The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster)
Abstract
This study compared the effects of centrally administered oxytocin (OT) and arginine vasopressin (AVP) on partner preference formation and social contact in male and female prairie voles (Microtus ochrogaster). After 1 hr of cohabitation and pretreatment with either AVP or OT, both males and females exhibited increased social contact and significant preference for the familiar partner. After pretreatment with either an OT receptor antagonist (OTA) or an AVP (V1a) receptor antagonist (AVPA), neither OT nor AVP induced a partner preference. In addition, treatment with OT+OTA or AVP+AVPA was associated with low levels of social contact in both sexes. Either AVP or OT is sufficient to facilitate social contact if either the OT or AVP receptor is available. However, the formation of partner preferences may require access to both AVP and OT receptors.
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Infusion of oxytocin into the brains of female prairie voles and vasopressin in males facilitated pair-bonding even in the absence of actual mating.
“Infusion of oxytocin into the brains of female prairie voles and vasopressin in males, for instance, facilitated pair-bonding even in the absence of actual mating (Cho et al. 1999; Insel and Hulihan 1995; Williams et al. 1994; Winslow et al. 1993).”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Cho et al. 1999
The findings are consistent with those in other mammals, particularly monogamous rodent species where oxytocin plays a critical role in pair-bond formation.
“These findings are consistent with those reported for other mammals, particularly monogamous rodent species in which OT has shown to play a critical role in the formation of pair-bonds (Cho et al., 1999; Insel and Hulihan, 1995; Williams et al., 1994).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Cho et al., 1999
Intracerebroventricular oxytocin can induce partner preference and bonding in both male and female prairie voles.
“However, nonspecific intracerebroventricular administration of OXT can induce a partner preference and bonding in both males and females (10).”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [10]
The CD38-KO mouse has a deficit in OT secretion and is impaired in its ability to recognize familiar conspecifics.
“This mutant has a deficit in OT secretion and is also impaired in its ability to recognize familiar conspecifics.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [21]
Expressing CD-38 in the hypothalamus using a lenti-viral vector or by infusing OT was able to rescue the social recognition deficit in CD38-KO mice.
“Expressing CD-38 in the hypothalamus using a lenti-viral vector or by infusing OT was able to rescue this deficit [21].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [21]
In rodents, the VP system regulates partner preference in prairie voles in sex-specific ways.
“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Cho et al., 1999
Because some sex-specific effects were dose-dependent and required a higher dose in one sex, such effects may result from sex differences in sensitivity to VP or OT systems.
“Because some of these sex-specific effects were dose-dependent and required a higher dose in one sex (i.e., role of VP on partner preference in prairie voles with higher doses required in females; Cho et al., 1999), this further suggests that such sex-specific effects may be the result of sex differences in sensitivity to VP or OT systems.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Cho et al., 1999
Oxytocin is associated with maternal behavior and adult pair-bond formation (partner preference) behavior in rodents.
“Oxytocin (OT), a neuropeptide hormone found exclusively in mammals, is associated with maternal behavior (1,2) and adult pair-bond formation (partner preference) behavior (3,4) in rodents.”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [4]
Adult male prairie voles are responsive to oxytocin but require higher dosages than females to induce a partner preference.
“Adult males are also responsive to OT, but require higher dosages than females to induce a partner preference (4).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [4]
In male prairie voles, AVP plays a critical role in the regulation of partner preferences.
“In male prairie voles, AVP plays a critical role in the regulation of partner preferences, although it is likely that OT also plays a role [18, 19].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [18]
Exogenous central oxytocin infusions facilitate partner preference formation in both sexes.
“Although exogenous central OT infusions facilitate partner preference formation in both sexes (Cho et al., 1999)”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Cho et al., 1999
Central OT administration enhances partner preference formation in both female and male prairie voles.
“and central OT administration enhances partner preference formation in both females and males (Cho et al., 1999).”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Cho et al., 1999
Oxytocin can bind to AVPR1A receptors, which have been linked to social functioning.
“Finally, oxytocin can also bind to AVPR1A receptors25, which have also been linked to social functioning26.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [25]
Earlier work in voles has suggested that either OT or AVP may support a general tendency toward social contact.
“Earlier work in voles has suggested that either OT or AVP may support a general tendency toward social contact (Cho et al., 1999).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Cho et al., 1999
ICV administration of oxytocin or injection of oxytocin directly into the nucleus accumbens can induce partner preferences in absence of mating.
“For instance, ICV administration of oxytocin or injection of oxytocin directly into the nucleus accumbens can induce partner preferences in absence of mating (Cho et al., 1999).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Cho et al., 1999
OT has been shown to regulate fundamental mechanisms underlying mate fidelity.
“OT has been shown to regulate fundamental mechanisms underlying mate fidelity.”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Cho et al., 1999
Blocking endogenous OT activity diminished a partner-preference and inhibited pair-bond formation in prairie voles.
“Blocking endogenous OT activity diminished a partner-preference and inhibited pair-bond formation in prairie voles (Cho et al., 1999).”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Cho et al., 1999
This behavioral pattern is consistent with findings in prairie voles that OT increases preferential associations with a pair-mate.
“This behavioral pattern is consistent with findings in prairie voles that OT increases preferential associations with a pair-mate (Williams et al., 1994; Cho et al., 1999).”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Cho et al., 1999
In prairie voles, intracerebroventricular injections of OT induced a partner-preference in both males and females.
“In prairie voles, intracerebroventricular injections of OT induced a partner-preference in both males and females (Cho et al., 1999)”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Cho et al., 1999
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“However, there has been extensive work conducted on female prairie voles (Cho et al., 1999; Fowler et al., 2002; Insel and Hulihan, 1995; Williams et al., 1992; Witt et al., 1991) and it will be noted when data were collected using female subjects.”
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“…(OXTR) densities in the medial prefrontal cortex and nucleus accumbens (NAcc) compared with polygamous montane voles (Shapiro and Insel, 1992) and exogenous administration of OXT into the cerebrospinal fluid of male and female prairie voles induces their partner preferences (Cho et al., 1999).”
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Self-citation
- Authors
- Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S.
- Affiliations
- University of Maryland, College Park (US)
- Venue
- Behavioral Neuroscience
- Published
- 1999
- Volume
- 113
- Issue
- 5
- Pages
- 1071-1079
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2071543008
- Cited by
- 529
- References
- 33
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 13 · 2023: 13 · 2022: 24 · 2021: 9 · 2020: 12 · 2019: 31 · 2018: 30 · 2017: 32 · 2016: 28 · 2015: 29 · 2014: 29 · 2013: 24 · 2012: 32
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh001050-03, 5r01hd032675-06)
- National Institute of Mental Health (MH01050)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32675)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- oxytocin, vasopressin, mate preferences, Microtus ochrogaster, social contact, oxytocin receptor antagonist, sex differences, social bonding, neuropeptides
- MeSH terms
- Animals, Arginine Vasopressin, Behavior, Animal, Arvicolinae, Female, Hormone Antagonists, Humans, Male, Oxytocin, Pair Bond, Sex Factors, Social Behavior, Vasoconstrictor Agents
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