Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species: Metabolism, oxidative stress, and signal transduction

Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723

Photocatalysis on TiO2 Surfaces: Principles, Mechanisms, and Selected Results

Linsebigler, A. L., Lu, G., & Yates, J. T. (1995) · Chemical Reviews · doi:10.1021/cr00035a013 · Cited by 11,575

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

Photodynamic therapy for cancer

Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1071 · Cited by 6,758

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452

Photodynamic therapy of cancer: An update

Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Carbon quantum dots and their applications

Lim, S. Y., Shen, W., & Gao, Z. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00269e · Cited by 4,976

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744

Photodynamic Therapy

Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., & Peng, Q. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.12.889 · Cited by 4,716

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373

Plasmonics for extreme light concentration and manipulation

Schuller, J. A., Barnard, E. S., Cai, W., Jun, Y. C., White, J. S., & Brongersma, M. L. (2010) · Nature Materials · doi:10.1038/nmat2630 · Cited by 4,364

Optical properties of biological tissues: A review

Jacques, S. L. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/11/r37 · Cited by 4,008

Integrins in cancer: biological implications and therapeutic opportunities

Desgrosellier, J. S., & Cheresh, D. A. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2748 · Cited by 3,736

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633

Reactive oxygen species in cancer

Liou, G.-Y., & Storz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,382

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172

Thermo- and pH-responsive polymers in drug delivery☆

SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023

Nanoparticles in Photodynamic Therapy

Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,980

Second window for in vivo imaging

Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848

The Fluorescent Toolbox for Assessing Protein Location and Function

Giepmans, B. N. G., Adams, S. R., Ellisman, M. H., & Tsien, R. Y. (2006) · Science · doi:10.1126/science.1124618 · Cited by 2,770

Antimicrobial activity of metals: mechanisms, molecular targets and applications

Lemire, J. A., Harrison, J. J., & Turner, R. J. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3028 · Cited by 2,746

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699

Photodynamic therapy and anti-tumour immunity

Castano, A. P., Mroz, P., & Hamblin, M. R. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1894 · Cited by 2,676

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662

Production of large amounts of hydrogen peroxide by human tumor cells.

Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,526

Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates

Costas, M., Mehn, M. P., Jensen, M. P., & Que, L. (2004) · Chemical Reviews · doi:10.1021/cr020628n · Cited by 2,472

Functional Nanomaterials for Phototherapies of Cancer

Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,425

Signal transduction by reactive oxygen species

Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322

Upconversion Luminescent Materials: Advances and Applications

Zhou, J., Liu, Q., Feng, W., Sun, Y., & Li, F. (2015) · Chemical Reviews · doi:10.1021/cr400478f · Cited by 2,254

Physical Mechanisms of Generation and Deactivation of Singlet Oxygen

Schweitzer, C., & Schmidt, R. (2003) · Chemical Reviews · doi:10.1021/cr010371d · Cited by 2,123

BODIPY dyes in photodynamic therapy

Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35216h · Cited by 2,104

Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy

Bonnett, R. (1995) · Chemical Society Reviews · doi:10.1039/cs9952400019 · Cited by 2,039

The role of porphyrin chemistry in tumor imaging and photodynamic therapy

Ethirajan, M., Chen, Y., Joshi, P., & Pandey, R. K. (2011) · Chem. Soc. Rev. · doi:10.1039/b915149b · Cited by 2,034

ROS stress in cancer cells and therapeutic implications

Pelicano, H., Carney, D., & Huang, P. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.01.004 · Cited by 2,006

Chemistry and biology of reactive oxygen species in signaling or stress responses

Dickinson, B. C., & Chang, C. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.607 · Cited by 1,821

Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

Carlson, C., Hussain, S. M., Schrand, A. M., K. Braydich-Stolle, L., Hess, K. L., Jones, R. L., & Schlager, J. J. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp712087m · Cited by 1,814

The present and future role of photodynamic therapy in cancer treatment

Brown, S. B., Brown, E. A., & Walker, I. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01529-3 · Cited by 1,771

Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects

Florea, A.-M., & Büsselberg, D. (2011) · Cancers · doi:10.3390/cancers3011351 · Cited by 1,759

Gold nanostructures: engineering their plasmonic properties for biomedical applications

Hu, M., Chen, J., Li, Z.-Y., Au, L., Hartland, G. V., Li, X., Marquez, M., & Xia, Y. (2006) · Chemical Society Reviews · doi:10.1039/b517615h · Cited by 1,756

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Manke, A., Wang, L., & Rojanasakul, Y. (2013) · BioMed Research International · doi:10.1155/2013/942916 · Cited by 1,727

Activatable Photosensitizers for Imaging and Therapy

Lovell, J. F., Liu, T. W. B., Chen, J., & Zheng, G. (2010) · Chemical Reviews · doi:10.1021/cr900236h · Cited by 1,717

