Health and Health Risk Factors
Hsieh, N., & Ruther, M. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.11.016 · Cited by 152
Marital happiness and sleep disturbances in a multi-ethnic sample of middle-aged women
Troxel, W. M., Buysse, D. J., Hall, M., & Matthews, K. A. (2009) · Behavioral Sleep Medicine · doi:10.1080/15402000802577736 · Cited by 142
Evidence for Neuroinflammatory and Microglial Changes in the Cerebral Response to Sleep Loss
Wisor, J. P., Schmidt, M. A., & Clegern, W. C. (2011) · Sleep · doi:10.1093/sleep/34.3.261 · Cited by 141
Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
Carroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.024 · Cited by 129
Self-citation
Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers
Ruiz, F. S., Andersen, M. L., Martins, R. C., Zager, A., Lopes, J. D., & Tufik, S. (2012) · Innate Immunity · doi:10.1177/1753425910385962 · Cited by 132
Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance
Abedelmalek, S., Chtourou, H., Aloui, A., Aouichaoui, C., Souissi, N., & Tabka, Z. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2432-7 · Cited by 128
Elevating the perspective on human stress genomics
Cole, S. W. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.06.008 · Cited by 123
Fatigue in Inflammatory Bowel Diseases: Etiologies and Management
Nocerino, A., Nguyen, A., Agrawal, M., Mone, A., Lakhani, K., & Swaminath, A. (2020) · Advances in Therapy · doi:10.1007/s12325-019-01151-w · Cited by 126
Association between sleep deficiency and cardiometabolic disease: implications for health disparities
Rangaraj, V. R., & Knutson, K. L. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.535 · Cited by 120
Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol
Raison, C. L., Rye, D. B., Woolwine, B. J., Vogt, G. J., Bautista, B. M., Spivey, J. R., & Miller, A. H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.019 · Cited by 116
Short Sleep Duration is Associated with the Development of Impaired Fasting Glucose: The Western New York Health Study
Rafalson, L., Donahue, R. P., Stranges, S., Lamonte, M. J., Dmochowski, J., Dorn, J., & Trevisan, M. (2010) · Annals of Epidemiology · doi:10.1016/j.annepidem.2010.05.002 · Cited by 118
Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation
Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.013 · Cited by 105
Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health
Mullington, J. M., Abbott, S. M., Carroll, J. E., Davis, C. J., Dijk, D.-J., Dinges, D. F., Gehrman, P. R., Ginsburg, G. S., Gozal, D., Haack, M., et al. (2016) · Sleep · doi:10.5665/sleep.5616 · Cited by 105
Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Cho, H. J., Seeman, T. E., Kiefe, C. I., Lauderdale, D. S., & Irwin, M. R. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.02.023 · Cited by 108
Self-citation
Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production
Prather, A. A., Marsland, A. L., Hall, M., Neumann, S. A., Muldoon, M. F., & Manuck, S. B. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.008 · Cited by 106
Disturbed Sleep and Inflammatory Cytokines in Depressed and Nondepressed Pregnant Women: An Exploratory Analysis of Pregnancy Outcomes
Okun, M. L., Luther, J. F., Wisniewski, S. R., & Wisner, K. L. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829cc3e7 · Cited by 94
Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans
Aho, V., Ollila, H. M., Rantanen, V., Kronholm, E., Surakka, I., van Leeuwen, W. M. A., Lehto, M., Matikainen, S., Ripatti, S., Härmä, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077184 · Cited by 93
Cellular Aging and Restorative Processes: Subjective Sleep Quality and Duration Moderate the Association between Age and Telomere Length in a Sample of Middle-Aged and Older Adults
Cribbet, M. R., Carlisle, M., Cawthon, R. M., Uchino, B. N., Williams, P. G., Smith, T. W., Gunn, H. E., & Light, K. C. (2014) · Sleep · doi:10.5665/sleep.3308 · Cited by 93
Non-Pharmacological Treatment of Insomnia
Siebern, A. T., Suh, S., & Nowakowski, S. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0142-9 · Cited by 88
C-reactive protein Levels and Sleep Disturbances: Observations Based on The Northern Finland 1966 Birth Cohort Study
Liukkonen, T., Räsänen, P., Ruokonen, A., Laitinen, J., Jokelainen, J., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318157cb96 · Cited by 83
Association between maternal sleep duration and quality, and the risk of preterm birth: a systematic review and meta-analysis of observational studies
Wang, L., & Jin, F. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-2814-5 · Cited by 73
Post-traumatic Stress Disorder and Cardiovascular Disease
Burg, M. M., & Soufer, R. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0770-5 · Cited by 72
A longitudinal study of sleep duration in pregnancy and subsequent risk of gestational diabetes: findings from a prospective, multiracial cohort
Rawal, S., Hinkle, S. N., Zhu, Y., Albert, P. S., & Zhang, C. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.11.1051 · Cited by 69
Sleep Deprivation and Divergent Toll-like Receptor-4 Activation of Cellular Inflammation in Aging
Carroll, J. E., Carrillo, C., Olmstead, R., Witarama, T., Breen, E. C., Yokomizo, M., Seeman, T. E., & Irwin, M. R. (2015) · Sleep · doi:10.5665/sleep.4398 · Cited by 67
Self-citation
Increased CD4 counts, pain and depression are correlates of lower sleep quality in treated HIV positive patients with low baseline CD4 counts
Redman, K. N., Karstaedt, A. S., & Scheuermaier, K. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.002 · Cited by 62
