Interplay of Good Bacteria and Central Nervous System: Cognitive Aspects and Mechanistic Considerations

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Effects of stress throughout the lifespan on the brain, behaviour and cognition

Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729

Metagenomic Analysis of the Human Distal Gut Microbiome

Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228

The pro- and anti-inflammatory properties of the cytokine interleukin-6

Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212

Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091

Formation of propionate and butyrate by the human colonic microbiota

Louis, P., & Flint, H. J. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13589 · Cited by 3,028

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.

(2015) · PubMed Central · Cited by 2,540

Succession of microbial consortia in the developing infant gut microbiome

Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

Altered fecal microbiota composition in patients with major depressive disorder

Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275

Insights into the ageing mind: a view from cognitive neuroscience

Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012

Gut microbiota are related to Parkinson's disease and clinical phenotype

Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748

The role of acetylcholine in learning and memory

Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683

Bacteria as vitamin suppliers to their host: A gut microbiota perspective

LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.08.005 · Cited by 1,613 · cited 1×

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,530

Inhibition of Histone Deacetylase Activity by Butyrate

Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515

Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448

The neurobiology of social cognition

Adolphs, R. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00202-6 · Cited by 1,432

Developmental mechanisms that generate precise patterns of neuronal connectivity

Goodman, C. S., & Shatz, C. J. (1993) · Cell · doi:10.1016/s0092-8674(05)80030-3 · Cited by 1,425

The composition of the gut microbiota throughout life, with an emphasis on early life

Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,414

Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice

Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392

Comparative genomics of the lactic acid bacteria.

Makarova, K., Slesarev, A., Wolf, Y., Sorokin, A., Mirkin, B., Koonin, E., Pavlov, A., Pavlova, N., Karamychev, V., Polouchine, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607117103 · Cited by 1,391

Principles and clinical implications of the brain-gut-enteric microbiota axis

Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324

Psychobiotics: A novel class of psychotropic

Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287

Mechanisms of fear extinction

Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277

Gut microbiota and aging

O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202

Consumption of fermented milk product with probiotic modulates brain activity

Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.047 · Cited by 1,184

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156

Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.

Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113

Control of brain development, function, and behavior by the microbiome

Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093

Microbiota and neurodevelopmental windows: implications for brain disorders

Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089

Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses

O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069

Psychobiotics and the manipulation of bacteria–gut–brain signals

Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068

Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature

Fijan, S. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110504745 · Cited by 1,059

Impacts of gut bacteria on human health and diseases

Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052

Sodium butyrate inhibits histone deacetylation in cultured cells

Candido, E. (1978) · Cell · doi:10.1016/0092-8674(78)90305-7 · Cited by 1,036

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999

The core gut microbiome, energy balance and obesity

Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993

The microbiome-gut-brain axis: from bowel to behavior

Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990

Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children

Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 961

Brain-gut-microbe communication in health and disease

Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952

The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat

Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · cited 3×

Intestinal microbiota in functional bowel disorders: a Rome foundation report

Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939

Bacterial infection causes stress-induced memory dysfunction in mice

Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909

Dietary (n-3) Fatty Acids and Brain Development1

Innis, S. M. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.4.855 · Cited by 906

Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates

Sonnenburg, E. D., & Sonnenburg, J. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.003 · Cited by 901

Benefaction of probiotics for human health: A review

George Kerry, R., Patra, J. K., Gouda, S., Park, Y., Shin, H.-S., & Das, G. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.01.002 · Cited by 898

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885

An epigenetic blockade of cognitive functions in the neurodegenerating brain

Gräff, J., Rei, D., Guan, J.-S., Wang, W.-Y., Seo, J., Hennig, K. M., Nieland, T. J. F., Fass, D. M., Kao, P. F., Kahn, M., et al. (2012) · Nature · doi:10.1038/nature10849 · Cited by 853

The Gut Microbiota and Alzheimer’s Disease

Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852

Microglia: Scapegoat, saboteur, or something else?

Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836

On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis

Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829

Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome

Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

Lü, Y., Christian, K. M., & Lu, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 807

Probiotic species in the modulation of gut microbiota: An overview

Azad, M. A. K., Sarker, M., Li, T., & Yin, J. (2018) · BioMed Research International · doi:10.1155/2018/9478630 · Cited by 803

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793

Passage of cytokines across the blood–brain barrier

Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 763

Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour

Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760

Ecological Role of Lactobacilli in the Gastrointestinal Tract: Implications for Fundamental and Biomedical Research

Walter, J. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00753-08 · Cited by 756

Gastrointestinal Microflora Studies in Late‐Onset Autism

Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742

Anxiety disorders in older adults: a comprehensive review

Wolitzky-Taylor, K. B., Castriotta, N., Lenze, E. J., Stanley, M. A., & Craske, M. G. (2010) · Depression and Anxiety · doi:10.1002/da.20653 · Cited by 726

Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication

Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Zheng, P., Zeng, B., Liu, M., Chen, J., Pan, J., Han, Y., Liu, Y., Cheng, K., Zhou, C., Wang, H., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau8317 · Cited by 704

Gut Bifidobacteria Populations in Human Health and Aging

Arboleya, S., Watkins, C., Stanton, C., & Ross, R. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01204 · Cited by 701

The composition of the gut microbiota shapes the colon mucus barrier

Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700

Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories

Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676

A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood

Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · cited 1×

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

Bourassa, M. W., Alim, I., Bultman, S. J., & Ratan, R. R. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.009 · Cited by 667

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis

McFarland, L. V., Evans, C. T., & Goldstein, E. J. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00124 · Cited by 666

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

Asano, Y., Hiramoto, T., Nishino, R., Aiba, Y., Kimura, T., Yoshihara, K., Koga, Y., & Sudo, N. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2012 · Cited by 659

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651

Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis

Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637

Regulation of prefrontal cortex myelination by the microbiota

Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635

Gastrointestinal microbiota in children with autism in Slovakia

Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632

Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior

Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632

Monostrain, multistrain and multispecies probiotics—A comparison of functionality and efficacy

Timmerman, H. M., Koning, C. J. M., Mulder, L., Rombouts, F. M., & Beynen, A. C. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.05.012 · Cited by 631

Gut microbiota and Covid-19- possible link and implications

Dhar, D., & Mohanty, A. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198018 · Cited by 625

Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

Abdullahi, W., Tripathi, D. K., & Ronaldson, P. T. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00095.2018 · Cited by 623

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tόth, J., Holvoet, L., Farré, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305690 · Cited by 615

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

Ait-Belgnaoui, A., Durand, H., Cartier, C., Chaumaz, G., Eutamene, H., Ferrier, L., Houdeau, E., Fioramonti, J., Bueno, L., & Theodorou, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.024 · Cited by 612

Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline

Yurko‐Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A. D., Salem, N., Stedman, M., & MIDAS Investigators (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.01.013 · Cited by 604

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

Crumeyrolle-Arias, M., Jaglin, M., Bruneau, A., Vancassel, S., Cardona, A., Daugé, V., Naudon, L., & Rabot, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.014 · Cited by 581

Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Ota, M., Koga, N., Hattori, K., & Kunugi, H. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.038 · Cited by 576

Beneficial psychological effects of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers

Messaoudi, M., Violle, N., Bisson, J.-F., Desor, D., Javelot, H., & Rougeot, C. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16108 · Cited by 574

Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Kim, C.-S., Cha, J., Sim, M., Jung, S., Chun, W. Y., Baik, H. W., & Shin, D.-M. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa090 · Cited by 572

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease

Rinaldi, P., Polidori, M. C., Metastasio, A., Mariani, E., Mattioli, P., Cherubini, A., Catani, M., Cecchetti, R., Senin, U., & Mecocci, P. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00031-9 · Cited by 571

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · cited 2×

The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins

McNulty, N. P., Yatsunenko, T., Hsiao, A., Faith, J. J., Muegge, B. D., Goodman, A. L., Henrissat, B., Oozeer, R., Cools-Portier, S., Gobert, G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002701 · Cited by 559

Impact of consuming a milk drink containing a probiotic on mood and cognition

Benton, D., Williams, C., & Brown, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602546 · Cited by 554

Production of gaba (γ - aminobutyric acid) by microorganisms: a review

Dhakal, R., Bajpai, V. K., & Baek, K.-H. (2012) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822012000400001 · Cited by 545

Identifying personal microbiomes using metagenomic codes

Franzosa, E. A., Huang, K. H., Meadow, J. F., Gevers, D., Lemon, K. P., Bohannan, B. J. M., & Huttenhower, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423854112 · Cited by 526

Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier

Peng, L., He, Z., Chen, W., Holzman, I. R., & Lin, J. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000250014.92242.f3 · Cited by 518

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513

Probiotic Lactobacillus plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: a double-blind, randomized, placebo controlled study

Rudzki, L., Ostrowska, L., Pawlak, D., Małus, A., Pawlak, K., Waszkiewicz, N., & Szulc, A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.010 · Cited by 499

Health benefits of probiotics: are mixtures more effective than single strains?