Untitled work

(1989) · PubMed · Cited by 1,639

An overview of nanoparticles commonly used in fluorescent bioimaging

Wolfbeis, O. S. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00392f · Cited by 1,631

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Sabharwal, S. S., & Schumacker, P. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3803 · Cited by 1,622

Combining immunotherapy and targeted therapies in cancer treatment

Vanneman, M., & Dranoff, G. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3237 · Cited by 1,586

Controlling upconversion nanocrystals for emerging applications

Zhou, B., Shi, B., Jin, D., & Liu, X. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.251 · Cited by 1,503

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,499

In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers

Idris, N. M., Gnanasammandhan, M. K., Zhang, J., Ho, P. C., Mahendran, R., & Zhang, Y. (2012) · Nature Medicine · doi:10.1038/nm.2933 · Cited by 1,464

A review of NIR dyes in cancer targeting and imaging

Luo, S., Zhang, E., Su, Y., Cheng, T., & Shi, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.024 · Cited by 1,432

A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Ge, J., Lan, M., Zhou, B., Liu, W., Guo, L., Wang, H., Jia, Q., Niu, G., Huang, X., Zhou, H., et al. (2014) · Nature Communications · doi:10.1038/ncomms5596 · Cited by 1,406

Mechanisms of nanotoxicity: Generation of reactive oxygen species

Fu, P. P., Xia, Q., Hwang, H.-M., Ray, P. C., & Yu, H. (2014) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2014.01.005 · Cited by 1,398

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Estrella, V., Chen, T., Lloyd, M., Wojtkowiak, J., Cornnell, H. H., Ibrahim-Hashim, A., Bailey, K., Balagurunathan, Y., Rothberg, J. M., Sloane, B. F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2796 · Cited by 1,397

Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

Hong, G., Diao, S., Antaris, A. L., & Dai, H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00008 · Cited by 1,394

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Zhang, C., Bu, W., Ni, D., Zhang, S., Li, Q., Yao, Z., Zhang, J., Yao, H., Wang, Z., & Shi, J. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510031 · Cited by 1,269

Singlet oxygen: there is indeed something new under the sun

Ogilby, P. R. (2010) · Chemical Society Reviews · doi:10.1039/b926014p · Cited by 1,266

Persistent oxidative stress in cancer

Toyokuni, S., Okamoto, K., Yodoi, J., & Hiai, H. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01368-b · Cited by 1,219

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

Soignet, S. L., Maslak, P., Wang, Z.-G., Jhanwar, S., Calleja, E., Dardashti, L. J., Corso, D., DeBlasio, A., Gabrilove, J., Scheinberg, D. A., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391901 · Cited by 1,213

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Dong, H., Du, S.-R., Zheng, X.-Y., Lyu, G.-M., Sun, L.-D., Li, L.-D., Zhang, P.-Z., Zhang, C., & Yan, C.-H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00091 · Cited by 1,126

Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica

Mal, N. K., Fujiwara, M., & Tanaka, Y. (2003) · Nature · doi:10.1038/nature01362 · Cited by 1,094

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

Trachootham, D., Zhou, Y., Zhang, H., Demizu, Y., Chen, Z., Pelicano, H., Chiao, P. J., Achanta, G., Arlinghaus, R. B., Liu, J., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.009 · Cited by 1,080

Low-potential stable NADH detection at carbon-nanotube-modified glassy carbon electrodes

Musameh, M., Wang, J., Merkoci, A., & Lin, Y. (2002) · Electrochemistry Communications · doi:10.1016/s1388-2481(02)00451-4 · Cited by 1,066

Through-skull fluorescence imaging of the brain in a new near-infrared window

Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,061

The physics, biophysics and technology of photodynamic therapy

Wilson, B. C., & Patterson, M. S. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/9/r01 · Cited by 1,006

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

He, C., Liu, D., & Lin, W. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00125 · Cited by 1,001

Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics

Hola, K., Zhang, Y., Wang, Y., Giannelis, E. P., Zboril, R., & Rogach, A. L. (2014) · Nano Today · doi:10.1016/j.nantod.2014.09.004 · Cited by 992

In vitro and in vivo two-photon luminescence imaging of single gold nanorods

Wang, H., Huff, T. B., Zweifel, D. A., He, W., Low, P. S., Wei, A., & Cheng, J.-X. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504892102 · Cited by 950

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947

Balancing repair and tolerance of DNA damage caused by alkylating agents

Fu, D., Calvo, J. A., & Samson, L. D. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3185 · Cited by 947

Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941

A Review of Progress in Clinical Photodynamic Therapy

Huang, Z. (2005) · Technology in Cancer Research & Treatment · doi:10.1177/153303460500400308 · Cited by 908

Recent progress in tumor pH targeting nanotechnology

Lee, E. S., Gao, Z., & Bae, Y. H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.003 · Cited by 866

A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms

Shu, X., Lev-Ram, V., Deerinck, T. J., Qi, Y., Ramko, E. B., Davidson, M. W., Jin, Y., Ellisman, M. H., & Tsien, R. Y. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001041 · Cited by 827

Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles

Wang, C., Tao, H., Cheng, L., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.007 · Cited by 824

The tumour microenvironment as a target for chemoprevention

Albini, A., & Sporn, M. B. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2067 · Cited by 823

H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells

Chen, H., Tian, J., He, W., & Guo, Z. (2015) · Journal of the American Chemical Society · doi:10.1021/ja511420n · Cited by 813

Self-illuminating quantum dot conjugates for in vivo imaging

So, M.-K., Xu, C., Loening, A. M., Gambhir, S. S., & Rao, J. (2006) · Nature Biotechnology · doi:10.1038/nbt1188 · Cited by 807

Applications of Aptamers as Sensors

Cho, E. J., Lee, J.-W., & Ellington, A. D. (2009) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.112851 · Cited by 788

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

Wang, Y., Zhou, K., Huang, G., Hensley, C., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J. (2014) · Nature Materials · doi:10.1038/nmat3819 · Cited by 773

Clinical Translation of Nanomedicine

Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 772

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

Šimůnek, T., Štěrba, M., Popelová, O., Adamcová, M., Hrdina, R., & Geršl, V. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70018-0 · Cited by 769

Reactive oxygen species generation and signaling in plants

Tripathy, B. C., & Oelmüller, R. (2012) · Plant Signaling & Behavior · doi:10.4161/psb.22455 · Cited by 764

Nanoparticles as vehicles for delivery of photodynamic therapy agents

Bechet, D., Couleaud, P., Frochot, C., Viriot, M.-L., Guillemin, F., & Barberi-Heyob, M. (2008) · Trends in Biotechnology · doi:10.1016/j.tibtech.2008.07.007 · Cited by 760

Overview of Therapeutic Ultrasound Applications and Safety Considerations

Miller, D. L., Smith, N. B., Bailey, M. R., Czarnota, G. J., Hynynen, K., Makin, I. R. S., & Bioeffects Committee of the American Institute of Ultrasound in Medicine (2012) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2012.31.4.623 · Cited by 752

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach

Fang, X., & Tan, W. (2010) · Accounts of Chemical Research · doi:10.1021/ar900101s · Cited by 747

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

Gupta, S. C., Hevia, D., Patchva, S., Park, B., Koh, W., & Aggarwal, B. B. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4414 · Cited by 732

Subcellular targeting strategies for drug design and delivery

Rajendran, L., Knölker, H.-J., & Simons, K. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2897 · Cited by 708

Light‐Triggered Theranostics Based on Photosensitizer‐Conjugated Carbon Dots for Simultaneous Enhanced‐Fluorescence Imaging and Photodynamic Therapy

Huang, P., Lin, J., Wang, X., Wang, Z., Zhang, C., He, M., Wang, K., Chen, F., Li, Z., Shen, G., et al. (2012) · Advanced Materials · doi:10.1002/adma.201200650 · Cited by 703

Photoradiation Therapy. II. Cure of Animal Tumors With Hematoporphyrin and Light23

Dougherty, T. J., Grindey, G. B., Fiel, R., Weishaupt, K. R., & Boyle, D. G. (1975) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/55.1.115 · Cited by 693

Drug-induced oxidative stress and toxicity

Deavall, D. G., Martin, E. A., Horner, J. M., & Roberts, R. (2012) · Journal of Toxicology · doi:10.1155/2012/645460 · Cited by 689

Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

Lin, J., Wang, S., Huang, P., Wang, Z., Chen, S., Niu, G., Li, W., He, J., Cui, D., Lu, G., et al. (2013) · ACS Nano · doi:10.1021/nn4011686 · Cited by 661

Iron Oxychloride (FeOCl): An Efficient Fenton-Like Catalyst for Producing Hydroxyl Radicals in Degradation of Organic Contaminants

Yang, X.-J., Xu, X.-M., Xu, J., & Han, Y.-F. (2013) · Journal of the American Chemical Society · doi:10.1021/ja409130c · Cited by 647

Tumor microenvironment: The role of the tumor stroma in cancer

Li, H., Fan, X., & Houghton, J. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21159 · Cited by 646

Acidic and basic properties of hydroxylated metal oxide surfaces

Boehm, H. P. (1971) · Discussions of the Faraday Society · doi:10.1039/df9715200264 · Cited by 628