Preexisting mild sleep disturbance as a vulnerability factor for inflammation-induced depressed mood: a human experimental study
Cho, H. J., Eisenberger, N. I., Olmstead, R., Breen, E. C., & Irwin, M. R. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.23 · Cited by 64
Self-citation
Improved sleep efficiency after anti-tumor necrosis factor α therapy in rheumatoid arthritis patients
Taylor-Gjevre, R. M., Gjevre, J. A., Skomro, R. P., Nair, B. V., & Lim, H. J. (2011) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x11416862 · Cited by 61
Sleep disturbances and inflammatory biomarkers in schizophrenia: focus on sex differences
Lee, E. E., Ancoli-Israel, S., Eyler, L. T., Tu, X. M., Palmer, B. W., Irwin, M. R., & Jeste, D. V. (2019) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.09.017 · Cited by 58
Self-citation
Differential acute effects of sleep on spontaneous and stimulated production of tumor necrosis factor in men
Dimitrov, S., Besedovsky, L., Born, J., & Lange, T. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.11.017 · Cited by 56
Sleep and future cardiovascular risk: prospective analysis from the English Longitudinal Study of Ageing
Jackowska, M., & Steptoe, A. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.530 · Cited by 56
Social Media Use and Its Link to Physical Health Indicators
Lee, D. S., Jiang, T., Crocker, J., & Way, B. M. (2022) · Cyberpsychology, Behavior, and Social Networking · doi:10.1089/cyber.2021.0188 · Cited by 53
Sleep and inflammatory markers in different psychiatric disorders
Krysta, K., Krzystanek, M., Bratek, A., & Krupka-Matuszczyk, I. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-015-1492-3 · Cited by 53
Sleep Disturbance and Older Adults' Inflammatory Responses to Acute Stress
Heffner, K. L., Ng, H. M., Suhr, J. A., France, C. R., Marshall, G. D., Pigeon, W. R., & Moynihan, J. A. (2012) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31824361de · Cited by 52
The Relationship and Potential Mechanistic Pathways Between Sleep Disturbances and Maternal Hyperglycemia
Izci-Balserak, B., & Pien, G. W. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0459-8 · Cited by 52
Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery
Pellegrino, R., Sunaga, D. Y., Guindalini, C., Martins, R. C. S., Mazzotti, D. R., Wei, Z., Daye, Z. J., Andersen, M. L., & Tufik, S. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00058.2012 · Cited by 42
Nervous system regulation of the cancer genome
Cole, S. W. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.11.008 · Cited by 41
Perceived Immune Status and Sleep: A Survey among Dutch Students
Donners, A. A. M. T., Tromp, M. D. P., Garssen, J., Roth, T., & Verster, J. C. (2015) · Sleep Disorders · doi:10.1155/2015/721607 · Cited by 40
Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise
Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. D. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.018 · Cited by 38
Sleep duration and area-level deprivation in twins
Watson, N. F., Horn, E., Duncan, G. E., Buchwald, D., Vitiello, M. V., & Turkheimer, E. (2016) · SLEEP · doi:10.5665/sleep.5320 · Cited by 33
Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients
Fornadi, K., Lindner, A., Czira, M. E., Szentkiralyi, A., Lazar, A. S., Zoller, R., Turanyi, C. Z., Veber, O., Novak, M., Mucsi, I., et al. (2012) · International Urology and Nephrology · doi:10.1007/s11255-011-0095-7 · Cited by 32
Cross-Translational Studies in Human and Drosophila Identify Markers of Sleep Loss
Thimgan, M. S., Gottschalk, L., Toedebusch, C., McLeland, J., Rechtschaffen, A., Gilliland-Roberts, M., Duntley, S. P., & Shaw, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061016 · Cited by 26
Sleep, stress, and immunity
Prather, A. A. (2019) · Sleep and Health · doi:10.1016/b978-0-12-815373-4.00024-1 · Cited by 27
One's sex, sleep, and posttraumatic stress disorder
Kobayashi, I., Cowdin, N., & Mellman, T. A. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-29 · Cited by 22
Paradoxical sleep deprivation impairs mouse survival after infection with malaria parasites
Lungato, L., Gazarini, M. L., Paredes-Gamero, E. J., Tufik, S., & D’Almeida, V. (2015) · Malaria Journal · doi:10.1186/s12936-015-0690-7 · Cited by 21

Authors: Irwin, M. R.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Irwin, Michael R.
ORCID: Irwin, Michael R.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2006-09-18
Volume: 166
Issue: 16
Pages: 1756
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.166.16.1756
OpenAlex: W2148230248
Cited by: 850
References: 44
Citations by year: 2026: 30 · 2025: 54 · 2024: 48 · 2023: 45 · 2022: 65 · 2021: 42 · 2020: 41 · 2019: 42 · 2018: 44 · 2017: 41 · 2016: 48 · 2015: 54 · 2014: 36 · 2013: 59 · 2012: 48
FWCI: 36.16
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA13239, R01AA013239)
National Institute on Aging (AG 18367, R01AG018367)
National Heart, Lung, and Blood Institute (HL 079955, R01HL079955)
National Institute of Mental Health (MH-55253, R01MH055253, T32MH019925, T32 MH 19925)
National Institute on Drug Abuse (R01DA016541, DA 16541)
National Institute of Allergy and Infectious Diseases (AI 52737, R01AI052737)
National Center for Research Resources (M-01RR00827, (M01 RR00865), M01RR000865, M01RR000827)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep deprivation, inflammation, monocytes, interleukin-6, TNF-α, inflammatory cytokines, cytokine gene transcription, NF-κB signaling, leukocyte gene expression, immune activation
MeSH terms: Adult, Female, Flow Cytometry, Humans, Male, Middle Aged, Monocytes, RNA, Messenger, Sleep Deprivation, Transcription, Genetic, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks