The DOI matches its Crossref record; 139 of the 140 references it cites were found in a registry or an index.
The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior
Open accessAbstract
Social neuroscience is rapidly exploring the complex territory between perception and action where recognition, value, and meaning are instantiated. This review follows the trail of research on oxytocin and vasopressin as an exemplar of one path for exploring the "dark matter" of social neuroscience. Studies across vertebrate species suggest that these neuropeptides are important for social cognition, with gender- and steroid-dependent effects. Comparative research in voles yields a model based on interspecies and intraspecies variation of the geography of oxytocin receptors and vasopressin V1a receptors in the forebrain. Highly affiliative species have receptors in brain circuits related to reward or reinforcement. The neuroanatomical distribution of these receptors may be guided by variations in the regulatory regions of their respective genes. This review describes the promises and problems of extrapolating these findings to human social cognition, with specific reference to the social deficits of autism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In animals, oxytocin increases social approach and social memory,1 both of which are impaired in persons with autism.”
From Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder (2021) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“Research on monogamous mammals, particularly prairie voles, has shown that the neuropeptide oxytocin (OXT) promotes the formation of pair-bonds in females, with a related peptide, argininevasopressin being more important in males (Donaldson and Young, 2008;Insel, 2010).”
From Oxytocin Modulates Social Distance between Males and Females (2012) · cites this paper as Insel, 2010
The cited source says what the claim attributes to it.
In the citing paper
“The last candidate gene we examined, the oxytocin receptor, has long been associated with the display of social behavior in rodents [34].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [34]
In the citing paper
“These studies suggest that oxytocin facilitates affiliation and social attachment [548].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [548]
In the citing paper
“Studies suggest that a contributive mechanism regulating in-group cooperation during intergroup conflicts in humans involves the neuropeptide hormone oxytocin, known to influence trust, coordination, and social cognition, although evidence from natural settings is lacking.”
From Oxytocin reactivity during intergroup conflict in wild chimpanzees (2017) · cites this paper as [6]
In the citing paper
“It is thought that the interface between oxytocin and the dopaminergic reward system may contribute to the success of mother-infant and pair-bonding processes [18,[75][76][77].”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [18]
In the citing paper
“However, oxytocin receptor distributions are highly variable across species, and to some extent within species (Insel, 2010), suggesting considerable functional variation is likely between species (Goodson and Thompson, 2010) and within species (Insel, 2010).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Insel, 2010
In the citing paper
“However, oxytocin receptor distributions are highly variable across species, and to some extent within species (Insel, 2010), suggesting considerable functional variation is likely between species (Goodson and Thompson, 2010) and within species (Insel, 2010).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Insel, 2010
In the citing paper
“Furthermore, it facilitates social cognition, enhances social memory, social recognition and attention, and operates in the reward centers of the brain (Insel, 2010).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Insel, 2010
In the citing paper
“This is potentially a crucial feature of social bond formation and maintenance (Broad et al., 2006; Insel, 2010).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Insel, 2010
In the citing paper
“Systemic loss of either oxytocin or oxytocin receptors (Oxt−/− and Oxtr−/−) disrupts maternal nurturing behaviours in mice7,8.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [7]
In the citing paper
“Clinical studies have linked autism and Asperger’s disorders and attention-deficit/hyperactivity disorders to oxytocin deficiency7,8,54, and the potential use of exogenous oxytocin to treat these conditions is being assessed in clinical trials10,11,54–57.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [7]
In the citing paper
“This neuropeptide is crucial in many aspects of social behavior, including affiliation6 and reward.7”
From Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment (2016) · cites this paper as [6]
In the citing paper
“One of the most exciting findings from recent OT studies is that the peptide appears to rescue some social deficits in individuals with psychopathological conditions (for a review, see: Insel, 2010; Meyer-Lindenberg et al., 2011).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Insel, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. (2000) · Psychological Review · doi:10.1037/0033-295x.107.3.411 · Cited by 3,308
Strong association of de novo copy number mutations with autism
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795
Advances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Glessner, J. T., Wang, K., Cai, G., Korvatska, O., Kim, C. E., Wood, S., Zhang, H., Estes, A., Brune, C. W., Bradfield, J. P., et al. (2009) · Nature · doi:10.1038/nature07953 · Cited by 1,421
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Self-citationCommon genetic variants on 5p14.1 associate with autism spectrum disorders
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 3×
“AVP, given centrally to prairie vole males who have not mated, induces each of these pair bonding behaviors (Wang et al., 1994; Winslow et al., 1993).”
