A new and rapid colorimetric determination of acetylcholinesterase activity

Ellman, George L., Courtney, K.Diane, Andres, Valentino, Featherstone, Robert M.·1961·Biochemical Pharmacology

DOI 10.1016/0006-2952(61)90145-9

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Makhaeva, G. F., Kovaleva, N. V., Boltneva, N. P., Lushchekina, S. V., Astakhova, T. Y., Rudakova, E. V., Proshin, A. N., Serkov, I. V., Radchenko, E. V., Palyulin, V. A., et al. (2020) · Molecules · doi:10.3390/molecules25173915 · Cited by 53
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“The activity of AChE (µmol/min/mg) was determined at 412 nm, using the method of Ellman et al. (1961) with slight modifications [89].”
Method
Equilibrium constants of the reactions of choline acetyltransferase, carnitine acetyltransferase, and acetylcholinesterase under physiological conditions.
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“A microtiter plate version of the Ellman’s assay was used to determine the activity of human and Torpedo californica acetylcholinesterase enzymes [27].”
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“It was established by Ellman et al. (1961) and is based on the reaction of thiocholine (one of the products of enzymatic hydrolysis of acetylthiocholine) with DTNB (Ellman’s reagent), forming a yellow product (5-mercapto- 2-nitrobenzoic acid and its dissociated forms) at pH 8 which can be detected at 405 nm (Komersova…”
Background
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Ecdysteroids from the flowers of Aerva javanica
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Authors: Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M.
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 1961-07
Volume: 7
Issue: 2
Pages: 88-95
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/0006-2952(61)90145-9
OpenAlex: W1971048984
Cited by: 27,126
References: 0
FWCI: 16.87
Type: journal article
Language: en
Open access: closed

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A new and rapid colorimetric determination of acetylcholinesterase activity

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