Chapman, C. M. C., Gibson, G. R., & Rowland, I. R. (2011) · European Journal of Nutrition · doi:10.1007/s00394-010-0166-z · Cited by 497

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?

Ohira, H., Tsutsui, W., & Fujioka, Y. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17006 · Cited by 492

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Thomas, C. M., Hong, T., van Pijkeren, J. P., Hemarajata, P., Trinh, D. V., Hu, W., Britton, R. A., Kalkum, M., & Versalovic, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031951 · Cited by 491

Adult hippocampal neurogenesis is regulated by the microbiome

Ogbonnaya, E. S., Clarke, G., Shanahan, F., Dinan, T. G., Cryan, J. F., & O’Leary, O. F. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.023 · Cited by 491

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation

Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472

Gut microbiota: A player in aging and a target for anti-aging intervention

Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465

A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist?

Forbes, J. D., Chen, C., Knox, N., Marrie, R. A., El-Gabalawy, H. S., de Kievit, T. R., Alfa, M. J., Bernstein, C. N., & Domselaar, G. V. (2018) · Microbiome · doi:10.1186/s40168-018-0603-4 · Cited by 461

Parkinson risk in idiopathic REM sleep behavior disorder

Postuma, R. B., Gagnon, J., Bertrand, J., Marchand, D. G., & Montplaisir, J. Y. (2015) · Neurology · doi:10.1212/wnl.0000000000001364 · Cited by 455

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453

Maternal prenatal stress is associated with the infant intestinal microbiota

Zijlmans, M. A. C., Korpela, K., Riksen-Walraven, J. M., de Vos, W. M., & de Weerth, C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.006 · Cited by 438

Probiotic gut effect prevents the chronic psychological stress‐induced brain activity abnormality in mice

Ait‐Belgnaoui, A., Colom, A., Braniste, V., Ramalho, L., Marrot, A., Cartier, C., Houdeau, E., Theodorou, V., & Tompkins, T. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12295 · Cited by 434

The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

Berni Canani, R., Di Costanzo, M., & Leone, L. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-4 · Cited by 431

Interleukin‐10 generation in atopic children following oral Lactobacillus rhamnosus GG

Pessi, T., Sütas, Y., Hurme, M., & Isolauri, E. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00948.x · Cited by 430

Immune–neural connections: how the immune system’s response to infectious agents influences behavior

McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429

Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

Slykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., Rowden, J., Stone, P., Crane, J., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.013 · Cited by 422

Bifidobacteria exert strain‐specific effects on stress‐related behavior and physiology in BALB /c mice

Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418

Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease

Kobayashi, Y., Sugahara, H., Shimada, K., Mitsuyama, E., Kuhara, T., Yasuoka, A., Kondo, T., Abe, K., & Xiao, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13368-2 · Cited by 411

The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.

Appleton, J. (2018) · Europe PMC (PubMed Central) · Cited by 411

Gastrointestinal microbiology enters the metagenomics era

Frank, D. N., & Pace, N. R. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f2b0e8 · Cited by 410

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

Yang, X., Yu, D., Xue, L., Li, H., & Du, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.07.001 · Cited by 407

Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis

Hold, G. L., Pryde, S. E., Russell, V. J., Furrie, E., & Flint, H. J. (2002) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2002.tb00904.x · Cited by 406

Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

Govindarajan, N., Agis-Balboa, R. C., Walter, J., Sananbenesi, F., & Fischer, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110080 · Cited by 405

Butyrate modulates oxidative stress in the colonic mucosa of healthy humans

Hamer, H. M., Jonkers, D. M. A. E., Bast, A., Vanhoutvin, S. A. L. W., Fischer, M. A. J. G., Kodde, A., Troost, F. J., Venema, K., & Brummer, R.-J. M. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2008.11.002 · Cited by 400