Studies on Treatment of Acute Promyelocytic Leukemia With Arsenic Trioxide: Remission Induction, Follow-Up, and Molecular Monitoring in 11 Newly Diagnosed and 47 Relapsed Acute Promyelocytic Leukemia Patients

Niu, C., Yan, H., Yu, T., Sun, H.-P., Liu, J.-X., Li, X.-S., Wu, W., Zhang, F.-Q., Chen, Y., Zhou, L., et al. (1999) · Blood · doi:10.1182/blood.v94.10.3315.422k16_3315_3324 · Cited by 625

Mesoporous‐Silica‐Coated Up‐Conversion Fluorescent Nanoparticles for Photodynamic Therapy

Qian, H. S., Guo, H. C., Ho, P. C., Mahendran, R., & Zhang, Y. (2009) · Small · doi:10.1002/smll.200900692 · Cited by 619

5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research

Peng, Q., Berg, K., Moan, J., Kongshaug, M., & Nesland, J. M. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08549.x · Cited by 615

Beating cancer in multiple ways using nanogold

Dreaden, E. C., Mackey, M. A., Huang, X., Kang, B., & El-Sayed, M. A. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00180e · Cited by 605

Versatile Photosensitizers for Photodynamic Therapy at Infrared Excitation

Zhang, P., Steelant, W., Kumar, M., & Scholfield, M. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0700707 · Cited by 600

Biocompatible Polymeric Nanoparticles Degrade and Release Cargo in Response to Biologically Relevant Levels of Hydrogen Peroxide

de Gracia Lux, C., Joshi-Barr, S., Nguyen, T., Mahmoud, E., Schopf, E., Fomina, N., & Almutairi, A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303372u · Cited by 598

A genetically encoded photosensitizer

Bulina, M. E., Chudakov, D. M., Britanova, O. V., Yanushevich, Y. G., Staroverov, D. B., Chepurnykh, T. V., Merzlyak, E. M., Shkrob, M. A., Lukyanov, S., & Lukyanov, K. A. (2006) · Nature Biotechnology · doi:10.1038/nbt1175 · Cited by 589

Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy

Zhu, W., Dong, Z., Fu, T., Liu, J., Chen, Q., Li, Y., Zhu, R., Xu, L., & Liu, Z. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600676 · Cited by 588

Perfluorocarbon‐Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer

Song, G., Liang, C., Yi, X., Zhao, Q., Cheng, L., Yang, K., & Liu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201504617 · Cited by 587

Upconverting nanoparticles: a versatile platform for wide-field two-photon microscopy and multi-modal in vivo imaging

Park, Y. I., Lee, K. T., Suh, Y. D., & Hyeon, T. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00173g · Cited by 571

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

Doroshow, J. H., & Davies, K. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35747-2 · Cited by 540

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Huang, P., Xu, C., Lin, J., Wang, C., Wang, X., Zhang, C., Zhou, X., Guo, S., & Cui, D. (2011) · Theranostics · doi:10.7150/thno/v01p0240 · Cited by 535

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S.-I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H., & Hara, E. (2006) · Nature Cell Biology · doi:10.1038/ncb1491 · Cited by 528

A Mitochondria‐Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia

Lv, W., Zhang, Z., Zhang, K. Y., Yang, H., Liu, S., Xu, A., Guo, S., Zhao, Q., & Huang, W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604130 · Cited by 523

Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence

Zhang, C., Zhao, K., Bu, W., Ni, D., Liu, Y., Feng, J., & Shi, J. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201408472 · Cited by 516

A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

Mi, P., Kokuryo, D., Cabral, H., Wu, H., Terada, Y., Saga, T., Aoki, I., Nishiyama, N., & Kataoka, K. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.72 · Cited by 512

NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions

Machleidt, T., Woodroofe, C. C., Schwinn, M. K., Méndez, J., Robers, M. B., Zimmerman, K., Otto, P., Daniels, D. L., Kirkland, T. A., & Wood, K. V. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00143 · Cited by 491

CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin

Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481

Upconversion Nanoparticles for Photodynamic Therapy and Other Cancer Therapeutics

Wang, C., Cheng, L., & Liu, Z. (2013) · Theranostics · doi:10.7150/thno.5284 · Cited by 456

Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome‐Localized Photosensitizers for Two‐Photon Photodynamic Therapy

Huang, H., Yu, B., Zhang, P., Huang, J., Chen, Y., Gasser, G., Ji, L., & Chao, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201507800 · Cited by 449

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

Kawanishi, S., Hiraku, Y., Pinlaor, S., & Ma, N. (2006) · Biological Chemistry · doi:10.1515/bc.2006.049 · Cited by 449

Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome

Li, W.-P., Su, C.-H., Chang, Y.-C., Lin, Y.-J., & Yeh, C.-S. (2016) · ACS Nano · doi:10.1021/acsnano.5b06175 · Cited by 437

