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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

Barnes, Peter J., Karin, Michael·1997·New England Journal of Medicine

Abstract

In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the inflammatory state.1 These activated cells produce many other mediators of inflammation.What causes these diseases is still a mystery, but the disease process results from an interplay of genetic and environmental factors. Genes, such as those for atopy in asthma and for HLA antigens in rheumatoid arthritis and inflammatory bowel disease, may determine a patient's susceptibility to the disease and the disease's severity, but environmental factors, often unknown, . . .

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Cited by

Metadata

Authors
Barnes, P. J., & Karin, M.
Venue
New England Journal of Medicine
Published
1997-04-10
Volume
336
Issue
15
Pages
1066-1071
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2331176038
Cited by
4,669
References
7
FWCI
71.65
Type
journal article
Language
en
Open access
closed

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