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists

Thomas, S., Izard, J., Walsh, E. K., Batich, K. A., Chongsathidkiet, P., Clarke, G. A., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 400

Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

Feng, W., Ao, H., & Peng, C. Y. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01354 · Cited by 376

Immune and neuroendocrine mechanisms of stress vulnerability and resilience

Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374

The role of probiotics in children with autism spectrum disorder: A prospective, open-label study

Shaaban, S. Y., El Gendy, Y. G., Mehanna, N. S., El-Senousy, W. M., El-Feki, H. S. A., Saad, K., & El-Asheer, O. M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1347746 · Cited by 374

Alzheimer’s disease and gut microbiota

Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371

Folate Production by Bifidobacteria as a Potential Probiotic Property

Pompei, A., Cordisco, L., Amaretti, A., Zanoni, S., Matteuzzi, D., & Rossi, M. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01763-06 · Cited by 369

Microbiota alteration is associated with the development of stress-induced despair behavior

Marin, I. A., Goertz, J. E., Ren, T., Rich, S. S., Onengut-Gumuscu, S., Farber, E., Wu, M., Overall, C. C., Kipnis, J., & Gaultier, A. (2017) · Scientific Reports · doi:10.1038/srep43859 · Cited by 369

Bifidobacteria modulate cognitive processes in an anxious mouse strain

Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365

Memory and the NMDA Receptors

Li, F. R., & Tsien, J. Z. (2009) · New England Journal of Medicine · doi:10.1056/nejmcibr0902052 · Cited by 363

Neurotransmitters as food supplements: the effects of GABA on brain and behavior

Boonstra, E., de Kleijn, R., Colzato, L. S., Alkemade, A., Forstmann, B. U., & Nieuwenhuis, S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01520 · Cited by 357

A meta-analysis of the use of probiotics to alleviate depressive symptoms

Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W.-S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.063 · Cited by 357

Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF

Pang, P. T., & Lu, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.07.002 · Cited by 356

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.11.018 · Cited by 355

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

Latham, T., Mackay, C. L., Sproul, D., Karim, M., Culley, J., Harrison, D. J., Hayward, L., Langridge‐Smith, P. R. R., Gilbert, N., & Ramsahoye, B. H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks066 · Cited by 340

Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson’s Disease

Caputi, V., & Giron, M. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061689 · Cited by 338

Voices from within: gut microbes and the CNS

Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

Walsh, M. E., Bhattacharya, A., Sataranatarajan, K., Qaisar, R., Sloane, L., Rahman, M. M., Kinter, M., & Van Remmen, H. (2015) · Aging Cell · doi:10.1111/acel.12387 · Cited by 334

Effect of probiotics on central nervous system functions in animals and humans: a systematic review

Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334

The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential

Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329

Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: A cross-sectional study

Shen, Y., Xu, J., Li, Z., Huang, Y., Yuan, Y., Wang, J., Zhang, M., Hu, S., & Liang, Y. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.01.002 · Cited by 328

A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression

Romijn, A. R., Rucklidge, J. J., Kuijer, R. G., & Frampton, C. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416686694 · Cited by 323

The gut microbiome composition associates with bipolar disorder and illness severity

Evans, S. J., Bassis, C. M., Hein, R., Assari, S., Flowers, S. A., Kelly, M., Young, V. B., Ellingrod, V. E., & McInnis, M. G. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.007 · Cited by 318

Inflamm-ageing

Cevenini, E., Monti, D., & Franceschi, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32835ada13 · Cited by 317

Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice

Swidsinski, A. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i8.1131 · Cited by 314

The Infant Microbiome

Yang, I. H., Corwin, E. J., Brennan, P. A., Jordan, S., Murphy, J. R., & Dunlop, A. L. (2015) · Nursing Research · doi:10.1097/nnr.0000000000000133 · Cited by 310

Probiotics Modulate Host-Microbe Interaction in the Placenta and Fetal Gut: A Randomized, Double-Blind, Placebo-Controlled Trial

Rautava, S., Collado, M. C., Salminen, S., & Isolauri, E. (2012) · Neonatology · doi:10.1159/000339182 · Cited by 297