Self-citationPromoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Self-citationOxytocin increases generosity in humans
Zak, P. J., Stanton, A. A., & Ahmadi, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001128 · Cited by 831
de Bono, M., & Bargmann, C. I. (1998) · Cell · doi:10.1016/s0092-8674(00)81609-8 · Cited by 819
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 2×
“In fact, OT appears to reduce the amygdala response to emotional expression irrespective of valence (Domes et al., 2007a).”
The vertebrate social behavior network: Evolutionary themes and variations
Goodson, J. L. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.02.003 · Cited by 771
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Self-citationPlasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689
Molecular detection of pheromone signals in mammals: from genes to behaviour
Dulac, C. G., & Torello, A. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1140 · Cited by 662
Structure and expression of a human oxytocin receptor
Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628
Physiological substrates of mammalian monogamy: The prairie vole model
Sue Carter, C., Courtney Devries, A., & Getz, L. L. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00070-h · Cited by 615
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
Gray, J. M., Karow, D. S., Lu, H., Chang, A. J., Chang, J. S., Ellis, R. E., Marletta, M. A., & Bargmann, C. I. (2004) · Nature · doi:10.1038/nature02714 · Cited by 591
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · cited 2×
“Wang and his colleagues have demonstrated the importance of an interaction between OT and dopamine, specifically the dopamine D2 receptor, in the nucleus accumbens for pair bond formation in female prairie voles (Aragona et al., 2003; Curtis et al., 2006; Liu and Wang, 2003).”
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
Gregory, S. G., Connelly, J. J., Towers, A. J., Johnson, J., Biscocho, D., Markunas, C. A., Lintas, C., Abramson, R. K., Wright, H. H., Ellis, P., et al. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-62 · Cited by 576
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 565
A neurobiological basis of social attachment.
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.726 · Cited by 553
Microsatellite instability generates diversity in brain and sociobehavioral traits
Hammock, E. A. D., & Young, L. J. (2005) · Science · doi:10.1126/science.1111427 · Cited by 545
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518
The Brain as a Target for Steroid Hormone Action
McEwen, B. S., Davis, P. G., Parsons, B., & Pfaff, D. W. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000433 · Cited by 512
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488
A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans
Macosko, E. Z., Pokala, N., Feinberg, E. H., Chalasani, S. H., Butcher, R. A., Clardy, J., & Bargmann, C. I. (2009) · Nature · doi:10.1038/nature07886 · Cited by 475
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn004 · Cited by 474
Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Eriksson, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803081105 · Cited by 460
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425
The Computation of Social Behavior
Behrens, T. E. J., Hunt, L. T., & Rushworth, M. F. S. (2009) · Science · doi:10.1126/science.1169694 · Cited by 407 · cited 2×
“Recently, researchers have begun to address these questions with human neuroimaging studies seeking to map various aspects of higher-order processing of social information and even develop computational principles for the neural basis of social cognition (Behrens et al., 2009).”
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402
Young (1999) · doi:10.1038/23650 · Cited by 389
Choleris, E., Gustafsson, J.-Å., Korach, K. S., Muglia, L. J., Pfaff, D. W., & Ogawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0631699100 · Cited by 386
Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).
Wang, Z., Ferris, C. F., & De Vries, G. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.400 · Cited by 381
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378
Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor.
Sugimoto, T., Saito, M., Mochizuki, S., Watanabe, Y., Hashimoto, S., & Kawashima, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47129-3 · Cited by 376
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366
A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K., & Wang, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03483.2003 · Cited by 351
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349
Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124125 · Cited by 322
Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
Lim, M. M., & Young, L. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.008 · Cited by 322
Ross, H. E., Freeman, S. M., Spiegel, L. L., Ren, X., Terwilliger, E. F., & Young, L. J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5039-08.2009 · Cited by 322
Neural control of maternal behaviour and olfactory recognition of offspring
