Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Abstract
Oxytocin binding (Bmax) was found to be higher in the ventral tegmental area (VTA) and the medial preoptic area (MPOA) at midparturition compared with Pregnancy Days 15-17 or Postpartum Days 5-7 in rat dams. Pup retrieval and assuming a nursing posture over pups were blocked in parturient dams by infusions of an oxytocin antagonist into the VTA or MPOA and by infusions of a vasopressin (V1) antagonist into the MPOA. These results implicate oxytocin in the VTA and MPOA and vasopressin in the MPOA, as well as a parturition-associated rise in oxytocin binding in these sites in the postpartum activation of maternal behavior.
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Onset of maternal behavior can be prevented by injection of an OTR antagonist into the VTA.
“The onset of maternal behavior can be prevented by injection of an OTR antagonist into the VTA (Pedersen et al 1994).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Pedersen et al 1994
The oxytocin and dopaminergic systems work in concert to promote rodent maternal behaviors.
“The oxytocin and dopaminergic systems have been shown to work in concert to promote rodent maternal behaviors56”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [56]
Oxytocin antagonists applied within the VTA impair both pup retrieval and time spent in nursing postures over pups in parturient dams.
“whereas oxytocin antagonists applied within the VTA impair both pup retrieval and time spent in nursing postures over pups in parturient dams (Pedersen et al., 1994).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Pedersen et al., 1994
Downstream oxytocin signalling specifically in the ventral tegmental area has been shown to affect pup retrieval.
“Downstream oxytocin signalling specifically in the ventral tegmental area (VTA)4,6,37,38 (Fig. 5a) has been shown to affect pup retrieval39.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [39]
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- Authors
- Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Pedersen, Cort A.
- Venue
- Behavioral Neuroscience
- Published
- 1994-12
- Volume
- 108
- Issue
- 6
- Pages
- 1163-1171
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2072080093
- Cited by
- 475
- References
- 48
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 14 · 2023: 12 · 2022: 18 · 2021: 19 · 2020: 31 · 2019: 21 · 2018: 22 · 2017: 27 · 2016: 32 · 2015: 24 · 2014: 26 · 2013: 24 · 2012: 16
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd025255-05)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 25255)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, maternal behavior, postpartum period, ventral tegmental area, medial preoptic area, vasopressin, childbirth, oxytocin antagonist, vasopressin V1 receptor antagonist, pup retrieval, rats
- MeSH terms
- Animals, Brain Mapping, Female, Labor, Obstetric, Lactation, Maternal Behavior, Oxytocin, Pregnancy, Pregnancy, Animal, Preoptic Area, Vasopressins, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats
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