Femtosecond Absorption Spectroscopy of Transition Metal Charge-Transfer Complexes

McCusker, J. K. (2003) · Accounts of Chemical Research · doi:10.1021/ar030111d · Cited by 433

Cell-Specific and pH-Activatable Rubyrin-Loaded Nanoparticles for Highly Selective Near-Infrared Photodynamic Therapy against Cancer

Tian, J., Ding, L., Xu, H.-J., Shen, Z., Ju, H., Jia, L., Bao, L., & Yu, J.-S. (2013) · Journal of the American Chemical Society · doi:10.1021/ja408286k · Cited by 416

Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers

Kotagiri, N., Sudlow, G. P., Akers, W. J., & Achilefu, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.17 · Cited by 404

Mice Lacking Catalase Develop Normally but Show Differential Sensitivity to Oxidant Tissue Injury

Ho, Y.-S., Xiong, Y., Ma, W., Spector, A., & Ho, D. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404800200 · Cited by 403

Theranostic Probe Based on Lanthanide‐Doped Nanoparticles for Simultaneous In Vivo Dual‐Modal Imaging and Photodynamic Therapy

Park, Y. I., Kim, H. M., Kim, J. H., Moon, K. C., Yoo, B., Lee, K. T., Lee, N., Choi, Y., Park, W., Ling, D., et al. (2012) · Advanced Materials · doi:10.1002/adma.201202433 · Cited by 395

Blood-vessel closure using photosensitizers engineered for two-photon excitation

Collins, H. A., Khurana, M., Moriyama, E. H., Mariampillai, A., Dahlstedt, E., Balaz, M., Kuimova, M. K., Drobizhev, M., Yang, V. X. D., Phillips, D., et al. (2008) · Nature Photonics · doi:10.1038/nphoton.2008.100 · Cited by 395

Energy transfer in a bioluminescent system

Morin, J. G., & Hastings, J. W. (1971) · Journal of Cellular Physiology · doi:10.1002/jcp.1040770305 · Cited by 393

Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications

Idris, N. M., Jayakumar, M. K. G., Bansal, A., & Zhang, Y. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00158c · Cited by 385

A review of in‐vivo optical properties of human tissues and its impact on PDT

Sandell, J. L., & Zhu, T. C. (2011) · Journal of Biophotonics · doi:10.1002/jbio.201100062 · Cited by 384

Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells

Liu, K., Liu, X., Zeng, Q., Zhang, Y., Tu, L., Liu, T., Kong, X., Wang, Y., Cao, F., Lambrechts, S. A. G., et al. (2012) · ACS Nano · doi:10.1021/nn300436b · Cited by 382

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

Chen, H., Wang, G. D., Chuang, Y.-J., Zhen, Z., Chen, X., Biddinger, P., Hao, Z., Liu, F., Shen, B., Pan, Z., et al. (2015) · Nano Letters · doi:10.1021/nl504044p · Cited by 381

Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization

Wang, S., Huang, P., & Chen, X. (2016) · Advanced Materials · doi:10.1002/adma.201601498 · Cited by 381

The Challenge To Relate the Physicochemical Properties of Colloidal Nanoparticles to Their Cytotoxicity

Rivera-Gil, P., Jimenez De Aberasturi, D., Wulf, V., Pelaz, B., Del Pino, P., Zhao, Y., De La Fuente, J. M., Ruiz De Larramendi, I., Rojo, T., Liang, X.-J., et al. (2013) · Accounts of Chemical Research · doi:10.1021/ar300039j · Cited by 376

Photochromic Metal–Organic Frameworks: Reversible Control of Singlet Oxygen Generation

Park, J., Feng, D., Yuan, S., & Zhou, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201408862 · Cited by 376

Titania Coated Upconversion Nanoparticles for Near-Infrared Light Triggered Photodynamic Therapy

Lucky, S. S., Muhammad Idris, N., Li, Z., Huang, K., Soo, K. C., & Zhang, Y. (2015) · ACS Nano · doi:10.1021/nn503450t · Cited by 376

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

Huang, C.-C., Chia, W.-T., Chung, M.-F., Lin, K.-J., Hsiao, C.-W., Jin, C., Lim, W.-H., Chen, C.-C., & Sung, H.-W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01784 · Cited by 372

Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy

Ozlem, S., & Akkaya, E. U. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808389t · Cited by 372

Reactive Oxygen Species in Cancer: A Dance with the Devil

Schumacker, P. T. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.01.007 · Cited by 367

Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy

Wang, J., Zhu, G., You, M., Song, E., Shukoor, M. I., Zhang, K., Altman, M. B., Chen, Y., Zhu, Z., Huang, C. Z., et al. (2012) · ACS Nano · doi:10.1021/nn300694v · Cited by 357

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Kamkaew, A., Chen, F., Zhan, Y., Majewski, R. L., & Cai, W. (2016) · ACS Nano · doi:10.1021/acsnano.6b01401 · Cited by 355

Current Progress in Reactive Oxygen Species (ROS)‐Responsive Materials for Biomedical Applications

Lee, S. H., Gupta, M. K., Bang, J. B., Bae, H., & Sung, H. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201200423 · Cited by 351

Supramolecular Photonic Therapeutic Agents

McDonnell, S. O., Hall, M. J., Allen, L. T., Byrne, A., Gallagher, W. M., & O'Shea, D. F. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0553497 · Cited by 346

Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor.