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

Najjar, S., Najjar, A., Chong, D. J., Pramanik, B. K., Kirsch, C., Kuzniecky, R., Pacia, S. V., & Azhar, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01896-0 · Cited by 292

Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome–gut–brain axis

Davari, S., Talaei, S. A., Alaei, H., & salami, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.055 · Cited by 290

Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice

Liu, Y.-W., Liu, W., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S. Z., & Tsai, Y.-C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.018 · Cited by 290

Introduction to intestinal microecology

Luckey, T. D. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.12.1292 · Cited by 288

Gut microbiota and gastrointestinal health: current concepts and future directions

Aziz, Q., Doré, J., Emmanuel, A., Guarner, F., & Quigley, E. M. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12046 · Cited by 280

The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases

Zapata, H. J., & Quagliarello, V. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13310 · Cited by 279

Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.005 · Cited by 276 · cited 10×

Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Ohland, C. L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., & Madsen, K. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.008 · Cited by 273

Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: a randomised, double-blind, placebo-controlled study

Lew, L.-C., Hor, Y.-Y., Yusoff, N. A. A., Choi, S.-B., Yusoff, M. S. B., Roslan, N. S., Ahmad, A., Mohammad, J. A. M., Abdullah, M. F. I. L., Zakaria, N., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.010 · Cited by 272

Cold pressor stress impairs performance on working memory tasks requiring executive functions in healthy young men.

Schoofs, D., Wolf, O. T., & Smeets, T. (2009) · Behavioral Neuroscience · doi:10.1037/a0016980 · Cited by 269

Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine

Kiraly, D. D., Walker, D. M., Calipari, E. S., Labonté, B., Issler, O., Peña, C. J., Ribeiro, E., Russo, S. J., & Nestler, E. J. (2016) · Scientific Reports · doi:10.1038/srep35455 · Cited by 267

Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods

Nishino, R., Mikami, K., Takahashi, H., Tomonaga, S., Furuse, M., Hiramoto, T., Aiba, Y., Koga, Y., & Sudo, N. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12110 · Cited by 266

Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats

Azm, S. A. N., Djazayeri, A., Safa, M., Azami, K., Ahmadvand, B., Sabbaghziarani, F., Sharifzadeh, M. S., & Vafa, M. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0648 · Cited by 262

A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode

Painold, A., Mörkl, S., Kashofer, K., Halwachs, B., Dalkner, N., Bengesser, S., Birner, A., Fellendorf, F. T., Platzer, M., Queissner, R., et al. (2018) · Bipolar Disorders · doi:10.1111/bdi.12682 · Cited by 258

Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

Ni, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900603 · Cited by 255

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

Microbiota medicine: towards clinical revolution

Gebrayel, P., Nicco, C., Khodor, S. A., Biliński, J., Caselli, E., Comelli, E. M., Egert, M., Giaroni, C., Karpiński, T. M. M., Łoniewski, I., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03296-9 · Cited by 307

Fermented foods: An update on evidence-based health benefits and future perspectives

Diez‐Ozaeta, I., & Astiazaran, O. J. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111133 · Cited by 176

Role of Microbiota-Derived Extracellular Vesicles in Gut-Brain Communication

Cuesta, C. M., Guerri, C., Ureña, J., & Pascual, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084235 · Cited by 142

Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases

Hou, S., Yu, J., Li, Y., Zhao, D., & Zhang, Z. (2025) · Advanced Science · doi:10.1002/advs.202413197 · Cited by 97

Cognitive Function and the Microbiome

Gareau, M. G. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.001 · Cited by 138

Relationship between the gut microbiome and brain function

Mohajeri, M. H., La Fata, G., Steinert, R. E., & Weber, P. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy009 · Cited by 376

Unlocking the mind-gut connection: Impact of human microbiome on cognition

Castells‐Nobau, A., Mayneris‐Perxachs, J., & Fernández‐Real, J. M. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.07.019 · Cited by 31

The effects of gut microbiota on CNS function in humans

Tillisch, K. (2014) · Gut Microbes · doi:10.4161/gmic.29232 · Cited by 144

Probiotics in human mental health and diseases—A minireview

Sivamaruthi, B. S., Prasanth, M. I., Kesika, P., & Chaiyasut, C. (2021) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v18i4.29 · Cited by 44