Kendrick, K. M., Da Costa, A. P. C., Broad, K. D., Ohkura, S., Guevara, R., Lévy, F., & Keverne, E. B. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00218-9 · Cited by 311
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309
Wärnmark, A., Treuter, E., Wright, A. P. H., & Gustafsson, J.-A. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0384 · Cited by 308
Knafo, A., Israel, S., Darvasi, A., Bachner‐Melman, R., Uzefovsky, F., Cohen, L., Feldman, E., Lerer, E., Laiba, E., Raz, Y., et al. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00341.x · Cited by 302
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 296
Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295
Self-citationBester‐Meredith, J. K., Young, L. J., & Marler, C. A. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1522 · Cited by 285
Forebrain peptides modulate sexually polymorphic vocal circuitry
Goodson, J. L., & Bass, A. H. (2000) · Nature · doi:10.1038/35001581 · Cited by 281
Thibonnier, M., Auzan, C., Madhun, Z. T., Wilkins, P. L., Berti‐Mattera, L. N., & Clauser, É. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41863-1 · Cited by 281
Brain vasopressin is an important regulator of maternal behavior independent of dams’ trait anxiety
Bosch, O. J., & Neumann, I. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807412105 · Cited by 280
Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli
de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002) · Nature · doi:10.1038/nature01169 · Cited by 279
The prairie vole: An emerging model organism for understanding the social brain
McGraw, L. A., & Young, L. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.006 · Cited by 276
Kim, S.-J., Young, L. J., Gonen, D., Veenstra-VanderWeele, J., Courchesne, R., Courchesne, E., Lord, C., Leventhal, B. L., Cook Jr, E. H., & Insel, T. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001125 · Cited by 265
Self-citationPost-learning intranasal oxytocin modulates human memory for facial identity
Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.004 · Cited by 262
Actions of Estrogens and Progestins on Nerve Cells
Pfaff, D. W., & McEwen, B. S. (1983) · Science · doi:10.1126/science.6297008 · Cited by 260
Mesotocin and nonapeptide receptors promote estrildid flocking behavior
Goodson, J. L., Schrock, S. E., Klatt, J. D., Kabelik, D., & Kingsbury, M. A. (2009) · Science · doi:10.1126/science.1174929 · Cited by 241
Yirmiya, N., Rosenberg, C., Levi, S., Salomon, S., Shulman, C., Nemanov, L., Dina, C., & Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001812 · Cited by 232
Smith, A. S., Ågmo, A., Birnie, A. K., & French, J. A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.12.004 · Cited by 228
Meyer‐Lindenberg, A., Kolachana, B. S., Gold, B., Olsh, A., Nicodemus, K. K., Mattay, V. S., Dean, M. C., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.54 · Cited by 221
Vasopressin, oxytocin and social behaviour
Keverne, E. B., & Curley, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.006 · Cited by 219
An intrinsic vasopressin system in the olfactory bulb is involved in social recognition
Tobin, V. A., Hashimoto, H., Wacker, D. W., Takayanagi, Y., Langnaese, K., Caquineau, C., Noack, J., Landgraf, R., Onaka, T., Leng, G., et al. (2010) · Nature · doi:10.1038/nature08826 · Cited by 213
Examination of AVPR1a as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001503 · Cited by 212
Insel, T. R., Gelhard, R., & Shapiro, L. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90321-e · Cited by 209
Self-citationFebo, M., Numan, M., & Ferris, C. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3604-05.2005 · Cited by 197
Arginine Vasopressin and Oxytocin Modulate Human Social Behavior
Ebstein, R. P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., Riebold, M., Salomon, S., & Yirmiya, N. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04541.x · Cited by 196
Young, L. J., Winslow, J. T., Nilsen, R., & Insel, T. R. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.3.599 · Cited by 196
Self-citationLiu, X., Kawamura, Y., Shimada, T., Otowa, T., Koishi, S., Sugiyama, T., Nishida, H., Hashimoto, O., Nakagami, R., Tochigi, M., et al. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2009.140 · Cited by 195
Maternal behavior deficits in nulliparous oxytocin knockout mice
Pedersen, C. A., Vadlamudi, S. V., Boccia, M. L., & Amico, J. A. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00162.x · Cited by 190
Kendrick, K. M., Keverne, E. B., Baldwin, B. A., & Sharman, D. F. (2008) · Neuroendocrinology · doi:10.1159/000124638 · Cited by 187
Oxytocin induction of short-latency maternal behavior in nulliparous, estrogen-primed female rats
FAHRBACH, S. (1984) · Hormones and Behavior · doi:10.1016/0018-506x(84)90016-3 · Cited by 187 · cited 1×
“Adult virgin females primed with estrogen and injected centrally with OT were reported to exhibit full maternal behavior, including nest building and crouching over pups in a nursing posture (Fahrbach et al., 1984; Pedersen et al., 1982; although also see Rubin et al., 1983).”