Henderson, B. W., & Fingar, V. H. (1987) · PubMed · Cited by 342

Perfluorocarbon‐Based Oxygen Carriers: Review of Products and Trials

Castro, C. I., & Briceno, J. C. (2010) · Artificial Organs · doi:10.1111/j.1525-1594.2009.00944.x · Cited by 334

ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., Yoon, H. I., Cho, Y. W., Swierczewska, M., Lee, S., et al. (2016) · Scientific Reports · doi:10.1038/srep23200 · Cited by 327

Genetically encoded biosensors based on engineered fluorescent proteins

Frommer, W. B., Davidson, M. W., & Campbell, R. E. (2009) · Chemical Society Reviews · doi:10.1039/b907749a · Cited by 319

Singlet-Oxygen Chemiluminescence in Peroxide Reactions

Adam, W., Kazakov, D. V., & Kazakov, V. P. (2005) · Chemical Reviews · doi:10.1021/cr0300035 · Cited by 313

Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation

Zheng, G., Chen, J., Stefflova, K., Jarvi, M., Li, H., & Wilson, B. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611142104 · Cited by 303

Plasmonic nanomaterials for biodiagnostics

D. Howes, P., Rana, S., & M. Stevens, M. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60346f · Cited by 302

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

Shieh, Y.-A., Yang, S.-J., Wei, M.-F., & Shieh, M.-J. (2010) · ACS Nano · doi:10.1021/nn901374b · Cited by 299

Hyperbaric oxygen therapy and cancer—a review

Moen, I., & Stuhr, L. E. B. (2012) · Targeted Oncology · doi:10.1007/s11523-012-0233-x · Cited by 298

Nanophotosensitizers toward advanced photodynamic therapy of Cancer

Lim, C.-K., Heo, J., Shin, S., Jeong, K., Seo, Y. H., Jang, W.-D., Park, C. R., Park, S. Y., Kim, S., & Kwon, I. C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.09.012 · Cited by 293

Singlet Oxygen Production by Peptide-Coated Quantum Dot−Photosensitizer Conjugates

Tsay, J. M., Trzoss, M., Shi, L., Kong, X., Selke, M., Jung, M. E., & Weiss, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja070713i · Cited by 291

Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity

Ramanathan, B., Jan, K.-Y., Chen, C.-H., Hour, T.-C., Yu, H.-J., & Pu, Y.-S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1162 · Cited by 287

Ultrasound imaging

Wells, P. N. T. (2006) · Physics in Medicine and Biology · doi:10.1088/0031-9155/51/13/r06 · Cited by 287

Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy

Punjabi, A., Wu, X., Tokatli-Apollon, A., El-Rifai, M., Lee, H., Zhang, Y., Wang, C., Liu, Z., Chan, E. M., Duan, C., et al. (2014) · ACS Nano · doi:10.1021/nn505051d · Cited by 284

Synergistic Assembly of Heavy Metal Clusters and Luminescent Organic Bridging Ligands in Metal–Organic Frameworks for Highly Efficient X-ray Scintillation

Wang, C., Volotskova, O., Lu, K., Ahmad, M., Sun, C., Xing, L., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja500671h · Cited by 283

Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3

Chen, H., Niu, G., Wu, H., & Chen, X. (2016) · Theranostics · doi:10.7150/thno.13242 · Cited by 282

Quantum Dot/Bioluminescence Resonance Energy Transfer Based Highly Sensitive Detection of Proteases

Yao, H., Zhang, Y., Xiao, F., Xia, Z., & Rao, J. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700280 · Cited by 275

A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

Turan, I. S., Yildiz, D., Turksoy, A., Gunaydin, G., & Akkaya, E. U. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201511345 · Cited by 274

Storable, thermally activated, near-infrared chemiluminescent dyes and dye-stained microparticles for optical imaging

Baumes, J. M., Gassensmith, J. J., Giblin, J., Lee, J.-J., White, A. G., Culligan, W. J., Leevy, W. M., Kuno, M., & Smith, B. D. (2010) · Nature Chemistry · doi:10.1038/nchem.871 · Cited by 273

Photoactivation switch from type II to type I reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia

Ding, H., Yu, H., Dong, Y., Tian, R., Huang, G., Boothman, D. A., Sumer, B. D., & Gao, J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.019 · Cited by 271

Nanocomposite‐Based Photodynamic Therapy Strategies for Deep Tumor Treatment

Hu, J., Tang, Y., Elmenoufy, A. H., Xu, H., Cheng, Z., & Yang, X. (2015) · Small · doi:10.1002/smll.201501923 · Cited by 262

Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy

Wu, X., Chen, J., Wu, M., & Zhao, J. X. (2015) · Theranostics · doi:10.7150/thno.10257 · Cited by 258

Enhancement of the Catalytic Activity of Supported Gold Nanoparticles for the Fenton Reaction by Light

Navalon, S., de Miguel, M., Martin, R., Alvaro, M., & Garcia, H. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108816p · Cited by 254

Carbon‐Nanotube‐Based Glucose/O2 Biofuel Cells

Yan, Y., Zheng, W., Su, L., & Mao, L. (2006) · Advanced Materials · doi:10.1002/adma.200600028 · Cited by 252

On The Latest Three‐Stage Development of Nanomedicines based on Upconversion Nanoparticles

Fan, W., Bu, W., & Shi, J. (2016) · Advanced Materials · doi:10.1002/adma.201505678 · Cited by 252

Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid

Yuan, Q., Zhang, Y., Chen, T., Lu, D., Zhao, Z., Zhang, X., Li, Z., Yan, C.-H., & Tan, W. (2012) · ACS Nano · doi:10.1021/nn3018365 · Cited by 251

A threshold concept for cancer therapy

Kong, Q., Beel, J. A., & Lillehei, K. O. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0982 · Cited by 250

Quantum Dot/Bioluminescence Resonance Energy Transfer Based Highly Sensitive Detection of Proteases

Yao, H., Zhang, Y., Xiao, F., Xia, Z., & Rao, J. (2007) · Angewandte Chemie · doi:10.1002/ange.200700280 · Cited by 249

Protease-Activated Drug Development

Choi, K. Y., Swierczewska, M., Lee, S., & Chen, X. (2012) · Theranostics · doi:10.7150/thno.4068 · Cited by 245

Singlet Oxygen Generation via Two-Photon Excited FRET

Dichtel, W. R., Serin, J. M., Edder, C., Fréchet, J. M. J., Matuszewski, M., Tan, L.-S., Ohulchanskyy, T. Y., & Prasad, P. N. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031647x · Cited by 243

New Two-Photon Activated Photodynamic Therapy Sensitizers Induce Xenograft Tumor Regressions after Near-IR Laser Treatment through the Body of the Host Mouse

Starkey, J. R., Rebane, A. K., Drobizhev, M. A., Meng, F., Gong, A., Elliott, A., McInnerney, K., & Spangler, C. W. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4162 · Cited by 242

Dual‐Stage‐Light‐Guided Tumor Inhibition by Mitochondria‐Targeted Photodynamic Therapy

Han, K., Lei, Q., Wang, S., Hu, J., Qiu, W., Zhu, J., Yin, W., Luo, X., & Zhang, X. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500590 · Cited by 241

Principles of two-photon excitation fluorescence microscopy and other nonlinear imaging approaches

Oheim, M., Michael, D. J., Geisbauer, M., Madsen, D., & Chow, R. H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.005 · Cited by 241

The emerging role of reactive oxygen species in cancer therapy

Renschler, M. F. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.02.031 · Cited by 237

ROS as a tumour suppressor?

Ramsey, M. R., & Sharpless, N. E. (2006) · Nature Cell Biology · doi:10.1038/ncb1106-1213 · Cited by 237

Physical, Chemical, and Biological Structures based on ROS‐Sensitive Moieties that are Able to Respond to Oxidative Microenvironments

Tapeinos, C., & Pandit, A. (2016) · Advanced Materials · doi:10.1002/adma.201505376 · Cited by 237

Photodynamic Therapy for Cancer: Principles

Wilson, B. C. (2002) · Canadian Journal of Gastroenterology · doi:10.1155/2002/743109 · Cited by 232

Singlet oxygen-induced apoptosis of cancer cells using upconversion fluorescent nanoparticles as a carrier of photosensitizer

Guo, H., Qian, H., Idris, N. M., & Zhang, Y. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2009.11.004 · Cited by 226

Triple-functional core–shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro

Qiao, X.-F., Zhou, J.-C., Xiao, J.-W., Wang, Y.-F., Sun, L.-D., & Yan, C.-H. (2012) · Nanoscale · doi:10.1039/c2nr30938f · Cited by 224

A New Method To Determine the Generation of Hydroxyl Radicals in Illuminated TiO2Suspensions