Oxytocin Facilitation of Maternal Behavior in Sheepa
Keverne, E. B., & Kendrick, K. M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34348.x · Cited by 183
Gobrogge, K. L., Liu, Y., Young, L. J., & Wang, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908620106 · Cited by 178
Consequences of Early Experiences and Exposure to Oxytocin and Vasopressin Are Sexually Dimorphic
Carter, C. S., Boone, E. M., Pournajafi-Nazarloo, H., & Bales, K. L. (2009) · Developmental Neuroscience · doi:10.1159/000216544 · Cited by 176
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172
McCauley, J. L., Li, C., Jiang, L., Olson, L. M., Crockett, G., Gainer, K., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-1 · Cited by 168
Insel, T. R. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00445.x · Cited by 164
Self-citationAnatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163
Fatherhood affects dendritic spines and vasopressin V1a receptors in the primate prefrontal cortex
Kozorovitskiy, Y., Hughes, M., Lee, K., & Gould, E. (2006) · Nature Neuroscience · doi:10.1038/nn1753 · Cited by 158
Sex, parturition and motherhood without oxytocin?
Russell, J., & Leng, G. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570343 · Cited by 150
Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
Ring, R. H., Schechter, L. E., Leonard, S. K., Dwyer, J. M., Platt, B. J., Graf, R., Grauer, S. M., Pulicicchio, C. M., Resnick, L., Rahman, Z. U., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.016 · Cited by 144
van Kesteren, R. E., Smit, A. B., Lange, R. D., Kits, K. S., Golen, F. A. V., van der Schors, R. C., de With, N. D., Burke, J. F., & Geraerts, W. P. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05989.1995 · Cited by 136
Neuropeptides and the social brain: potential rodent models of autism
Lim, M. M., Bielsky, I. F., & Young, L. J. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.006 · Cited by 129
Shapiro, L. E., & Insel, T. R. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230502 · Cited by 128
Self-citationIsrael, S., Lerer, E., Shalev, I., Uzefovsky, F., Reibold, M., Bachner‐Melman, R., Granot, R., Bornstein, G., KNAFO, A., & Yirmiya, N. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00434-2 · Cited by 122
van Kesteren, R. E., Smit, A. B., Dirks, R. W., de With, N. D., Geraerts, W. P., & Joosse, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4593 · Cited by 120
Dopamine regulation of social choice in a monogamous rodent species
Aragona, B. J. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.015.2009 · Cited by 119
Phelps, S. M., & Young, L. J. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10902 · Cited by 116
Aragona, B. J., & Wang, Z. (2004) · ILAR Journal · doi:10.1093/ilar.45.1.35 · Cited by 113
Co-evolution of Ligand-Receptor Pairs in the Vasopressin/Oxytocin Superfamily of Bioactive Peptides
van Kesteren, R. E., Tensen, C. P., Smit, A. B., van Minnen, J., Kolakowski, L. F., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E., & Geraerts, W. P. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3619 · Cited by 113
Schorscher-Petcu, A., Dupré, A., & Tribollet, E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.016 · Cited by 111
Neural basis of maternal behavior in the rat
Numan, M. J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90006-6 · Cited by 104
The effects of peptides on partner preference formation are predicted by habitat in prairie voles
Cushing, B. S., Martin, J. O., Young, L. J., & Carter, C. S. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2000.1633 · Cited by 99
Lauritsen, M. B., Als, T. D., Dahl, H. A., Flint, T. J., Wang, A. G., Vang, M., Kruse, T. A., Ewald, H., & Mors, O. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001754 · Cited by 82
The Neurobiology of Social Bonds
Kendrick, K. M. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01262.x · Cited by 80
Mizumoto, Y., Kimura, T., & Ivell, R. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00195-0 · Cited by 79
Rubin, B. S., Menniti, F. S., & Bridges, R. S. (1983) · Hormones and Behavior · doi:10.1016/0018-506x(83)90014-4 · Cited by 75
Wang, Z., Toloczko, D., Young, L. J., Moody, K., Newman, J. D., & Insel, T. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00636-7 · Cited by 75 · cited 3×
“AVP, given centrally to prairie vole males who have not mated, induces each of these pair bonding behaviors (Wang et al., 1994; Winslow et al., 1993).”
BackgroundSelf-citationCurtis, J. T., Liu, Y., Aragona, B. J., & Wang, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.126 · Cited by 74
Oxytocin receptors in brain cortical regions are reduced in haploinsufficient (+/−) reeler mice
Liu, W., Pappas, G. D., & Carter, C. S. (2005) · Neurological Research · doi:10.1179/016164105x35602 · Cited by 73
OPHIR, A., CAMPBELL, P., HANNA, K., & PHELPS, S. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.07.009 · Cited by 66
Chapter 4 Oxytocin: who needs it?