Schwarz, P. F., Turro, N. J., Bossmann, S. H., Braun, A. M., Wahab, A.-M. A. A., & Dürr, H. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp971315c · Cited by 223

Red Blood Cell‐Facilitated Photodynamic Therapy for Cancer Treatment

Tang, W., Zhen, Z., Wang, M., Wang, H., Chuang, Y., Zhang, W., Wang, G. D., Todd, T., Cowger, T., Chen, H., et al. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504803 · Cited by 215

Aptamer–Drug Conjugates

Zhu, G., Niu, G., & Chen, X. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00291 · Cited by 213

Dual-Surface Modified Virus Capsids for Targeted Delivery of Photodynamic Agents to Cancer Cells

Stephanopoulos, N., Tong, G. J., Hsiao, S. C., & Francis, M. B. (2010) · ACS Nano · doi:10.1021/nn1014769 · Cited by 211

Nanoscale theranostics for physical stimulus-responsive cancer therapies

Chen, Q., Ke, H., Dai, Z., & Liu, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.018 · Cited by 210

Remote‐Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide‐Modified Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy

Kolemen, S., Ozdemir, T., Lee, D., Kim, G. M., Karatas, T., Yoon, J., & Akkaya, E. U. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510064 · Cited by 207

Perfluorochemical Emulsions Can Increase Tumor Radiosensitivity

Teicher, B. A., & Rose, C. M. (1984) · Science · doi:10.1126/science.6695191 · Cited by 204

Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions.

Spahn, D. R. (1999) · Critical Care · doi:10.1186/cc364 · Cited by 200

Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG

Qi, Y. B., Garren, E. J., Shu, X., Tsien, R. Y., & Jin, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204096109 · Cited by 200

A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics

Tian, J., Zhou, J., Shen, Z., Ding, L., Yu, J.-S., & Ju, H. (2015) · Chemical Science · doi:10.1039/c5sc01721a · Cited by 197

Strong Two-Photon Absorption of Self-Assembled Butadiyne-Linked Bisporphyrin

Ogawa, K., Ohashi, A., Kobuke, Y., Kamada, K., & Ohta, K. (2003) · Journal of the American Chemical Society · doi:10.1021/ja035056i · Cited by 191

X-Ray-Induced Nanoparticle-Based Photodynamic Therapy of Cancer

Zou, X., Yao, M., Ma, L., Hossu, M., Han, X., Juzenas, P., & Chen, W. (2014) · Nanomedicine · doi:10.2217/nnm.13.198 · Cited by 186

Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer‐Guided G‐Quadruplex DNA Carrier and Near‐Infrared Light

Yuan, Q., Wu, Y., Wang, J., Lu, D., Zhao, Z., Liu, T., Zhang, X., & Tan, W. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201305707 · Cited by 185

A genetically targetable near-infrared photosensitizer

He, J., Wang, Y., Missinato, M. A., Onuoha, E., Perkins, L. A., Watkins, S. C., St Croix, C. M., Tsang, M., & Bruchez, M. P. (2016) · Nature Methods · doi:10.1038/nmeth.3735 · Cited by 181

The Role of Oxygen in Cutaneous Photodynamic Therapy

Fuchs, J., & Thiele, J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00370-5 · Cited by 177

Protease-Triggered Photosensitizing Beacon Based on Singlet Oxygen Quenching and Activation

Chen, J., Stefflova, K., Niedre, M. J., Wilson, B. C., Chance, B., Glickson, J. D., & Zheng, G. (2004) · Journal of the American Chemical Society · doi:10.1021/ja047392k · Cited by 175

Effects of Surface Chemistry on the Generation of Reactive Oxygen Species by Copper Nanoparticles

Shi, M., Kwon, H. S., Peng, Z., Elder, A., & Yang, H. (2012) · ACS Nano · doi:10.1021/nn300445d · Cited by 175

Pharmacokinetics and Side Effects of Perfluorocarbon-Based Blood Substitutes

Flaim, S. F. (1994) · Artificial Cells, Blood Substitutes, and Biotechnology · doi:10.3109/10731199409138801 · Cited by 174

Reactive Oxygen Species Mediated Activation of a Dormant Singlet Oxygen Photosensitizer: From Autocatalytic Singlet Oxygen Amplification to Chemicontrolled Photodynamic Therapy

Durantini, A. M., Greene, L. E., Lincoln, R., Martínez, S. R., & Cosa, G. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b10288 · Cited by 174

A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS

Yu, Z., Pan, W., Li, N., & Tang, B. (2016) · Chemical Science · doi:10.1039/c6sc00737f · Cited by 173

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813

Photosensitizers for Photodynamic Therapy

Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081

Second near-infrared photothermal materials for combinational nanotheranostics

Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941

Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications

Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Cai, X., & Liu, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000845 · Cited by 796