Insel, T. R., Gingrich, B., & Young, L. J. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33005-4 · Cited by 62
Self-citationDonaldson, Z. R., Kondrashov, F. A., Putnam, A. S., Bai, Y., Stoinski, T., Hammock, E. A. D., & Young, L. J. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-180 · Cited by 62
On switches and knobs, microsatellites and monogamy
Young, L. J., & Hammock, E. A. D. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.02.010 · Cited by 58
Neuropeptides and non‐human primate social deficits associated with pathogenic rearing experience
Winslow, J. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.03.003 · Cited by 57
Kanwisher, N. (2006) · Science · doi:10.1126/science.1123983 · Cited by 53
Targeted Reduction of Oxytocin Expression Provides Insights into its Physiological Roles
Young, W. S., Shepard, E. A., DeVries, A. C., Zimmer, A., LaMarca, M. E., Ginns, E. I., Amico, J. A., Nelson, R. J., Hennighausen, L. G., & Wagner, K. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_30 · Cited by 51
Distribution of Corticotropin-Releasing Factor and Urocortin 1 in the Vole Brain
Lim, M. M., Tsivkovskaia, N. O., Bai, Y., Young, L. J., & Ryabinin, A. E. (2006) · Brain, Behavior and Evolution · doi:10.1159/000094360 · Cited by 48
Insel, T. R., Winslow, J. T., WILLIAMS, J. R., Hastings, N., Shapiro, L. E., & Carter, C. S. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90194-d · Cited by 44
Self-citationBittel, D. C., Kibiryeva, N., Dasouki, M., Knoll, J. H. M., & Butler, M. G. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31132 · Cited by 44
Opposing Regulation of Pair Bond Formation by cAMP Signaling within the Nucleus Accumbens Shell
Aragona, B. J., & Wang, Z. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3216-07.2007 · Cited by 42
Mating system and avpr1a promoter variation in primates
Rosso, L., Keller, L., Kaessmann, H., & Hammond, R. L. (2008) · Biology Letters · doi:10.1098/rsbl.2008.0122 · Cited by 36
Identification of an orally active, nonpeptidyl oxytocin antagonist.
Pettibone, D. J., Clineschmidt, B. V., Kishel, M. T., Lis, E. V., Reiss, D. R., Woyden, C. J., Evans, B., Freidinger, R. M., Veber, D. F., & Cook, M. J. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10269-3 · Cited by 28
Bruins, J., Kovács, G. L., Abbes, A. P., Burbach, J. P. H., van den Akker, E. L. T., Engel, H., FRANKEN, A., & de Wied, D. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.06.001 · Cited by 23
YOUNG, L. J., WAYMIRE, K. G., NILSEN, R., MACGREGOR, G. R., WANG, Z., & INSEL, T. R. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51955.x · Cited by 20
Self-citationGenetics of vasopressin receptors
Thibonnier, M. (2004) · Current Hypertension Reports · doi:10.1007/s11906-004-0006-8 · Cited by 19
Variation of the oxytocin/neurophysin I (OXT) gene in four human populations
Xu, Y., Xue, Y., Asan, Daly, A., Wu, L., & Tyler‐Smith, C. (2008) · Journal of Human Genetics · doi:10.1007/s10038-008-0292-0 · Cited by 13
Wang (1996) · doi:10.1002/(sici)1096-9861(19960318)366:4
Self-citation
Cited by
Sorted by citations
The origins and nature of compassion focused therapy
Gilbert, P. (2014) · British Journal of Clinical Psychology · doi:10.1111/bjc.12043 · Cited by 1,593
Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., DeRubeis, R. J., et al. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3628 · Cited by 1,292
Chanda, M. L., & Levitin, D. J. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.02.007 · Cited by 1,247
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
The neuroendocrinology of social isolation
Cacioppo, J. T., Cacioppo, S., Capitanio, J. P., & Cole, S. W. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015240 · Cited by 977
Metadata
- Authors
- Insel, T. R.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Insel, Thomas R.
- ORCID
- Insel, Thomas R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 65
- Issue
- 6
- Pages
- 768-779
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2847497
- OpenAlex
- W2166273490
- Cited by
- 1,044
- References
- 140
- Citations by year
- 2026: 30 · 2025: 30 · 2024: 32 · 2023: 53 · 2022: 57 · 2021: 64 · 2020: 68 · 2019: 65 · 2018: 73 · 2017: 72 · 2016: 76 · 2015: 75 · 2014: 98 · 2013: 80 · 2012: 89
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Keywords
- oxytocin, vasopressin, affiliative behavior, social cognition, oxytocin receptor, vasopressin V1a receptor, voles, social behavior genetics, reward systems, autism spectrum disorder, gender differences, steroid hormones, neuropeptides
- MeSH terms
- Animals, Humans, Nerve Net, Neurosciences, Oxytocin, Social Behavior, Protein Biosynthesis, Vasopressins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
